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| 1 | Chemotherapy options in elderly and frail patients with metastatic colorectal cancer (MRC FOCUS2): an open-label, randomised factorial trial显示文摘 | Matthew T Seymour Lindsay C Thompson Harpreet S Wasan Gary Middleton Alison E Brewster Stephen F Shepherd M Sinead O’Mahony Timothy S Maughan Mahesh Parmar Ruth E Langley | 2011 | The Lancet2011，，9779： | 2 |
| 2 | Tumor Necrosis Factor α Is Toxic to Embryonic Mesencephalic Dopamine Neurons显示文摘 | Susan O McGuire Zao Dung Ling Jack W Lipton Caryl E Sortwell Timothy J Collier Paul M Carvey | 2001 | Experimental Neurology2001，，2： | 1 |
| 3 | Governance of Red Tourism in China:Per spec t ive s on Power a nd Gu a n x i显示文摘 | S h e n g n a n(Na n c y) Z h a o D a l l e n J Timothy | 2015 | Tou r i smManagement2015，，2： | 1 |
| 4 | Southern Ocean iron enrichment experiment: Carbon cycling in high-and low-Si waters 显示文摘 | Coale K H Johnson K S Chavez F P Buesseler K O Barber R T Brzezinski M A Cochlan W P Millero F J Falkowski P G Bauer J E Wanninkhof R H Kudela R M Altabet M A Hales B E Takahashi T Landry M R Bidigare R R Wang Xiujun Chase Z Strutton P G Friederich G E Gorbunov M Y Lance V P Hilting A K Hiscock M R Demarest M Hiscock W T Sullivan K F Tanner S J Gordon R M Hunter C N Elrod V A Fitzwater S E Jones J L Tozzi S Koblizek M Roberts A E Herndon J Brewster J Ladizinsky N Smith G Cooper D Timothy D Brown S L Selph K E Sheridan C C Twining B S Johnson Z I | 2004 | Science2004，304，5669： | 1 |
| 5 | 1999 update: ACC/AHA guidelines for the management of patients with acute myocardial infarction显示文摘 | Thomas J Ryan Elliott M Antman Neil H Brooks Robert M Califf L.David Hillis Loren F Hiratzka Elliot Rapaport Barbara Riegel Richard O Russell Earl E Smith W.Douglas Weaver Raymond J Gibbons Joseph S Alpert Kim A Eagle Timothy J Gardner Arthur Garson Gabri | 1999 | Journal of the American College of Cardiology1999，，3： | 1 |
| 6 | Using functional traits and phylogenetic trees to examine the assembly of tropical tree communities显示文摘 | Baraloto C Hardy O J Timothy Paine C E | 2012 | Journal of Ecology2012，100，： | 1 |
| 7 | Impact of cold storage on glucosinolate levels in seed-sprouts of broccoli,rocket, white radish and kohlrabi显示文摘 | Lesleigh E F Timothy J O Lung S W | 2007 | Postharvest Biology and Technology2007，44，2： | 1 |
| 8 | A Token-based Data Cleaning Technique for Data Warehouse Systems 显示文摘 | Timothy E O Ezeife C I | 2004 | ACM SIGMOD Record2004，8，2： | 1 |
| 9 | Addition of Polarzation and Diffuse Functions to the LANL2DZ Basis Set for P-Block Elements显示文摘 | Catherine E Check Timothy O Faust John M Bailey | 2001 | J Phys Chem A2001，105，： | 1 |
| 10 | Determination of norepinephrine in small volume plasma samples by stable-isotope dilution gas chromatography - tandem mass spectrometry with negative ion chemical ionization 显示文摘 | Kuhlenbeck Debra L O' Neill Timothy P Mack Catherine E | 2000 | J Chromatography B2000，738，2： | 1 |
| 11 | Impact of cold storage on glucosinolate levels in seed-sprouts of broccoli, rocket, white radish and kohl-rabi显示文摘 | LESLEIGH E F TIMOTHY J O LUNG S W | 2007 | Postharvest Biology and Technology2007，44，2： | 1 |
| 12 | Image-based drill templates for cervical pedicle screw placement Laboratory in- vestigatiori 显示文摘 | Timothy C R Brent I) O Gary E C | 2009 | Journal of Neurosurgery2009，1，： | 1 |
| 13 | Review fibrillation and sroke prevention显示文摘 | Janice E O Timothy P C Christopher S G | 1992 | Age and Ageing1992，21，： | 1 |
| 14 | An Introduction to Efficiency and Productivity Analysis显示文摘 | Timothy J Coelli D S Prassada Rao Chirstopher J O' Donnell George E Battese | 2005 | Second Edition2005，，2005： | 1 |
| 15 | 1999 update: ACC/AHA guidelines for the management of patients with acute myocardial infarction显示文摘 | Thomas J Ryan Elliott M Antman Neil H Brooks Robert M Califf L.David Hillis Loren F Hiratzka Elliot Rapaport Barbara Riegel Richard O Russell Earl E Smith W.Douglas Weaver Raymond J Gibbons Joseph S Alpert Kim A Eagle Timothy J Gardner Arthur Garson Gabri | 1999 | Journal of the American College of Cardiology1999，，3： | 1 |
| 16 | Simulating long-term effect of Hyrcanian forest loss on phosphorus loading at the sub-watershed level显示文摘Conversion of forest land to farmland in the Hyrcanian forest of northern Iran increases the nutrient input, especially the phosphorus(P) nutrient, thus impacting the water quality. Modeling the effect of forest loss on surface water quality provides valuable information for forest management. This study predicts the future impacts of forest loss between 2010 and 2040 on P loading in the Tajan River watershed at the sub-watershed level. To understand drivers of the land cover, we used Land Change Modeler(LCM) combining with the Soil Water Assessment Tool(SWAT) model to simulate the impacts of land use change on P loading. We characterized priority management areas for locating comprehensive and cost-effective management practices at the sub-watershed level. Results show that agricultural expansion has led to an intense deforestation. During the future period 2010–2040, forest area is expected to decrease by 34,739 hm^2. And the areas of pasture and agriculture are expected to increase by 7668 and 27,071 hm^2, respectively. In most sub-watersheds, P pollution will be intensified with the increase in deforestation by the year 2040. And the P concentration is expected to increase from 0.08 to 2.30 mg/L in all of sub-watersheds by the year 2040. It should be noted that the phosphorous concentration exceeds the American Public Health Association′s water quality standard of 0.2 mg/L for P in drinking water in both current and future scenarios in the Tajan River watershed. Only 30% of sub-watersheds will comply with the water quality standards by the year 2040. The finding of the present study highlights the importance of conserving forest area to maintain a stable water quality. | Fatemeh RAJAEI Abbas E SARI Abdolrassoul SALMANMAHINY Timothy O RANDHIR Majid DELAVAR Reza D BEHROOZ Alireza M BAVANI | 2018 | Journal of Arid Land2018，10，3： | 0 |
| 17 | Potential of damage associated molecular patterns in synergising radiation and the immune response in oesophageal cancer显示文摘BACKGROUND There is an intimate crosstalk between cancer formation,dissemination,treatment response and the host immune system,with inducing tumour cell death the ultimate therapeutic goal for most anti-cancer treatments.However,inducing a purposeful synergistic response between conventional therapies and the immune system remains evasive.The release of damage associated molecular patterns(DAMPs)is indicative of immunogenic cell death and propagation of established immune responses.However,there is a gap in the literature regarding the importance of DAMP expression in oesophageal adenocarcinoma(OAC)or by immune cells themselves.AIM To investigate the effects of conventional therapies on DAMP expression and to determine whether OAC is an immunogenic cancer.METHODS We investigated the levels of immunogenic cell death-associated DAMPs,calreticulin(CRT)and HMGB1 using an OAC isogenic model of radioresistance.DAMP expression was also assessed directly using ex vivo cancer patient T cells(n=10)and within tumour biopsies(n=9)both pre and post-treatment with clinically relevant chemo(radio)therapeutics.RESULTS Hypoxia in combination with nutrient deprivation significantly reduces DAMP expression by OAC cells in vitro.Significantly increased frequencies of T cell DAMP expression in OAC patients were observed following chemo-(radio)therapy,which was significantly higher in tumour tissue compared with peripheral blood.Patients with high expression of HMGB1 had a significantly better tumour regression grade(TRG 1-2)compared to low expressors.CONCLUSION In conclusion,OAC expresses an immunogenic phenotype with two distinct subgroups of high and low DAMP expressors,which correlated with tumour regression grade and lymphatic invasion.It also identifies DAMPs namely CRT and HMGB1 as potential promising biomarkers in predicting good pathological responses to conventional chemo(radio)therapies currently used in the multimodal management of locally advanced disease. | Noel E Donlon Maria Davern Andrew Sheppard Fiona O'Connell Brendan Moran Timothy S Nugent Aisling Heeran James J Phelan Anshul Bhardwaj Christine Butler Narayanasamy Ravi Claire L Donohoe Niamh Lynam-Lennon Stephen Maher John V Reynolds Joanne Lysaght | 2023 | World Journal of Gastrointestinal Oncology2023，15，8： | 0 |
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