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| 1 | Structure of the receptor-activated human TRPC6 and TRPC3 ion channels显示文摘TRPC6 和 TRPC3 是属于正规短暂受体潜力(TRPC ) 的家庭的激活受体的 nonselective 阳离子隧道隧道。他们被 diacylglycerol 激活,一个类脂化合物秒送信人。TRPC6 和 TRPC3 涉及许多生理的过程并且在人的基因疾病含有。这里我们在场在有最新识别的高亲密关系的禁止者 BTDM 的建筑群的人的 TRPC6 homotetramer 的结构由单个粒子的 cryo 电子显微镜学解决了到 3.8?分辨率。我们也在 4.4 点介绍人的 TRPC3 的结构吗?分辨率。这些结构显示出塑造钟的 cytosolic 层在保持 transmembrane 层的二层的体系结构。包括 N 终端 ankyrin 重复和 C 终端卷卷, cytosolic 领域的广泛的内部子单元的相互作用贡献 tetramer 集会。高亲密关系的禁止者 BTDM 在 S5-S6 毛孔领域和电压之间挤像传感器的领域禁止隧道开。我们的结构揭开 TRPC 隧道的分子的建筑学并且为理解这些隧道的机制提供一个结构的基础。 | Qinglin Tang Wenjun Guo Li Zheng Jing-Xiang Wu Meng Liu Xindi Zhou Xiaolin Zhang Lei Chen | 2018 | Cell Research2018，28，7： | 10 |
| 2 | Suppression of murine breast cancer metastasis by selective inhibition of CXCR4 by synthetic polypeptide derived from viral macrophage inflammatory protein Ⅱ显示文摘Stromal cell-derived factor-1 and its receptor CXC chemokine receptor-4(CXCR4)have been implicated in breast cancer metastasis.A significant association between HER2 and CXCR4 expression has been observed in human breast tumor tissues,and overexpression of CXCR4 is essential for HER2-mediated tumor metastasis.Moreover,CXCR4 expression is low in normal breast tissues and high in malignant tumors,suggesting that a blockade of CXCR4 may limit tumor metastasis.The present study investigated the action of a synthetic antagonist 21-mer peptide derived from viral macrophage inflammatory protein Ⅱ against CXCR4(NT21MP)in inhibiting metastasis in vitro and in vivo.The results showed that chemotaxis of SKBR3 cells toward SDF-1αwas reduced by NT21MP in a dose-dependent manner(P<0.05).NT21MP inhibited tumor growth at 500μg/kg and in combination with Herceptin,the anti-HER2 antibody.The in vivo metastatic assay showed that NT21MP significantly inhibited pulmonary metastasis,and the number of metastatic tumor nodes on the surface of the lung was greatly decreased.Compared with the saline-treated control group,PCNA expression was dose-dependently decreased by NT21MP,the percentage of apoptotic cells was increased,and CXCR4 mRNA and protein expression were downregulated.In conclusion,NT21MP inhibits cellular proliferation,promotes apoptosis by downregulating CXCR4 expression,and suppresses the progression of primary and metastatic tumors.CXCR4 may be a useful therapeutic target for breast cancer,and NT21MP may serve as a potential target drug for the treatment of breast cancer metastasis. | YANG QingLin DING YongXing CHEN ChangJie TANG Jie ZHANG Ju YANG ZhiFeng | 2010 | Chinese Science Bulletin2010，55，20： | 6 |
| 3 | Number of Species and Geographical Distribution of Diospyros L.(Ebenaceae) in China显示文摘Diospyros L. is the largest, most widely distributed, and economically important genus of the family Ebenaceae. However, various researchers disagree on the number of species and geographical distribution of Diospyros in China. For the purpose of providing a scientific basis for the effective protection and rational use of Diospyros, the present study involved a comprehensive review of the literature, electronic databases, and herbaria as well as field investigations. The results showed as the following.(1) While 174 scientific names have been published for various taxa of Diospyros in China, by screening and excluding synonyms, 65 species names were considered acceptable; these account for about 12%of the total species of Diospyros globally.(2) A review of herbarium specimens documented that Diospyros occurs in 28 administrative regions of China, more than the literature records. Species richness decreases from south to north in China while Guangxi, Yunnan, Guangdong, and Hainan have the greatest number of species.(3) Among the 65 relatively reliable Diospyros species, 45 species are endemic to China and 18 species are stenochoric. Some species may have become extinct as a result of environmental degradation and the status of some germplasm remain unresolved. In brief, Chinese Diospyros includes abundant, China-specific, and widely distributed features. Nevertheless, comprehensive species delimitation and the analysis of phylogenetic relationships will still require further study. | Donglan Tang Qinglin Zhang Liqing Xu Dayong Guo Zhengrong Luo | 2019 | Horticultural Plant Journal2019，5，2： | 4 |
| 4 | Site-Specifc Gene Targeting Using Transcription Activator-Like Effector(TALE)-Based Nuclease in Brassica oleracea显示文摘Site-specifc recognition modules with DNA nuclease have tremendous potential as molecular tools for genome targeting.The type III transcription activator-like effectors(TALEs)contain a DNA binding domain consisting of tandem repeats that can be engineered to bind user-defned specifc DNA sequences.We demonstrated that customized TALE-based nucleases(TALENs),constructed using a method called'unit assembly',specifcally target the endogenous FRIGIDA gene in Brassica oleracea L.var.capitata L.The results indicate that the TALENs bound to the target site and cleaved double-strand DNA in vitro and in vivo,whereas the effector binding elements have a 23 bp spacer.The T7 endonuclease I assay and sequencing data show that TALENs made double-strand breaks,which were repaired by a non-homologous end-joining pathway within the target sequence.These data show the feasibility of applying customized TALENs to target and modify the genome with deletions in those organisms that are still in lacking gene target methods to provide germplasms in breeding improvement. | Zijian Sun Nianzu Li Guodong Huang Junqiang Xu Yu Pan Zhimin Wang Qinglin Tang Ming Song Xiaojia Wang | 2013 | Journal of Integrative Plant Biology2013，55，11： | 3 |
| 5 | Genome-wide identi?cation of loci affecting seed glucosinolate contents in Brassica napus L.显示文摘Glucosinolates are amino acid-derived secondary metabolites that act as chemical defense agents against pests.However,the presence of high levels of glucosinolates severely diminishes the nutritional value of seed meals made from rapeseed(Brassica napus L.).To identify the loci affecting seed glucosinolate cont ent(SGC),we con ducted genome-wide resequencing in a population of 307 diverse B.napus accessions from the three B.napus ecotype groups,namely,spring,winter,and semi-winter.These resequencing data were used for a genome-wide association study(GWAS)to identify the loci affecting SGC.In the three ecotype groups,four comm on and four ecotype-specific haplotype blocks(HBs)were significantly associated with SGC.To identify candidate genes controlling SGC,transcriptome analysis was carried out in 36 accessions showing extreme SGC values.Analyses of haplotypes,genomic variation,and candidate gene expression pointed to five and three candidate genes in the common and spring group-specific HBs,respectively.Our expression analyses dem on strated that additive effects of the three candidate genes in the spring group-specific HB play important roles in the SGC of B.napus. | Dayong Wei Yixin Cui Jiaqin Mei Lunwen Qian Kun Lu Zhi-Min Wang Jiana Li Qinglin Tang Wei Qian | 2019 | Journal of Integrative Plant Biology2019，61，5： | 2 |
| 6 | Numerical methods and comparison for computing dark and bright solitons in the nonlinear Schrdinger equation显示文摘 | Bao Weizhu Tang Qinglin Xu Zhiguo | 2013 | Journal of Computational Physics2013，235，： | 1 |
| 7 | Fabrication and characteristics of nano LiFePO 4 /C composites with high capacity and high rate using nano Fe 2 O 3 as raw materials显示文摘 | BaoHua Rong YanWen Lu XueWen Liu QingLin Chen Kun Tang HuaZhen Yang XingYun Wu Fei Shen YanBin Chen YueFeng Tang YanFeng Chen | 2014 | Nano Energy2014，，： | 1 |
| 8 | A general static-headspace gas chromatographic method for determination of residual benzene in oral liquid pharmaceutical products显示文摘 | Hui Liu Qinglin Tang Robert J. Markovich Abu M. Rustum | 2010 | Journal of Pharmaceutical and Biomedical Analysis2010，，2： | 1 |
| 9 | Discriminant analysis of “Jinzaoshi” from persimmon ( Diospyros kaki Thunb.; Ebenaceae): A comparative study conducted based on morphological as well as ITS and mat K sequence analyses显示文摘 | Donglan Tang Yan Hu Qinglin Zhang Yong Yang Zhengrong Luo | 2014 | Scientia Horticulturae2014，，： | 1 |
| 10 | Expression of second mitochondria-derived activator of caspases, X-linked inhibitor of apoptosis protein, and caspase-3 in pituitary adenomas显示文摘Studies concerning correlations between pituitary adenomas and cell apoptosis have mainly focused on upstream apoptosis signaling, but seldom on downstream mediators. In the present study, second mitochondria-derived activator of caspases (Smac), X-linked inhibitor of apoptosis protein (XIAP), and caspase-3 protein were qualitatively analyzed using immunohistochemistry, and quantified by western blot. Smac, XIAP, and caspase-3 mRNA expressions were detected by reverse transcription-PCR. Results showed that XIAP protein and mRNA expressions were greater in the invasive pituitary adenoma group compared with the noninvasive pituitary adenoma group. However, Smac and caspase-3 protein and mRNA expressions were lower in the invasive pituitary adenoma group compared with the noninvasive pituitary adenoma group. In the invasive pituitary adenomas, Smac expression was positively correlated with caspase-3 protein and mRNA expression (Protein: r = 0.55, P < 0.01; mRNA: r = 0.50, P < 0.01). Smac and caspase-3 expressions were negatively correlated with XIAP protein and mRNA expression (Protein: r = -0.56, -0.64, P < 0.01; mRNA: r = -0.69, -0.67, P < 0.01). However, no significant differences in correlation among Smac, XIAP, and caspase-3 were detectable in noninvasive pituitary adenomas. These data indicated that high expression of XIAP and low expression of Smac and caspase-3 suppressed cell apoptosis and led to enhanced invasiveness of pituitary adenomas. Thus, Smac, XIAP, and caspase-3 may be useful markers in determining the invasive behavior of pituitary adenomas. | Dong Li Gang Huo Liang Wang Qinglin Feng Maoyuan Tang | 2011 | Neural Regeneration Research2011，6，7： | 1 |
| 11 | The K Domain Mediates Homologous and Heterologous Interactions Between FLC and SVP Proteins of Brassica juncea显示文摘The transcription factors FLOWERING LOCUS C(FLC) and SHORT VEGETATIVE PHASE(SVP) can interact to form homologous and heterologous protein complexes that regulate flowering time in Brassica juncea Coss.(Mustard). Previous studies showed that protein interactions were mediated by the K domain,which contains the subdomains K1,K2 and K3. However,it remains unknown how the subdomains mediate the interactions between FLC and SVP. In the present study,we constructed several mutants of subdomains K1–K3 and investigated the mechanisms involved in the heterologous interaction of BjFLC/BjSVP and in the homologous interaction of BjFLC/Bj FLC or BjSVP/BjSVP. Yeast two-hybrid and β-galactosidase activity assays showed that the 19 amino acids of the K1 subdomain in BjSVP and the 17 amino acids of the K1 subdomain in BjFLC were functional subdomains that interact with each other to mediate hetero-dimerization. The heterologous interaction was enhanced by the K2 subdomain of BjSVP protein,but weakened by its interhelical domain L2. The heterologous interaction was also enhanced by the K2 subdomain of BjFLC protein,but weakened by its K3 subdomain. The homologous interaction of BjSVP was mediated by the full K-domain. However,the homologous interaction of BjFLC was regulated only by its K1 and weakened by its K2 and K3 subdomains. The results provided new insights into the interactions between FLC and SVP,which will be valuable for further studies on the molecular regulation mechanisms of the regulation of flowering time in B. juncea and other Brassicaceae. | MA Guanpeng LIU Zhiyu YANG Puli XU Junqiang SONG Ming TANG Qinglin | 2015 | Horticultural Plant Journal2015，1，1： | 0 |
| 12 | Numerical Study of Quantized Vortex Interaction in theGinzburg-Landau Equation on Bounded Domains显示文摘In this paper,we study numerically quantized vortex dynamics and their interaction in the two-dimensional(2D)Ginzburg-Landau equation(GLE)with a dimensionless parameter#>0 on bounded domains under either Dirichlet or homogeneous Neumann boundary condition.We begin with a reviewof the reduced dynamical laws for time evolution of quantized vortex centers in GLE and show how to solve these nonlinear ordinary differential equations numerically.Then we present efficient and accurate numerical methods for discretizing the GLE on either a rectangular or a disk domain under either Dirichlet or homogeneous Neumann boundary condition.Based on these efficient and accurate numerical methods for GLE and the reduced dynamical laws,we simulate quantized vortex interaction of GLE with different#and under different initial setups including single vortex,vortex pair,vortex dipole and vortex lattice,compare them with those obtained from the corresponding reduced dynamical laws,and identify the cases where the reduced dynamical laws agree qualitatively and/or quantitatively as well as fail to agree with those from GLE on vortex interaction.Finally,we also obtain numerically different patterns of the steady states for quantized vortex lattices under the GLE dynamics on bounded domains. | Weizhu Bao Qinglin Tang | 2013 | Communications in Computational Physics2013，14，8： | 0 |
| 13 | Symbology of Feynman integrals from twistor geometries显示文摘We study the symbology of planar Feynman integrals in dimensional regularization by considering geometric configurations in momentum twistor space corresponding to their leading singularities(LS). Cutting propagators in momentum twistor space amounts to intersecting lines associated with loop and external dual momenta, including the special line associated with the point at infinity, which breaks dual conformal symmetry. We show that cross-ratios of intersection points on these lines, especially those on the infinity line, naturally produce symbol letters for Feynman integrals in D = 4-2∈, which include and generalize their LS. At one loop, we obtain all symbol letters using intersection points from quadruple cuts for integrals up to pentagon kinematics with two massive corners, which agree perfectly with canonical differential equation(CDE) results. We then obtain all two-loop letters, for up to four-mass box and one-mass pentagon kinematics, by considering more intersections arising from two-loop cuts. Finally we comment on how cluster algebras appear from this construction, and importantly how we may extend the method to non-planar integrals. | Song He Jiahao Liu Yichao Tang Qinglin Yang | 2024 | Science China(Physics,Mechanics & Astronomy)2024，67，3： | 0 |
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