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| 1 | Intravenous immune globulin suppresses angiogenesis in mice and humans显示文摘Human intravenous immune globulin(IVIg),a purified IgG fraction composed of~60%IgG1 and obtained from the pooled plasma of thousands of donors,is clinically used for a wide range of diseases.The biological actions of IVIg are incompletely understood and have been attributed both to the polyclonal antibodies therein and also to their IgG(IgG)Fc regions.Recently,we demonstrated that multiple therapeutic human IgG1 antibodies suppress angiogenesis in a target-independent manner via FcγRI,a high-affinity receptor for IgG1.Here we show that IVIg possesses similar anti-angiogenic activity and inhibited blood vessel growth in five different mouse models of prevalent human diseases,namely,neovascular age-related macular degeneration,corneal neovascularization,colorectal cancer,fibrosarcoma and peripheral arterial ischemic disease.Angioinhibition was mediated by the Fc region of IVIg,required FcγRI and had similar potency in transgenic mice expressing human FcγRs.Finally,IVIg therapy administered to humans for the treatment of inflammatory or autoimmune diseases reduced kidney and muscle blood vessel densities.These data place IVIg,an agent approved by the US Food and Drug Administration,as a novel angioinhibitory drug in doses that are currently administered in the clinical setting.In addition,they raise the possibility of an unintended effect of IVIg on blood vessels. | Reo Yasuma Valeria Cicatiello Takeshi Mizutani Laura Tudisco Younghee Kim Valeria Tarallo Sasha Bogdanovich Yoshio Hirano Nagaraj Kerur Shengjian Li Tetsuhiro Yasuma Benjamin J Fowler Charles B Wright Ivana Apicella Adelaide Greco Arturo Brunetti Balamurali K Ambati Sevim Barbasso Helmers Ingrid E Lundberg Ondrej Viklicky Jeanette HW Leusen J Sjef Verbeek Bradley D Gelfand Ana Bastos-Carvalho Sandro De Falco Jayakrishna Ambati | 2016 | Signal Transduction and Targeted Therapy2016，1，1： | 3 |
| 2 | ABH and Lewis antigen distributions in blood,saliva and gastric mucosa and H pylori infection in gastric ulcer patients显示文摘瞄准:调查 ABH 和路易斯抗原在红血球,口水和胃的上皮的表示,以及在 H pylori 和胃的上皮的损害的存在之间的协会。方法:在 H 感染 pylori 的胃溃疡病人的红血球,口水和胃粘膜的 ABH 和路易斯血型抗原的分发被分析。有胃溃疡的 42 个病人被学习,并且五十个健康个人被用作控制组。血型抗原被直接红血球凝聚, dot-ELISA 和免疫决定在红血球,口水和胃粘膜标本的组织化学的方法分别地。为 H pylori 感染的诊断被常规光显微镜学和 ELISA 执行。结果:IgG H pylori specific 抗体的更高的 seroprevalence 与控制组(60%) 相比在胃溃疡病人(90%) 被观察。我们在 H 感染 pylori 的病人观察了显型 O, A2 和路易斯 b 的重要增加。这些抗原的表示在溃疡性的损害和肠的组织变形的区域有进步改变。结论:ABH 和路易斯血型抗原是为在胃的上皮的细胞的改变的好指示物。 | LuisaCaricioMartins TerezaCristinadeOliveiraCorvelo Henrique Takeshi Oti RosanedoSocorroPompeuLoiola DéliaCristinaFigueiraAguiar KatarineAnt niadosSantosBarile RenataKellyCostadoAmaral HivanaPatriciaMeloBarbosa AmandaAlvesFecury JuciclaytonTavaresdeSouza | 2006 | World Journal of Gastroenterology2006，12，7： | 3 |
| 3 | Inflammatory and Injury Responses to Ischemic Stroke in Obese Mice显示文摘 | Satoshi Terao Gokhan Yilmaz Karen Y. Stokes Mami Ishikawa Takeshi Kawase D Neil Granger | 2008 | Stroke2008，，3： | 2 |
| 4 | Amyloid Precursor Proteins Inhibit Heme Oxygenase Activity and Augment Neurotoxicity in Alzheimer’s Disease显示文摘 | Masaaki Takahashi Sylvain Doré Christopher D Ferris Taisuke Tomita Akira Sawa Herman Wolosker David R Borchelt Takeshi Iwatsubo Seong-Hun Kim Gopal Thinakaran Sangram S Sisodia Solomon H Snyder | 2000 | Neuron2000，，2： | 1 |
| 5 | The activation of nitric oxide synthase by copper ion is mediated by intracellular Ca^2 mobilization in human puhnoaary arterial endothelial cells显示文摘 | Yoshiki D Takeshi I Shingo A | 1998 | Br J Pharmacol1998，125，： | 1 |
| 6 | The Constituents of Eucommia Ulmoides Oliver VI Isolation of a New Sesquilignan and Neolignan Glycosides显示文摘 | TAKESHI D TAKAKO I SHIZUKE K | 1987 | Chem Pharm Bull1987，35，5： | 1 |
| 7 | 18F-FDG Accumulation with PET for differentiation between benign and malignant lesion in the thorax显示文摘 | Yoshiki D Tassuro T Takeshi I | 2003 | J Nucl Med2003，44，4： | 1 |
| 8 | The current clinicalproblems for early phase of diabetic nephropathy and ap-proach for pathogenesis of diabetic nephropathy 显示文摘 | Toshio D Akira M Takeshi M | 2008 | Dia-betes Res Clin Pract2008，82，1： | 1 |
| 9 | Electrical properties of low-inductance barium strontium titanate thin film decoupling capacitors显示文摘 | Kazuaki K Takeshi S John D B | 2004 | J Eur Ceram Soc2004，24，： | 1 |
| 10 | Constituents and pharmacological effects of eucommia and siberian ginseng 显示文摘 | Takeshi D Sansei N Yoshihisa N | 2001 | J Acta Pharmacol Sic2001，22，12： | 1 |
| 11 | The constituent of eucommia ulmoides olive I -Isolation of ( + )-Mediovesinol-Di-o-β- D glucopyranoside 显示文摘 | Takeshi D | 1983 | J Chem Pharm Bu111983，31，9： | 1 |
| 12 | The constituent of Eucommia ulmoides Olive Ⅱ-solation of (+)-medioresinol di-O-β-D -glucopyranoside 显示文摘 | Takeshi D | 1983 | Chemical and Pharmaceutical Bulletin1983，31，： | 1 |
| 13 | Detection and sequencing of the microcystin LR-degrading gene, mlrA, from new bacteria isolated from Japanese lakes 显示文摘 | TAKESHI S KUNIHIRO O PARK H D | 2003 | Ferns Microbiology Letters2003，，229： | 1 |
| 14 | Effect of Particle Size Distribution on Pressure Drop and Concentration Profile in Pipeline Flow of Highly Concentrated Slurry显示文摘 | Kaushal D R Kimihiko Sato Takeshi Toyota | 2005 | International Journal of Multiphase Flow2005，31，7： | 1 |
| 15 | Constituents and pharmacological effects of Eucommia and Siberian ginseng显示文摘 | Takeshi D Sanei N Yoshihisa N | 2001 | Acta Pharmacol Sin2001，2，10： | 1 |
| 16 | Endothelium dependentvasorelaxant effects of the aqueous extracts of theeucommia ulmoides oliv leaf and nark : Implications on theirantihypertensive action 显示文摘 | Chiu Y K Chang X C Takeshi D | 2004 | Vascular Pharmacology2004，40，： | 1 |
| 17 | Construction of 3D hierarchical SnO2 microspheres from porous nanosheets towards NO decomposition 显示文摘 | LET H QUANG D T TAKESHI K | 2013 | Solid State Sei2013，15，： | 1 |
| 18 | The Effectiveness of 18 F-FDG PET/CT combined with STIR MRI for diagnosing nodal involvement in the thorax显示文摘 | Miwa M Yoshiki D Takeshi I | 2009 | J Nucl Med2009，50，： | 1 |
| 19 | Inhibition of GAPDH activity by poly (ADP-ribose) polymerase activates three major pathways of hyperglycemic damage in endothelial cells显示文摘 | XXULIANG D TAKESHI M DIANE E | 2003 | J Clin Invest2003，112，7： | 1 |
| 20 | The Effec- tiveness of 18F - FDG PET/CT combined with STIR MR/ for diagnosing nodal involvement in the thorax显示文摘 | Miwa M Yoshiki D Takeshi I | 2009 | J Nucl Med2009，50，： | 1 |
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