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| 1 | The modulation of co-stimulatory molecules by circulating exosomes in primary biliary cirrhosis显示文摘Exosomes 是 endocytic 起源的 nanoparticles,由由他们调制 cell-to-cell 通讯的能力的优点正在吸引增加的注意的无数房间人口藏匿了。他们也在许多免疫学的问题正在吸引注意,包括 autoimmunity 和,特别地调整 cytokine 和 chemokine 激活的他们的能力。主要胆汁的肝硬化(PBC ) 被认为一个模型自体免疫疾病,它对胆汁的上皮的房间有高度集中的细胞毒素的回答。我们与 PBC 和 30 健康控制(HC ) 从 29 个病人从血浆孤立 exosomes,并且用一个前 vivo 系统在 mononuclear 房间人口在 co-stimulatory 分子表示和 cytokine 生产上学习了这些 exosomes 的效果。我们也与 HC exosomes 相比在 PBC 识别了 microRNA (miRNA ) 人口。我们此处报导尽管 exosomes 不改变 cytokine 生产,他们显著地确实在介绍抗原的人口上改变 co-stimulatory 分子表示。进一步,我们在 CD14 + 单核白血球上表明了那 CD86 起来调整的表情,而在 CD11c + 上起来调整的 CD40 由从有 PBC 的病人的 exosomes 的树枝状的房间。另外,有在有 PBC 的病人的传播 exosomes 的 miRNA 表示的差别。这些数据基于 co-stimulatory 分子玩的观察有重要重要性在 T 房间激活的规定的一个微分角色。我们的观察显示从 PBC 的异常 exosomes 有选择地在介绍抗原的房间的不同子集导致 co-stimulatory 分子的表示。这些改变可以在自体免疫的肝疾病的致病包含。 | Takashi Tomiyama Guo-Xiang Yang Ming Zhao Weici Zhang Hajime Tanaka Jing Wang Patrick SC Leung Kazuiclli Okazaki Xiao-Song He Qianjin Lu Ross L Coppel Christopher L Bowlus M Eric Gershwin | 2017 | Cellular & Molecular Immunology2017，14，3： | 18 |
| 2 | Usefulness of Kyoto criteria as expanded selection criteria for liver transplantation for hepatocellular carcinoma显示文摘 | Toshimi Kaido Kohei Ogawa Akira Mori Yasuhiro Fujimoto Takashi Ito Koji Tomiyama Yasutsugu Takada Shinji Uemoto | 2013 | Surgery2013，，： | 3 |
| 3 | Effects of aging and persistent prehypertension on arterial stiffening显示文摘 | Hirofumi Tomiyama Hideki Hashimoto Chisa Matsumoto Mari Odaira Masanobu Yoshida Kazuki Shiina Mikio Nagata Akira Yamashina Nobutaka Doba Shigeaki Hinohara | 2011 | Atherosclerosis2011，，1： | 2 |
| 4 | Numerical Simulations on Countercurrent Gas-Liquid Flow in a PWR Hot Leg with Air-Water Flow in a 1/15th Scale-Model显示文摘 | N. Minami M. Murase Y. Utanohara I. Kinoshita A. Tomiyama | 2011 | Journal of Energy and Power Engineering2011，5，6： | 2 |
| 5 | 内镜下静脉曲张结扎术联合部分脾脏栓塞术:可明显改善伴有食管静脉曲张与血小板减少的肝硬化患者预后显示文摘The aim of this study was to assess the efficacy of the combination of endoscopic variceal ligation(EVL)and partial splenic embolization(PSE)compared with EVL alone in cirrhosis patients with thrombocytopenia.In a prospective study,84 cirrhosis patients with esophageal varices and thrombocytopenia(platelet count < 50,000/mm3)underwent EVL plus PSE(N = 42)or EVL alone(N = 42).Primary end points assessed during the follow-up period included the recurrence of varices,progression to variceal bleeding,and death.Comparison between combined treatment and variceal ligation alone by multivariate analysis showed a hazard ratio of 0.44 for the recurrence of varices(P = 0.02),0.19 for progression to variceal bleeding(P = 0.01),and 0.31 for death(P = 0.04).These results suggest that the combination of EVL plus PSE can prevent the recurrence of varices,progression to variceal bleeding,and death in cirrhosis patients with esophageal varices and thrombocytopenia. | Ohmoto K. Yoshioka N. Tomiyama Y. 王顺涛 | 2006 | 世界核心医学期刊文摘(胃肠病学分册)2006，2，9： | 2 |
| 6 | Masked hypertension and target organ damage in treated hypertensive patients显示文摘 | Tomiyama M Horio T Yoshii M | 2006 | Am J Hypertens2006，19，9： | 1 |
| 7 | Cut off value of the ankle brachial pressure index at which the accuracy of brachial-ankle pulse wave velocity measurement is diminished显示文摘 | Motobe K Tomiyama H Koji Y | 2005 | Circ J2005，69，1： | 1 |
| 8 | Predictors of progression from prehypertension to hypertension in Japanese men 显示文摘 | Tomiyama H Matsumoto C Yamada J | 2009 | Am J Hypertens2009，22，11： | 1 |
| 9 | Cytotoxic T-cell recognition of HIV-1 cross-cladn and clade-specific epitopes in HIV-1-infected Thai and Japanese patients显示文摘 | Fukada K Tomiyama H Wasi C | 2002 | AlDS2002，16，5： | 1 |
| 10 | Using the World HealthOrganization Classification of thymic epithelial neoplasms todescribe CT findings显示文摘 | Tomiyama N Johkoh T Mihara N | 2002 | AJR2002，179，1： | 1 |
| 11 | Successful birth after transfer of vitrified human blastocysts with use of a cryoloop eontainerless technique 显示文摘 | Mukaida T Nakamura S Tomiyama T | 2001 | Fertil Steril2001，76，： | 1 |
| 12 | Using the World Health Organization Classification of thymic epithelial neoplasms to de- scribe CT findings显示文摘 | Tomiyama N Johkoh T Mihara N | 2002 | AJR2002，179，4： | 1 |
| 13 | Bile du-ct wall thickness measured by intraductal US in patients who have not undergone previous biliary drainage显示文摘 | TAMADA K TOMIYAMA T OOHASHI A | | 0，，02： | 1 |
| 14 | Cloning and nudeotide sequencing of the membrane-bond L-sorbose dehydrogenase gene of Acetobacter liquefaeiem IFO 12258 and its expressin in Gluconobaeter oxydans 显示文摘 | Shinjoh M Tomiyama N | 1995 | Appl Environ Microbiology1995，61，2： | 1 |
| 15 | Reverse white-coat effect as an independent risk for microalbuminuria in treated hypertensive patients显示文摘 | Kato T Horio T Tomiyama M | 2007 | Nephrol Dial Transplant2007，22，3： | 1 |
| 16 | Supporting conceptual design based on the function-behavior-state modeler显示文摘 | Masaki I Tomiyama T | 1996 | AI EDAM1996，10，4： | 1 |
| 17 | C66 fullerene encaging a scandium dimer显示文摘 | Wang C R Kai T Tomiyama T | 2000 | Nature2000，408，6811： | 1 |
| 18 | Consevered primary structures in core capsids proteins and reassembly of core particles and outer capsids between Rice gall dwarf and Rice dwarf phytoreviruses 显示文摘 | Takahashi Y Tomiyama M Hibino H | 1994 | Journal of Virology1994，75，： | 1 |
| 19 | Prevalence of anemia according to stage of chronic kidney disease in a large screening cohort of Japanese显示文摘 | Kohagura K Tomiyama N Kinjo K | 2009 | Clin Exp Nephrol2009，13，6： | 1 |
| 20 | Validity,reproducibility,and clinical significance of noninvasive brachialankle pulse wave velocity measurement显示文摘 | Yamashina A Tomiyama H Takeda K | 2002 | Hypertens Res2002，25，3： | 1 |
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