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您的检索式：作者名="Timothy Baxter"
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| 1 | Critical size limit of biodegradable nanopartides for enhanced lymph node trafficking and paracortex penetration显示文摘Lymph node (LN) targeti ng through interstitial drain age of nan oparticles (NPs) is an attractive strategy to stimulate a pote nt immune respo nse, as LNs are the primary site for lymphocyte priming by antigen presenting cells (APCs) and triggering of an adaptive immune response. NP size has been shown to influence the efficiency of LN-targeting and retention after subcutaneous injection. For clinical translation, biodegradable NPs are preferred as carrier for vaccine delivery. However, the selective 'size gateM for effective LN-drainage, particularly the kinetics of LN trafficking, is less well defined. This is partly due to the challenge in generating size-controlled NPs from biodegradable polymers in the sub-100-nm range. Here, we report the preparation of three sets of poly(lactic-co-glycolic)-b-poly(ethylene-glycol)(PLGA-b-PEG) NPs with number average diameters of 20-, 40-, and 100-nm and narrow size distributions using flash nanoprecipitation. Using NPs labeled with a near-infrared dye, we showed that 20-nm NPs drain rapidly across proximal and distal LNs following subcutaneous inoculation in mice and are retai ned in LNs more effectively than NPs with a nu mber average diameter of 40-nm. The drain age of 100-nm NPs was n egligible. Furthermore, the 20-nm NPs showed the highest degree of penetration around the paracortex region and had enhanced access to dendritic cells in the LNs. Together, these data confirmed that small, size-controlled PLGA-b-PEG NPs at the lower threshold of about 30-nm are most effective for LN trafficking, retention, and APC uptake after s.c. administration. This report could inform the design of LN-targeted NP carrier for the delivery of therapeutic or prophylactic vaccines. | Gregory P. Howard Garima Verma Xiyu Ke Winter M. Thayer Timothy Hamerly Victoria K. Baxter John E. Lee Rhoel R. Dinglasan Hai-Quan Mao | 2019 | Nano Research2019，12，4： | 3 |
| 2 | Modeling of Gold Circular Sub-Wavelength Apertures on a Fiber Endface for Refractive Index Sensing显示文摘一条有限差别的时间域途径被用来在光纤维 endface 上调查圆形的亚波长孔的表面电浆子的刺激。这现象提供了敏感液体的基础折射索引传感器。建议传感器是紧缩的并且有潜力在生物医学的应用被过去常。 | Huy NGUYEN Gregory W. BAXTER Stephen F. COLLINS Fotios SIDIROGLOU Ann ROBERTS Timothy J. DAVIS | 2012 | Photonic Sensors2012，2，3： | 2 |
| 3 | The association between brain volumes, delirium duration, and cognitive outcomes in intensive care unit survivors: The VISIONS cohort magnetic resonance imaging study*显示文摘 | Max L. Gunther Alessandro Morandi Erin Krauskopf Pratik Pandharipande Timothy D. Girard James C. Jackson Jennifer Thompson Ayumi K. Shintani Sunil Geevarghese Russell R. Miller Angelo Canonico Kristen Merkle Christopher J. Cannistraci Baxter P. Rogers J. | 2012 | Critical Care Medicine2012，，7： | 1 |
| 4 | Temporal Patterns of Postoperative Complications显示文摘 | Thompson B Timothy Baxter | 2003 | Arch Surg2003，138，： | 1 |
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