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| 1 | Helicobacter pylori-infected animal models are extremely suitable for the investigation of gastric carcinogenesis显示文摘Although various animal models have been developed to clarify gastric carcinogenesis, apparent mechanism of gastric cancer was not clarified in recent years. Since the recognition of the pathogenicity of Helicobacter pylori (Hpylori), several animal models with Hpylori infection have been developed to confirm the association between Hpylori and gastric cancer. Nonhuman primate and rodent models were suitable for this study. Japanese monkey model revealed atrophic gastritis and p53mutation after long-term infection of Hpylori. Mongolian gerbil model showed the development of gastric carcinoma with H pylori infection alone, as well as with combination of chemical carcinogens, such as N-methylN-nitrosourea and N-methyl-N-nitro-N'-nitrosoguanidine.The histopathological changes of these animal models after Hpylori inoculation are closely similar to those in human beings with Hpylori infection. Eradication therapy attenuated the development of gastric cancer in Hpyloriinfected Mongolian gerbil. Although several features of animal models differ from those seen in human beings,these experimental models provide a starting point for further studies to clarify the mechanism of gastric carcinogenesis as a result of Hpylori infection and assist the planning of eradication therapy to prevent gastric carcinoma. | Masaaki Kodama Kazunari Murakami Ryugo Sato Tadayoshi Okimoto Akira Nishizono Toshio Fujioka | 2005 | World Journal of Gastroenterology2005，11，45： | 19 |
| 2 | Expression of mutant type-p53 products in H pylori-associated chronic gastritis显示文摘AIM:To investigate the mutation of p 53 immuno-histochemically in non-tumorous gastric mucosa with H pylori infection before and after H pylori eradication therapy.METHODS:53 subjects(36 male,17 female,mean age ± SEM,57.1 ± 12.1)undergoing endoscopic examination were included in this study.42 of 53 patients were H pylori-positive,and 11 were H pylori-negative.All H pylori-positive patients had successful eradication therapy.Biopsy specimens were taken from five points of the stomach,as recommended by the updated Sydney system.Immunohistochemical studies were performed by using primary antibodies against p53(DO-7 and PAb240).RESULTS:p53(DO-7 and PAb240)immunoreactivity was shown in the neck region of the gastric pits,however,quite a few cells were found to be immunopositive for p 53(PAb240)in the H pylori-infected gastric mucosa.The proportion of patients immunopositive for p 53(PAb240)was significantly reduced 6 mo after eradication [28/42(66.7%)to 6/42(14.3%)](P < 0.05),while the biopsies taken from H pylori-negative patients showed no immunoreactivity for p53(PAb240).p53(PAb240)-positive patients were divided into two groups by the number of positive cells detected:one with more than six positive cells per 10 gastric pits(group A,n = 12),and the other with less than five positive cells per 10 gastric pits(group B,n = 30).Atrophy scores in group A were significant higher than those in group B at the greater curvature of the antrum(group A:2.00 ± 0.14 vs group B:1.40 ± 0.15,P = 0.012),the lesser curvature of the corpus(group A:2.00 ± 0.21 vs group B:1.07 ± 0.23,P = 0.017),and the greater curvature of the corpus(group A:1.20 ± 0.30vs group B:0.47 ± 0.21,P = 0.031).Group A showed significant higher intestinal metaplasia scores than group B only at the lesser curvature of the antrum(group A:2.10 ± 0.41 vs group B:1.12 ± 0.29,P = 0.035).CONCLUSION:H pylori-associated chronic gastritis expressed the mutant-type p53,which was significantly associated with more severe atrophic and metaplastic changes.H pylori eradication led to a significant reduction in the expression of the mutant-type p53.It is considered that H pylori-infected chronic gastritis is associated with a genetic instability that leads to gastric carcinogenesis,and H pylori eradication may prevent gastric cancer. | Masaaki Kodama Kazunari Murakami Tadayoshi Okimoto Ryugo Sato Koichiro Watanabe Toshio Fujioka | 2007 | World Journal of Gastroenterology2007，13，10： | 13 |
| 3 | Aspirin-induced small bowel injuries and the preventive effect of rebamipide显示文摘AIM:To evaluate the influence of taking low-dose aspirin for 4 wk on small intestinal complications and to examine the preventive effect of rebamipide.METHODS:This study was conducted as a single-center,randomized,double-blind,cross-over,placebo-controlled study.Eleven healthy male subjects were enrolled.Each subject underwent video capsule endos-copy after 1 and 4 wk of taking aspirin and omepra-zole,along with either rebamipide or placebo therapy.The primary endpoint was to evaluate small bowel damage in healthy subjects before and after taking low-dose aspirin for 4 wk.RESULTS:The number of subjects with mucosal breaks(defined as multiple erosions and/or ulcers)were 1 at 1 wk and 1 at 4 wk on the jejunum,and 6 at 1 wk(P = 0.0061)and 7 at 4 wk on the ileum(P =0.0019).Rebamipide significantly prevented mucosal breaks on the ileum compared with the placebo group(P = 0.0173 at 1 wk and P = 0.0266 at 4 wk).CONCLUSION:Longer-term,low-dose aspirin adminis-tration induced damage in the small bowel.Rebamipide prevented this damage,and may be a candidate drug for treating aspirin-induced small bowel complications. | Kazuhiro Mizukami Kazunari Murakami Takashi Abe Kunimitsu Inoue Masahiro Uchida Tadayoshi Okimoto Masaaki Kodama Toshio Fujioka | 2011 | World Journal of Gastroenterology2011，17，46： | 8 |
| 4 | Successful outcomes of EMR-L with 3D-EUS for rectal carcinoids compared with historical controls显示文摘AIM: To assess the results of endoscopic mucosal re-section with a ligation device (EMR-L) combined with three dimensional endoscopic ultrasonography (3D-EUS) using an ultrasonic probe for rectal carcinoids. In addition, diagnosis of the depth and size of lesions by EUS was evaluated. METHODS: Between January 2003 and March 2007, 20 patients underwent EMR-L with 3D-EUS using an ultrasonic probe (group A). 3D-EUS was combined with EMR-L at the time of injection of sterile physiological saline into the submucosal layer. For comparison, 14 rectal carcinoids that had been treated by EMR-L with-out 3D-EUS between April 1998 and December 2002 were evaluated as historical controls (group B). EUS was conducted for all of the patients before treatment to evaluate tumor diameter and depth of invasion. The percentage of complete resection and the verti-cal resection margin were compared between the two groups. RESULTS: The depth of invasion upon histopathologi-cal examination was in complete agreement with the pre-operative fi ndings by EUS. The tumor diameter de-termined by EUS approximated that found in the tissue samples. There were no signifi cant differences in the gender, tumor sites or tumor diameters between the two groups. The rate of complete resection for groups A and B was 100% and 71%, respectively (P < 0.05). The vertical resection margin of group A was longer than that of group B. CONCLUSION: EMR-L is effective as an endoscopictreatment for rectal carcinoids. In combination with 3D-EUS, safe and complete resection is further as-sured. | Tsuyoshi Abe Tadayoshi Kakemura Sumio Fujinuma Iruru Maetani | 2008 | World Journal of Gastroenterology2008，14，25： | 7 |
| 5 | Influence of proton pump inhibitor treatment on Helicobacter pylori stool antigen test显示文摘AIM: To investigate the effects of proton pump inhibitor (PPI) treatment on stool antigen test using the TestMate pylori enzyme immunoassay. METHODS: This study assessed 28 patients [16 men and 12 women; mean age (63.1 ± 5.9) years; range, 25-84 years] who underwent stool antigen test and urea breath test (UBT) before and after PPI administration. RESULTS: Using the UBT as the standard, the sensitivity, specif icity and agreement of the stool antigen test in all 28 patients were 95.2%, 71.4%, and 89.3%, respectively, before PPI administration, and 88.9%, 90.9%, and 89.3%, respectively, after PPI treatment. Mean UBT values were 23.98% ± 5.33% before and 16.19% ± 4.75% after PPI treatment and, in 15 patients treated for ≥ 4 wk, were signif icantly lower after than before 4 wk of PPI treatment (12.58% ± 4.49% vs 24.53% ± 8.53%, P = 0.048). The mean optical density (A450/630) ratios on the stool antigen test were 1.16 ± 0.20 before and 1.17 ± 0.24 after PPI treatment (P = 0.989), and were 1.02 ± 0.26 and 0.69 ± 0.28, respectively, in the group treated for > 4 wk (P = 0.099). | Masaaki Kodama Kazunari Murakami Tadayoshi Okimoto Yoshihiro Fukuda Tadashi Shimoyama Masumi Okuda Chieko Kato Intetsu Kobayashi Toshio Fujioka | 2012 | World Journal of Gastroenterology2012，18，1： | 7 |
| 6 | Water-saving irrigation of paddy field to reduce nutrient runoff显示文摘The purpose of this work is to study the effect of a type of water-saving irrigation (WSI) on nutrient runoff of paddy field.The volume of surface drainage was maintained low by WSI.In particular,WSI effectively reduced surface drainage in rain events.Model simulation indicated that net runoff load of total nitrogen (TN) from the paddy field was increased by WSI.Meanwhile,net runoff loads of total phosphorus (TP) and total organic carbon (TOC) from the paddy field was decreased by WSI.Because ponding waters of the study fields were enriched with TP and TOC,WSI reduced runoff of these nutrients by controlling the volume of surface drainage.WSI could be considered an efficient method for reducing runoff loads and could conserve water quality in an agricultural watershed. | Tadayoshi Hitomi Yusaku Iwamoto Asa Miura Koji Hamada Kyoji Takaki Eisaku Shiratani | 2010 | Journal of Environmental Sciences2010，22，6： | 6 |
| 7 | Chemical Composition of the Essential Oil of Mastic Gum and their Antibacterial Activity Against Drug-Resistant Helicobacter pylori显示文摘Mastic gum is derived from the tree named Pistacia lentiscus that is grown only in Island Hios of Greek.Since Mastic was first reported to kill Helicobacter pylori(H.pylori)in 1998,there has been no further study to elucidate which component of mastic specifically shows the antimicrobial activity against H.pylori.In this study,we examined which component of mastic gum was responsible for anti-H.pylori activity.We prepared the essential oil of mastic gum and identified 20 constituents by GC–MS analysis.Ten standard components were assayed for anti-H.pylori activity,and it clarified that a-terpineol and(E)-methyl isoeugenol showed the anti-H.pylori activity against four different H.pylori strains that were established from patients with gastritis,gastric ulcer and gastric cancer.These components could be useful to overcome the drug-resistance H.pylori growth in stomach. | Tomofumi Miyamoto Tadayoshi Okimoto Michihiko Kuwano | 2014 | Natural Products and Bioprospecting2014，4，4： | 4 |
| 8 | Ten-year prospective follow-up of histological changes at five points on the gastric mucosa as recommended by the updated Sydney system after Helicobacter pylori eradication显示文摘 | Masaaki Kodama Kazunari Murakami Tadayoshi Okimoto Ryugo Sato Masahiro Uchida Takashi Abe Seiji Shiota Yoshifumi Nakagawa Kazuhiro Mizukami Toshio Fujioka | 2012 | Journal of Gastroenterology2012，，4： | 4 |
| 9 | Scenario analysis for reduction of pollutant load discharged from a watershed by recycling of treated water for irrigation显示文摘A model in which a river model was layered on a distributed model (double-layered model) was developed to analyse the transport of water and pollutants (nitrogen,phosphorus,and BOD as organic matter) in watersheds and rivers.The model was applied to the watershed of Abragafuchi Lake,Japan,where serious water pollution has occurred over three decades,and the applicability of the model was demonstrated.Scenarios of recycling of sewage treated-water into agriculture to reduce pollutant load discharged into the lake were analysed.The results showed that irrigating paddy fields with the sewage-treated water could contribute to conserving water and reducing pollutant load,with reduction rate in BOD,nitrogen,and phosphorus ranging from 6%–36%,16%–46%,and 18%–51%,respectively.Particularly,the results indicated that,irrigating paddy fields with the treated water during non-cropping periods and the accompanying reduction in withdrawn water from the river were more effective in reducing pollutant loads discharged into the lake.Further study is required on the effect of recycled water on crop cultivation and soil conditions for safe implementation. | Eisaku Shiratani Yoshiyuki Munakata Ikuo Yoshinaga Tomijiro Kubota Koji Hamada Tadayoshi Hitomi | 2010 | Journal of Environmental Sciences2010，22，6： | 3 |
| 10 | INHIBITION OF FARNESYL PROTEIN TRANSFERASE AND P21^(RAS) MEMEBRANE ASSOCIATION BY D-LIMONENE IN HUMAN PANCREAS TUMOR CELLS IN VITRO显示文摘INTRODUCTIONOncogenicRasproteinsarecausalyimplicatedincertainhumanmalignancies.About50%ofhumancoloncarcinomasand90%ofpancre... | Chen Xiaoguang 1 (陈晓光),Yoshihisa Yano 2, Tadayoshi Hasuma 2, Toshiko Yoshimata 2, Wang Yinna 2 and Shuzo Otani 2 1Department of Pharmacology, Institute of Materia Medica, CAMS & PUMC, Beijing 100050 2Department of Biochemistry | 1999 | Chinese Medical Sciences Journal1999，14，3： | 3 |
| 11 | Blood Pressure Management in Acute Intracerebral Hemorrhage: Relationship Between Elevated Blood Pressure and Hematoma Enlargement显示文摘 | Kazuhiro Ohwaki Eiji Yano Hiroshi Nagashima Masafumi Hirata Tadayoshi Nakagomi Akira Tamura | 2004 | Stroke: Journal of the American Heart Association2004，，6： | 2 |
| 12 | Thermo-chemo-radiotherapy for advanced bile duct carcinoma显示文摘AIM: Complete resection of the bile duct carcinoma is sometimes difficult by subepithelial spread in the duct wall or direct invasion of adjacent blood vessels. Nonresected extrahepatic bile duct carcinoma has a dismal prognosis,with a life expectancy of about 6 mo to 1 year. To improve the treatment results of locally advanced bile duct carcinoma, we have been conducting a clinical trial using regional hyperthermia in combination with chemoradiation therapy.METHODS: Eight patients complaining of obstructive jaundice with advanced extrahepatic bile duct underwent thermo-chemo-radiotherapy (TCRT). All tumors were located in the upper bile duct and involved hepatic bifurcation, and obstructed the bile duct completely.Radiofrequency capacitive hyperthermia was administered simultaneously with chemotherapeutic agents once weekly immediately following radiotherapy at 2 Gy.We administered heat to the patient for 40 min after the tumor temperature had risen to 42 ℃. The chemotherapeutic agents employed were cis-platinum (CDDP,50 mg/m2) in combination with 5-fluorouracil (5-FU,800 mg/m2) or methotrexate (MTX, 30 mg/m2) in combination with 5-FU (800 mg/m2). Number of heat treatments ranged from 2 to 8 sessions. The bile duct at autopsy was histologically examined in three patients treated with TCRT.RESULTS: In respect to resolution of the bile duct, there were three complete regression (CR), two partial regression (PR), and three no change (NC). Mean survival was 13.2±10.8 mo (mean±SD). Four patients survived for more than 20 mo. Percutaneous transhepatic biliary drainage (PTBD) tube could be removed in placement of self-expandable metallic stent into the patency-restored bile duct after TCRT. No major side effects occurred. At autopsy, marked hyalinization or fibrosis with necrosis replaced extensively bile duct tumor and wall, in which suppressed cohesiveness of carcinoma cells and degenerative cells were sparsely observed.CONCLUSION: Although the number of cases is rather small, TCRT in the treatment of locally advanced bile duct carcinoma is promising in raising local control and thus,long-term survival. | Terumi Kamisawa Yuyang Tu Naoto Egawa Katsuyuki Karasawa Tadayoshi Matsuda Kouji Tsuruta Atsutake Okamoto | 2005 | World Journal of Gastroenterology2005，11，27： | 2 |
| 13 | Searchable Encryption Revisited: Consistency Properties, Relation to Anonymous IBE, and Extensions显示文摘 | Michel Abdalla Mihir Bellare Dario Catalano Eike Kiltz Tadayoshi Kohno Tanja Lange John Malone-Lee Gregory Neven Pascal Paillier Haixia Shi | 2008 | Journal of Cryptology2008，，3： | 2 |
| 14 | Surgical Strategy for Spinal Metastases显示文摘 | Katsuro Tomita Norio Kawahara Tadayoshi Kobayashi Akira Yoshida Hideki Murakami Tomoyuki Akamaru | 2001 | Spine2001，，3： | 2 |
| 15 | Reductive electrochemical decomposition of chloroform on metal electrodes显示文摘 | Noriyuki Sonoyama Kohjiro Hara Tadayoshi Sakata | 1997 | Chemistry Letters1997，26，2： | 1 |
| 16 | Influence of cardiac output on plasma propofol concentrations during constant infusion in swine 显示文摘 | Tadayoshi K Koji M Tomiei K | 2002 | Anesthesiology2002，96，6： | 1 |
| 17 | Comparison of air kerma between C-arm CT and 64-multidetector-row CT using a phantom显示文摘 | Seiki Hosokawa Nobuyuki Kawai Morio Sato Hiroki Minamiguchi Motoki Nakai Kazuhiro Murotani Tadayoshi Nishioku Shintaro Shirai Tetsuo Sonomura | 2014 | Japanese Journal of Radiology2014，，5： | 1 |
| 18 | Influence of hemorrhage on propofol pseudo - steady state concentration显示文摘 | Tomiei K Tadayoshi K Koji M | 2002 | Anesthesiology2002，97，5： | 1 |
| 19 | Characteristics of Streptlcoccus suis isolated from patients in Japan显示文摘 | Bin C Akihito W Tadayoshi I | 2006 | Jpn J Infect Dis2006，59，： | 1 |
| 20 | Simulation for progress of solid-liquid coexisting zone in con- tinuous casting of carbon steels 显示文摘 | Tadayoshi Takahashi Ken-ichi Ohsasa Noriyuki Katayama | 1990 | Tetsu-to-Hagane1990，76，5： | 1 |
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