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| 1 | 美国国立老化研究所与阿尔茨海默病协会诊断指南写作组:阿尔茨海默病临床前阶段的定义显示文摘阿尔茨海默病(AD)的病理生理过程在痴呆诊断的多年前就开始了。这一长期的AD“临床前”阶段是治疗干预的关键机会,但需进一步阐明AD的病理级联过程和临床症状出现之间的联系。美国国立老化研究所和AD协会召集了一个国际工作组对AD生物标志物、流行病学和神经心理学的证据进行综述并提出建议,以确定能够预测由“正常”认知到轻度认知功能障碍(MCI)及AD痴呆的最佳预测指标。根据目前已有的主要科学证据,我们提出了一个概念性的框架和用于操作的研究标准,以通过纵向临床研究来验证和改进这些模型。这些建议仅用于研究目的,目前不涉及临床应用。我们希望这些建议能提供一个共识,以推进临床前AD的研究,最终推动更早期治疗干预的进展,使得一些疾病减缓药物的疗效发挥最大。 | Sperling RA Aisen PS Beckett LA Bennett DA Craft S Fagan AM Iwatsubo T Jack CR Jr Kaye J Montine TJ Park DC Reiman EM Rowe CC Siemers E Stern Y Yaffe K Carrillo MC Thies B Morrison-Bogorad M Wagster MV Phelps CH 贾建平(译) 郭起浩(译) 黄丽(译) 陆璐(译) 张逸驰(译) 邢怡(译) | 2012 | 中华神经科杂志2012，45，5： | 22 |
| 2 | Osteoprotegerin: A Novel Secreted Protein Involved in the Regulation of Bone Density显示文摘 | W.S Simonet D.L Lacey C.R Dunstan M Kelley M.-S Chang R Lüthy H.Q Nguyen S Wooden L Bennett T Boone G Shimamoto M DeRose R Elliott A Colombero H.-L Tan G Trail J Sullivan E Davy N Bucay L Renshaw-Gegg T.M Hughes D Hill W Pattison P Campbell S Sander G Van | 1997 | Cell1997，，2： | 6 |
| 3 | Effect of Cry3Bb transgenic corn and tefluthrin on the soil microbial communi- ty: Biomass, activity, and diversity显示文摘 | DEVARE M H JONES C M THIES J E | 2004 | Journal of Environ-mental Quality2004，33，： | 1 |
| 4 | Microbial community development in the rhizosphere of apple trees at a replant disease site显示文摘 | Rumberger A Merwin I A Thies J E | 2007 | Soil Biology & Biochemistry2007，39，7： | 1 |
| 5 | Strict priori constraints for maximum likelihood blind deconvolution显示文摘 | Thiébaut E Conan J M | 1995 | Journal of the Optical Society of America A:Optics Image Science and Vision1995，12，3： | 1 |
| 6 | In-field rates of decomposition and microbial communities colonizing residues vary by depth of residue placement and plant part, but not by crop genotype for residues from two CrylAb Bt corn hybrids and their non-transgenic isolines显示文摘 | Londofio-R L M Tarkalson D Thies J E | 2013 | Soil Biology & Biochemistry2013，57，： | 1 |
| 7 | Stability of black carbon in soils across a climatic gradient显示文摘 | CHENG C H LEHMANN J THIES J E | 2008 | Journal of Geophysical Research:Biogeosciences(2005-2012)2008，113，2： | 1 |
| 8 | MARK/PAR1 kinase is a regulator of microtubule-dependent transport in axons显示文摘 | Mandelkow E Thies E Trinczek B | 2004 | J Cell Biol2004，167，1： | 1 |
| 9 | Eleetroanalytical investigations on eleetrodeposited lead dioxide 显示文摘 | DEV1LLIERS D DINH THI M T MAHE E | 2004 | Journal of Electroanalytical Chemistry2004，573，2： | 1 |
| 10 | Transgenic Bt rice does not affect enzyme activities and microbial composition in the rhizosphere during crop development显示文摘 | Liu W Lu H H Wu W X Wei Q K Chen Y X and Thies J E | | 0，，： | 1 |
| 11 | Electroanalytical investigations on electrodeposited lead dioxide显示文摘 | Devilliers D Dinh Thi M T Mahé E | | 0，，： | 1 |
| 12 | Oxidation of blackcarbon by biotic and abiotic processes显示文摘 | CHENG C H LEHMANN J THIES J E | 2006 | Organic Geochemistry2006，37，： | 1 |
| 13 | Soil microbial community responses to Bt transgernic rice residue decomposition in a paddy field显示文摘 | Lu H Wu W Chen Y Wang H Devare M and Thies J E | | 0，，： | 1 |
| 14 | Electroanalytical investigations on electrodeposited lead dioxide显示文摘 | Devilliers D Thi MTD Mahe E | 2004 | Journal of Electroanalytical Chemistry2004，573，2： | 1 |
| 15 | Contribution of land-atmosphere coupling to recent European summer heat waves 显示文摘 | Fischer E M Senevirame S I I thi D | 2007 | Geophysical Research Letters2007，34，06： | 1 |
| 16 | Decomposition of Bt transgenic rice residues and response of soil microbial community in rapeseed-rice cropping system显示文摘 | Lu H Wu W Chen Y Zhang X Devare M and Thies J E | | 0，，： | 1 |
| 17 | LaNiO3 nanopowder prepared by an 'amorphous citrate' route显示文摘 | Ngo Thi Hong Le Jos'e M Calder'on - Moreno M'onica Popa | 2006 | Journal of the European Ceramic Society2006，，26： | 1 |
| 18 | Oxidation of blackcarbon by biotic and abiotic processes显示文摘 | Cheng C H Lehmann J Thies J E | 2006 | Organic Geochemistry2006，37，11： | 1 |
| 19 | Missorting of Tau in neurons causes degen-eration of synapses that can be rescued by the kinase MARK2/Par-1显示文摘 | Thies E Mandelkow EM | 2007 | J Neurosci2007，27，： | 1 |
| 20 | Effect of Cry3Bb transgen- ic corn and tefluthrin on the soil microbial community: Bio- mass, activity and diversity 显示文摘 | Devare M H Jones C M Thies J E | 2004 | Environmental Quality2004，33，： | 1 |
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