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| 1 | 维甲酸导致胎鼠神经脊源性器官异常显示文摘为证实我们的假设,即维甲酸物质不但能导致胎鼠颅面部的畸形,而且还能造成胸颈部内分泌腺(胸腺、甲状腺和甲状旁腺)的异常,这些器官的形成都是与神经脊细胞的移入有关的。于孕期第10天给母鼠125mg/kg全反型维甲酸(All-fran-retinoic acid),对照组给予相应量的载体溶液。分娩前24小时剖腹取出胎鼠,10%福尔马林浸泡固定10天,双管手术显微镜下解剖,检查颅、面部,心脏,大血管,胸腺,并对甲状腺,甲状旁腺进行组织学研究。对照组10只胎鼠未发现畸形,而实验组20只胎鼠中,有17只(85%)出现颅面部畸形,14只(70%)有心血管畸形,而胸腺、甲状腺、甲状旁腺和甲状腺畸形分别有14只(70%)、15只(75%)和7只(35%)。结果表明,维甲酸能导致胎鼠中鳃弓衍化而成并需神经脊参与的器官组织结构异常。 | 余家康 夏慧敏 Gonzalez S Diez Pardo JA Tovar JA | 2003 | 新生儿科杂志2003，18，6： | 3 |
| 2 | Combining Clinical, Pathology, and Gene Expression Data to Predict Recurrence of Hepatocellular Carcinoma显示文摘 | Augusto Villanueva Yujin Hoshida Carlo Battiston Victoria Tovar Daniela Sia Clara Alsinet Helena Cornella Arthur Liberzon Masahiro Kobayashi Hiromitsu Kumada Swan N. Thung Jordi Bruix Philippa Newell Craig April Jian–Bing Fan Sasan Roayaie Vincenzo Mazzaf | 2011 | Gastroenterology2011，，5： | 3 |
| 3 | 维甲酸致胎鼠骨骼畸形模型的建立显示文摘目的利用维甲酸胎鼠模型,观察其骨骼畸形出现的情况,探讨骨骼畸形的发生机制。方法于孕期第10天经胃管给SD母鼠注入125 mg/kg体重全反式维甲酸,对照组仅予载体溶液。分娩前24 h剖腹取出胎鼠,实验组和对照组分别随机各取20只和10只胎鼠去除软组织,行骨软骨双重染色法,显微镜观察骨骼情况。结果实验组胎鼠体重(4.294±0.670)g与对照组(4.743±0.542)g比较,差异有统计学意义(P<0.05)。对照组未见骨骼畸形。维甲酸组有18只(90%)胎鼠可见明显的全身骨骼畸形,最常见的畸形分别是长骨畸形(80%)、腕掌跗跖骨缺如(80%)、胸廓外形异常(80%)、椎体畸形(75%)、骨盆畸形(70)和脊椎裂(65%)。结论维甲酸有较强的胎鼠骨骼致畸作用,这种作用是多部位的。维甲酸大鼠是研究骨骼先天性畸形的实用工具模型。 | 余家康 夏慧敏 Juan A Tovar | 2006 | 中华实验外科杂志2006，23，10： | 2 |
| 4 | Underexpression of VHL and over-expression of HDAC-1 ,HIF-1 alpha,LL-37,and IAP-2 in af- fected skin biopsies of patients with psoriasis显示文摘 | Tovar LE Cancino JC Garsia VF | 2007 | Int J Dermatol2007，46，3： | 1 |
| 5 | A soy protein diet alters hepatic lipid metabolism gene expression and reduces serum lipids and re- nal fibrogenic cytokines in rats with chronic nephrotic syndrome 显示文摘 | Tovar AR Murguia F Cruz C | 2002 | J Nutr2002，132，9： | 1 |
| 6 | Effect of growth hormone on bacterial translocation in experimental short-bowel syndrome显示文摘 | I. Eizaguirre P. Aldazabal M. J. Barrena J. M. Garcia-Arenzana C. Ariz S. Candelas J. A. Tovar | 1999 | Pediatric Surgery International (-)1999，，3： | 1 |
| 7 | White Adipose Tissue as Endocrine Organ and Its Role in Obesity显示文摘 | Maria Eugenia Frigolet Vázquez-Vela Nimbe Torres Armando R. Tovar | 2008 | Archives of Medical Research2008，，8： | 1 |
| 8 | Angiotensin-converting enzyme i/d polymorphism in patients with malignant hypertension显示文摘 | Espinel E Tovar JL Borrellas J | 2005 | J Clin Hypertens(Greenwich)2005，7，1： | 1 |
| 9 | Modulation of the subcellular distribution of calmodulin by melatonin in MDCK cells显示文摘 | Anton TF Martinez I Tovar R | 1998 | J Pineal Res1998，24，1： | 1 |
| 10 | Sensing the fat:Fatty acid metabolism in the hypothalamus and the melanocortin system显示文摘 | LOPEZ M TOVAR S VAZQUEz MJ | 2005 | Peptides2005，26，9： | 1 |
| 11 | Pivotal Role of mTOR Signaling in Hepatocellular Carcinoma显示文摘 | Augusto Villanueva Derek Y. Chiang Pippa Newell Judit Peix Swan Thung Clara Alsinet Victoria Tovar Sasan Roayaie Beatriz Minguez Manel Sole Carlo Battiston Stijn van Laarhoven Maria I. Fiel Analisa Di Feo Yujin Hoshida Steven Yea Sara Toffanin Alex Ramos | 2008 | Gastroenterology2008，，6： | 1 |
| 12 | Hermite-sinusoi- dal-Gaussian beams in complex optical systems显示文摘 | L W Casperson D G Hall A A Tovar | 1998 | JOSA A1998，15，4： | 1 |
| 13 | Synthesis and evaluation of pyrido-thieno-pyrimidines as potent and selective Cdc7 kinase inhibitors 显示文摘 | Zhao C L Tovar C Yin X F | 2009 | Bioorg Med Chem Lett2009，19，： | 1 |
| 14 | Improved Diagnosis ofPleural Tuberculosis Using the Microscopic-Observation Drug-Susceptibility Technique显示文摘 | Tovar M Siedner MJ Gilman RH | 2008 | Clin Infect Dis2008，46，6： | 1 |
| 15 | Regulation of growth hormone secrelagogue receptor gene expression in the areuate nucleus of the rat by leptin and ghrelin显示文摘 | Nogueiras R Tovar S Mitchell SE | 2004 | Diabetes2004，53，10： | 1 |
| 16 | Angiotensin- converting enzyme i/d polymorphism in patients with malignant hypertension显示文摘 | Espinel E Tovar JL Borrellas J | 2005 | J Clin Hypertens2005，7，： | 1 |
| 17 | Supporting real-time distributed computer-controlled systems with multi-hop P-NET networks显示文摘 | | 2000 | Control Engineering Practice2000，，7： | 1 |
| 18 | TopologyOptimization Using a Hybrid Cellular AutomatonMethod with Local Control Rules显示文摘 | Tovar A Patel N M Niebur G L | 2006 | Journal ofMechanical Design2006，128，11： | 1 |
| 19 | The mitosome, a novel organelle related to mitochondria in the amitochondrial parasite Entamoeba histolytica显示文摘 | Tovar J Fischer A Clark CG | 1999 | Mol Microbiol1999，32，： | 1 |
| 20 | Ghrelin elicits a marked stimulatory effect on GH secretion in freely-moving rats显示文摘 | SEOANE LM TOVAR S BALDEELLI R | 2000 | Eur J Endocrinol2000，143，： | 1 |
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