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| 1 | Passive expansion of sub-maximally dilated transjugular intrahepatic portosystemic shunts and assessment of clinical outcomes显示文摘AIM To assess for passive expansion of sub-maximally dilated transjugular intrahepatic portosystemic shunts(TIPS) and compare outcomes with maximally dilated TIPS.METHODS Polytetrafluoroethylene covered TIPS(Viatorr) from July 2002 to December 2013 were retrospectively reviewed at two hospitals in a single institution. Two hundred and thirty patients had TIPS maximally dilated to 10 mm(m TIPS), while 43 patients who were at increased risk for hepatic encephalopathy(HE), based on clinical evaluation or low pre-TIPS portosystemic gradient(PSG), had 10 mm TIPS sub-maximally dilated to 8 mm(sm TIPS). Group characteristics(age, gender, Model for End-Stage Liver Disease score, post-TIPS PSG and clinical outcomes were compared between groups, including clinical success(ascites or varices), primary patency,primary assisted patency, and severe post-TIPS HE. A subset of fourteen patients with sm TIPS underwent follow-up computed tomography imaging after TIPS creation, and were grouped based on time of imaging(< 6 mo and > 6 mo). Change in diameter and crosssectional area were measured with 3D imaging software to evaluate for passive expansion.RESULTS Patient characteristics were similar between the sm TIPS and m TIPS groups, except for pre-TIPS portosystemic gradient, which was lower in the sm TIPS group(19.4 mm Hg ± 6.8 vs 22.4 mm Hg ± 7.1, P = 0.01). Primary patency and primary assisted patency between sm TIPS and m TIPS was not significantly different(P = 0.64 and 0.55, respectively). Four of the 55 patients(7%) with sm TIPS required TIPS reduction for severe refractory HE, while this occurred in 6 of the 218 patients(3%) with m TIPS(P = 0.12). For the 14 patients with follow-up computed tomography(CT) imaging, the median imaging follow-up was 373 d. There was an increase in median TIPS diameter, median percent diameter change, median area, and median percent area change in patients with CT follow-up greater than 6 mo after TIPS placement compared to follow-up within 6 mo(8.45 mm, 5.58%, 56.04 mm^2, and 11.48%, respectively, P = 0.01).CONCLUSION Passive expansion of sm TIPS does occur but clinical outcomes of sm TIPS and m TIPS were similar. Sub-maximal dilation can prevent complications related to overshunting in select patients. | Michael C Hsu Charles N Weber S William Stavropoulos Timothy W Clark Scott O Trerotola Richard D Shlansky Goldberg Michael C Soulen Gregory J Nadolski | 2017 | World Journal of Hepatology2017，9，12： | 11 |
| 2 | Recommendations for Comprehensive Stroke Centers: A Consensus Statement From the Brain Attack Coalition显示文摘 | Mark J. Alberts Richard E. Latchaw Warren R. Selman Timothy Shephard Mark N. Hadley Lawrence M. Brass Walter Koroshetz John R. Marler John Booss Richard D. Zorowitz Janet B. Croft Ellen Magnis Diane Mulligan Andrew Jagoda Robert O’Connor C Michael Cawley | 2005 | Stroke2005，，7： | 2 |
| 3 | Chemotherapy options in elderly and frail patients with metastatic colorectal cancer (MRC FOCUS2): an open-label, randomised factorial trial显示文摘 | Matthew T Seymour Lindsay C Thompson Harpreet S Wasan Gary Middleton Alison E Brewster Stephen F Shepherd M Sinead O’Mahony Timothy S Maughan Mahesh Parmar Ruth E Langley | 2011 | The Lancet2011，，9779： | 2 |
| 4 | Effect of intensive treatment of hyperglycaemia on microvascular outcomes in type 2 diabetes: an analysis of the ACCORD randomised trial显示文摘 | Faramarz Ismail-Beigi Timothy Craven Mary Ann Banerji Jan Basile Jorge Calles Robert M Cohen Robert Cuddihy William C Cushman Saul Genuth Richard H Grimm Bruce P Hamilton Byron Hoogwerf Diane Karl Lois Katz Armand Krikorian Patrick O'Connor Rodica Pop-Bus | 2010 | The Lancet2010，，9739： | 2 |
| 5 | In vivo ionizing irradiations produce deletions in the hprt gene of human T-lymphocytes显示文摘 | Janice A Niklas J Patrick O' Neill Timothy C Hunter | 1991 | Mutat Res1991，250，： | 1 |
| 6 | An improved generalized Amber force field(GAFF)for urea显示文摘 | GUL A O WOLFGANG P TIMOTHY C | 2010 | Journal of Molecular Modeling2010，16，9： | 1 |
| 7 | Metal-organic chemical vapour deposition of lead scandiumtantalate: chemical issues and precursor selection 显示文摘 | ANTHONY C J TIMOTHY J L HYWEL O D | 2000 | Polyhedron2000，19，： | 1 |
| 8 | Associations between Recent Exposure to Ambient Fine Particulate Matter and Blood Pressure in the Multi-Ethnic Study of Atherosclerosis (MESA)显示文摘 | Auchincloss Amy H Roux Ana V Diez Dvonch J Timothy Brown Patrick L Barr R Graham Daviglus Martha L Goff David C Kaufman Joel D O’Neill Marie S | 2008 | Environmental Health Perspectives2008，，4： | 1 |
| 9 | Effect of intensive treatment of hyperglycaemia on microvascular outcomes in type 2 diabetes: an analysis of the ACCORD randomised trial显示文摘 | Faramarz Ismail-Beigi Timothy Craven Mary Ann Banerji Jan Basile Jorge Calles Robert M Cohen Robert Cuddihy William C Cushman Saul Genuth Richard H Grimm Bruce P Hamilton Byron Hoogwerf Diane Karl Lois Katz Armand Krikorian Patrick O’Connor Rodica Pop-Bus | 2010 | 2010 (9739)2010，，9739： | 1 |
| 10 | Governance of Red Tourism in China:Per spec t ive s on Power a nd Gu a n x i显示文摘 | S h e n g n a n(Na n c y) Z h a o D a l l e n J Timothy | 2015 | Tou r i smManagement2015，，2： | 1 |
| 11 | Southern Ocean iron enrichment experiment: Carbon cycling in high-and low-Si waters 显示文摘 | Coale K H Johnson K S Chavez F P Buesseler K O Barber R T Brzezinski M A Cochlan W P Millero F J Falkowski P G Bauer J E Wanninkhof R H Kudela R M Altabet M A Hales B E Takahashi T Landry M R Bidigare R R Wang Xiujun Chase Z Strutton P G Friederich G E Gorbunov M Y Lance V P Hilting A K Hiscock M R Demarest M Hiscock W T Sullivan K F Tanner S J Gordon R M Hunter C N Elrod V A Fitzwater S E Jones J L Tozzi S Koblizek M Roberts A E Herndon J Brewster J Ladizinsky N Smith G Cooper D Timothy D Brown S L Selph K E Sheridan C C Twining B S Johnson Z I | 2004 | Science2004，304，5669： | 1 |
| 12 | Using functional traits and phylogenetic trees to examine the assembly of tropical tree communities显示文摘 | Baraloto C Hardy O J Timothy Paine C E | 2012 | Journal of Ecology2012，100，： | 1 |
| 13 | Life cycle analysis of UK coal fired power plants显示文摘 | NASER A O TIMOTHY T C | 2008 | Energy Conversion and Management2008，，49： | 1 |
| 14 | Use of magnetic fields in solvent extraction显示文摘 | Timothy S C Ridge O | 1989 | Separation and Purification Methods1989，18，1： | 1 |
| 15 | A Token-based Data Cleaning Technique for Data Warehouse Systems 显示文摘 | Timothy E O Ezeife C I | 2004 | ACM SIGMOD Record2004，8，2： | 1 |
| 16 | Viscoelastic properties of human cortical bone tissue depend on gender and elastic modulus显示文摘 | Ziheng Wu Timothy C O Glen L N | 2012 | Journal of Orthopaedic Research2012，5，： | 1 |
| 17 | Direct comparison of nanoindentation and macroscopic measurements of bone viscoelasticity显示文摘 | Tara N S Jingzhou Zhang Timothy C O | 2011 | Journal of the Mechanical Behavior of Biomedical Material2011，4，： | 1 |
| 18 | Evolution of surface roughness during copper electrodeposition in the presence of additives: comparison of experiments and Monte Carlo simulations显示文摘 | Timothy O D Jason C G Richard C A | 2003 | Journal of the Electrochemical Society2003，150，5： | 1 |
| 19 | Plasma Torch Igniter for Scramjets 显示文摘 | Timothy C W Walter F O B Northam G B | 1989 | Journal of Propulsion andPower1989，5，5： | 1 |
| 20 | Image-based drill templates for cervical pedicle screw placement Laboratory in- vestigatiori 显示文摘 | Timothy C R Brent I) O Gary E C | 2009 | Journal of Neurosurgery2009，1，： | 1 |
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