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| 1 | Hypoxia-inducible factor 2α is a negative regulator of osteoblastogenesis and bone mass accrual显示文摘Osteoblasts,which are the bone-forming cells,operate in a hypoxic environment.The transcription factors hypoxia-inducible factor-1α(HIF1)and HIF2 are key mediators of the cellular response to hypoxia.Both are expressed in osteoblasts.HIF1 is known to be a positive regulator of bone formation.Conversely,the role of HIF2 in the control osteoblast biology is still poorly understood.In this study,we used mouse genetics to demonstrate that HIF2 is an inhibitor of osteoblastogenesis and bone mass accrual.Moreover,we provided evidence that HIF2 impairs osteoblast differentiation at least in part,by upregulating the transcription factor Sox9.Our findings constitute a paradigm shift,as activation of the hypoxia-signaling pathway has traditionally been associated with increased bone formation through HIF1.Inhibiting HIF2 could thus represent a therapeutic approach for the treatment of the low bone mass observed in chronic diseases,osteoporosis,or aging. | Christophe Merceron Kavitha Ranganathan Elizabeth Wang Zachary Tata Shreya Makkapati Mohd Parvez Khan Laura Mangiavini Angela Qing Yao Laura Castellini Benjamin Levi Amato J.Giaccia Ernestina Schipani | 2019 | Bone Research2019，7，1： | 7 |
| 2 | Enoxaparin Prevents Portal Vein Thrombosis and Liver Decompensation in Patients With Advanced Cirrhosis显示文摘 | Erica Villa Calogero Cammà Marco Marietta Monica Luongo Rosina Critelli Stefano Colopi Cristina Tata Ramona Zecchini Stefano Gitto Salvatore Petta Barbara Lei Veronica Bernabucci Ranka Vukotic Nicola De Maria Filippo Schepis Aimilia Karampatou Cristian Ca | 2012 | Gastroenterology2012，，5： | 5 |
| 3 | Titanium dioxide photocatalysis显示文摘 | Akira Fujishima Tata N. Rao Donald A. Tryk | 2000 | Journal of Photochemistry & Photobiology C: Photochemistry Reviews2000，，1： | 3 |
| 4 | Amphibian metamorphosis as a model for studying the developmental actions of thyroid hormone显示文摘The thyroid hormones L-thyroxine and triiodo-L-thyronine have profound effects on postembryonic development of most vertebrates. Analysis of their action in mammals is vitiated by the exposure of the developing foetus to a number of maternal factors which do not allow one to specifically define the role of thyroid hormone (TH)or that of other hormones and factors that modulate its action. Amphibian metamorphosis is obligatorily dependent on TH which can initiate all the diverse physiological manifestations of this postembryonic developmental process(morphogenesis, cell death, re-structuring, etc.) in free-living embryos and larvae of most anurans. This article will first describe the salient features of metamorphosis and its control by TH and other hormones. Emphasis will be laid on the key role played by TH receptor (TR), in particular the phenomenon of TR gene autoinduction, in initiating the developmental action of TH. Finally, it will be argued that the findings on the control of amphibian metamorphosis enhance our understanding of the regulation of postembryonic development by TH in other vertebrate species. | TATA JAMSHED R (National Institute for Medical Research, The Ridgeway,Mill Hill, London NW7 1AA, UK.Tel: +44-181-959 3666 Fax: +JJ-181-913 8583E-mail: jtata@nimr. mrc. ac. uk) | 1998 | Cell Research1998，8，4： | 3 |
| 5 | An Updated Overview on Wnt Signaling Pathways: A Prelude for More显示文摘 | Tata Purushothama Rao Michael Kühl | 2010 | Circulation Research2010，，12： | 2 |
| 6 | 育龄期妊娠和非妊娠女性的初次脑卒中发生率比较:以英国人口为基础的队列研究显示文摘与相似年龄的非妊娠女性相比,妊娠女性的脑卒中风险可能增加,但这种风险的严重程度和影响时机尚不清楚。该研究调查了育龄女性初次发生脑卒中事件的风险,并比较了在妊娠期间与产后早期与平时的风险差异。 | 刘莉 叶鹏 Ban L Sprigg N Abdul Sultan A Nelson-Piercy C Bath PM Ludvigsson JF Stephansson O Tata LJ | 2017 | 中华高血压杂志2017，25，5： | 2 |
| 7 | A bot- tom-up approach to workflow cooperation for short-term virtual en- terprises显示文摘 | Samir Tata Kais Klai Nomane Ould Ahmod M'bareck | 2008 | IEEE Transactions on Services Computer2008，1，4： | 1 |
| 8 | Selective clinical ultrasound signals mediate differential gene transfer and expression in two human prostate cancer cell lines: LnCap and PC-3显示文摘 | Tata DB Dunn F Tindall DJ | | 0，，： | 1 |
| 9 | Linear programming with fuzzy variables显示文摘 | MALEKI H R TATA M MASHINCHI M | 2000 | Fuzzy Sets and Systems2000，109，1： | 1 |
| 10 | Pre-emptive intraperito- neal local anaesthesia: an effective method in immediate post-operative pain management and metabolic stress response in laparoscopic appendicectomy, a randomized, double-blind- ed, placebo-controlled study 显示文摘 | Thanapal MR Tata MD Tan A J | 2014 | ANZ J Surg2014，84，1： | 1 |
| 11 | Estimating the selectivity oftf-idf based cosine similarity predicates 显示文摘 | TATA S PATEL J M | 2007 | ACM Sigmod Record2007，36，2： | 1 |
| 12 | Determination of glycated hemoglobins in the rat:comparison between two different chromatographic methods and application in experimental diabetology显示文摘 | De Tata V Novelli M Bombara M | 1996 | Res Exp Med (Berl)1996，196，1： | 1 |
| 13 | The Influence of Accounts on Perceived Social Loafing in Work Teams显示文摘 | Tata J | 2002 | The International Journal of Conflict Management2002，13，3： | 1 |
| 14 | Estimating the parameters of a fuzzy Linear regression model显示文摘 | Arabpour A R Tata M | 2008 | Iranian Journal of Fuzzy Systems2008，5，2： | 1 |
| 15 | Titanium dioxide photocatalysis显示文摘 | Akira Fujishima Tata N Rao Donald A Tryk | 2000 | Journal of Photochemistry and Photobiology C: Photochemistry Reviews2000，1，： | 1 |
| 16 | mTOR-dependent abnormalities in autophagy characterize human malformations of cortical development: evidence from focal cortical dysplasia and tuberous sclerosis 显示文摘 | Yasin SA Ali AM Tata M et at | 2013 | Acta Neuropathol2013，126，2： | 1 |
| 17 | Implicit Theories of Account-Giving: Influence of Culture and Gender 显示文摘 | Tata J | 2000 | International Journal of Intercultural Relations2000，，24： | 1 |
| 18 | Psychiatric morbidity among patients with recurrent miscarriage显示文摘 | Craig M Tata P Regan L | 2002 | J Psychosom Obstct Gynaecol2002，23，3： | 1 |
| 19 | Amphibian metamorphosis as a model for the developmental actions of thyroid hormone 显示文摘 | Tata JR | 2006 | Mol Cell Endocrinol2006，246，： | 1 |
| 20 | TiO2 photocatalysts and diamond electrodes 显示文摘 | FUJISHIMA A RAO TATA N TRYK D A | 2000 | Electrochimica Acta2000，45，46： | 1 |
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