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| 1 | Reduced striatal volumes in Parkinson’s disease:a magnetic resonance imaging study显示文摘Background:The presence and extent of structural changes in the brain as a consequence of Parkinson’s disease(PD)is still poorly understood.Methods:High-resolution 3-tesla T1-weighted structural magnetic resonance images in sixty-five PD and 27 age-matched healthy control participants were examined.Putamen,caudate,and intracranial volumes were manually traced in the axial plane of 3D reconstructed images.Striatal nuclei volumes were normalized to intracranial volume for statistical comparison.Disease status was assessed using the Unified Parkinson’s Disease Rating Scale and Hoehn and Yahr scale.Cognitive status was assessed using global status tests and detailed neuropsychological testing.Results:Both caudate and putamen volumes were smaller in PD brains compared to controls after adjusting for age and gender.Caudate volumes were reduced by 11%(p=0.001)and putamen volumes by 8.1%(p=0.025).PD striatal volumes were not found to be significantly correlated with cognitive or motor decline.Conclusion:Small,but significant reductions in the volume of both the caudate and putamen occur in PD brains.These reductions are independent of the effects of age and gender,however the relation of these reductions to the functional loss of dopamine,which is characteristic of PD,remains unclear. | Toni L Pitcher Tracy R Melzer Michael R MacAskill Charlotte F Graham Leslie Livingston Ross J Keenan Richard Watts John C Dalrymple-Alford Tim J Anderson | 2012 | Translational Neurodegeneration2012，1，1： | 2 |
| 2 | Effect of replacing dietary inorganic forms of zinc,manganese,and copper with complexed sources on lactation and reproductive performance of dairy cows显示文摘 | Toni F Grigoletto L Rapp C J | 2007 | Professional Animal Scientist2007，23，4： | 1 |
| 3 | Conditioning of aluminium- based water treatment sludge with Fenton's reagent: Effectiveness and optimising study to improve dewaterability 显示文摘 | Tony M A Zhao Y Q Fu J F | 2008 | Chemosphere2008，72，4： | 1 |
| 4 | Duality-based algo- rithms for total variation regularized image restoration 显示文摘 | Zhu M Q Wright Stephen J Chan Tony F | 2010 | Com- putational Optimization and Applications2010，47，3： | 1 |
| 5 | Conditioning of aluminium-based water treatment sludge with Fenton's reagent:Effectivenessand optimizing study to improve dewaterability显示文摘 | Maha A Tony Y Q Zhao J F Fu | 2008 | Chemosphere2008，72，4： | 1 |
| 6 | Purification and characterization of an alkaline serine endopeptidase from a feather-degrading Xanthomonos maltophila strain显示文摘 | De Toni C H Richter M F Chagas J R | 2002 | Canadian Journal of Microbiology2002，48，： | 1 |
| 7 | Conditioning of aluminium-based water treatment sludge with Fenton’s reagent:Effectiveness and optimising study to improve dewaterability显示文摘 | Maha A Tony Y Q Zhao J F Fu | 2008 | Chemosphere2008，72，4： | 1 |
| 8 | Neurological deterioration in acute ischemic stroke:potential predictors and associated factors in the European Cooperative Acute Stroke Study (ECASS)显示文摘 | Dávalos A Toni D Iweins F Lesaffre E Bastianello S Castillo J | 1999 | Stroke[J]1999，30，： | 1 |
| 9 | Mycoplasma bovls in- duces apoptosis of bovine lymphoeytes显示文摘 | Tony J Bush V Rosenhusch R F | 2002 | FEMS Immunol Meal Microhiol2002，，32： | 1 |
| 10 | Characterization of a lympho-inhibitory pepitide produced by mycoplasma bovis显示文摘 | Tony J Vanden B Ricardo F | 2004 | Biochemical and Biophysical Research Communications2004，315，： | 1 |
| 11 | Convergence acceleration operator for multiobjective optimization显示文摘 | Salem F A Tony J D Griffin I A | 2009 | IEEE transactions on Evolutionary Computation2009，13，4： | 1 |
| 12 | Use of fractional myocardial flow reserve to assess the functional significance of intermediate coronary stenoses显示文摘 | William F Fearon Atsushi Takagi Allen Jeremias Alan C Yeung James D Joye David J Cohen Tony M Chou Morton J Kern Paul G Yock | 2000 | The American Journal of Cardiology2000，，9： | 1 |
| 13 | pH-Responsive microgel dispersions for repairing damaged load-bearing soft tissue 显示文摘 | TONY J F BRIAN R S | 2008 | Soft Matter2008，4，5： | 1 |
| 14 | Conditioning of aluminium- based water treatment sludge with Fenton's reagent: effectiveness and optimising study to improve dewaterability 显示文摘 | Tony M A Zhao Y Q Fu J F | 2008 | Chemosphere2008，72，4： | 1 |
| 15 | Real-time differential carrier phase GPS-aided INS显示文摘 | Jay A F Tony D G Matthew J B | 2000 | IEEE Transactions on Control Systems Technology2000，8，4： | 1 |
| 16 | Growth patterns of Escherichia coli O157 : H7 in ground beef treated with nisin,chelators,organic acids and their combinations immobilized in calcium alginate gels显示文摘 | Tony J F Hung-Chi T | 2003 | Food Microbiology2003，20，2： | 1 |
| 17 | Modeling Volatility for the Chinese Equity Market显示文摘 | Frank J F Radu T Tony Wu | 2004 | Annals of Economics and Finance2004，，5： | 1 |
| 18 | Investigating Tendon Fascicle Structure-function Relationships in a Transgenic-age Mouse Mode Using Multiple Regression Models显示文摘 | Paul S R Tony W L Abbas F J | 2004 | Annals of Biomedical Engineering2004，32，7： | 1 |
| 19 | Duality-based algorithms for total variation regularized image restoration显示文摘 | Zhu Mingqiang Stephen J Wright Tony F Chan | 2010 | Computational Optimization and Applications2010，47，3： | 1 |
| 20 | Characterization of the immune response to Mycoplasma bovies lung infection显示文摘 | Tony J Vanden Bush Ricardo F | 2003 | Veterinary Innunology and Immunopathology2003，94，： | 1 |
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