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| 1 | The increase in surface CXCR4 expression on lung extravascular neutrophils and its effects on neutrophils during endotoxin-induced lung injury显示文摘Inflammatory stimuli,such as a microbes or lipopolysaccharides,induce a rapid release of neutrophils from the bone marrow and promote neutrophil migration into inflamed sites to promote host defense.However,an excess accumulation and retention of neutrophils in inflamed tissue can cause severe tissue injuries in the later stages of inflammation.Recent studies have reported that both CXCL12 levels in injured lungs and its receptor,CXCR4,on accumulated neutrophils in injured lungs,increased;furthermore,these studies showed that the CXCL12/CXCR4 signaling pathway participated in neutrophil accumulation in the later stages of lipopolysaccharide(LPS)-induced lung injury.However,the mechanisms underlying this increase in surface CXCR4 expression in neutrophils remain unclear.In this study,we found that surface CXCR4 expression increased in extravascular,but not intravascular,neutrophils in the lungs of LPS-induced lung injury model mice.Furthermore,ex vivo studies revealed that CXCL12 acted not only as a chemoattractant,but also as a suppressor of cell death for the lung neutrophils expressing CXCR4.Sulfatide,one of the native ligands for L-selectin,induced the increase of surface CXCR4 expression on isolated circulating neutrophils,suggesting that the activation of L-selectin may be involved in the increase in surface CXCR4.Our findings show that surface CXCR4 levels on neutrophils increase after extravasation into injured lungs,possibly through the activation of L-selectin.The CXCL12/CXCR4 signaling pathway plays an important role in the modulation of neutrophil activity during acute lung injury,not only by promoting chemotaxis but also by suppressing cell death. | Mitsuhiro Yamada Hiroshi Kubo Seiichi Kobayashi Kota Ishizawa Mei He Takaya Suzuki Naoya Fujino Hiroyuki Kunishima Masamitsu Hatta Katsushi Nishimaki Tetsuji Aoyagi Kouichi Tokuda Miho Kitagawa Hisakazu Yano Hirokazu Tamamura Nobutaka Fujii Mitsuo Kaku | 2011 | Cellular & Molecular Immunology2011，8，4： | 6 |
| 2 | 大蒜播种机排种器及开沟器设计与控制(摘选) | Jiraporn Benjaphragairat Hai Sakurai Nobutaka Ito | 2011 | 农业工程2011，1，2： | 5 |
| 3 | Isolation of collagen from fish waste material — skin, bone and fins显示文摘 | Takeshi Nagai Nobutaka Suzuki | 1999 | Food Chemistry1999，，3： | 4 |
| 4 | A potent chemotherapeutic strategy in prostate cancer: S-(methoxytrityl)-L-cysteine, a novel Eg5 inhibitor显示文摘基于 Docetaxel 的联合化疗为阉割抵抗的前列腺癌症仍然是占优势的治疗。然而, taxane 相关的药抵抗和 neurotoxicity 提示了我们开发代用品治疗策略。Eg5 (kinesin 锭子蛋白质) 为双极的锭子形成关键并且在有丝分裂的早阶段期间复制染色体分离,为癌症化疗作为一个吸引人的目标出现了。这研究的目的是调查 S-(methoxytrityl )-L-cysteine (S (MeO ) TLC ) 的 anticancer 功效,在前列腺癌症的一个新奇 Eg5 禁止者。Eg5 表示在人的前列腺癌症房间线被检验,织物 microarrays 从临床的标本被构造。在前列腺癌症房间的 S (MeO ) TLC 的 Antiproliferative 活动被房间生存能力试金估计。anticancer 效果和在前列腺癌症房间的 S (MeO ) TLC 的禁止的机制被 Hoechst 染色,流动 cytometry 和 immunofluorescence 进一步探索。另外,下的异种皮移植模型上的 S (MeO ) TLC 的 antitumor 效果被估计。Eg5 表示在 PC3, DU145 和 LNCaP 房间被识别。多于前列腺癌症的一半,临床的标本显示了 Eg5 表示。S (MeO ) TLC 与测试的另外的四个 Eg5 禁止者相比在前列腺癌症房间展出了更多的强大的 anticancer 活动。S (MeO ) TLC 在逮捕与不同 monopolar 锭子形成在有丝分裂划分房间以后导致了房间死亡。S (MeO ) TLC 展出了它的重要禁止的活动(P < 0.05 ) 通过有丝分裂的拘捕的正式就职也在下的异种皮移植上当模特儿。我们断定 Eg5 是为前列腺癌症化疗的一个好目标,并且 S (MeO ) TLC 是在前列腺癌症答应 anticancer 代理人的一个有势力。 | Nai-Dong Xing Sen-Tai Ding Ryoichi Saito Koji Nishizawa Takashi Kobayashi Takahiro Inoue Shinya Oishi Nobutaka Fujii Jia-Jv Lv Osamu Ogawax Hiroyuki Nishiyama | 2011 | Asian Journal of Andrology2011，13，2： | 4 |
| 5 | Comparison of He/icobacter py/ori infection and gastric mucosal histological features of gastric ulcer patients with chronic gastritis patients显示文摘AIM: To compare Helicobacter pyloriinfection and gastric mucosal histological features of gastric ulcer patients with chronic gastritis patients in different age groups and from different biopsy sites.METHODS: The biopsy specimens were taken from the antrum, corpus and upper angulus of gastric ulcer and chronic gastritis patients. Giemsa staining, improved Toluidine-blue staining and H pylori-specific antibody immune staining were performed as appropriate for the histological diagnosis of H pylori infection. Hematoxylineosin staining was used for the histological diagnosis of activity of H pylori infection, mucosal inflammation,glandular atrophy and intestinal metaplasia and scored into four grades according to the Updated Sydney System.RESULTS: Total rate of H pylori infection, mucosal inflammation, activity of H pylori infection, glandular atrophy and intestinal metaplasia in 3 839 gastric ulcer patients (78.5%, 97.4%, 82.1%, 61.1% and 64.2%,respectively) were significantly higher than those in 4 102chronic gastritis patients (55.0%, 90.3%, 56.2%, 36.8%,and 37.0%, respectively, P<0.05). The rate of H pylori colonization of chronic gastritis in <30 years, 31-40 years,41-50 years, 51-60 years, 61-70 years and >70 years age groups in antrum was 33.3%, 41.7%, 53.6%, 57.3%,50.7%, 43.5%, respectively; in corpus, it was 32.6%,41.9%, 53.8%, 60.2%, 58.0%, 54.8%, respectively; in angulus, it was 32.4%, 42.1%, 51.6%, 54.5%, 49.7%,43.5%, respectively. The rate of Hpyloricolonization of gastric ulcer in <30 years, 31-40 years, 41-50 years,51-60 years, 61-70 years and >70 years age groups in antrum was 60.5%, 79.9%, 80.9%, 66.8%, 59.6%, 45.6%,respectively; in corpus, it was 59.7%, 79.6%, 83.6%,80.1%, 70.6%, 59.1%, respectively; in angulus, it was61.3%, 77.8%, 75.3%, 68.8%, 59.7%, 45.8%,respectively. The rate of H pylori colonization at antrum was similar to corpus and angulus in patients, below50 years, with chronic gastritis and in patients, below40 years, with gastric ulcer. In the other age- groups,the rate of H pylori colonization was highest in corpus,lower in antrum and lowest in angulus (all P<0.05). The rates of glandular atrophy and intestinal metaplasia were higher and earlier in H pylori-positive patients than those without H pylori infection (both P<0.01). In comparison of gastric ulcer patients with chronic gastritis patients,the rate of glandular atrophy and intestinal metaplasia was higher in H pylori-positive patients with gastric ulcer than in H pylori-positive patients with chronic gastritis(both P<0.01); the rate of glandular atrophy and intestinal metaplasia were also higher in H pylori-negative patients with gastric ulcer than in H pylori-negative patients with chronic gastritis (both P<0.01). Both glandular atrophy and intestinal metaplasia were much more commonly identified in the angulus than in the antrum, lowest in corpus (all P<0.01).CONCLUSION: Rate of H pylori infection, glandular atrophy and intestinal metaplasia in gastric ulcer were higher than in chronic gastritis in all-different age -groups. Distribution of H pylori colonization is pangastric in the younger patients. It is highest in corpus, lower in antrum and lowest in angulus in the older age groups. Progression of glandular atrophy and intestinal metaplasia seem to have a key role in the distribution of H pylori colonization. H pylori appears to be the most important risk factor for the development of glandular atrophy and intestinal metaplasia, but it is not the only risk. | Chuan Zhang Nobutaka Yamada Yun-Lin Wu Min Wen Takeshi Matsuhisa Norio Matsukura | 2005 | World Journal of Gastroenterology2005，11，7： | 3 |
| 6 | Spontaneous rupture of splenic hamartoma in a patient with hepatitis C virus-related cirrhosis and portal hypertension:A case report and review of the literature显示文摘自发的破裂是脾的错构瘤的稀罕复杂并发症。文学的评论揭示了仅仅四个如此的盒子。就我们的知识而言,这是与肝肝硬化和门静脉高血压联系的脾的错构瘤的自发的破裂的第一份报告。一个 53 岁的女人,被跟随在上面因为大动脉的解剖和丙肝病毒(HCV ) 联系了肝肝硬化,与突然的左胸和肩膀疼痛被提交。腹的超声证明流血的 intraabdominal,和显示的计算断层摄影术脾肿大破裂。突现的脾切除术被执行。手术后的功课是平静的,并且病人在第 13 手术后的天被解除。病理揭示了肿瘤是一个破裂的脾的错构瘤。非肿胀的脾的实质揭示了充血变化。我们认为肝肝硬化和门静脉高血压的存在是为脾的错构瘤的自发的破裂的风险因素。 | Yasuji Seyama Nobutaka Tanaka Yoshio Suzuki Motoki Nagai Takatoshi Furuya Yukihiro Nomura Jimpei Ishii Masakazu Nobori | 2006 | World Journal of Gastroenterology2006，12，13： | 3 |
| 7 | Whole-breast radiotherapy with shorter fractionation schedules following breast-conserving surgery: short-term morbidity and preliminary outcomes显示文摘 | Osamu Fujii Jyunichi Hiratsuka Naomi Nagase Ryuji Tokiya Eisaku Yoden Hiroshi Sonoo Nobutaka Murashima Shigemichi Iha Yoshinari Imajyo | 2008 | Breast Cancer2008，，1： | 2 |
| 8 | Isolation and characterisation of collagen from the outer skin waste material of cuttlefish ( Sepia lycidas )显示文摘 | Takeshi Nagai Eiji Yamashita Kei Taniguchi Norio Kanamori Nobutaka Suzuki | 2001 | Food Chemistry2001，，4： | 2 |
| 9 | Collagen from common minke whale ( Balaenoptera acutorostrata ) unesu显示文摘 | Takeshi Nagai Nobutaka Suzuki Toshio Nagashima | 2008 | Food Chemistry2008，，2： | 2 |
| 10 | Regeneration of Hippocampal Pyramidal Neurons after Ischemic Brain Injury by Recruitment of Endogenous Neural Progenitors显示文摘 | Hirofumi Nakatomi Toshihiko Kuriu Shigeo Okabe Shin-ichi Yamamoto Osamu Hatano Nobutaka Kawahara Akira Tamura Takaaki Kirino Masato Nakafuku | 2002 | Cell2002，，4： | 2 |
| 11 | Effects of aging and persistent prehypertension on arterial stiffening显示文摘 | Hirofumi Tomiyama Hideki Hashimoto Chisa Matsumoto Mari Odaira Masanobu Yoshida Kazuki Shiina Mikio Nagata Akira Yamashina Nobutaka Doba Shigeaki Hinohara | 2011 | Atherosclerosis2011，，1： | 2 |
| 12 | Helicobacter pylori eradication therapy for the remnant stomach after gastrectomy显示文摘 | Norio Matsukura Takashi Tajiri Shunji Kato Akiyoshi Togashi Gotaro Masuda Itsuo Fujita Akira Tokunaga Nobutaka Yamada | 2003 | Gastric Cancer2003，，2： | 2 |
| 13 | Collagen of the skin of ocellate puffer fish ( Takifugu rubripes )显示文摘 | Takeshi Nagai Yoko Araki Nobutaka Suzuki | 2002 | Food Chemistry2002，，2： | 2 |
| 14 | Supra-angular biopsy is more reliable for atrophy recognization:analysis of 1598 cases for gastric mucosal histological examination显示文摘INTRODUCTIONChronic gastritis might be a disease of the highestmorbidity in the world.Since Warren and Marshallsuccessfully isolated and cultured Helicobacter pylori(H.pylori)from a gastric antrum biopsy,intensive researches produced a historic change inthe etiology and treatment of gastroduodenaldiseases.Stimulated by this | Nobutaka Yamada | 2000 | World Journal of Gastroenterology2000，6，6： | 2 |
| 15 | Attenuation of Brain Damage and Cognitive Impairment by Direct Renin Inhibition in Mice With Chronic Cerebral Hypoperfusion显示文摘 | Yi-Fei Dong Keiichiro Kataoka Kensuke Toyama Daisuke Sueta Nobutaka Koibuchi Eiichiro Yamamoto Kenichiro Yata Hidekazu Tomimoto Hisao Ogawa Shokei Kim-Mitsuyama | 2011 | Hypertension2011，，4： | 2 |
| 16 | Isolation and characterisation of collagen from the outer skin waste material of cuttlefish ( Sepia lycidas )显示文摘 | Takeshi Nagai Eiji Yamashita Kei Taniguchi Norio Kanamori Nobutaka Suzuki | 2001 | Food Chemistry2001，，4： | 2 |
| 17 | Primary site resection is superior for incurable metastatic colorectal cancer显示文摘AIM:To investigate survival in patients treated with FOLFOX followed by primary site resection or palliative surgery for incurable metastatic colorectal cancer. METHODS:Between 2001 and 2009,a total of 98 patients with colorectal adenocarcinoma and non-resectable metastases were diagnosed and treated with the new systemic agent chemotherapy regimen FOLFOX. Primary site resection was carried out in 38 patients, creation of a colostomy or bypass without resection was carried out in 36 patients,and 23 were not operated on because of advanced disease.The survival times of patients in different groups were analyzed. RESULTS:There were no differences between the patients regarding their general condition,concurrent disease,or tumor stage according to AJCC classification.The median survivals of the three groups were 30.6,20.8,and 12.7 mo(log-rank P value<0.05),respectively.The postoperative complication rate was higher in the primary site resection group than in the palliative surgery group. CONCLUSION:The results indicate that there are benefits from primary site resection for incurable metastatic colorectal cancer with systemic chemotherapy. | Yusuke Tanoue Nobutaka Tanaka Yukihiro Nomura | 2010 | World Journal of Gastroenterology2010，16，28： | 2 |
| 18 | Cancer immunotherapy for pancreatic cancer utilizing α-gal epitope/natural anti-Gal antibody reaction显示文摘Pancreatic ductal adenocarcinoma(PDAC) has the poorest prognosis of all malignancies and is largely resistant to standard therapy. Novel treatments against PDAC are desperately needed. Anti-Gal is the most abundant natural antibody in humans,comprising about 1% of immunoglobulins and is also naturally produced in apes and Old World monkeys. The anti-Gal ligand is a carbohydrate antigen called 'α-gal epitopes' with the structure Galα1-3Galβ1-4Glc NAc-R. These epitopes are expressed as major carbohydrate antigens in non-primate mammals,prosimians,and New World monkeys. Anti-Gal is exploited in cancer vaccines to increase the immunogenicity of antigen-presenting cells(APCs). Cancer cells or PDAC tumor lysates are processed to express α-gal epitopes. Vaccination with these components results in in vivo opsonization by anti-Gal Ig G in PDAC patients. The Fc portion of the vaccine-bound anti-Gal interacts with Fcγ receptors of APCs,inducing uptake of the vaccine components,transport of the vaccine tumor membranes to draining lymph nodes,and processing and presentation of tumor-associated antigens(TAAs). Cancer vaccines expressing α-gal epitopes elicit strong antibody production against multiple TAAs contained in PDAC cells and induce activation of multiple tumor-specific T cells. Here,we review new areas of clinical importance related to the α-gal epitope/anti-Gal antibody reaction and the advantages in immunotherapy against PDAC. | Masahiro Tanemura Eiji Miyoshi Hiroaki Nagano Hidetoshi Eguchi Katsuyoshi Matsunami Kiyomi Taniyama Nobutaka Hatanaka Hiroki Akamatsu Masaki Mori Yuichiro Doki | 2015 | World Journal of Gastroenterology2015，21，40： | 2 |
| 19 | Intra-Arterial Infusion Chemotherapy Using Cisplatin With Radiotherapy for Stage III Squamous Cell Carcinoma of the Cervix显示文摘 | Yuko Kaneyasu Nobutaka Nagai Yasushi Nagata Yasutoshi Hashimoto Shintaro Yuki Yuji Murakami Masahiro Kenjo Hideaki Kakizawa Naoyuki Toyota Hisaya Fujiwara Yoshiki Kudo Katsuhide Ito | 2009 | International Journal of Radiation Oncology Biology Physics2009，，2： | 1 |
| 20 | Valuation of a 1-methyl4- phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-treated C57 black mouse model for parkinsonism 显示文摘 | NOBUTAKA A YOSHIO G | 1990 | Brain Res1990，515，： | 1 |
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