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| 1 | Risk factors and prevention of biliary anastomotic complications in adult living donor liver transplantation显示文摘AIM: To evaluate risk factors of biliary anastomotic complications (BACs) and outcomes according to type of biliary reconstruction. METHODS: A total of 33 consecutive adult living donor liver transplantation (LDLT) were reviewed, 17 of which had undergone Duct-to-Duct anastomosis (D-D). The remaining 16 patients received Roux-en-Y anastomosis (R-Y). The perioperative factors, such as the type of graft and the number of graft bile ducts, were analyzed retrospectively. RESULTS: The overall incidence of BACs was 39.4%. The incidence of BACs was significantly higher in the patients with than without neoadjuvant chemotherapy (71.4% vs 10%, P = 0.050). There was no signifi cant difference in the incidence of biliary leakage in patients with D-D vs those with R-Y. The incidence of biliary strictures following the healing of biliary leakage was significantly higher in D-D (60%) than in R-Y (0%) (P = 0.026). However, the incidence of BACs related bacteremia was signifi cantly higher in R-Y than in D-D (71.4% vs 0%, P = 0.008). In D-D, use of T-tube stent remarkably reduced the incidence of BACs, compared with straight tube stent (0% vs 50%, P = 0.049). CONCLUSION: Our experience showed an increase of BACs related bacteremia in the patients with R-Y. Therefore, D-D might be a preferred biliary reconstruction. However, the surgical refi nement of D-D should be required because of the high incidence of biliary strictures. Use of the T-tube stent might lead to a signifi cant reduction of BACs in D-D. | Satoshi Yamamoto Yoshinobu Sato Hiroshi Oya Hideki Nakatsuka Takashi Kobayashi Yoshiaki Hara Takaoki Watanabe Isao Kurosaki Katsuyoshi Hatakeyama | 2007 | World Journal of Gastroenterology2007，13，31： | 6 |
| 2 | Video-assisted living donor hemihepatectomy through a 12-cm incision for adult-to-adult liver transplantation显示文摘 | Isao Kurosaki Satoshi Yamamoto Chie Kitami Naoyuki Yokoyama Hideki Nakatsuka Takashi Kobayashi Takaoki Watanabe Hiroshi Oya Yoshinobu Sato Katsuyoshi Hatakeyama | 2006 | Surgery2006，，5： | 1 |
| 3 | Animal models of bipolar disorder显示文摘 | Kato T Mie K Takaoki K | 2007 | Neurosci Biobehavl R2007，31，6： | 1 |
| 4 | Vector-averaged gravity regulates gene expression of receptor activator of NF- kappaB (RANK) ligand and osteoprotegerin in bone marrow stromal cells via cyclic AMP/protein kinase A pathway显示文摘 | Kanematsu M Yoshimura K Takaoki M | 2002 | Bone2002，30，4： | 1 |
| 5 | Vector-av-eraged gravity regulates gene expression of receptoractivator of NF- KI3 (RANK) ligand and osteoprotegerin in bone ( RANK ) ligand and osteoprotegerin in bonemarrow stromal cells via cyclic AMP/protein kinase A pathway显示文摘 | KANEMATSU M YOSHIMURA K TAKAOKI M | 2012 | Bone2012，30，4： | 1 |
| 6 | Impaired antibody response against T-dependentantigens in rhino mice显示文摘 | Takaoki M Kawaji H | 1980 | Immunology1980，40，1： | 1 |
| 7 | Cyclic AMP-dependent Cl-secretion induced by thromboxane A2 in isolated human colon显示文摘 | Naoki H Tomoyuki S Takaoki U | 2005 | Physiol2005，562，2： | 1 |
| 8 | Vector-averaged gravity regulates gene expression of receptor activator of NF-kappaB (RANK) ligand and osteoprotegerin in bone marrow stromal cells via cyclic AMP/protein kinase A pathway显示文摘 | Kanematsu M Yoshimura K Takaoki M Sato A | 2002 | Bone2002，30，： | 1 |
| 9 | Vector-averaged gravity regulates gene expression of receptor activator of NF-κβ(RANK) ligand and osteoprotegerin in bone marrow stromal cells via cyclic AMP/protein kinase A pathway显示文摘 | KANEMATSU M YOSHIMURA K TAKAOKI M | 2002 | Bone2002，30，4： | 1 |
| 10 | Cutaneous lymphomas in Tokyo:analy- sis of 62 cases in a dermatology clinic 显示文摘 | Takaoki Ishiji Yuko | 2010 | International Journal Of Dermatology2010，44，3： | 1 |
| 11 | Synthesis of titanium (IV) complexes that contain theBis (silylamide)ligand of the type TiCi2-cocatalystsystem 显示文摘 | NOMURA K NAGA N TAKAOKI K | 1998 | J Mol Catal A Chem1998，130，： | 1 |
| 12 | Sunitinib-induced hyperammonemic encephalopathy in metastatic gastrointestinal stromal tumors:A case report显示文摘BACKGROUND Sunitinib,a multi-targeted tyrosine kinase inhibitor(TKI),has been approved for the salvage treatment of gastrointestinal stromal tumors(GIST).Hyperammonemic encephalopathy is a rare but severe complication of sunitinib use.Here,we present the case of a 66-year-old male with metastatic GIST without underlying liver cirrhosis who developed sunitinib-induced hyperammonemic encephalopathy.CASE SUMMARY A 66-year-old male with metastatic GIST was admitted because of reduced consciousness.Imatinib was administered as the first-line systemic therapy.He experienced repeated episodes of peritonitis due to tumor perforation,and surgery was performed.Progressive disease was confirmed based on increased liver metastasis,and sunitinib was initiated as a salvage treatment.However,23 d after the third course of sunitinib,he presented to the emergency room with an episode of altered consciousness and behavioral changes.Based on the patient clinical history and examination findings,sunitinib-induced encephalopathy was suspected.Sunitinib was discontinued,and the patient was treated for hyperammonemia.The patient had a normal level of consciousness four days later,and the serum ammonia level gradually decreased.No further neurological symptoms were reported in subsequent follow-ups.CONCLUSION TKI-induced hyperammonemic encephalopathy is potentially life-threatening.Patients receiving TKIs experiencing adverse reactions should undergo systemic evaluation and prompt treatment. | Takaoki Hayakawa Shinsuke Funakoshi Yasuo Hamamoto Kenro Hirata Takanori Kanai | 2023 | World Journal of Clinical Cases2023，11，31： | 0 |
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