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| 1 | Angiogenesis in a 3D model containing adipose tissue stem cells and endothelial cells is mediated by canonical Wnt signaling显示文摘Adipose-derived stromal cells(ASCs) have gained great attention in regenerative medicine. Progress in our understanding of adult neovascularization further suggests the potential of ASCs in promoting vascular regeneration, although the specific cues that stimulate their angiogenic behavior remain controversial. In this study, we established a three-dimensional(3D) angiogenesis model by co-culturing ASCs and endothelial cells(ECs) in collagen gel and found that ASC-EC-instructed angiogenesis was regulated by the canonical Wnt pathway. Furthermore, the angiogenesis that occurred in implants collected after injections of our collagen gelbased 3D angiogenesis model into nude mice was confirmed to be functional and also regulated by the canonical Wnt pathway. Wnt regulation of angiogenesis involving changes in vessel length, vessel density,vessel sprout, and connection numbers occurred in our system. Wnt signaling was then shown to regulate ASCmediated paracrine signaling during angiogenesis through the nuclear translocation of β-catenin after its cytoplasmic accumulation in both ASCs and ECs. This translocation enhanced the expression of nuclear cofactor Lef-1 and cyclin D1 and activated the angiogenic transcription of vascular endothelial growth factor A(VEGFA), basic fibroblast growth factor(bF GF), and insulin-like growth factor 1(IGF-1). The angiogenesis process in the 3D collagen model appeared to follow canonical Wnt signaling, and this model can help us understand the importance of the canonical Wnt pathway in the use of ASCs in vascular regeneration. | Xiaoxiao Cai Jing Xie Yang Yao Xiangzhu Cun Shiyu Lin Taoran Tian Bofeng Zhu Yunfeng Lin | 2017 | Bone Research2017，5，4： | 6 |
| 2 | Diallyl trisulfide induces apoptosis and inhibits proliferation of A549 cells in vitro and in vivo显示文摘肺癌症是在整个世界的癌症相关的死亡的领先的原因。在最近的年里,肺的腺癌在频率超过了有鳞的房间癌并且是在许多国家的肺癌症的占优势的形式。流行病学的调查显示出在消费和死亡从许多癌症评估的大蒜(瞀或蒜之类 sativum ) 之间的一种反的关系。Diallyl trisulfide (DATS ) 是导出大蒜的混合物之一(是也知道:organosulfer 混合物,振荡) 。DATS 能导致 apoptosis 并且禁止许多癌症细胞线的生长。我们的学习证明 DATS 导致的 apoptotic 事件是通过导致了 Bax/Bcl-2 和 caspase-3, -8, 和 -9 的活动的比率的起来规定的 anti-apoptotic Bcl-2 的重要减少的线粒体依赖者 caspase 串联。最后, DATS 导致了 apoptosis 并且在一个集中依赖者和时间依赖者举止禁止了增长。由与 A549 异种皮移植建立女 BALB/c 裸体老鼠的一个动物模特儿,没有与控制组相比引起重量损失或任何另外的副作用,而且,我们在裸体老鼠发现 DATS 的那口头的 gavage A549 异种皮移植的显著地延迟的生长。在 vitro 并且在 vivo 的所有证据建议 DATS 能是理想的反癌症药。 | Wenjun Li Hui Tian Lin Li Shuhai Li Weiming Yue Zhitao Chen Lei Qi Wensi Hu Yingchao Zhu Bin Hao Cun Gao Libo Si Fei Gao | 2012 | Acta Biochimica et Biophysica Sinica2012，44，7： | 6 |
| 3 | Tea Consumption is Associated with Increased Risk of Kidney Stones in Northern Chinese: A Cross-sectional Study显示文摘Kidney stones are a common urinary system condition that can progress to kidney disease.Previous studies on the association between tea consumption and kidney stones are inconsistent.A cross‐sectional study to investigate the association between tea consumption and kidney stones was conducted from 2013 to 2014 and recruited 9,078northern Chinese adults.A total of 8,807participants were included in the final analysis. | WU Zhong Biao JIANG Tian LIN Guo Bing WANG You Xin ZHOU Yong CHEN Zhen Qian XU Yong Ming YE Hai Bo CHEN Bo Jun BAO Xiao Zhao ZHANG Cun Ming | 2017 | Biomedical and Environmental Sciences2017，30，12： | 5 |
| 4 | Impact of Temperature on Mortality in Three Major Chinese Cities显示文摘Objective To study the relation between temperature and mortality by estimating the temperature-related mortality in Beijing,Shanghai,and Guangzhou.Methods Data of daily mortality,weather and air pollution in the three cities were collected.A distributed lag nonlinear model was established and used in analyzing the effects of temperature on mortality.Current and future net temperature-related mortality was estimated.Results The association between temperature and mortality was J-shaped,with an increased death risk of both hot and cold temperature in these cities.The effects of cold temperature on health lasted longer than those of hot temperature.The projected temperature-related mortality increased with the decreased cold-related mortality.The mortality was higher in Guangzhou than in Beijing and Shanghai.Conclusion The impact of temperature on health varies in the 3 cities of China,which may have implications for climate policy making in China. | ZHANG Jing LI Tian Tian TAN Jian Guo HUANG Cun Rui KAN Hai Dong | 2014 | Biomedical and Environmental Sciences2014，27，7： | 5 |
| 5 | Abscisic acid signaling negatively regulates nitrate uptake via phosphorylation of NRT1.1 by SnRK2s in Arabidopsis显示文摘Nitrogen(N)is a limiting nutrient for plant growth and productivity.The phytohormone abscisic acid(ABA)has been suggested to play a vital role in nitrate uptake in fluctuating N environments.However,the molecular mechanisms underlying the involvement of ABA in N deficiency responses are largely unknown.In this study,we demonstrated that ABA signaling components,particularly the three subclass Ⅲ SUCROSE NON-FERMENTING1(SNF1)-RELATED PROTEIN KINASE 2 S(SnRK2)proteins,function in root foraging and uptake of nitrate under N deficiency in Arabidopsis thaliana.The snrk2.2 snrk2.3 snrk2.6 triple mutant grew a longer primary root and had a higher rate of nitrate influx and accumulation compared with wild-type plants under nitrate deficiency.Strikingly,SnRK2.2/2.3/2.6 proteins interacted with and phosphorylated the nitrate transceptor NITRATE TRANSPORTER1.1(NRT1.1)in vitro and in vivo.The phosphorylation of NRT1.1 by SnRK2 s resulted in a significant decrease of nitrate uptake and impairment of root growth.Moreover,we identified NRT1.1Ser585 as a previously unknown functional site:the phosphomimetic NRT1.1S585 D was impaired in both low-and high-affinity transport activities.Taken together,our findings provide new insight into how plants fine-tune growth via ABA signaling under N deficiency. | Hang Su Tian Wang Chuanfeng Ju Jinping Deng Tianqi Zhang Mengjiao Li Hui Tian Cun Wang | 2021 | Journal of Integrative Plant Biology2021，63，3： | 4 |
| 6 | Triboelectric nanogenerator enhanced multilayered antibacterial nanofiber air filters for efficient removal of ultrafine particulate matter显示文摘我们开发了 multilayered 抗菌剂 polyimide (PI ) nanofiber 空气为把极其细小的微粒物质(下午) 从周围的空气移开过滤的提高的高效率的旋转摩擦电 nanogenerator (R-TENG ) 。比作单人赛分层的 PI nanofiber 过滤器, multilayered nanofiber 过滤器能完全与比 0.54 m 大的直径粒子移开所有,表演为更小的下午粒子提高移动效率。在与 aR-TENG 连接以后,为极其细小的粒子的 filer 的移动效率进一步被提高。为极其细小的微粒物质的最高的移动效率在 53.3 nm 的直径是 94.1% ,平均移动效率到达 89.9% 。尽管有层数字的增加,这部电影的每单个层的厚度减少了,并且因此,过滤器的全部的压力落下减少了而不是增加。而且,因为银 nanoparticles 的小数量的增加, nanofiber 电影展出了高抗菌剂活动。有零个臭氧版本和低压力落下的这种技术为清洗空气,薄雾处理,和细菌的控制是适当的。 | Guang Qin Gu Chang Bao Han Jing Jing Tian Tao Jiang Chuan He Cun Xin Lu Yu Bai Jin Hui Nie Zhou Li Zhong Lin Wang | 2018 | Nano Research2018，11，8： | 4 |
| 7 | A new phenanthraquinone from the roots of Peucedanum praeruptorum显示文摘新混合物, 9,10-dihydrophenanthrinic 酸, 9,10-dione-3,4-methylenedioxy-8-methoxy (1 ) 从 Peucedanum praeruptorum Dunn 的根被孤立根据光谱证据。 | Cun Zhang Li Li Yong Qing Xiao Wen Li Xiao Jie Yin Guo Fang Tian Dong Dong Chen Yun Wang | 2010 | Chinese Chemical Letters2010，21，7： | 4 |
| 8 | Mechanisms of abnormal overpressure generation in Kuqa foreland thrust belt and their impacts on oil and gas reservoir formation显示文摘Based on overview for mechanism of abnormaloverpressure generation in sedimentary basins, an insightdiscussion is made by the authors for the distribution, fea-tures and generation mechanisms of abnormal overpressurein the Kuqa foreland thrust belt. The abnormal overpressurein the Kelasu structure zone west to the Kuqa forelandthrust belt was primarily distributed in Eogene to lowerCretaceous formations; structural compression and struc-tural emplacement as well as the containment of Eogenegyps-salt formation constituted the main mechanisms for thegeneration of abnormal overpressure. The abnormal over-pressure zone in the eastern Yiqikelike structure zone wasdistributed primarily in lower Jurassic Ahe Group, resultingfrom hydrocarbon generation as well as structural stressother than from under-compaction. Various distributionsand generating mechanisms have different impacts upon theformation of oil and gas reservoirs. K-E reservoir in the Ke-lasu zone is an allochthonous abnormal overpressure system.One of the conditions for reservoir accumulation is the mi-gration of hydrocarbon (T-J hydrocarbon source rock) alongthe fault up to K-E reservoir and accumulated into reservoir.And this migration process was controlled by the abnormaloverpressure system in K-E reservoir. The confined abnor-mal overpressure system in the Yiqikelike structure zoneconstituted the main cause for the poor developing of dis-solved porosity in T-J reservoir, resulting in poor physicalproperty of reservoir. The poor physical property of T-J res-ervoir of Yinan 2 structure was the main cause for the ab-sence of oil accumulation, but the presence of natural gasreservoir in the structure. | PI Xuejun XIE Huiwen ZHANG Cun TIAN Zuoji | 2002 | Chinese Science Bulletin2002，47，S1： | 3 |
| 9 | Down-regulation of MTA1 protein leads to the inhibition of migration, invasion, and angiogenesis of non-small-cell lung cancer cell line显示文摘联系转移的蛋白质 1 (MTA1 ) 高表示在许多人的好攻击的肿瘤被检测了并且在象侵略,转移,和 angiogenesis 那样的恶意的生物行为起重要作用。然而,在调整 non-small-cell 肺癌症(NSCLC ) 的恶意的行为的 MTA1 蛋白质的特定的角色和机制房间仍然保持不清楚。阐明 MTA1 蛋白质的详细函数,我们下面调整在由在 vitro 的 RNA 干扰(RNAi ) 的 NSCLC 房间线的 MTA1 蛋白质表达式,并且发现 MTA1 蛋白质的下面规定显著地禁止了 95D 房间的移植和侵略潜力。进一步的研究表明 MTA1 蛋白质的下面规定显著地减少了矩阵 metalloproteinase-9 的活动,它能是为 95D 房间移植和侵略的抑制负责的机制。另外,试管形成试金证明 MTA1-siRNA 95D 房间的调节媒介导致的完全的试管的数字比 95D 房间的显著地小。这些调查结果证明那 MTA1 蛋白质在调整 95D 房间的迁居,侵略,和 angiogenesis 潜力起重要作用,由 RNAi 建议那条 MTA1 蛋白质下面规定可能是一条新奇治疗学的途径禁止 NSCLC 的前进。 | Shuhai Li Hui Tian Weiming Yue Lin Li Cun Gao Libo Si Wenjun Li Wensi Hu Lei Qi Ming Lu | 2013 | Acta Biochimica et Biophysica Sinica2013，45，2： | 2 |
| 10 | In-depth research on direct torque control of permanent magnet synchronous显示文摘 | Hu Yuwen Tian Cun Gu Yikang | 2002 | Industrial Electronics Society IEEE 2002 28th Annual Conference2002，2，58： | 1 |
| 11 | Direct torque control system and sensorless technique of permanent magnet synchronous motor显示文摘 | Hu Yuwen Tian Cun etc | 2003 | Chinese journal aeronautics (S1000-9361)2003，16，2： | 1 |
| 12 | Low-temperature solvothermal synthesis of visible-light-responsive S doped TiO2 nanocrystal 显示文摘 | YANG Gui Dong YAN Zi Feng XIAO Tian Cun | 2012 | Appl Surf Sci2012，258，8： | 1 |
| 13 | Direct torque control system and sensorless techniqueof permanent magnet synchronous motor显示文摘 | Hu Yuwen Tian Cun You Zhiqing | 2003 | Chinese Journal of Aeronaultics2003，16，2： | 1 |
| 14 | In-depth research on direct torque control of permanent magnet synchronous motor 显示文摘 | Hu Yuwen Tian Cun Gu Yikang | 2002 | IECON 02 Industrial Electronics Society2002，，2： | 1 |
| 15 | Direct Torque Control System and Sensorless Technique of Permanent Magnet Synchronous Motor显示文摘 | Hu Yu-wen TIAN Cun YOU zhi-qiang | 2003 | CHINFSE JOURNAL OF AERONAUTICS2003，16，2： | 1 |
| 16 | 7,2'-DIDESACETOXY AUSTROSPICATINE, A NEW TAXANOID FROM THE BARKS OF TAXUS WALLICHIANA ZUCC显示文摘7,2'-DIDESACETOXY AUSTROSPICATINE, A NEW TAXANOID FROM THE BARKS OF TAXUS WALLICHIANA ZUCC7,2'-DIDESACETOXYAUSTROSPICATINE,AN... | Jun Zeng ZHANG Qi Cheng FANG Xiao Tian LIANG and Cun Heng HE (Institute of Materia Medica, Chinese Academy of Medical Sciences and Pekinq Union Medical College, Beijing 100050) | 1994 | Chinese Chemical Letters1994，5，6： | 0 |
| 17 | Selective Determination of Epinephrine by Using an Improved Modification of the Trihydroxyindole Method显示文摘A simple and selective method for the determination of epinephrine is putforward, which is an improved modification of the trihydroxyindole method. Experimentindicated that in borax buffer (pH=8.7) and with mercaptoethanol as the reducing reagent,dopa and dopamine did not form fluorescence products, so it is possible to determineepinephrine selectively. | Jing He YANG Chang Lun TONG Gut Ling ZHANG Xia WU Cun Guo Lin Jing Tian HU(Department of Chemistry, Shandong University, Jinan 250100) | 1998 | Chinese Chemical Letters1998，9，3： | 0 |
| 18 | A Novel Pentadecanuclear Neodymium Cluster: Synthesis and Structure of [Nd_(15)(μ_4-tyr)_(10)(μ_3-OH)_(20)(μ_2-OH)_4(OH)_(10)(μ_2-H_2O)-(H_2O)_(10)][Na(ClO_4)_2]·61H_2O显示文摘The title complex was synthesized by dissolving tyrosine (tyr) in an aqueous solution ofNd(ClO4)3 at NpH5, and its crystal stfucture was determined by X-ray diffraction methods. Thecomplex is a novel pentadecanuclear with the 15 Nd3+ ions connected by μ3-OH- ions. The tyrosineligands are all in their anionic form, and each coordinates to the neodymium ions via the nitrogenatom of the amino group and the two carboxyl oxygen atoms. The molecule a barrel structure. | Rui Yao WANG Zhe Ming WANG Song GAO Tian Zhu JIN Zhi Da CHEN Chun Hua YAN Guang Xian XU (State Key Laboratory of Rare Earth Material Chemistry and ApplicationsPeking UniverSity, Beijing 100871)Cun Heng HE (National Research Center for Analysis of Dr | 1998 | Chinese Chemical Letters1998，9，12： | 0 |
| 19 | GTPase ROP6 negatively modulates phosphate deficiency through inhibition of PHT1;1 and PHT1;4 in Arabidopsis thaliana显示文摘Phosphorus,an essential macroelement for plant growth and development,is a major limiting factor for sustainable crop yield.The Rho of plant(ROP)GTPase is involved in regulating multiple signal transduction processes in plants,but potentially including the phosphate deficiency signaling pathway remains unknown.Here,we identified that the rop6 mutant exhibited a dramatic tolerant phenotype under Pi-deficient conditions,with higher phosphate accumulation and lower anthocyanin content.In contrast,the rop6 mutant was more sensitive to arsenate(As(V))toxicity,the analog of Pi.Immunoblot analysis displayed that the ROP6 protein was rapidly degraded through ubiquitin/26S proteasome pathway under Pi-deficient conditions.In addition,pull-down assay using GST-RIC1 demonstrated that the ROP6 activity was decreased obviously under Pi-deficient conditions.Strikingly,protein-protein interaction and two-voltage clamping assays demonstrated that ROP6 physically interacted with and inhibited the key phosphate uptake transporters PHT1;1 and PHT1;4 in vitro and in vivo.Moreover,genetic analysis showed that ROP6 functioned upstream of PHT1;1 and PHT1;4.Thus,we conclude that GTPase ROP6 modulates the uptake of phosphate by inhibiting the activities of PHT1;1 and PHT1;4 in Arabidopsis. | Huiling Gao Tian Wang Yanting Zhang Lili Li Chuanqing Wang Shiyuan Guo Tianqi Zhang Cun Wang | 2021 | Journal of Integrative Plant Biology2021，63，10： | 0 |
| 20 | CARBONIUM CYCLIZATION—STUDIES ON LIGNANS CONTAINING THE DIBENZOCYCLOOCTADIENE SYSTEM.Ⅰ显示文摘Schisandrin(1)under the Ritter reaction conditions(conc.H2SO4/CH3CN)gave trace amounts of the expected acetamidoderivatives(2a,2b).The main product is 5a,from intramolecular car-bonium cyclization. | Rui TAN Qi Tai ZHENG Cun Heng HE Xiao Tian LIANG Institute of Materia Medica,Nan-wei Road,Beijing 100050 | 1990 | Chinese Chemical Letters1990，1，1： | 0 |
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