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| 1 | A Virulent PEDV Strain FJzz1 with Genomic Mutations and Deletions at the High Passage Level Was Attenuated in Piglets via Serial Passage In Vitro显示文摘Highly virulent porcine epidemic diarrhea virus(PEDV)strains re-emerged and circulated in China at the end of 2010,causing significant economic losses in the pork industry worldwide.To understand the genetic dynamics of PEDV during its passage in vitro,the PEDV G2 strain FJzzl was serially propagated in Vero cells for up to 200 passages.The susceptibility and adaptability of the FJzzl strain increased gradually as it was serially passaged in vitro.Sequence analysis revealed that amino acid(aa)changes were mainly concentrated in the S glycoprotein,which accounted for 72.22%-85.71%of all aa changes.A continuous aa deletion(^(55)I^(56)G^(57)E→^(55)K^(56)Δ^(57)Δ)occurred in the N-terminal domain of S1(Sl-NTD).To examine how the aa changes affected its virulence,FJzzl-F20 and FJzzl-F200 were selected to simultaneously evaluate their pathogenicity in suckling piglets.All the piglets in the FJzzl-F20-infected group showed typical diarrhea at 24 h postinfection,and the piglets died successively by 48 h postinfection.However,the clinical signs of the piglets in the FJzzl-F200-infected group were significantly weaker,and no deaths occurred.The FJzzl-F200-infected group also showed a lower level of fecal viral shedding and lower viral loads in the intestinal tissues,and no obvious histopathological lesions.TypeⅠandⅢinterferon were induced in the FJzzl-F200 infection group,together with pro-inflammatory cytokines,such as TNF-α,IL-1βand IL-8.These results indicate that the identified genetic changes may contribute to the attenuation of FJzzl strain,and the attenuated FJzzl-F200 may have the potential for developing PEDV live-attenuated vaccines. | Pengfei Chen Xiongwei Zhao Shuting Zhou Tianxing Zhou Xiangmei Tan Xia Wu Wu Tong Fei Gao Lingxue Yu Yifeng Jiang Hai Yu Zhibiao Yang Guangzhi Tong Yanjun Zhou | 2021 | Virologica Sinica2021，36，5： | 4 |
| 2 | Synthesis of montmorillonite-chitosan hollow and hierarchical mesoporous spheres with single-template layer-by-layer assembly显示文摘In order to develop a facile and precisely controlled approach to synthesize hierarchical mesoporous materials with tailored property, in this work, a novel study was carried out to fabricate montmorillonitechitosan hollow and hierarchical mesoporous spheres(MMTNS@CS-HMPHS) based on single-template layer-by-layer(Lb L) assembly. Scanning electron microscopy(SEM), transmission electron microscopy(TEM), specific surface area analysis and X-ray photoelectron spectroscopy(XPS) analyses were carried out to characterize the morphology and surface properties of MMTNS@CS-HMPHS. Benefitting from the unique lamellar structure of MMTNS, mesoporous channels are formed on the shell of MMTNS@CS hollow spheres, resulting in high surface area. Moreover, the surface functionalization and pore size of MMTNS@CS-HMPHS can be easily tuned, due to the tailored property through Lb L assembly method.Besides the unique microstructure, MMTNS@CS-HMPHS also possesses the active sites generated from both MMT and chitosan, which greatly promotes its performance in fields of adsorption, drug delivery and catalyst supports, etc. | Peng Chen Yunliang Zhao Tianxing Chen Tingting Zhang Shaoxian Song | 2019 | Journal of Materials Science & Technology2019，35，10： | 4 |
| 3 | Algorithm of Micro-Grooving and Imaging Processing for the Generation of High-Resolution Structural Color Images显示文摘The use of submicron structures for structural coloration of surfaces has broad applications for color filters,projection displays,virtual reality,and anti-counterfeiting.Currently,structural color images lack high resolution due to low manufacturing accuracy.In this study,the axial-feed fly cutting(AFC)method is proposed to fabricate submicron grooves for the diffraction of visible light to create structural color images.We establish the relationship between the color information in the pixels of the original image and the parameters of the array units corresponding to the pixels.An algorithm to determine groove spacing and the tool path is established,and array units with the desired groove spacing are machined to reproduce the structural color images.The submicron grooves fabricated by AFC have high quality and good consistency.Due to the excellent diffraction performance of the machined grooves,images with high saturation and resolution can be reproduced.It is verified that images with various colors can be efficiently fabricated using the proposed method and algorithm. | Tianfeng Zhou Yupeng He Tianxing Wang Xiaobin Dong Peng Liu Wenxiang Zhao Yao Hu Jiwang Yan | 2020 | Nanomanufacturing and Metrology2020，3，3： | 4 |
| 4 | A review of the techniques for the mold manufacturing of micro/nanostructures for precision glass molding显示文摘Micro/nanostructured components play an important role in micro-optics and optical engineering,tribology and surface engineering,and biological and biomedical engineering,among other fields.Precision glass molding technology is the most efficient method of manufacturing micro/nanostructured glass components,the premise of which is meld manufacturing with complementary micro/nanostructures.Numerous mold manufacturing methods have been developed to fabricate extremely small and high-quality micro/nanostructures to satisfy the demands of functional micro/nanostructured glass components for various applications.Moreover,the service performance of the mold should also be carefully considered.This paper reviews a variety of technologies for manufacturing micro/nanostructured molds.The authors begin with an introduction of the extreme requirements of mold materials.The following section provides a detailed survey of the existing micro/nanostructured mold manufacturing techniques and their corresponding mold materials,including nonmechanical and mechanical methods.This paper concludes with a detailed discussion of the authors recent research on nickel-phosphorus(Ni-P)mold manufacturing and its service performance. | Tianfeng Zhou Yupeng He Tianxing Wang Zhanchen Zhu Ruzhen Xu Qian Yu Bin Zhao Wenxiang Zhao Peng Liu Xibin Wang | 2021 | International Journal of Extreme Manufacturing2021，3，4： | 3 |
| 5 | Antigenic characterization of SARS-CoV-2 Omicron subvariants XBB.1.5,BQ.1,BQ.1.1,BF.7 and BA.2.75.2显示文摘Dear Editor,Recently,a number of new Omicron subvariants related to BA.4/5 and BA.2.75 have emerged and shown remarkable antibody evasion capacities,in particular BF.7,BQ.1,BQ.1.1,BA.2.75.2,XBB and XBB.1.5.1 Unsurprisingly,these new subvariants are quickly gaining prevalence worldwide.In fact,some of them have outcompeted BA.5 in the USA according to CDC’s national genomic surveillance data in which,as of 6th February 2023,XBB.1.5,BQ.1.1,BQ.1,XBB and BF.7 have achieved a dominance of 66.4%,19.9%,7.3%,2.3%and 0.5%in the USA,as compared to 0.5%for BA.5.In this report,using plasma samples collected from individuals following different vaccination strategies and COVID-19 convalescent donors,we performed pseudoviral neutralization assays to confirm severe reductions in neutralization titers against BF.7,BQ.1,BQ.1.1,BA.2.75.2,XBB and XBB.1.5 in comparison to other Omicron sub-lineages.XBB and XBB.1.5 were shown to be remarkably resistant to plasma neutralization in all tested cohorts.By comparing the differential neutralization profiles,we found that a heterologous booster with an aerosolized vaccine following 2 doses of inactivated vaccine seemed to be superior to other vaccination strategies. | Airu Zhu Peilan Wei Miao Man Xuesong Liu Tianxing Ji Jiantao Chen Canjie Chen Jiandong Huo Yanqun Wang Jincun Zhao | 2023 | Signal Transduction and Targeted Therapy2023，8，4： | 1 |
| 6 | Potential of endophytic bacteria isolated from Sophora alopecuroides nodule in biological control against Verticillium wilt disease显示文摘 | Lin Tianxing Zhao Longfei Yang Yazhen | 2013 | Australian Journal of Crop Science2013，7，1： | 1 |
| 7 | Growth and in situ transformation of TiO2 and HTiOF3 crystals on chitosan-polyvinyl alcohol co-polymer substrates under vapor phase hydrothermal conditions显示文摘拥有的 chitosan 聚乙烯化合物的白酒(CS/PVA ) 共聚物底层很多氨基并且氢氧根组被用作底层导致直接生长并且在 situ 在 HF 蒸汽阶段下面的 titanate 晶体的顺序的转变热水的条件。这个过程包含四个不同形成 / 转变阶段。有明确的六角形的形状的 HTiOF 3 晶体在舞台期间被形成我,并且随后被转变成 { 001 } faceted 锐钛矿 TiO 2 水晶 nanosheets 在阶段 II 期间。有趣地,形成的锐钛矿 TiO 2 晶体进一步分别地在阶段 III 和 IV 期间被转变成十字形、空的 squareshaped HTiOF 3 晶体。尽管在热水的条件下面的 TiO 2 水晶阶段和方面转变以前被报导了,在在不同 titanate 之间的 situ 水晶转变,混合物一直不是广泛地报导了。如此的水晶形成 / 转变由于在 CS/PVA 底层的大量氨基的组的存在是可能的。当拥有仅仅氢氧根组的纤维素被用作底层时,直接形成 { 001 } faceted TiO 2 nanocrystal 表被观察(而非任何顺序的水晶转变) 。这底层器官的功能的导致组的水晶形成 / 转变途径能对另外的材料系统适用。 | Tianxing Wu Guozhong Wang Xiaoguang Zhu Porun Liu Xian Zhang Haimin Zhang Yunxia Zhang Huijun Zhao | 2016 | Nano Research2016，9，3： | 1 |
| 8 | Numerical Investigation of the Influence of Fuel Concentration Gradient on Propane/Oxygen Detonation Propagation显示文摘In this paper,one-and two-dimensional numerical simulations are carried out to study the effects of fuel concentration gradients(such as steep,intermediate and shallow)on the detonation wave behavior.The equivalent ratio range of detonation propagation,the quenching mechanism and the change of cell size are discussed in detail.The simulation results show,as the fuel concentration gradient increases,the detonation wavefront decays faster and decouples into a leading shock and a following flame at equivalence ratios of 0.68,0.64 and 0.62,respectively.Moreover,there are two modes of the quenching mechanism.One occurs in the steep gradient that the detonation wave fails rapidly.The O_(2)in front of the detonation wave passes through the detonation wave and forms some unburned O_(2)pockets.The unburned pockets are affected by the marginal walls and reduce the heat release.The other occurs in the intermediate and shallow gradients that more triple points will survive in the flow field,which leads to a difference in the propagation speed of the detonation wavefront.This makes the detonation wavefront bent and deformed.The unburned O_(2)pockets are affected by the strong instability near the triple points and show different distribution characteristics compared with the steep gradient,which may be helpful to the detonation propagation.In addition,as the fuel concentration gradient increases,the triple points moving toward the wall gradually disappear while the triple points that move toward the center can continue to survive,which leads to the gradual increase in cell size and irregularity of the cell structure. | SHAO Xiaofeng WU Tianxing MENG Qingyang ZHAO Ningbo QI Lei ZHENG Hongtao | 2023 | Journal of Thermal Science2023，32，6： | 0 |
| 9 | Investigation on the Anisotropic Transformation Surfaces of Super-Elastic NiTi Shape Memory Alloys Under Multiaxial Cyclic Loading Conditions显示文摘The cyclic transformation behaviors of polycrystalline super-elastic NiTi shape memory alloys (SMAs)under multiaxial loading paths with different angles between axial and torsional loading orientations were experimentally investigated.The experimental results showed that the start stresses of forward and reverse transformations decreased with the increase'in the number of cycles and exhibit obvious anisotropic evolutions.The start stresses of forward and reverse transformations in the tensile and torsional directions did not satisfy the yon Mises criterion.The shape of transformation surface during the forward and reverse transformations evolved with the increase in the number of cycles.Then,new cyclic anisotropic transformation surfaces were established by introducing an anisotropic tensor into the von Mises equivalent stress based on a typical transformation criterion related to J2 and J3.Moreover,the evolution equations of material parameters used in the proposed transformation surfaces were established to describe the subsequent evolutions of transformation surfaces.Finally,the start stresses of forward and reverse transformations predicted using the proposed transformation surfaces were compared with the experimental results.It shows that the proposed transformation surfaces can reasonably describe the start stresses of forward and reverse transformations,which are helpful for establishing a three-dimensional cyclic constitutive model to describe the cyclic transformation behaviors of super-elastic NiTi SMAs. | Bo Qiu Qianhua Kan Tianxing Zhao Xi Xie Guozheng Kang | 2018 | Acta Mechanica Solida Sinica2018，31，6： | 0 |
| 10 | Microwear analysis of a bone-handled microblade excavated at Shangzhai site in Beijing: Evidences from ESEM显示文摘The conventional wisdom has been challenged recently that microblades with handles are only tools for hunting and gathering in the Neolithic Age. Some scholars argued that microblades actually played an important part in the early agricultural development in the Neolithic. However, both of these opinions lacked direct evidence. Environmental scanning electron microscopy (ESEM) is used to analyze the residues of the bone-handled microblade excavated at the Shangzhai site in Pinggu, Beijing. The ESEM observation and EDX analysis show that at the edge of this bone-handled microblade are Ca, P, C, O or C, N, O, etc, which provide direct evidence for determining its function, namely that this microblade may have been dealt with animals. In addition, there was a layer of glue at the back of the microblade with barium and zinc salt distributed evenly in it, this new discovery sheds new light on adhesive technology in ancient China. | CUI TianXing YANG Qin YU JinCheng ZHOU ShuangLin ZHAO ChaoHong | 2010 | Science China Earth Sciences2010，53，9： | 0 |
| 11 | Fatigue Life Prediction for NiTi Shape Memory Alloy Micro-tubes Under Uniaxial Stress-Controlled One-Way Shape Memory Cyclic Loading显示文摘By choosing the dissipation energy as the damage variable,corresponding damage evolution equations are established,respectively,for the mechanical cyclic loading part and the thermal one during the thermo-mechanical cyclic loading of NiTi shape memory alloys(SMAs)involving one-way shape memory effect(simply denoted as the OWSME cycling).And then,the evolution law of total damage is obtained by a superposition of such two damage parts.Finally,the uniaxial OWSME fatigue lives of NiTi SMA micro-tubes are predicted by combining the proposed damage model with an adopted failure criterion.The results show that all the predicted fatigue lives are located within the twice scatter band with regard to the experimental ones,and most of them are located within a scatter band of 1.5 times.It is indicated that the predicted OWSME fatigue lives are in good agreement with the experimental ones. | Tianxing Zhao Guozheng Kang | 2022 | Acta Mechanica Solida Sinica2022，35，1： | 0 |
| 12 | Nanodevices engineering and spin transport properties of MnBi_(2)Te_(4) monolayer显示文摘Two-dimensional(2D)magnetic materials are essential for the development of the next-generation spintronic technologies.Recently,layered van der Waals(vdW)compound MnBi2Te4(MBT)has attracted great interest,and its 2D structure has been reported to host coexisting magnetism and topology.Here,we design several conceptual nanodevices based on MBT monolayer(MBT-ML)and reveal their spin-dependent transport properties by means of the first-principles calculations.The pn-junction diodes and sub-3-nm pin-junction field-effect transistors(FETs)show a strong rectifying effect and a spin filtering effect,with an ideality factor n close to 1 even at a reasonably high temperature.In addition,the pip-and nin-junction FETs give an interesting negative differential resistive(NDR)effect.The gate voltages can tune currents through these FETs in a large range.Furthermore,the MBT-ML has a strong response to light.Our results uncover the multifunctional nature of MBT-ML,pave the road for its applications in diverse next-generation semiconductor spin electric devices. | Yipeng An Kun Wang Shijing Gong Yusheng Hou Chunlan Ma Mingfu Zhu Chuanxi Zhao Tianxing Wang Shuhong Ma Heyan Wang Ruqian Wu Wuming Liu | 2021 | npj Computational Materials2021，，1： | 0 |
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