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| 1 | Refining pathological evaluation of neoadjuvant therapy for adenocarcinoma of the esophagus显示文摘AIM:To assess tumour regression grade(TRG)and lymph node downstaging to help define patients who benefit from neoadjuvant chemotherapy.METHODS:Two hundred and eighteen consecutive patients with adenocarcinoma of the esophagus or gastro-esophageal junction treated with surgery alone or neoadjuvant chemotherapy and surgery between 2005and 2011 at a single institution were reviewed.Triplet neoadjuvant chemotherapy consisting of platinum,fluoropyrimidine and anthracycline was considered for operable patients(World Health Organization performance status≤2)with clinical stage T2-4 N0-1.Response to neoadjuvant chemotherapy(NAC)was assessed using TRG,as described by Mandard et al.In addition lymph node downstaging was also assessed.Lymph node downstaging was defined by cN1 at diagnosis:assessed radiologically(computed tomography,positron emission tomography,endoscopic ultrasonography),then pathologically recorded as N0 after surgery;ypN0 if NAC given prior to surgery,or pN0if surgery alone.Patients were followed up for 5 years post surgery.Recurrence was defined radiologically,with or without pathological confirmation.An association was examined between t TRG and lymph node downstaging with disease free survival(DFS)and a comprehensive range of clinicopathological characteristics.RESULTS:Two hundred and eighteen patients underwent esophageal resection during the study interval with a mean follow up of 3 years(median follow up:2.552,95%CI:2.022-3.081).There was a 1.8%(n=4)inpatient mortality rate.One hundred and thirty-six(62.4%)patients received NAC,with 74.3%(n=101)of patients demonstrating some signs of pathological tumour regression(TRG 1-4)and 5.9%(n=8)having a complete pathological response.Forty four point one percent(n=60)had downstaging of their nodal disease(cN1 to ypN0),compared to only 15.9%(n=13)that underwent surgery alone(pre-operatively overstaged:cN1 to pN0),(P<0.0001).Response to NAC was associated with significantly increased DFS(mean DFS;TRG 1-2:5.1years,95%CI:4.6-5.6 vs TRG 3-5:2.8 years,95%CI:2.2-3.3,P<0.0001).Nodal down-staging conferred a significant DFS advantage for those patients with a poor primary tumour response to NAC(median DFS;TRG 3-5 and nodal down-staging:5.533 years,95%CI:3.558-7.531 vs TRG 3-5 and no nodal down-staging:1.114 years,95%CI:0.961-1.267,P<0.0001).CONCLUSION:Response to NAC in the primary tumour and in the lymph nodes are both independently associated with improved DFS. | Fergus Noble Luke Nolan Adrian C Bateman James P Byrne Jamie J Kelly Ian S Bailey Donna M Sharland Charlotte N Rees Timothy J Iveson Tim J Underwood Andrew R Bateman | 2013 | World Journal of Gastroenterology2013，19，48： | 4 |
| 2 | Accelerated drying of button mushrooms, brussels sprouts and cauliflower by ap- plying power ultrasound and its rehydration properties 显示文摘 | Anet R J Timothy J M Larysa P B | 2007 | Journal of Food Engineering2007，81，3： | 1 |
| 3 | Impacts and kinematic adjustments during an exhaustive run显示文摘 | Timothy R Derrick Darrin Dereu Scott P Mclean | | 0，，34： | 1 |
| 4 | Influence of the molar mass distribution on the elongational behavior of polymer solutions in capillary breakup显示文摘 | Lucy E R Timothy P S Justin J C | | 0，，1： | 1 |
| 5 | Capripoxvirus tissue tropism and shedding:A quantitative study in experimentally infected sheep and goats显示文摘 | Timothy R B Shawn L B Geoff R P | 2008 | Virology2008，，371： | 1 |
| 6 | Politics as a m oderator of the accountability--iob satisfaction relationship: Evidence across three studies显示文摘 | Breaux Denise M Munyon Timothy P Hochwarter Wayne A and Ferris Gerald R | 2009 | Journal of Management2009，，2： | 1 |
| 7 | Securityen- hancement with optimal QoS using EAP-AKA in hybrid coupled 3G -Wlan convergence network显示文摘 | R Shankar Timothy tkajkumar K and P Dananjayan | 2010 | International Journal OfUbiComp2010，，3： | 1 |
| 8 | Insomnia:pathophysiology and implica- tions for treatment 显示文摘 | Thomas R Timothy R Ron P | 2007 | Sleep Medicine Reviews2007，11，1： | 1 |
| 9 | A systems approach to modeling drug release from polymer microspheres to accelerate in vitro to in vivo translation 显示文摘 | Timothy D K Steven R L Robert S P | 2015 | Journal of Controlled Release2015，211，： | 1 |
| 10 | To- wards iron-catalysed suzuki biaryl cross-coupling:Un- usual reactivity of 2-halobenzyl halides 显示文摘 | Robin B B Timothy G Dominic R P | 2015 | Synthe- sis2015，47，12： | 1 |
| 11 | A new flashi- ness index: characteristics and applications to midwestern rivers and streams显示文摘 | BAKER D B RICHARDS R P TIMOTHY T ct al | 2004 | Journal of the American Water Resources Association2004，40，2： | 1 |
| 12 | Performance and health monitoring of the Stafford Medical Building using embedded sensors 显示文摘 | Dryver R Huston Peter L Fuhr Timothy P Ambrose | 1992 | Smart Mater Struet1992，，1： | 1 |
| 13 | An electrokinetic study on a synthetic adsorbent of crystalline calcium silicate hydrate and its mechanism of endotoxin removal 显示文摘 | Qun Wang John P Zhang Timothy R Smith | 2005 | Colloids and Surfaces B: Biointerfaces2005，，44： | 1 |
| 14 | Intelligent civil structures-activities in Vermont 显示文摘 | Dryver R Huston Peter L Fuhr Timothy P Ambrose | 1994 | Smart Mater Struct1994，，3： | 1 |
| 15 | Symptom status and quality of life following prostatectomy 显示文摘 | Fowler F J Wenberg J E Timothy R P | 1988 | JAMA1988，259，20： | 1 |
| 16 | Dimensional instability of doped lanthanum chromite显示文摘 | TIMOTHY R A JEFFRY W S LARRY K R P | 1996 | J Electrochem Soc1996，143，9： | 1 |
| 17 | Serum test for assessment of patients with Bence Jones myeloma显示文摘 | Arthur R Bradwell Hugh D Carr-Smith Graham P Mead Timothy C Harvey Mark T Drayson | 2003 | The Lancet2003，，9356： | 1 |
| 18 | Face recognition using direct, weighted linear discriminant analysis and modular subspaces 显示文摘 | JEFFERY R P TIMOTHY F G | 2005 | Pattern Recognition2005，4，38： | 1 |
| 19 | Molecular Films of Thiol-derivatized Tetraphenylporphyrins on Gold:FilmFormation and Electroeatalytic Dioxygen Reduction 显示文摘 | James E H Timothy A P Murray R W | 1993 | Langmuir1993，9，11： | 1 |
| 20 | Southern Ocean iron enrichment experiment: Carbon cycling in high-and low-Si waters 显示文摘 | Coale K H Johnson K S Chavez F P Buesseler K O Barber R T Brzezinski M A Cochlan W P Millero F J Falkowski P G Bauer J E Wanninkhof R H Kudela R M Altabet M A Hales B E Takahashi T Landry M R Bidigare R R Wang Xiujun Chase Z Strutton P G Friederich G E Gorbunov M Y Lance V P Hilting A K Hiscock M R Demarest M Hiscock W T Sullivan K F Tanner S J Gordon R M Hunter C N Elrod V A Fitzwater S E Jones J L Tozzi S Koblizek M Roberts A E Herndon J Brewster J Ladizinsky N Smith G Cooper D Timothy D Brown S L Selph K E Sheridan C C Twining B S Johnson Z I | 2004 | Science2004，304，5669： | 1 |
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