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| 1 | Severe scrub typhus infection: Clinical features, diagnostic challenges and management显示文摘Scrub typhus infection is an important cause of acute undifferentiated fever in South East Asia. The clinical picture is characterized by sudden onset fever with chills and non-specific symptoms that include headache, myalgia, sweating and vomiting. The presence of an eschar, in about half the patients with proven scrub typhus infection and usually seen in the axilla, groin or inguinal region, is characteristic of scrub typhus. Common laboratory findings are elevated liver transaminases, thrombocytopenia and leukocytosis. About a third of patients admitted to hospital with scrub typhus infection have evidence of organ dysfunction that may include respiratory failure, circulatory shock, mild renal or hepatic dysfunction, central nervous system involvement or hematological abnormalities. Since the symptoms and signs are non-specific and resemble other tropical infections like malaria, enteric fever, dengue or leptospirosis, appropriate laboratory tests are necessary to confirm diagnosis. Serological assays are the mainstay of diagnosis as they are easy to perform; the reference test is the indirect immunofluorescence assay(IFA) for the detection of Ig M antibodies. However in clinical practice, the enzyme-linked immuno-sorbent assay is done due to the ease of performing this test and a good sensitivity and sensitivity when compared with the IFA. Paired samples, obtained at least two weeks apart, demonstrating a ≥ 4 fold rise in titre, is necessary for confirmation of serologic diagnosis. The mainstay of treatment is the tetracycline group of antibiotics or chloramphenicol although macrolides are used alternatively. In mild cases, recovery is complete. In severe cases with multi-organ failure, mortality may be as high as 24%. | John Victor Peter Thomas I Sudarsan John Anthony J Prakash George M Varghese | 2015 | World Journal of Critical Care Medicine2015，4，3： | 13 |
| 2 | Efficacy and safety of liquid nitrogen cryotherapy for treatment of Barrett's esophagus显示文摘AIM To evaluate the efficacy and safety of liquid nitrogen cryotherapy as a primary or rescue treatment for BE,with and without dysplasia,or intramucosal adenocarcinoma (IMC).METHODS This was a retrospective,single-center study carried out in a tertiary care center including 45 patients with BE who was treatment-na?ve or who had persistent intestinal metaplasia(IM),dysplasia,or IMC despite prior therapy.Barrett's mucosa was resected via EMR when clinically appropriate,then patients underwent cryotherapy until eradication or until deemed to have failed treatment.Surveillance biopsies were taken at standard intervals.RESULTS From 2010 through 2014,33 patients were studied regarding the efficacy of cryotherapy.Overall,29 patients (88%) responded to cryotherapy,with 84% having complete regression of all dysplasia and cancer.Complete eradication of cancer and dysplasia was seen in 75% of subjects with IMC; the remaining two subjects did not respond to cryotherapy.Following cryotherapy,15 patients with high-grade dysplasia (HGD) had 30% complete regression,50% IM,and 7% low-grade dysplasia (LGD); one subject had persistent HGD.Complete eradication of dysplasia occurred in all 5 patients with LGD.In 5 patients with IM,complete regression occurred in 4,and IM persisted in one.In 136 cryotherapy sessions amongst 45 patients,adverse events included chest pain (1%),stricture (4%),and one gastrointestinal bleed in a patient on dual antiplatelet therapy who had previously undergone EMR.CONCLUSION Cryotherapy is an efficacious and safe treatment modality for Barrett's esophagus with and without dysplasia or intramucosal adenocarcinoma. | Kristen Suchniak-Mussari Charles E Dye Matthew T Moyer Abraham Mathew Thomas J McGarrity Eileen M Gagliardi Jennifer L Maranki John M Levenick | 2017 | World Journal of Gastrointestinal Endoscopy2017，9，9： | 4 |
| 3 | ACC/AHA guidelines for the management of patients with unstable angina and non–st-segment elevation myocardial infarction显示文摘 | Eugene Braunwald Elliott M Antman John W Beasley Robert M Califf Melvin D Cheitlin Judith S Hochman Robert H Jones Dean Kereiakes Joel Kupersmith Thomas N Levin Carl J Pepine John W Schaeffer Earl E Smith David E Steward Pierre Theroux Raymond J Gibbons J | 2000 | Journal of the American College of Cardiology2000，，3： | 4 |
| 4 | Gastrointestinal and liver disease in patients with schizophrenia:A narrative review显示文摘Schizophrenia is a severe mental illness which can have a devastating impact onan individual’s quality of life. Comorbidities are high amongst patients and lifeexpectancy is approximately 15 years less than the general population. Despite thewell-known increased mortality, little is known about the impact of gastrointestinaland liver disease on patients with schizophrenia. We aimed to reviewthe literature and to make recommendations regarding future care. Literaturesearches were performed on PubMed to identify studies related to gastrointestinaland liver disease in patients with schizophrenia. High rates of chronic liverdisease were reported, with Non-Alcoholic Fatty Liver Disease being of particularconcern;antipsychotics and metabolic syndrome were contributing factors. Ratesof acute liver failure were low but have been associated with antipsychotic useand paracetamol overdose. Coeliac disease has historically been linked to schizophrenia;however, recent research suggests that a causal link is yet to be proven.Evidence is emerging regarding the relationships between schizophrenia andpeptic ulcer disease, inflammatory bowel disease and irritable bowel syndrome;clinical vigilance regarding these conditions should be high. Patients with schizophreniapoorly engage with bowel cancer screening programmes, leading to latediagnosis and increased mortality. Clozapine induced constipation is a significantissue for many patients and requires close monitoring. There is a significantburden of gastrointestinal and liver disease amongst patients with schizophrenia.Better levels of support from all members of the medical team are essential toensure that appropriate, timely care is provided. | Rebecca K Grant William M Brindle Mhairi C Donnelly Pauline M McConville Thomas G Stroud Lorenzo Bandieri John N Plevris | 2022 | World Journal of Gastroenterology2022，28，38： | 2 |
| 5 | The Use of Simvastatin for the Prevention of Gallstones in the Lithogenic Prairie Dog Model显示文摘 | Kurt G Davis MD Thomas M Wertin MD John P Schriver MD FACS | 2003 | Obesity Surgery2003，，6： | 2 |
| 6 | Engeneering application for flame显示文摘 | Thomas C Mocealy John M Koffskey | 1965 | Plating Metal Process1965，，1： | 2 |
| 7 | A novel tunnd structure containing enclathrated hydrogen peroxide:4Na2SO4 · 2H2O2· NaCl显示文摘 | ADAMS JOHN M PRITCHARD ROBIN G THOMAS JOHN M | 1978 | Journal of Chemical Society Chem Conm1978，，3： | 1 |
| 8 | Effective primary isolation of wild-type canine distemper virus in MDCK,MV1 Lu and Vero cells without nucleotide sequence changes within the entire haemagglutinin protein gene and in subgenomic sections of the fusion and phospho protein genes显示文摘 | John A L Thomas P M Michael J K | 2004 | Virology2004，118，： | 1 |
| 9 | The role of computed tomogramphy with contrast and small bowel follow-through in management of small bowel obstruction 显示文摘 | James JP Thomas M John P | 1999 | Am J Surg1999，177，3： | 1 |
| 10 | Neuroanatomical Abnormalities and Cognitive Impairments Are Shared by Adults with Attention-Deficit/Hyperactivity Disorder and Their Unaffected First-Degree Relatives显示文摘 | Valentino Antonio Pironti Meng-Chuan Lai Ulrich Müller Chris Martin Dodds John Suckling Edward Thomas Bullmore Barbara Jacquelyn Sahakian | 2013 | Biological Psychiatry2013，，： | 1 |
| 11 | Biofibres and biocomposites 显示文摘 | John M J Thomas S | 2008 | Carbohy- drate Polymers2008，71，3： | 1 |
| 12 | Remediation of Cr(Ⅵ) and Pb(Ⅱ) Aqueous Solutionsusing Supported Nanoscale Zero-value Iron显示文摘 | Sherman M John G Thomas E | 2000 | Environment Science & Technology2000，34，12： | 1 |
| 13 | Enzymology of electron transport : Energy generation with geochemical consequences 显示文摘 | Thomas J D Jim K F John M Z | 2005 | Reviews in Mineralogy and Geochemistry2005，59，1： | 1 |
| 14 | Predictors of multi-organ dysfunction in heatstroke 显示文摘 | G M Varghese G John K Thomas O C Abraham D Mathai | 2005 | Emerg Med J2005，22，： | 1 |
| 15 | Idotype-pulsed dendritic cell vaccination for B-cell lymphoma clinical and immune responses in 35 patients 显示文摘 | John M Timmeman Debra K Czerwinski Thomas A Romald levy | 2002 | Blood2002，99，5： | 1 |
| 16 | Does hyperparathy- roidism cause pancreatitis? A South Indian experience and a review of published work 显示文摘 | Jacob JJ John M Thomas N | 2006 | ANZ J Surg2006，76，8： | 1 |
| 17 | Plutonium hydride,sesquioxide and monoxide monohydride,pyrophoricty and catalysis of plutonium corrosion显示文摘 | John M H Thomas H A | 2001 | J Alloys and Compnd2001，320，： | 1 |
| 18 | Biofibres and bioeomposites 显示文摘 | John M J Thomas S | 2008 | Carbohydr Polym2008，71，3： | 1 |
| 19 | Green fluorescent protein as a quantitative tool显示文摘 | Nicola J Hack Brian Billups Peter B Guthrie John H Rogers Elizabeth M Muir Thomas N Parks Stanley B Kater | 2000 | Journal of Neuroscience Methods2000，，2： | 1 |
| 20 | Burden of valvular heart diseases: a population-based study显示文摘 | Vuyisile T Nkomo Julius M Gardin Thomas N Skelton John S Gottdiener Christopher G Scott Maurice Enriquez-Sarano | 2006 | The Lancet . 2006 (9540)2006，，： | 1 |
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