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| 1 | Near stoichiometric silicon carbide from an economical polysilane precursor显示文摘 | SEYFERTH D TIMOTHY G HENRY J | 1992 | J Am Ceram Soc1992，75，5： | 2 |
| 2 | The temporal price relationship between S&P 500 futures prices and the S&P 500 index显示文摘 | Kawaller Ira G Paul D Koch Timothy W Koch | 1987 | Journal of Finance1987，5，： | 2 |
| 3 | Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome:A multicenter retrospective study显示文摘BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIM To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with IBS.METHODS In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United States,the United Kingdom,and Ireland.Depressive,anxiety,and somatization symptoms and sociodemographic characteristics were collected.Four functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive models.We also performed separate analyses for sex and IBS subtypes.SNP scores were calculated as the number of minor alleles of the SNPs above.The impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx assays.RESULTS Depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(F_(depressive)=7.475,P_(depressive)=0.006;F_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(F=7.710,P-linear trend=0.006)in IBS.The potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant receptors.CONCLUSION We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with IBS.The SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS. | Sabrina Berens Yuanjun Dong Nikola Fritz Jutta Walstab Mauro D'Amato Tenghao Zheng Verena Wahl Felix Boekstegers Justo Lorenzo Bermejo Cristina Martinez Stefanie Schmitteckert Egbert Clevers Felicitas Engel Annika Gauss Wolfgang Herzog Robin Spiller Miriam Goebel-Stengel Hubert Mönnikes Viola Andresen Frieling Thomas Jutta Keller Christian Pehl Christoph Stein-Thöringer Gerard Clarke Timothy G Dinan Eamonn M Quigley Gregory Sayuk Magnus Simrén Jonas Tesarz Gudrun Rappold Lukas van Oudenhove Rainer Schaefert Beate Niesler | 2022 | World Journal of Gastroenterology2022，28，21： | 2 |
| 4 | LIGHT, a New Member of the TNF Superfamily, and Lymphotoxin α Are Ligands for Herpesvirus Entry Mediator显示文摘 | Davide N Mauri Reinhard Ebner Rebecca I Montgomery Kristine D Kochel Timothy C Cheung Guo-Liang Yu Steve Ruben Marianne Murphy Roselyn J Eisenberg Gary H Cohen Patricia G Spear Carl F Ware | 1998 | Immunity1998，，： | 1 |
| 5 | Finding drug targets in microbial genomes 显示文摘 | Timothy D R Steven R G Herve T | 2001 | Res Focus2001，6，17： | 1 |
| 6 | Effect of organic amendments and slow-release nitrogen fertilizer on willow biomass production and soil chemical characteristics 显示文摘 | Hector G A Russell D B Timothy A V | 2003 | Biomass Bioenerg2003，25，： | 1 |
| 7 | Transparent conducting Nnc oxide thin films doped with aluminum and molybdenum显示文摘 | JOEL N D TIMOTHY A G DAVID M W TERESA M B MATTHEW Y BOBBY T TIMOTHY J C | 2007 | Journal V-acuum Society Technology2007，25，4： | 1 |
| 8 | Survival and growth ofJuvenile fluted giant clams, Tridacna squamosa, in large-scale grow-out trials in the Solomon Islands显示文摘 | Timothy P F Johann D B Mark G | 1997 | Aquaculture1997，148，23： | 1 |
| 9 | Milankovitch climatic origin of mid-Cretaceous black shale rhythms in central Italy显示文摘 | TIMOTHY D H ALFRED G F | 1986 | Nature1986，321，： | 1 |
| 10 | The Relationship of Hamstrings and Quadriceps Strength to Anterior Cruciate Ligament Injury in Female Athletes显示文摘 | Gregory D Myer Kevin R Ford Kim D Barber Foss Chunyan Liu Todd G Nick Timothy E Hewett | 2009 | Clinical Journal of Sport Medicine2009，，1： | 1 |
| 11 | Design of linear dispersion codes: asymptotic guidelines and their implementation 显示文摘 | Rainy H G Timothy N D | 2005 | IEEE Transactions on Wireless Communications2005，4，6： | 1 |
| 12 | The clinical impor- tance of meniscal tears demonstrated by magnetic remnance imaging in osteoarthritis of the knee显示文摘 | Timothy B Daniel G Peter D | 2003 | Journal of Bone and Joint Surgery (Am)2003，85，1： | 1 |
| 13 | A papillomavirus-like particle (VLP) vaccine displaying HPV16 L2 epitopes induces cross-neutralizing antibodies to HPV11显示文摘 | Slupetzky K Ratish G Timothy D C | 2006 | Vaccine2006，25，2007： | 1 |
| 14 | Material estimation with terahertz time-domain spectroscopy显示文摘 | TIMOTHY D D RICHARD G B DANIEL M M | 2001 | Journal of Optical Society of America A2001，18，7： | 1 |
| 15 | Selling to tourists : Indonesian street vendors显示文摘 | Timothy D J Wall G | 1997 | Annals of Tourism Research1997，24，2： | 1 |
| 16 | Bi-cell surface plasmon resonance detection of aptamer mediated thrombin capture in serum显示文摘 | RINOSH J M ROMAN G D TIMOTHY A S | 2011 | Biosensors and Bioelectronics2011，26，12： | 1 |
| 17 | Pathogenomics of the Ra-lstonia solanacearum spacies complex显示文摘 | Stephane G Timothy P D | 2012 | Annual Review of Phytopathology2012，50，： | 1 |
| 18 | Material parameter estimation with terahertz time-domain spectroscopy显示文摘 | Timothy D D Richard G B Daniel M M | 2001 | Journal of the Optical Society of America A2001，18，7： | 1 |
| 19 | Andrews'diseases of the skin:clinical dermatology显示文摘 | Richard B Odom William D James Timothy G | 2001 | ninth edition2001，27，： | 1 |
| 20 | Material parameter estimation with terahertz time domain spectroscopy显示文摘 | Timothy D D Richard G B Daniel M M | 2001 | Journal of the Optical Society of America A: Optics Image Science and Vision2001，18，7： | 1 |
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