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| 1 | 臂间血压差与脑卒中的关系显示文摘为了检测同时测量的双臂血压差值是否可识别踝臂血压指数〈0.90的受试者,及是否能预测未来心血管事件,Hirofumi等收集来自10个队列的日本受试者13 317人的数据(基于一般人群的队列,既往有心血管事件病史的队列及有心血管病危险因素的队列)进行荟萃分析。 | 刘青 叶鹏 Hirofumi T Toshiaki O Toshiharu N Chisa M Kazuomi K Satoshi H Yoshikuni K Toyoshi I Yasutaka M Katsuhiko K Yasuharu T Motoyuki N Takayoshi O Hirotaka W Masanori M Mitsuru O Norihisa I Michinari N Tetsuo S Charalambos V Akira Y | 2018 | 中华高血压杂志2018，26，6： | 3 |
| 2 | Effects of aging and persistent prehypertension on arterial stiffening显示文摘 | Hirofumi Tomiyama Hideki Hashimoto Chisa Matsumoto Mari Odaira Masanobu Yoshida Kazuki Shiina Mikio Nagata Akira Yamashina Nobutaka Doba Shigeaki Hinohara | 2011 | Atherosclerosis2011，，1： | 2 |
| 3 | Combination of fluvastatin with pegylated interferon/ribavirin therapy reduces viral relapse in chronic hepatitis C infected with HCV genotype 1b显示文摘 | Masanori Atsukawa Akihito Tsubota Chisa Kondo Norio Itokawa Yoshiyuki Narahara Katsuhisa Nakatsuka Satomi Hashimoto Takeshi Fukuda Yoko Matsushita Hideko Kidokoro Tamaki Kobayashi Hidenori Kanazawa Choitsu Sakamoto | 2012 | J Gastroenterol Hepatol2012，，1： | 2 |
| 4 | Ankle brachial pressure index and carotid intima-media thickness as atherosclerosis markers in Japanese diabetics显示文摘 | Chisa H Osamu O Sayaka K | 2004 | Diabetes Research and Clinical Practice2004，66，3： | 1 |
| 5 | Effects of transjugular intrahepatic portosystemic shunt on changes in the small bowel mucosa of cirrhotic patients with portal hypertension显示文摘 | Yoko Matsushita Yoshiyuki Narahara Shunji Fujimori Hidenori Kanazawa Norio Itokawa Takeshi Fukuda Yoko Takahashi Chisa Kondo Hideko Kidokoro Masanori Atsukawa Katsuhisa Nakatsuka Choitsu Sakamoto | 2013 | Journal of Gastroenterology2013，，5： | 1 |
| 6 | 17-β-estradiol degradation by TiO2 photocatalysis as a means of reducing estrogenic activity显示文摘 | O Yoshihisa R Ken-ichi N Chisa | 2002 | Environ Sci Technol2002，36，19： | 1 |
| 7 | Multiple halo nevi in siblings显示文摘 | Chisa N | 1965 | Arch Dermatol1965，92，4： | 1 |
| 8 | Self-sterilizing and self-cleaning of silicone catheters coated with TiO2 photoeatalyst thin films: A Preclinieal work显示文摘 | Yoshihisa Ohko Yosuke Utsumi Chisa Niwa | 2001 | J Biomed Mater Res-Appl Biomater2001，58，： | 1 |
| 9 | Immobilization of bioactive FGF-2 into cubic proteinous microcrystals (Bombyx mori cypovirus polyhedra) that are insoluble in a physiological cellular environment 显示文摘 | Mori Hajime and shukunami Chisa | 2007 | Journal of Biological Chemistry2007，282，17： | 1 |
| 10 | Serum amyloid a protein as a predictor of cardiac rupture in acute myocar- dial infarction patients following primary coronary angio- plasty显示文摘 | Toshiro K Hiroshi N Chisa T | 2006 | Circ J2006，70，43： | 1 |
| 11 | Adrenocorticotropic hormone-secreting pancreatic neuroendocrine carcinoma with multiple organ infections and widespread thrombosis:A case report显示文摘BACKGROUND Ectopic adrenocorticotropic hormone(ACTH)-secreting neuroendocrine tumors are rare diseases.Patients with ACTH-secreting pancreatic neuroendocrine carcinomas have a poor prognosis.Infections and coagulopathies have been reported as the cause of death.However,detailed clinical descriptions of the morbid complications of ACTH-secreting neuroendocrine carcinomas have not been reported.CASE SUMMARY A 78-year-old Japanese woman consulted a medical center due to systemic edema and epigastric discomfort.Laboratory analysis revealed hypercortisolemia with increased ACTH secretion without diurnal variation in serum cortisol level.An enhanced computed tomography(CT)scan revealed a 3-cm tumor in the pancreatic head.The cytological material from endoscopic ultrasound-guided fine-needle aspiration was compatible with ACTHsecreting pancreatic neuroendocrine carcinoma.The Ki-67 index was 40%.She was transferred to Mie University Hospital for surgical treatment.The patient was diagnosed with urinary tract infection,cytomegalovirus hepatitis,esophageal candidiasis,pulmonary infiltrates suspicious for Pneumocystis carinii pneumonia,peripheral deep vein thrombosis,pulmonary embolism,and disseminated intravascular coagulation.The multiple organ infections and thromboses responded well to antimicrobial and anticoagulant therapy.Radioisotope studies disclosed a pancreatic tumor and a metastatic lesion in the liver,whereas somatostatin receptor scintigraphy showed negative findings,suggesting the primary and metastatic tumors were poorly differentiated.A CT scan before admission showed no metastatic liver lesion,suggesting that the pancreatic tumor was rapidly progressing.Instead of surgery,antitumor chemotherapy was indicated.The patient was transferred to another hospital to initiate chemotherapy.However,she died four months later due to the rapidly progressive tumor.CONCLUSION ACTH-secreting pancreatic neuroendocrine neoplasm is a rare disease with a very poor prognosis.The clinical course and acute complications of the tumor remain unreported.Here we report the clinical course of a rapidly progressive case of ACTH-secreting pancreatic neuroendocrine tumor that developed infectious complications due to many types of pathogens in multiple organs,widespread thromboses,pulmonary embolism,and disseminated intravascular coagulation. | Akihiro Yoshihara Kota Nishihama Chisa Inoue Yuko Okano Kazuhito Eguchi Soichiro Tanaka Kanako Maki Valeria Fridman D'Alessandro Atsuro Takeshita Taro Yasuma Mei Uemura Toshinari Suzuki Esteban C Gabazza Yutaka Yano | 2022 | World Journal of Clinical Cases2022，10，17： | 1 |
| 12 | Objective evaluation of emotion using analysis of brain wave (English) 显示文摘 | HARUMI M ERIKO H CHISA N | 2011 | Journal of Textile Engineering2011，57，3： | 1 |
| 13 | LDL oxiditiin in patients with severe carotid atherisclerisis: A studyy of in vitro and in vivo oxidation Markers显示文摘 | Magyi E Chisa R Melissano G | 1994 | Arteriosclerosis and thrombosis1994，14，12： | 1 |
| 14 | Noggin regulation of bone morphogenetic protein (BMP) 2/7 heterodimer activity in vitro显示文摘 | Wei Zhu Jaehon Kim Christina Cheng Bernard A. Rawlins Oheneba Boachie-Adjei Ronald G. Crystal Chisa Hidaka | 2006 | Bone2006，，1： | 1 |
| 15 | M1- and M2-macrophage polarization in rat liver cirrhosis induced by thioacetamide (TAA), focusing on Iba1 and galectin-3显示文摘 | Kavindra Kumara Wijesundera Takeshi Izawa Anusha Hemamali Tennakoon Hiroshi Murakami Hossain M. Golbar Chisa Katou-Ichikawa Miyuu Tanaka Mitsuru Kuwamura Jyoji Yamate | 2014 | Experimental and Molecular Pathology2014，，3： | 1 |
| 16 | Serumamyloid A protein as a predictor of cardiac rupture in acutemyocardial infarction patients following primary coronary angioplasty显示文摘 | Toshiro Katayama Hiroshi Nakashima Chisa Takagi | 2006 | Circulation2006，，： | 1 |
| 17 | Accelerated Blood Clearance Phenomenon Upon Repeated Injection of PEG-modified PLA-nanoparticles显示文摘 | Tsutomu Ishihara Miho Takeda Haruka Sakamoto Ayumi Kimoto Chisa Kobayashi Naoko Takasaki Kanae Yuki Ken-ichiro Tanaka Mitsuko Takenaga Rie Igarashi Taishi Maeda Naoki Yamakawa Yoshinari Okamoto Masami Otsuka Tatsuhiro Ishida Hiroshi Kiwada Yutaka Mizushim | 2009 | Pharmaceutical Research2009，，10： | 1 |
| 18 | Sodium-glucose co-transporter-2 inhibitor-associated euglycemic diabetic ketoacidosis that prompted the diagnosis of fulminant type-1 diabetes:A case report显示文摘Fulminant type 1 diabetes mellitus(FT1DM)is a subtype of type 1 diabetes mellitus characterized by an abrupt onset and a rapid and complete functional loss of isletβcells.It is a very rare disease generally associated with ketoacidosis and the absence of circulating pancreatic islet-related autoantibodies.Diabetic ketoacidosis with normal blood glucose levels has been reported during sodiumglucose co-transporter 2(SGLT2)inhibitor therapy.CASE SUMMARY The patient was a 43-year-old woman that consulted a medical practitioner for malaise,thirst,and vomiting.Blood analysis showed high blood glucose levels(428 mg/dL),a mild increase of hemoglobin A1c(6.6%),and increased ketone bodies in urine.The patient was diagnosed with type 2 diabetes mellitus.The patient was initially treated with insulin,which was subsequently changed to an oral SGLT2 inhibitor.Antibodies to glutamic acid decarboxylase were negative.Four days after receiving oral SGLT2 inhibitor,she consulted at Mie University Hospital,complaining of fatigue and vomiting.Laboratory analysis revealed diabetic ketoacidosis with almost normal blood glucose levels.The endogenous insulin secretion was markedly low,and the serum levels of islet-related autoantibodies were undetectable.We made the diagnosis of FT1DM with concurrent SGLT2 inhibitor-associated euglycemic diabetic ketoacidosis.The patient's general condition improved after therapy with intravenous insulin and withdrawal of oral medication.She was discharged on day 14 with an indication of multiple daily insulin therapy.CONCLUSION This patient is a rare case of FT1DM that developed SGLT2 inhibitor-associated diabetic ketoacidosis with almost normal blood glucose levels.This case report underscores the importance of considering the diagnosis of FT1DM in patients with negative circulating autoantibodies and a history of hyperglycemia that subsequently develop euglycemic diabetic ketoacidosis following treatment with a SGLT2 inhibitor. | Taro Yasuma Yuko Okano Soichiro Tanaka Kota Nishihama Kazuhito Eguchi Chisa Inoue Kanako Maki Akihiro Uchida Mei Uemura Toshinari Suzuki Corina N D'Alessandro-Gabazza Esteban C Gabazza Yutaka Yano | 2021 | World Journal of Clinical Cases2021，9，13： | 1 |
| 19 | Maturational differences in superficial and deep zone articular chondrocytes显示文摘 | Chisa Hidaka Christina Cheng Deborah Alexandre Madhu Bhargava Peter A. Torzilli | 2006 | Cell and Tissue Research2006，，1： | 1 |
| 20 | Usefulness of portal vein pressure for predicting the effects of tolvaptan in cirrhotic patients显示文摘AIM: To elucidate influencing factors of treatment response, then tolvaptan has been approved in Japan for liquid retention.METHODS: We herein conducted this study to clarify the influencing factors in 40 patients with decompensated liver cirrhosis complicated by liquid retention. Tolvaptan was administered at a dosage of 7.5 mg once a day for patients with conventional diuretic-resistant hepatic edema for 7 d. At the initiation of tolvaptan, the estimated hepatic venous pressure gradient(HVPG) value which was estimated portal vein pressure was measured using hepatic venous catheterization. We analyzed the effects of tolvaptan and influencing factors associated with treatment response.RESULTS: Subjects comprised patients with a median age of 65(range, 40-82) years. According to the ChildPugh classification, class A was 3 patients, class B was 19, and class C was 18. Changes from the baseline in body weight were-1.0 kg(P = 2.04 × 10^(-6)) and-1.3 kg(P = 1.83 × 10^(-5)), respectively. The median HVPG value was 240(range, 105-580) mm H2 O. HVPG was only significant influencing factor of the weight loss effect. When patients with body weight loss of 2 kg or greater from the baseline was defined as responders, receiver operating characteristic curve analysis showed that the optimal HVPG cutoff value was 190 mm H_2 O in predicting treatment response. The response rate was 87.5%(7/8) in patients with HVPG of 190 mm H2 O or less, whereas it was only 12.5%(2/16) in those with HVPG of greater than 190 mm H2O(P = 7.46 × 10^(-4)). We compared each characteristics factors between responders and non-responders. As a result, HVPG(P = 0.045) and serum hyaluronic acid(P = 0.017) were detected as useful factors.CONCLUSION: The present study suggests that tolvaptan in the treatment of liquid retention could be more effective for patients with lower portal vein pressure. | Ai Nakagawa Masanori Atsukawa Akihito Tsubota Chisa Kondo Tomomi Okubo Taeang Arai Norio Itokawa Yoshiyuki Narahara Katsuhiko Iwakiri | 2016 | World Journal of Gastroenterology2016，22，21： | 1 |
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