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| 1 | New pyrometallurgical process of EAF dust treatment with CaO addition显示文摘The non-carbothermic zinc pyrometallurgical processing of electric arc furnace(EAF) dust was investigated on a laboratory scale. The main objective of this process was to convert highly stable zinc ferrite(Zn Fe2O4), which accounts for more than half of total zinc in the EAF dust, into Zn O and Ca2Fe2O5 by Ca O addition. The EAF dust was mixed with Ca O powder in various ratios, pressed into pellets, and heated in a muffle furnace in air at temperatures ranging from 700 to 1100°C for a predetermined holding time. All Zn Fe2O4 was transformed into Zn O and Ca2Fe2O5 at a minimum temperature of 900°C within 1 h when sufficient Ca O to achieve a Ca/Fe molar ratio of 1.1 was added. However, at higher temperatures, excess Ca O beyond the stoichiometric ratio was required because it was consumed by reactions leading to the formation of compounds other than Zn Fe2O4. The evaporation of halides and heavy metals in the EAF dust was also studied. These components could be preferentially volatilized into the gas phase at 1100°C when Ca O was added. | Romchat Chairaksa-Fujimoto Yosuke Inoue Naoyoshi Umeda Satoshi Itoh Tetsuya Nagasaka | 2015 | International Journal of Minerals,Metallurgy and Materials2015，22，8： | 7 |
| 2 | Partially hydrolyzed guar gum attenuates non-alcoholic fatty liver disease in mice through the gut-liver axis显示文摘BACKGROUND The gut-liver axis has attracted much interest in the context of chronic liver disease pathogenesis.Prebiotics such as dietary fibers were shown to attenuate non-alcoholic fatty liver disease(NAFLD)by modulating gut microbiota.Partially hydrolyzed guar gum(PHGG),a water-soluble dietary fiber,has been reported to alleviate the symptoms of various intestinal diseases and metabolic syndromes.However,its effects on NAFLD remain to be fully elucidated.To determine whether treatment with PHGG attenuates NAFLD development in mice through the gut-liver axis.METHODS Seven-week-old male C57BL/6J mice with increased intestinal permeability were fed a control or atherogenic(Ath)diet(a mouse model of NAFLD)for 8 wk,with or without 5%PHGG.Increased intestinal permeability was induced through chronic intermittent administration of low-dose dextran sulfate sodium.Body weight,liver weight,macroscopic findings in the liver,blood biochemistry[aspartate aminotransferase(AST)and alanine aminotransferase(ALT),total cholesterol,triglyceride,free fatty acids,and glucose levels],liver histology,myeloperoxidase activity in liver tissue,mRNA expression in the liver and intestine,serum endotoxin levels in the portal vein,intestinal permeability,and microbiota and short-chain fatty acid(SCFA)profiles in the cecal samples were investigated.RESULTS Mice with increased intestinal permeability subjected to the Ath diet showed significantly increased serum AST and ALT levels,liver fat accumulation,liver inflammatory(tumor necrosis factor-αand monocyte chemotactic protein-1)and fibrogenic(collagen 1a1 andαsmooth muscle actin)marker levels,and liver myeloperoxidase activity,which were significantly attenuated by PHGG treatment.Furthermore,the Ath diet combined with increased intestinal permeability resulted in elevated portal endotoxin levels and activated toll-like receptor(TLR)4 and TLR9 expression,confirming that intestinal permeability was significantly elevated,as observed by evaluating the lumen-to-blood clearance of fluorescein isothiocyanate-conjugated dextran.PHGG treatment did not affect fatty acid metabolism in the liver.However,it decreased lipopolysaccharide signaling through the gut-liver axis.In addition,it significantly increased the abundance of cecal Bacteroides and Clostridium subcluster XIVa.Treatment with PHGG markedly increased the levels of SCFAs,particularly,butyric acid,acetic acid,propionic acid,and formic acid,in the cecal samples.CONCLUSION PHGG partially prevented NAFLD development in mice through the gut-liver axis by modulating microbiota and downstream SCFA profiles. | Shun Takayama Kazuhiro Katada Tomohisa Takagi Takaya Iida Tomohiro Ueda Katsura Mizushima Yasuki Higashimura Mayuko Morita Tetsuya Okayama Kazuhiro Kamada Kazuhiko Uchiyama Osamu Handa Takeshi Ishikawa Zenta Yasukawa Tsutomu Okubo Yoshito Itoh Yuji Naito | 2021 | World Journal of Gastroenterology2021，27，18： | 4 |
| 3 | Analysis of electronic structures of 3d transition metal-doped TiO 2 based on band calculations显示文摘 | Tsutomu Umebayashi Tetsuya Yamaki Hisayoshi Itoh Keisuke Asai | 2002 | Journal of Physics and Chemistry of Solids2002，，10： | 2 |
| 4 | Dynamic functional relay between insulin signaling during fasting and feeding显示文摘 | Naoto Kubota Tetsuya Kubota Shinsuke Itoh | 2008 | Cell Metabolism2008，8，： | 1 |
| 5 | BACKGROUND AND CLINICAL IMPACT OF TISSUE CONGESTION IN RIGHT-LOBE LIVING-DONOR LIVER GRAFTS: A MAGNETIC RESONANCE IMAGING STUDY显示文摘 | Hidekazu Yamamoto Yoji Maetani Tetsuya Kiuchi Takashi Ito Satoshi Kaihara Hiroto Egawa Kyo Itoh Yasuo Kamiyama Koichi Tanaka | 2003 | Transplantation2003，，1： | 1 |
| 6 | Selfassembly and micropatterning of spherical-particle assemblies 显示文摘 | Yoshitake Masuda Tetsuya Itoh Kunihito Koumoto | 2005 | Advanced Material2005，17，7： | 1 |
| 7 | Expression of Cdx2 and the phenotype of advanced gastric cancers: relationship with prognosis显示文摘 | Tsutomu Mizoshita Tetsuya Tsukamoto Hayao Nakanishi Ken-ichi Inada Naotaka Ogasawara Takashi Joh Makoto Itoh Yoshitaka Yamamura Masae Tatematsu | 2003 | Journal of Cancer Research and Clinical Oncology2003，，12： | 1 |
| 8 | Expression of Cdx1 and Cdx2 mRNAs and relevance of this expression to differentiation in human gastrointestinal mucosa — with special emphasis on participation in intestinal metaplasia of the human stomach显示文摘 | Tsutomu Mizoshita Ken-ichi Inada Tetsuya Tsukamoto Yasuhiro Kodera Yoshitaka Yamamura Takashi Hirai Tomoyuki Kato Takashi Joh Makoto Itoh Masae Tatematsu | 2001 | Gastric Cancer2001，，4： | 1 |
| 9 | Cloning and expression of the Saccharomycopsis fibuligera glucoamylase gene in Saccharomyces cerevisiae显示文摘 | Ichiro Yamashita Tetsuya Itoh Sakuzo Fukui | 1985 | Appl Microbiol Biotechnol1985，23，： | 1 |
| 10 | Nucleotide sequence of the α -amylase gene(ALP1) in the yeast Saccharomycopsisfibuligera显示文摘 | Tetsuya Itoh Ichiro Yamashita Sakuzo Fukui | 1987 | FEBS Letters1987，219，2： | 1 |
| 11 | New EAF dust treatment process with the aid of strong magnetic field显示文摘 | SATOSHI ITOH AKIRA TSUBONE KAZUYO MATSUBAE-YOKOYAMA KENICHI NAKAJIMA TETSUYA NAGASAKA | 2008 | ISIJ International2008，48，10： | 1 |
| 12 | Expression of the intestine-specific transcription factors, Cdx1 and Cdx2, correlates shift to an intestinal phenotype in gastric cancer cells显示文摘 | Tsutomu Mizoshita Ken-ichi Inada Tetsuya Tsukamoto Koji Nozaki Takashi Joh Makoto Itoh Yoshitaka Yamamura Toshikazu Ushijima Shigeo Nakamura Masae Tatematsu | 2003 | Journal of Cancer Research and Clinical Oncology2003，，1： | 1 |
| 13 | Analysis of electionic structure of 3d transition metal-doped TiO2 based on band calculations显示文摘 | Tsutomu Umebayashi Tetsuya Yamaki Hisayoshi Itoh | 2002 | J Phys Chem Solids2002，63，10： | 1 |
| 14 | Th1/Th2 cytokine profiles and their relationship to clinical features in patients with chronic hepatitis C virus infection显示文摘 | Satoshi Sobue Tomoyuki Nomura Tetsuya Ishikawa Satomi Ito Katsuhisa Saso Hirotaka Ohara Takashi Joh Makoto Itoh Shinichi Kakumu | 2001 | Journal of Gastroenterology2001，，8： | 1 |
| 15 | Th1/Th2 cytokine profiles and their relationship to clinical features in patients with chronic hepatitis C virus infection显示文摘 | Satoshi Sobue Tomoyuki Nomura Tetsuya Ishikawa Satomi Ito Katsuhisa Saso Hirotaka Ohara Takashi Joh Makoto Itoh Shinichi Kakumu | 2001 | Journal of Gastroenterology2001，，8： | 1 |
| 16 | Accurate pedicle screw insertion under the control of a computer-assisted image guiding system: Laboratory test and clinical study显示文摘 | Mikio Kamimura Sohei Ebara Hidehiro Itoh Yutaka Tateiwa Tetsuya Kinoshita Kunio Takaoka | 1999 | Journal of Orthopaedic Science1999，，3： | 1 |
| 17 | Th1/Th2 cytokine profiles and their relationship to clinical features in patients with chronic hepatitis C virus infection显示文摘 | Satoshi Sobue Tomoyuki Nomura Tetsuya Ishikawa Satomi Ito Katsuhisa Saso Hirotaka Ohara Takashi Joh Makoto Itoh Shinichi Kakumu | 2001 | Journal of Gastroenterology2001，，8： | 1 |
| 18 | Alteration of aquaporin mRNA expression after smallbowel resection in the rat residual ileum and colon显示文摘 | Tomoyuki Tsujikawa Akihiko Itoh Tetsuya Fukun | 2003 | JGastroenterol Hepatol2003，18，： | 1 |
| 19 | Clinical characteristics and prevalence of GB virus C, SEN virus, and HFE gene mutation in Japanese patients with nonalcoholic steatohepatitis显示文摘 | Norihito Yamauchi Yoshito Itoh Yasuhito Tanaka Masashi Mizokami Masahito Minami Atsuhiro Morita Tetsuya Toyama Kanji Yamaguchi Hideki Fujii Takeshi Okanoue | 2004 | Journal of Gastroenterology2004，，7： | 1 |
| 20 | Dynamic Functional Relay between Insulin Receptor Substrate 1 and 2 in Hepatic Insulin Signaling during Fasting and Feeding显示文摘 | Naoto Kubota Tetsuya Kubota Shinsuke Itoh Hiroki Kumagai Hideki Kozono Iseki Takamoto Tomoka Mineyama Hitomi Ogata Kumpei Tokuyama Mitsuru Ohsugi Takayoshi Sasako Masao Moroi Kaoru Sugi Shigeru Kakuta Yoichiro Iwakura Tetsuo Noda Shin Ohnishi Ryozo Nagai | 2008 | Cell Metabolism2008，，1： | 1 |
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