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| 1 | Randomized trial in malignant biliary obstruction:Plastic vs partially covered metal stents显示文摘AIM:To compare efficacy and complications of par-tially covered self-expandable metal stent(pcSEMS)to plastic stent(PS)in patients treated for malignant,infrahilar biliary obstruction.METHODS:Multicenter prospective randomized clinical trial with treatment allocation to a pcWallstent(SEMS)or a 10 French PS.Palliative patients aged≥18,for infrahilar malignant biliary obstruction and a Karnofsky performance scale index>60%from 6 participating North American university centers.Primary endpoint was time to stent failure,with secondary outcomes of death,adverse events,Karnofsky performance score and short-form-36 scale administered on a three-monthly basis for up to 2 years.Survival analyses were performed for stent failure and death,with Cox proportional hazards regression models to determine significant predictive characteristics.RESULTS:Eighty-five patients were accrued over 37mo,42 were randomized to the SEMS group and 83patients were available for analyses.Time to stent failure was 385.3±52.5 d in the SEMS and 153.3±19.8 d in the PS group,P=0.006.Time to death did not differ between groups(192.3±23.4 d for SEMS vs211.5±28.0 d for PS,P=0.70).The only significant predictor was treatment allocation,relating to the time to stent failure(P=0.01).Amongst other measured outcomes,only cholangitis differed,being more common in the PS group(4.9%vs 24.5%,P=0.029).The small number of patients in follow-up limits longitudinal assessments of performance and quality of life.From an initially planned 120 patients,only 85 patients were recruited.CONCLUSION:Partially covered SEMS result in a longer duration till stent failure without increased complication rates,yet without accompanying measurable benefits in survival,performance,or quality of life. | Peter L Moses Khalid M AlNaamani Alan N Barkun Stuart R Gordon Roger D Mitty M Stanley Branch Thomas E Kowalski Myriam Martel Viviane Adam | 2013 | World Journal of Gastroenterology2013，19，46： | 6 |
| 2 | ACC/AHA guidelines for the management of patients with unstable angina and non–st-segment elevation myocardial infarction显示文摘 | Eugene Braunwald Elliott M Antman John W Beasley Robert M Califf Melvin D Cheitlin Judith S Hochman Robert H Jones Dean Kereiakes Joel Kupersmith Thomas N Levin Carl J Pepine John W Schaeffer Earl E Smith David E Steward Pierre Theroux Raymond J Gibbons J | 2000 | Journal of the American College of Cardiology2000，，3： | 4 |
| 3 | Should antibiotics be administered before arthroscopic knee surgery? A systematic review of the literature显示文摘AIM To explore the current evidence surrounding the administration of prophylactic antibiotics for arthroscopic knee surgery. METHODS Databases were searched from inception through May of 2018 for studies examining prophylactic antibiotic use and efficacy in knee arthroscopy. Studies with patient data were further assessed for types of arthroscopic procedures performed,number of patients in the study,use of antibiotics,and outcomes with the intention of performing a pooled analysis. Data pertaining to 'deep tissue infection' or 'septic arthritis' were included in our analysis. Reported data on superficial infection were not included in our data analysis. For the pooled analysis,a relative risk ratio was calculated and χ~2 tests were used to assess for statistical significance between rates of infection amongst the various patient groups. Post hoc power analyses were performed to compute the statistical power obtained from our sample sizes. Number needed to treat analyses were performed for statistically significant differences by dividing 1 by the difference between the infection rates of the antibiotic and no antibiotic groups. An alpha value of 0.05 was used for our analysis. Study heterogeneity was assessed by Cochrane's Q test as well as calculation of the I^2 value.RESULTS A total of 49682 patients who underwent knee ar-throscopy for a diverse set of procedures across 19 studies met inclusion critera for pooled analysis. For those not undergoing graft procedures,there were 27 cases of post-operative septic arthritis in 34487 patients(0.08%) who received prophylactic antibiotics and 16 cases in 10911(0.15%) who received none [risk ratio(RR) = 0.53,95% confidence interval(CI): 0.29-0.99,P = 0.05]. A sub-group analysis in which bony procedures were excluded was performed which found no significant difference in infection rates between patients that received prophylactic antibiotics and patients that did not(P > 0.05). All anterior cruciate ligament reconstruction studies used prophylactic antibiotics,but two studies investigating the effect of soaking the graft in vancomycin in addition to standard intravenous(IV) prophylaxis were combined for analysis. There were 19 cases in 1095 patients(1.74%) who received IV antibioitics alone and no infections in 2034 patients who received IV antibiotics and had a vancomycin soaked graft(RR = 0.01,95%CI: 0.001-0.229,P < 0.01).CONCLUSION Prophylactic antibiotics are effective in preventing septic arthritis following simple knee arthroscopy. In procedures involving graft implantation,graft soaking reduces the rate of infection. | John Carney Nathanael Heckmann Erik N Mayer Ram K Alluri Carleton Thomas Vangsness George F Hatch Ⅲ Alexander E Weber | 2018 | World Journal of Orthopedics2018，9，11： | 2 |
| 4 | Axitinib versus sorafenib as first-line therapy in patients with metastatic renal-cell carcinoma: a randomised open-label phase 3 trial显示文摘 | Thomas E Hutson Vladimir Lesovoy Salman Al-Shukri Viktor P Stus Oleg N Lipatov Angel H Bair Brad Rosbrook Connie Chen Sinil Kim Nicholas J Vogelzang | 2013 | Lancet Oncology2013，，13： | 2 |
| 5 | The US national cholesterol education programe adult treatment panel Ⅲ(NCEPATP Ⅲ) prevalence of the meta bolic syndrome in a Chinese population显示文摘 | THOMAS G N HO S Y JANUS E D | 2005 | Diabetes Res Clin Pract2005，67，： | 1 |
| 6 | Crystal doping aided by rapid expansion of supercritical solutions 显示文摘 | Chandra V Matthew J M Thomas E N | 2002 | AAPS Pharm-SciTech2002，3，4： | 1 |
| 7 | Robust analysis of the yeast proteome under 50 kDa by molecular-massbased fractionation and top-down mass spectrometry显示文摘 | Kellie J F Catherman A D Durbin K R Tran J C Tipton J D Norris J L Witkowski C E 2nd Thomas P M Kelleher N L | | 0，，01： | 1 |
| 8 | Automated phase correction of FT NMR spectra by baseline Optimization显示文摘 | Brown Douglas E Campbell Thomas W Moore Richard N | 1989 | J Magn Reson1989，85，： | 1 |
| 9 | Modulation of E2F complexes during G to S phase transition in human p rimary Blymphocytes显示文摘 | Vander Sman J Thomas N S Lam E W | 1999 | J Biol Chem1999，274，17： | 1 |
| 10 | Effects of porcine circovims Type 2 (PCV2) maternal antibodies on experimental infection of piglets with PCV2 clinical and diagnostic laboratory immunology显示文摘 | McKeown N E Opriessnig T Thomas P | 2005 | 12:1 347-1 3512005，12，： | 1 |
| 11 | The Determination of the Plate Count for Large Molecules under Reversed-Phase Gradient Conditions显示文摘 | Uwe D N Hillary B H Thomas E W | 2010 | Journal of Chromatography A2010，1217，14： | 1 |
| 12 | The influence of genotype- environment interaction on the grain yields of 10 pigeonpea cultivars grown in Kenya 显示文摘 | WAMATU J N THOMAS E | 2002 | Journal of Agronomy and Crop Science2002，188，1： | 1 |
| 13 | Evidence for downy mildew races incucumber tested in Asia,Europe,and North America显示文摘 | SHETTY N V WEHNER T C THOMAS C E D0RUCH0WSKI RW VASANTH SHETTY K P | 2002 | ScientiaHorticulturae2002，94，3： | 1 |
| 14 | Use of amino-terminal pro-B-type natriuretic peptide to guide outpatient therapy of patients with chronic left ventricular systolic dysfunction 显示文摘 | JAMES L JANUZZI JR MD SHAFIQ U REHMAN M D ASIM A MOHAMMED M D ANJU BHARDWAJ M D LINDA BARAJAS R N JUSTINE BARAJAS HAN-NA KIM M D MPH AARON L BAGGISH M D RORY B WEINER M D ANNABEL CHEN-TOURNOUX MD JANE E MARSHALL RDCS STEPHANIE A MOORE M D WILLIAM D CARLSON M D GREGORY D LEWIS M D JORDAN SHIN M D DOROTHY SULLIVAN ANP KIMBERLY PARKS D O THOMAS J WANG M D SHAWN A GREGORY M D SHANMUGAM UTHAMALINGAM M D MARC J SEMIGRAN M D | 2011 | J Am Coll Cardiol2011，58，18： | 1 |
| 15 | What satisfies students:Mining student opinion data with regression and decision tree analysis显示文摘 | Thomas E H Galambos N | | 0，，03： | 1 |
| 16 | What satisfies students? Mining stu- dent - opinion data with regreasion and decision tree analysis 显示文摘 | THOMAS E H GALAMBOS N | 2004 | Re- search in Higher Edneetion2004，45，3： | 1 |
| 17 | The importance of cold and warm cardiac ischemia for survival after heart transplantation显示文摘 | Banner N R Thomas H L Curnow E | 2008 | Transplantation2008，86，4： | 1 |
| 18 | The Arabidopsis CDPK-SnRK superfamily of protein kinases显示文摘 | Hrabak E M Chan C W Gribskov M Harper J F Choi J H Halford N KUdla J Luan S Nimmo H G Sussman M R Thomas M Walker-simmons K Zhu J K Harmon A C | 2003 | Plant Physiology2003，132，： | 1 |
| 19 | A mechanism of protein localization: the signal hypothesis and bacteria 显示文摘 | SCOTT D E MICHAEL N H THOMAS I S | 1980 | J Cell Biol1980，86，： | 1 |
| 20 | A Dielectric Omnidirectional Reflector显示文摘 | Fink Y Winn J N Fan S Chen C Michel J Joannopoulos J D and Thomas E L | 1998 | Science1998，282，5394： | 1 |
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