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| 1 | KDOQI US Commentary on the 2012 KDIGO Clinical Practice Guideline for Glomerulonephritis显示文摘 | Laurence Beck Andrew S. Bomback Michael J. Choi Larry B. Holzman Carol Langford Laura H. Mariani Michael J. Somers Howard Trachtman Meryl Waldman | 2013 | American Journal of Kidney Diseases2013，，： | 2 |
| 2 | Melamine Nephrotoxicity is Mediated by Hyperuricemia显示文摘Objective We tested whether melamine nephrotoxicity was exacerbated by urate(a typical component of renal stones in humans)in rats with hyperuricemiainduced by the uricase inhibitor,potassium oxonate(Oxo).Methods Rats were exposed to melamine or Oxo alone or combinations of melamine(200-400 mg/kg)and Oxo(200-600 mg/kg)for 3 consecutive days.Kidney injury was evaluated by renal biochemical functions,histomorphology,and lipid peroxidation.Kidney crystals were analyzed for their composition.Results Nephrotoxicity was minimal in animals administered melamine or Oxo alone,but it was demonstrable in animals administered at least 800 mg/kg of the two compounds combined.All rats in the 400+600(melamine+Oxo)and 400+400 mg/kg groups and 4 out of 6 in the 200+600 mg/kg group died within 3 days;no rat died in the 200+400 or 200+200 mg/kg group.Dose-dependent renal damage resembling clinical findings in affected patients was observed in rats administered the two compounds.Crystal composition determination revealed the existence of melamine and uric acid in the affected kidneys,resembling human stones.Conclusion Our findings suggest that uric acid plays a key role in melamine-related kidney injury in humans.Future studies should consider uric acid together with melamine when examining adverse effects in humans. | ZHANG Long LI Hong Tian WANG Lin Lin TRACHTMAN Howard TRASANDE Leonardo WANG Pei Xin LIU Jian Meng | 2015 | Biomedical and Environmental Sciences2015，28，12： | 1 |
| 3 | Glomerular permeability activity: Prevalence and prognostic value in pediatric patients with idiopathic nephrotic syndrome显示文摘 | Howard Trachtman Laurence A Greenbaum | 2004 | American Journal of Kidney Diseases2004，44，4： | 1 |
| 4 | Clinical trial of extended-release felodipine in pediatric essential hypertension显示文摘 | Howard Trachtman Rachel Frank John D. Mahan Ronald Portman Irene Restaino Tej K. Matoo Conrad Tou Michael Klibaner | 2003 | Pediatric Nephrology2003，，6： | 1 |
| 5 | IPNA临床实践建议:儿童激素敏感型肾病综合征的诊断和治疗显示文摘特发性肾病综合征是最常见的儿童肾小球疾病,其特征是大量蛋白尿、低蛋白血症和(或)伴有水肿,全球每年儿童患病率为(1.15~16.90)每10万例。约有85%~90%的患者在接受糖皮质激素治疗的4~6周内可达到蛋白尿完全缓解,表现为激素敏感型肾病综合征(SSNS)。约70%~80%的SSNS患者在随访期间至少复发1次,其中多达50%的患者出现频繁复发或依赖糖皮质激素以维持蛋白尿缓解。为延长复发间隔时间,激素治疗的用药剂量和用药时长始终是热点问题之一,且患者出现激素相关并发症的概率较高。临床已应用多种激素助减药物(免疫抑制药物),但在疾病治疗过程中这些药物的选择和用药时机存在明显差异。因此,需要国际循证临床实践建议(CPRs)来指导临床实践、减少实践差异。国际儿科肾脏病学会(IPNA)召集专家小组通过对12个临床相关PICO(研究对象、干预措施、对照、结果/结局)问题进行系统的文献回顾,制定了关于儿童SSNS诊断和治疗的建议和分级。对治疗转归提出了新的定义,有助于指导治疗改变,并为重要的研究问题提供了参考。 | Agnes Trautmann Olivia Boyer Elisabeth Hodson Arvind Bagga Debbie S.Gipson Susan Samuel Jack Wetzels Khalid Alhas an Sushmita Banerjee Rajendra Bhimma Melvin Bonilla-Felix Francisco Cano Martin Christian Deirdre Hahn Hee Gyung Kang Koichi Nakanishi Hesham Safouh Howard Trachtman Hong Xu Wendy Cook Marina Vivarelli Dieter Hafner on behalf of the International Pediatric Nephrology Association 韩思雨(翻译) 季丽娜(翻译) | 2023 | 中国合理用药探索2023，20，2： | 1 |
| 6 | Chronic diabetic nephropathy: role of inducible nitric oxide synthase显示文摘 | Trachtman Howard Futterweit Stephen Pine Elyse | 2002 | Pediatr Nephrol2002，17，： | 1 |
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