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| 1 | Mucus production stimulated by IFN-AhR signaling triggers hypoxia of COVID-19显示文摘Silent hypoxia has emerged as a unique feature of coronavirus disease 2019(COVID-19).In this study,we show that mucins are accumulated in the bronchoalveolar lavage fluid(BALF)of COVID-19 patients and are upregulated in the lungs of severe respiratory syndrome coronavirus 2(SARS-CoV-2)-infected mice and macaques.We find that induction of either interferon(IFN)-P or IFN-y upon SARS-CoV-2 infection results in activation of aryl hydrocarbon receptor(AhR)signaling through an IDO-Kyn-dependent pathway,leading to transcriptional upregulation of the expression of mucins,both the secreted and membrane-bound,in alveolar epithelial cells.Consequently,accumulated alveolar mucus affects the blood-gas barrier,thus inducing hypoxia and diminishing lung capacity,which can be reversed by blocking AhR activity.These findings potentially explain the silent hypoxia formation in COVID-19 patients,and suggest a possible intervention strategy by targeting the AhR pathway. | Yuying Liu Jiadi Lv Jiangning Liu Man Li Jing Xie Qi Lv Wei Deng Nannan Zhou Yabo Zhou Jiangping Song Peng Wang Chuan Qin Wei-Min Tong Bo Huang | 2020 | Cell Research2020，30，12： | 5 |
| 2 | New insights of the Cenozoic Rotational Deformation of Crustal Blocks on the Southeastern Margin of the Tibetan Plateau and its Tectonic Implications显示文摘Objective The lateral extrusion of crustal materials around the southeastern edge of the Tibetan Plateau since the Oligocene is believed to be one of the main inducements of^1300 km latitudinal crustal convergence in the Tibetan Plateau,since the collision of India and Eurasia in the Paleogene.Two end-member models were used to describe the process of lateral extrusion of crustal | TONG Yabo ZHAO Yue PU Zongwen | 2017 | Acta Geologica Sinica(English Edition)2017，91，2： | 2 |
| 3 | Escaping alveolar macrophage endosomal retention explains massive expansion of SARS-CoV-2 delta variant显示文摘Dear Editor,Genetic variant Delta(B.1.617.2)of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),which possesses a remarkable ability to transmit and spread,is currently becoming predominant worldwide.Despite its great harm to human beings,how the Delta variant with T478K,P681R and L452R mutations achieves its ultrafast spread remains elusive.Entry of SARS-CoV-2 into host cells is mediated by a rapid enzymatic hydrolysis. | Zhenfeng Wang Yabo Zhou Linlin Bao Dan Li Jiadi Lv Dianheng Wang Shunshun Li Wei-Min Tong Jiangning Liu Chuan Qin Bo Huang | 2022 | Signal Transduction and Targeted Therapy2022，7，1： | 1 |
| 4 | ACE2 expression is regulated by AhR in SARS-CoV-2-infected macaques显示文摘During the current outbreak of coronavirus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),more than 115 million people have been infected,and 2.5 million have died.1,2 Despite such great harm to human health,the pathogenesis of COVID-19 remains unclear.As the first step in the pathogenetic process,viral entry is mediated by the binding of the SARS-CoV-2 surface spike(S)protein to angiotensin-converting enzyme 2(ACE2)on host cells,such as lung epithelial cells.As an alternative to S protein-blocking strategies,manipulating host cell ACE2 expression may exert an inhibitory effect on SARS-CoV-2 infection.However,the molecular mechanism regulating ACE2 expression remains unclear. | Jiadi Lv Pin Yu Zhenfeng Wang Wei Deng Linlin Bao Jiangning Liu Fengli Li Qiangqiang Zhu Nannan Zhou Qi Lv Guanpeng Wang Shunyi Wang Yabo Zhou Jiangping Song Wei-Min Tong Yuying Liu Chuan Qin Bo Huang | 2021 | Cellular & Molecular Immunology2021，18，5： | 1 |
| 5 | SARS-CoV-2 treatment effects induced by ACE2-expressing microparticles are explained by the oxidized cholesterolincreased endosomal pH of alveolar macrophages显示文摘Exploring the cross-talk between the immune system and advanced biomaterials to treat SARS-CoV-2 infection is a promising strategy.Here,we show that ACE2-overexpressing A549 cell-derived microparticles(AO-MPs)are a potential therapeutic agent against SARS-CoV-2 infection.Intranasally administered AO-MPs dexterously navigate the anatomical and biological features of the lungs to enter the alveoli and are taken up by alveolar macrophages(AMs).Then,AO-MPs increase the endosomal pH but decrease the lysosomal pH in AMs,thus escorting bound SARS-CoV-2 from phago-endosomes to lysosomes for degradation.This pH regulation is attributable to oxidized cholesterol,which is enriched in AO-MPs and translocated to endosomal membranes,thus interfering with proton pumps and impairing endosomal acidification.In addition to promoting viral degradation,AO-MPs also inhibit the proinflammatory phenotype of AMs,leading to increased treatment efficacy in a SARS-CoV-2-infected mouse model without side effects.These findings highlight the potential use of AO-MPs to treat SARS-CoV-2-infected patients and showcase the feasibility of MP therapies for combatting emerging respiratory viruses in the future. | Zhenfeng Wang Jiadi Lv Pin Yu Yajin Qu Yabo Zhou Li Zhou Qiangqiang Zhu Shunshun Li Jiangping Song Wei Deng Ran Gao Yuying Liu Jiangning Liu Wei-Min Tong Chuan Qin Bo Huang | 2022 | Cellular & Molecular Immunology2022，19，2： | 1 |
| 6 | Forecasting of production safety situation by combination model显示文摘 | Xu Yabo Wang Tong Song Bingxue | 2012 | Procedia Engineering2012，43，2012： | 1 |
| 7 | Airway administration of bisphosphate and dexamethasone inhibits SARS-CoV-2 variant infection by targeting alveolar macrophages显示文摘Dear Editor,Alveolar macrophages(AMs)are among the first immune cells to encounter SARS-CoV-2 during an infection due to their abundant numbers and physical location in the lungs.Thus,the reaction of AMs to SARS-CoV-2 has a profound impact on the outcome of the infection.In most cases,AMs can release cytokines and prime adaptive T-and B-cell immune responses to resolve the infection. | Zhenfeng Wang Yabo Zhou Linlin Bao Dan Li Jiadi Lv Dianheng Wang Shunshun Li Jiangning Liu Chuan Qin Wei-Min Tong Bo Huang | 2022 | Signal Transduction and Targeted Therapy2022，7，5： | 1 |
| 8 | Geomagnetic polarity transitions recorded in the Miocene lavas of the Wuyu basin,Tibet显示文摘Geomagnetic polarity transitions were the most important phenomena in the study of the geomagnetic field evolution and the earth's deep interior dynamics.The Miocene postcollisional ultrapotassic-potassic rocks are widely distributed in the Lhasa Block of southern Tibet.Paleomagnetic studies on the Wuyu Formation indicated that these volcanic rocks recorded the C5Bn.2n-C5Bn.1r and C5ACr-C5ACn geomagnetic polarity transitions.The virtual geomagnetic poles(VGPs) of these two polarity transitions were located in the Atlantic and the central Pacific,respectively.Due to data scarcity,it remains unclear whether VGP paths of Miocene geomagnetic polarity transitions were longitudinal preference and/or 90° away from the sampling sites. | TONG YaBo YANG ZhenYu PAN YongXin ZHENG LianDi SUN ZhiMing PEI JunLing ZHUANG ZhongHai | 2011 | Science China Earth Sciences2011，54，4： | 0 |
| 9 | An efficient approach for the treatment of radioactive waste perfluoropolyether lubricants via a synergistic effect of thermal catalysis and immobilization显示文摘Perfluoropolyether(PFPE)lubricants are a kind of high-molecular polymer with many excellent properties.However,the use of PFPEs in the nuclear industry can lead to partial decomposition and carrying radionuclides,resulting in a large amount of radioactive waste PFPE lubricants annually.Moreover,radioactive waste PFPE lubricants are difficult to be effectively treated due to their high stability,the risk of possible leakage of radionuclides,and hypertoxic fluorine-containing by-products.In this study,without any precedent,a strategy of Mn O_(2)-catalyzed decomposition and Na_(2)CO_(3)-immobilized conversion was proposed for PFPE lubricant decomposition and fluorine immobilization simultaneously based on the Lewis acid-base and oxygen vacancies concept.A high fluorine conversion efficiency of 95.4%was achieved.Meanwhile,the mechanism of decomposition suggested that Mn O_(2)mainly provided Lewis acid sites and attacked the(basic)fluorine or oxygen atoms in PFPE molecules.The decomposition of PFPE chains was proceed down and volatile fluorine-containing gas was released by partial electron transfer,intramolecular disproportionation reaction,and unzipping fashion.Subsequently,gas by-products could be further oxidized and then immobilized into fluoride salts by carbonate solid absorbents.Overall,this study provides a simple,safe,and potentially practical strategy for the harmless conversion of refractory fluorinated organic wastes,especially perfluoropolymers. | Xinhang Du Wenhua Tong Xinyu Zhou Jia Luo Yuqiu Liu Yabo Wang Panyu Li Yongkui Zhang | 2024 | Journal of Environmental Sciences2024，，2： | 0 |
| 10 | Thermodynamic behavior for generalized f(R) gravity with arbitrary coupling between matter and geometry显示文摘The thermodynamic behavior of field equations for the generalized f(R) gravity with arbitrary coupling between matter and geometry is studied in the two kinds of spacetime,i.e.,the both spatially homogenous,isotropic FRW universe and static,spherically symmetric black hole spacetime.The field equations of the generalized f(R) gravity with arbitrary coupling between matter and geometry can be cast to the form of the first law of thermodynamics with the reputed entropy production terms dS,which are quite general and can degenerate to the cases of Einstein's general relativity and pure f(R) gravity with non-coupling and nonminimal coupling as special cases.The appearance of the entropy production term dS illustrates that the horizon thermodynamics is non-equilibrium one for the generalized f(R) gravity with arbitrary coupling between matter and geometry. | WU YaBo ZHAO YueYue LU JianBo ZHANG Xin TONG HaiDan YANG Hao | 2012 | Science China(Physics,Mechanics & Astronomy)2012，55，12： | 0 |
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