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| 1 | Characteristics of postintensive care syndrome in survivors of pediatric critical illness: A systematic review显示文摘AIM To synthesize the available evidence focusing on morbidities in pediatric survivors of critical illness that fall within the defined construct of postintensive care syndrome(PICS) in adults, including physical, neurocognitive and psychological morbidities.METHODS A comprehensive search was conducted in MEDLINE, EMBASE, the Cochrane Library, Psyc INFO, and CINAHL using controlled vocabulary and key word terms to identify studies reporting characteristics of PICS in pediatric intensive care unit(PICU) patients. Two reviewers independently screened all titles and abstracts and performed data extraction. From the 3176 articles identified in the search, 252 abstracts were identified for full text review and nineteen were identified for inclusion in the review. All studies reporting characteristics of PICS in PICU patients were included in the final synthesis. RESULTS Nineteen studies meeting inclusion criteria published between 1995 and 2016 were identified and categorized into studies reporting morbidities in each of three categories-physical, neurocognitive and psychological. The majority of included articles reported prospective cohort studies, and there was significant variability in the outcome measures utilized. A synthesis of the studies indicate that morbidities encompassing PICS are well-described in children who have survived critical illness, often resolving over time. Risk factors for development of these morbidities include younger age, lower socioeconomic status, increased number of invasive procedures or interventions, type of illness, and increased benzodiazepine andnarcotic administration.CONCLUSION PICS-related morbidities impact a significant proportion of children discharged from PICUs. In order to further define PICS in children, more research is needed using standardized tools to better understand the scope and natural history of morbidities after hospital discharge. Improving our understanding of physical, neurocognitive, and psychological morbidities after critical illness in the pediatric population is imperative for designing interventions to improve long-term outcomes in PICU patients. | Elizabeth A Herrup Beth Wieczorek Sapna R Kudchadkar | 2017 | World Journal of Critical Care Medicine2017，6，2： | 7 |
| 2 | CDC25 mitotic inducer targeted by Chk1 DNA damage checkpoint kinase显示文摘 | Beth F Nicholas R Paul R | 1997 | Science1997，277，： | 1 |
| 3 | Serelaxin, recombinant human relaxin-2, for treatment of acute heart failure (RELAX-AHF): a randomised, placebo-controlled trial显示文摘 | John R Teerlink Gad Cotter Beth A Davison G Michael Felker Gerasimos Filippatos Barry H Greenberg Piotr Ponikowski Elaine Unemori Adriaan A Voors Kirkwood F Adams Maria I Dorobantu Liliana R Grinfeld Guillaume Jondeau Alon Marmor Josep Masip Peter S Pang | 2013 | The Lancet . 2013 (9860)2013，，9860： | 1 |
| 4 | Mechanical detection and measurement of the angular momentum of light显示文摘 | Beth R A | 1936 | Physical Review1936，50，2： | 1 |
| 5 | Peritoneal dialysis-relatedinfections recommendations:2005update显示文摘 | Beth P George R Bailie | 2006 | Perit Dial Int2006，，25： | 1 |
| 6 | Mechanical detection and measurement of the angualar momentum of light显示文摘 | Beth R A | 1936 | Phys Rev1936，50，： | 1 |
| 7 | An unusual presentation of emphysematous cystitis显示文摘 | John Weddle Beth Brunton David R Rittenhouse | 1998 | American Journal of Emergency Medicine1998，，7： | 1 |
| 8 | Balloon kyphoplastyfor the treatment of pathological fractures in the thoracicand lumbar spine caused by metastasis:one-year follow-up显示文摘 | Pflugmacher R Beth P Schroeder RJ | 2007 | Acta Radiol2007，48，1： | 1 |
| 9 | Mechanical detection and measurement of the angular momentum of light 显示文摘 | BETH R | 1936 | Physical Review1936，50，： | 1 |
| 10 | Trust-based navigation in distributed systems显示文摘 | Yahalom R Klein B Beth T | 1994 | Journal of Computing Systems1994，，： | 1 |
| 11 | Big effects from smallchanges: possible ways to explore nature's chemical diversity显示文摘 | Bode H B Bethe B H6fs R | 2002 | Chembiochem2002，3，7： | 1 |
| 12 | Intellectual Property Manage- ment in Publicly Funded R&D Centres-A Comparison of Univer- sity-based and Company-based Research Centres 显示文摘 | Beth Y Nola H D Stephen R | 2008 | Techno- vation2008，，28： | 1 |
| 13 | Peripheral Teflon catheters:factors determining incidence of phlebitis and duration ofcannulation显示文摘 | Comely OA Bethe U Pauls R | 2002 | Infect Control Hosp Epidemiol2002，23，5： | 1 |
| 14 | Mechanical detection and measurement of the angular momentum of light显示文摘 | Beth R A | 1936 | Physical Review1936，50，2： | 1 |
| 15 | Peripheral Teflon catheters: factors determining incidence of phlebitis and duration of cannulation显示文摘 | Cornely O A Bethe U Pauls R | 2002 | Infect Control Hosp Epide- miol2002，23，5： | 1 |
| 16 | Phase 3 study comparing tigecycline and ertapenem in patients with diabetic foot infections with and without osteomyelitis显示文摘 | Laszlo Lauf Zsófia Ozsvár Ismael Mitha Janos Reg?ly-Mérei John M. Embil Angel Cooper Mary Beth Sabol Nathalie Castaing Nathalie Dartois Jean Yan Gary Dukart Robert Maroko | 2013 | Diagnostic Microbiology & Infectious Disease2013，，： | 1 |
| 17 | Telomerase-Based Pharmacologic Enhancement of Antiviral Function of Human CD8^+T Lymphocytes 显示文摘 | Steven R F Beth D J Allison C C | 2008 | The Journal of Immunology2008，181，： | 1 |
| 18 | A model for the behaviour of magnetorheological materials 显示文摘 | JOLLY M R CARLSON J D MU'NOZ BETH C | 1996 | Smart Mater Struct1996，5，： | 1 |
| 19 | A PCR marker for detection in surface waters of faecal pollution derived from ducks显示文摘 | Megan L D Beth R Fariba N | 2007 | Water Research2007，41，： | 1 |
| 20 | Telomerase-Based Pharmacologic Enhancement of Antiviral Function of Human CD8+ T Lymphocytes显示文摘 | Steven R F Beth D J Allison C C | 2008 | The Journal of Immunology2008，181，： | 1 |
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