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| 1 | Study of Variable Turbulent Prandtl Number Model for Heat Transfer to Supercritical Fluids in Vertical Tubes显示文摘In order to improve the prediction performance of the numerical simulations for heat transfer of supercritical pressure fluids, a variable turbulent Prandtl number(Pr_t) model for vertical upward flow at supercritical pressures was developed in this study. The effects of Pr_t on the numerical simulation were analyzed, especially for the heat transfer deterioration conditions. Based on the analyses, the turbulent Prandtl number was modeled as a function of the turbulent viscosity ratio and molecular Prandtl number. The model was evaluated using experimental heat transfer data of CO_2, water and Freon. The wall temperatures, including the heat transfer deterioration cases, were more accurately predicted by this model than by traditional numerical calculations with a constant Pr_t. By analyzing the predicted results with and without the variable Pr_t model, it was found that the predicted velocity distribution and turbulent mixing characteristics with the variable Pr_t model are quite different from that predicted by a constant Pr_t. When heat transfer deterioration occurs, the radial velocity profile deviates from the log-law profile and the restrained turbulent mixing then leads to the deteriorated heat transfer. | TIAN Ran DAI Xiaoye WANG Dabiao SHI Lin | 2018 | Journal of Thermal Science2018，27，3： | 13 |
| 2 | Prevalence and prognostic implications of sarcopenia in older patients with coronary heart disease显示文摘Background Sarcopenia is a progressive and generalized skeletal muscle disorder that is associated with an increased likelihood of adverse outcomes, including falls, fractures, physical disability, and mortality. However, there have been few systematic studies of the prevalence and prognostic values of sarcopenia in older patients with coronary heart disease(CHD). This study aimed to investigate the prevalence of sarcopenia in hospitalized older patients with CHD, and to prospectively evaluate the effect of sarcopenia on the short-term prognosis of these patients. Methods Patients aged ≥ 65 years, with the diagnosis of CHD from Peking Union Medical College Hospital between December 2017 and November 2018, were included. Sarcopenia was diagnosed according to consensus of the Asian Working Group for Sarcopenia in 2014. Follow-up items included unscheduled return visits, occurrence of major adverse cardiac and cerebral events (MACCE), and all-cause mortality. The MACCE-free survival curve of sarcopenic and non-sarcopenic older patients with CHD was estimated by the Kaplan-Meier method. Cox regression analysis was used to analyze the association between sarcopenia and an unscheduled return visits, MACCE, and all-cause mortality. Results A total of 345 older patients with CHD were enrolled in the study, with a median age of 74 years. Among the patients, 78 (22.6%) were diagnosed with sarcopenia. During the follow-up time, there were significantly more unscheduled return visits in sarcopenic patients than in non-sarcopenic patients (34.2% vs. 21.8%,χ^2 = 4.418, P = 0.036), while there was no significant difference in the occurrence of MACCE (χ^2 = 2.869, P = 0.09) or all-cause mortality (χ^2 = 1.673, P = 0.196) between these patient groups. The Kaplan-Meier curve showed that the MACCE-free survival time of sarcopenic patients was significantly shorter than that in non-sarcopenic patients (χ^2 = 4.102, P = 0.043). After adjusting for sex, age, and the Charlson comorbidity index, sarcopenia was not an independent risk factor of unscheduled return visits (HR = 1.002, 95% CI: 0.556–1.807). However, the complication of anxiety and depression was an independent risk factor (HR = 1.876, 95% CI: 1.012–3.477, P = 0.046) for unscheduled return visits in older patients with CHD. Conclusions There is a high prevalence of sarcopenia among hospitalized older adults with CHD. A shorter MACCE-free survival time and more unscheduled return visits are found in sarcopenic older patients with CHD. Clinicians should pay more attention to the functional status of older patients with CHD, as well as identification and management of geriatric syndromes. | Ning ZHANG Wen-Ling ZHU Xiao-Hong LIU Wei CHEN Ming-Lei ZHU Lin KANG Ran TIAN | 2019 | Journal of Geriatric Cardiology2019，16，10： | 7 |
| 3 | Generation and characterization of stable pig pregastrulation epiblast stem cell lines显示文摘Pig epiblast-derived pluripotent stem cells are considered to have great potential and broad prospects for human therapeutic model developme nt and livestock breeding.Despite on going attempts since the 1990s,no stably defined pig epiblast-derived stem cell line has bee n established.Here,guided by in sights from a large-scale sin gle-cell tran scriptome an alysis of pig embryos from embryonic day(E)0 to E14,specifically,the tracing of pluripotency changes during epiblast development,we developed an in vitro culture medium for establishing and maintaining stable pluripotent stem cell lines from pig E10 pregastrulation epiblasts(pgEpiSCs).Enabled by chemical inhibition of WNT-related signaling in combination with growth factors in the FGF/ERK,JAK/STAT3,and Activin/Nodal pathways,pgEpiSCs maintain their pluripotency transcriptome features,similar to those of E10 epiblast cells,and normal karyotypes after more than 240 passages and have the potential to differentiate into three germ layers.Strikingly,ultradeep in situ Hi-C analysis revealed functional impacts of chromatin 3D-spatial associations on the transcriptional regulation of pluripote ncy marker genes in pgEpiSCs.I n practice,we con firmed that pgEpiSCs readily tolerate at least three rounds of successive gene editi ng and gene rated cloned gen e-edited live piglets.Our findings deliver on the long-a nticipated promise of pig pluripote nt stem cells and open new avenues for biological research,animal husbandry,and regenerative biomedicine. | Minglei Zhi Jinying Zhang Qianzi Tang Dawei Yu Shuai Gao Dengfeng Gao Pengliang Liu Jianxiong Guo Tang Hai Jie Gao Suying Cao Zimo Zhao Chongyang Li Xiaogang Weng Mengnan He Tianzhi Chen Yingjie Wang Keren Long Deling Jiao Guanglei Li Jiaman Zhang Yan Liu Yu Lin Daxin Pang Qianqian Zhu Naixin Chen Jingjing Huang Xinze Chen Yixuan Yao Jingcang Yang Zicong Xie Xianya Huang Mengxin Liu Ran Zhang Qiuyan Li Yiliang Miao Jianhui Tian Xingxu Huang Hongsheng Ouyang Bofeng Liu Wei Xie Qi Zhou Zhonghua Liu Caihong Zheng Mingzhou Li Jianyong Han | 2022 | Cell Research2022，32，4： | 3 |
| 4 | Engineered neutrophil apoptotic bodies ameliorate myocardial infarction by promoting macrophage efferocytosis and inflammation resolution显示文摘Inflammatory response plays a critical role in myocardial infarction(MI)repair.The neutrophil apoptosis and subsequent macrophage ingestion can result in inflammation resolution and initiate regeneration,while the therapeutic strategy that simulates and enhances this natural process has not been established.Here,we constructed engineered neutrophil apoptotic bodies(eNABs)to simulate natural neutrophil apoptosis,which regulated inflammation response and enhanced MI repair.The eNABs were fabricated by combining natural neutrophil apoptotic body membrane which has excellent inflammation-tropism and immunoregulatory properties,and mesoporous silica nanoparticles loaded with hexyl 5-aminolevulinate hydrochloride(HAL).The eNABs actively targeted to macrophages and the encapsulated HAL simultaneously initiated the biosynthesis pathway of heme to produce anti-inflammatory bilirubin after intracellular release,thereby further enhancing the anti-inflammation effects.In in vivo studies,the eNABs efficiently modulated inflammation responses in the infarcted region to ameliorate cardiac function.This study demonstrates an effective biomimetic construction strategy to regulate macrophage functions for MI repair. | Lili Bao Geng Dou Ran Tian Yajie Lv Feng Ding Siying Liu Ruifeng Zhao Lu Zhao Jun Zhou Lin Weng Yan Dong Bei Li Shiyu Liu Xin Chen Yan Jin | 2022 | Bioactive Materials2022，7，3： | 3 |
| 5 | Clinical epidemiology and disease burden of bronchiolitis in hospitalized children in China:a national cross-sectional study显示文摘Background Bronchiolitis is a common acute lower respiratory tract infection(ALRTI)and the most frequent cause of hospitalization of infants and young children with ALRTI.Respiratory syncytial virus is the main pathogen that leads to severe bronchiolitis.The disease burden is relatively high.To date,few descriptions of the clinical epidemiology and disease burden of children hospitalized for bronchiolitis are available.This study reports the general clinical epidemiological characteristics and disease burden of bronchiolitis in hospitalized children in China.Methods This study included the face sheet of discharge medical records collected from 27 tertiary children’s hospitals from January 2016 to December 2020 that were aggregated into the FUTang Update medical REcords(FUTURE)database.The sociodemographic variables,length of stay(LOS)and disease burden of children with bronchiolitis were analyzed and compared using appropriate statistical tests.Results In total,42,928 children aged 0–3 years were hospitalized due to bronchiolitis from January 2016 to December 2020,accounting for 1.5%of the total number of hospitalized children of the same age in the database during the period and 5.31%of the hospitalizations for ALRTI.The male to female ratio was 2.01:1.Meanwhile,more boys than girls were observed in different regions,age groups,years,and residences.The 1–2 year age group had the greatest number of hospitalizations for bronchiolitis,while the 29 days–6 months group had the largest proportion of the total inpatients and inpatients with ALRTI in the same age group.In terms of region,the hospitalization rate of bronchiolitis was the highest in East China.Overall,the number of hospitalizations from 2017 to 2020 showed a decreasing trend from that in 2016.Seasonally,the peak hospitalizations for bronchiolitis occurred in winter.Hospitalization rates in North China in autumn and winter were higher than those in South China,while hospitalization rates in South China were higher in spring and summer.Approximately,half of the patients with bronchiolitis had no complications.Among the complications,myocardial injury,abnormal liver function and diarrhea were more common.The median LOS was 6 days[interquartile range(IQR)=5–8],and the median hospitalization cost was 758 United States dollars(IQR=601.96–1029.53).Conclusions Bronchiolitis is a common respiratory disease in infants and young children in China,and it accounts for a higher proportion of both total hospitalizations and hospitalizations due to ALRTI in children.Among them,children aged 29 days–2 years are the main hospitalized population,and the hospitalization rate of boys is significantly higher than that of girls.The peak season for bronchiolitis is winter.Bronchiolitis causes few complications and has a low mortality rate,but the burden of this disease is heavy. | Jiao Tian Xin‑Yu Wang Lin‑Lin Zhang Meng‑Jia Liu Jun‑Hong Ai Guo‑Shuang Feng Yue‑Ping Zeng Ran Wang Zheng‑De Xie | 2023 | World Journal of Pediatrics2023，19，9： | 1 |
| 6 | Influencing factors of rat small intestinal epithelial cell cultivation and effects of radiation on cell proliferation显示文摘INTRODUCTIONCrypt epithelial cells in normal small intestineproliferate at a high speed. But they are verydifficult to culture in vitro and passage stably. A lotof studies have been done[1-16]. Some domestic labsisolated and cultured crypt cells from embryonalintestines and aseptic animal intestine, but failed.We introduced normal rat epithelial cell line-IEC-6from the USA and its living condition for stablepassage was successfully established after trials. Thecell line was testified to be the small intestinalepithelial cell by electron microscopy,immunihistochemistry and enzymatic histoch-emistry. It has been applied to some relatedresearch work[17-21]. It was found that manyfactors were involved in the culture system. Ourpresent study focuses on the culture method and theinfluencing factors on IEC-6. | Xin Ze Ran Yong Ping Su Yong Jiang Wei Guo Ping Ai Tian Min Cheng Yuan Lin Institute of Combined Injury, PLA, School of Preventive Medicine, Third Military Medical University. Chongqing 400038, China | 2001 | World Journal of Gastroenterology2001，7，1： | 1 |
| 7 | Vibration of L-shaped plates under a deterministic force or moment excitation: a case of statistical energy analysis application 显示文摘 | Tian Ran Lin Andy C C Tan Cheng Yah Douglas Hargreaves | 2011 | Journal of Sound and Vibration2011，20，330： | 1 |
| 8 | Zinc-finger protein 382 antagonises CDC25A and ZEB1 signaling pathway in breast cancer显示文摘Our previous studies found that Zinc-finger protein 382(ZNF382)played as a tumor suppressor gene in esophageal and gastric cancers,and a positive correlation between the high expression of ZNF382 and better outcome in breast cancer patients.However,the biological roles and mechanisms of ZNF382 in breast cancer remains unclear.We detected ZNF382 expression by reverse-transcription PCR(RT-PCR)and real-time quantitative PCR(qRT-PCR)in breast cancer cells and tissues,and explored the impacts and mechanisms of ectopic ZNF382 expression in breast cancer cells in vitro and in vivo,respectively.Our results revealed that ZNF382 was significantly down-regulated in breast cancer tissues compared with adjacent non-cancer tissues.Restoration of ZNF382 expression in silenced breast cancer cells not only inhibited tumor cell colony formation,viability,migration and invasion,and epithelial-mesenchymal-transition(EMT),but also induced apoptosis and G0/G1 arrest.In conclusion,ZNF382 could induce G0/G1 cell cycle arrest through inhibiting CDC25A signaling,and,inhibit cell migration,invasion and EMT by antagonizing ZEB1 signaling in breast cancer cells. | Shuman Li Xiaoqian He Yan Wang Weihong Chen Ran Sun Shaorong Tian Sanxiu He Chunyun Pu Chen Li Dishu Zhou Yu Jiang Qian Tao Lili Li Lin Ye Yue Wu Weiyan Peng Tingxiu Xiang | 2023 | Genes & Diseases2023，10，2： | 1 |
| 9 | Natural killer cell homing and trafficking in tissues and tumors:from biology to application显示文摘Natural killer(NK)cells,a subgroup of innate lymphoid cells,act as the first line of defense against cancer.Although some evidence shows that NK cells can develop in secondary lymphoid tissues,NK cells develop mainly in the bone marrow(BM)and egress into the blood circulation when they mature.They then migrate to and settle down in peripheral tissues,though some special subsets home back into the BM or secondary lymphoid organs.Owing to its success in allogeneic adoptive transfer for cancer treatment and its“off-the-shelf”potential,NK cell-based immunotherapy is attracting increasing attention in the treatment of various cancers.However,insufficient infiltration of adoptively transferred NK cells limits clinical utility,especially for solid tumors.Expansion of NK cells or engineered chimeric antigen receptor(CAR)NK cells ex vivo prior to adoptive transfer by using various cytokines alters the profiles of chemokine receptors,which affects the infiltration of transferred NK cells into tumor tissue.Several factors control NK cell trafficking and homing,including cell-intrinsic factors(e.g.,transcriptional factors),cell-extrinsic factors(e.g.,integrins,selectins,chemokines and their corresponding receptors,signals induced by cytokines,sphingosine-1-phosphate(S1P),etc.),and the cellular microenvironment.Here,we summarize the profiles and mechanisms of NK cell homing and trafficking at steady state and during tumor development,aiming to improve NK cell-based cancer immunotherapy. | Guang he Ran Yu qing Lin Lei Tian Tao Zhang Dong mei Yan Jian hua Yu You cai Deng | 2022 | Signal Transduction and Targeted Therapy2022，7，7： | 1 |
| 10 | A study of vibration and vibration control of ship structure显示文摘 | Lin Tian Ran Pan Jie O'Shea Peter | 2009 | Marine Structures2009，22，： | 1 |
| 11 | Evaluation of frequency dependent rubber mount stiffness and damping by impact test 显示文摘 | Tian Ran Lin Nabil H Farag Jie Pan | 2005 | Applied Acoustics2005，66，： | 1 |
| 12 | Evaluation of frequency dependent rubber mount stiffness and damping by impact test 显示文摘 | Tian Ran Lin Nabil H Farag Jie Pan | 2005 | Applied Acoustics2005，66，： | 1 |
| 13 | Advances in nuclear detection and readout techniques显示文摘“A Craftsman Must Sharpen His Tools to Do His Job,”said Confucius.Nuclear detection and readout techniques are the foundation of particle physics,nuclear physics,and particle astrophysics to reveal the nature of the universe.Also,they are being increasingly used in other disciplines like nuclear power generation,life sciences,environmental sciences,medical sciences,etc.The article reviews the short history,recent development,and trend of nuclear detection and readout techniques,covering Semiconductor Detector,Gaseous Detector,Scintillation Detector,Cherenkov Detector,Transition Radiation Detector,and Readout Techniques.By explaining the principle and using examples,we hope to help the interested reader underst and this research field and bring exciting information to the community. | Rui He Xiao‑Yang Niu Yi Wang Hong‑Wei Liang Hong‑Bang Liu Ye Tian Hong‑Lin Zhang Chao‑Jie Zou Zhi‑Yi Liu Yun‑Long Zhang Hai‑Bo Yang Ju Huang Hong‑Kai Wang Wei‑Jia Han Bei Cao Gang Chen Cong Dai Li‑Min Duan Rui‑Rui Fan Fang‑Fa Fu Jian‑Hua Guo Dong Han Wei Jiang Xian‑Qin Li Xin Li Zhuo‑Dai Li Yu‑Tie Liang Shun Liao De‑Xu Lin Cheng‑Ming Liu Guo‑Rui Liu Jun‑Tao Liu Ze Long Meng‑Chen Niu Hao Qiu Hu Ran Xiang‑Ming Sun Bo‑Tan Wang Jia Wang Jin‑Xiang Wang Qi‑Lin Wang Yong‑Sheng Wang Xiao‑Chuan Xia Hao‑Qing Xie He‑Run Yang Hong Yin Hong Yuan Chun‑Hui Zhang Rui‑Guang Zhao Ran Zheng Cheng‑Xin Zhao | 2023 | Nuclear Science and Techniques2023，34，12： | 0 |
| 14 | Characterization of Nocardia Plasmid pXT107显示文摘奴卡氏菌属, Rhodococcus 和 Streptomyces,放射菌类家庭的所有成员,是有满意、能形成菌丝体的高 G+C 的克积极的 eubacteria。我们这里报导奴卡氏菌属 sp 的最新识别的原生质标志 pXT107。107,最小的圆形的原生质标志之一在奴卡氏菌属发现了。pXT107 的完全的核苷酸顺序与 65% G+C 内容由 4335 bp 组成了,并且编码了一复制额外的遗传因子的 palindromic (议员) 和六假想蛋白质。议员,双海滨起源和 pXT107 的单个海滨的起源典型 rolling-circle-replication 原生质标志类似于那些,例如奴卡氏菌属的 pNI100, Rhodococcus 的 pRE8424 和 Streptomyces 的 pIJ101。Escherichia coli 奴卡氏菌属梭原生质标志 pHAQ22,包含 pXT107 的 rep 基因,能在奴卡氏菌属然而并非在 Streptomyces 宣传。 | Hai-Yang XIA Yong-Qiang TIAN Ran ZHANG Kai-Chun LIN Zhong-Jun QIN | 2006 | Acta Biochimica et Biophysica Sinica2006，38，9： | 0 |
| 15 | Deep Sc-RNA sequencing decoding the molecular dynamic architecture of the human retina显示文摘The human retina serves as a light detector and signals transmission tissue.Advanced insights into retinal disease mechanisms and therapeutic strategies require a deep understanding of healthy retina molecular events.Here,we sequenced the m RNA of over 0.6 million single cells from human retinas across six regions at nine different ages.Sixty cell sub-types have been identified from the human mature retinas with unique markers.We revealed regional and age differences of gene expression profiles within the human retina.Cell-cell interaction analysis indicated a rich synaptic connection within the retinal cells.Gene expression regulon analysis revealed the specific expression of transcription factors and their regulated genes in human retina cell types.Some of the gene’s expression,such as DKK3,are elevated in aged retinas.A further functional investigation suggested that over expression of DKK3 could impact mitochondrial stability.Overall,decoding the molecular dynamic architecture of the human retina improves our understanding of the vision system. | Lulin Huang Runze Li Lin Ye Shanshan Zhang Huaping Tian Mingyan Du Chao Qu Shujin Li Jie Li Mu Yang Biao Wu Ran Chen Guo Huang Ling Zhong Hongjie Yang Man Yu Yi Shi Changguan Wang Houbin Zhang Wei Chen Zhenglin Yang | 2023 | Science China(Life Sciences)2023，66，3： | 0 |
| 16 | Predictive Model and Risk Factors for Case Fatality of COVID-19: A Cohort of 21,392 Cases in Hubei, China显示文摘An increasing number of patients are being killed by coronavirus disease 2019(COVID-19),however,risk factors for the fatality of COVID-19 remain unclear.A total of 21,392 COVID-19 cases were recruited in the Hubei Province of China between December 2019 and February 2020,and followed up until March 18,2020.We adopted Cox regression models to investigate the risk factors for case fatality and predicted the death probability under specific combinations of key predictors.Among the 21,392 patients,1,020(4.77%)died of COVID-19.Multivariable analyses showed that factors,including age(R60 versus<45 years,hazard ratio[HR]=7.32;95%confidence interval[CI],5.42,9.89),sex(male versus female,HR=1.31;95%CI,1.15,1.50),severity of the disease(critical versus mild,HR=39.98;95%CI,29.52,48.86),comorbidity(HR=1.40;95%CI,1.23,1.60),highest body temperature(>39C versus<39C,HR=1.28;95%CI,1.09,1.49),white blood cell counts(>103109/L versus(4–10)3109/L,HR=1.69;95%CI,1.35,2.13),and lymphocyte counts(<0.83109/L versus(0.8–4)3109/L,HR=1.26;95%CI,1.06,1.50)were significantly associated with case fatality of COVID-19 patients.Individuals of an older age,who were male,with comorbidities,and had a critical illness had the highest death probability,with 21%,36%,46%,and 54%within 1–4 weeks after the symptom onset.Risk factors,including demographic characteristics,clinical symptoms,and laboratory factors were confirmed to be important determinants of fatality of COVID-19.Our predictive model can provide scientific evidence for a more rational,evidence-driven allocation of scarce medical resources to reduce the fatality of COVID-19. | Ran Wu Siqi Ai Jing Cai Shiyu Zhang Zhengmin(Min)Qian Yunquan Zhang Yinglin Wu Lan Chen Fei Tian Huan Li Mingyan Li Hualiang Lin | 2020 | The Innovation2020，1，2： | 0 |
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