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| 1 | Transparent conducting Nnc oxide thin films doped with aluminum and molybdenum显示文摘 | JOEL N D TIMOTHY A G DAVID M W TERESA M B MATTHEW Y BOBBY T TIMOTHY J C | 2007 | Journal V-acuum Society Technology2007，25，4： | 1 |
| 2 | Tranexamic acid for intracerebral haemorrhage within 2 hours of onset: protocol of a phase Ⅱ randomised placebo-controlled double-blind multicentre trial显示文摘Rationale Haematoma growth is common early after intracerebral haemorrhage(ICH),and is a key determinant of outcome.Tranexamic acid,a widely available antifibrinolytic agent with an excellent safety profile,may reduce haematoma growth.Methods and design Stopping intracerebral haemorrhage with tranexamic acid for hyperacute onset presentation including mobile stroke units(STOP-MSU)is a phase Ⅱ double-blind,randomised,placebo-controlled,multicentre,international investigator-led clinical trial,conducted within the estimand statistical framework.Hypothesis In patients with spontaneous ICH,treatment with tranexamic acid within 2 hours of onset will reduce haematoma expansion compared with placebo.Sample size estimates A sample size of 180 patients(90 in each arm)would be required to detect an absolute difference in the primary outcome of 20%(placebo 39%vs treatment 19%)under a two-tailed significance level of 0.05.An adaptive sample size re-estimation based on the outcomes of 144 patients will allow a possible increase to a prespecified maximum of 326 patients.Intervention Participants will receive 1 g intravenous tranexamic acid over 10 min,followed by 1 g intravenous tranexamic acid over 8 hours;or matching placebo.Primary efficacy measure The primary efficacy measure is the proportion of patients with haematoma growth by 24±6 hours,defined as either≥33%relative increase or≥6 mL absolute increase in haematoma volume between baseline and follow-up CT scan.Discussion We describe the rationale and protocol of STOP-MSU,a phase Ⅱ trial of tranexamic acid in patients with ICH within 2 hours from onset,based in participating mobile stroke units and emergency departments. | Nawaf Yassi Henry Zhao Leonid Churilov Bruce C V Campbell Teddy Wu Henry Ma Andrew Cheung Timothy Kleinig Helen Brown Philip Choi Jiann-Shing Jeng Annemarei Ranta Hao-Kuang Wang Geoffrey C Cloud Rohan Grimley Darshan Shah Neil Spratt Der-Yang Cho Karim Mahawish Lauren Sanders John Worthington Ben Clissold Atte Meretoja Vignan Yogendrakumar Mai Duy Ton Duc Phuc Dang Nguyen Thai My Phuong Huy-Thang Nguyen Chung Y Hsu Gagan Sharma Peter J Mitchell Bernard Yan Mark W Parsons Christopher Levi Geoffrey A Donnan Stephen M Davis | 2022 | Stroke & Vascular Neurology2022，7，2： | 1 |
| 3 | Treatment of heart failure guided by plasma aminoterminal brain natriuretic peptide (NBNP) concentrations显示文摘 | RICHARD W T CHRIDTOPHER M F TIMOTHY G Y | 2000 | Lancet2000，355，： | 1 |
| 4 | Treatment of heart failure guided by plasma aminoterminal brain natriuretic peptide(N-BNP) concentrations显示文摘 | Richard W T Chridtopher M F Timothy G Y | 2000 | Lancet2000，355，： | 1 |
| 5 | Caveolae targeting and regulation of large conductance Ca^2+ activated K^+ channels in vascular endothelial cells显示文摘 | Xiaoli W Dan Y Timothy E | 2005 | J Biol Chem2005，280，11： | 1 |
| 6 | Computer generated hologram with geometric occlusion using GPU-accelerated depth buffer rasterization for three-dimensional display显示文摘 | Rick H Y C Timothy D W | 2009 | Applied Optics2009，48，21： | 1 |
| 7 | Southern Ocean iron enrichment experiment: Carbon cycling in high-and low-Si waters 显示文摘 | Coale K H Johnson K S Chavez F P Buesseler K O Barber R T Brzezinski M A Cochlan W P Millero F J Falkowski P G Bauer J E Wanninkhof R H Kudela R M Altabet M A Hales B E Takahashi T Landry M R Bidigare R R Wang Xiujun Chase Z Strutton P G Friederich G E Gorbunov M Y Lance V P Hilting A K Hiscock M R Demarest M Hiscock W T Sullivan K F Tanner S J Gordon R M Hunter C N Elrod V A Fitzwater S E Jones J L Tozzi S Koblizek M Roberts A E Herndon J Brewster J Ladizinsky N Smith G Cooper D Timothy D Brown S L Selph K E Sheridan C C Twining B S Johnson Z I | 2004 | Science2004，304，5669： | 1 |
| 8 | Phylogenetic a- nalysis of the haemagglutinin gene of current wild-type canine distemper viruses from South Africa:lineage Africa显示文摘 | Timothy Y W Moritz van V Ana-Mari B | 2010 | Vet Mic2010，143，： | 1 |
| 9 | Phospholipid-sstabilized nanoparticles of cyclosporine A by rapid expansion from supercritical to aqueous solution 显示文摘 | Timothy J Y Keith P J Gary W P | 2003 | AAPS PharmSciTech2003，5，1： | 1 |
| 10 | Transparent conducting zinc oxide thin films doped with aluminum and molybdenum显示文摘 | JOEL N D TIMOTHY A G DAVID M W TERESA M B MATTHEW Y BOBBY T TIMOTHY J C | 2007 | Journal Vacuum Society Technology2007，25，4： | 1 |
| 11 | Phylogenetic analysis of the haemagglutinin gene of current wild-type canine distemper viruses from South Africa: Lineage Africa显示文摘 | Timothy Y W Moritzvan V Ana M B | 2010 | Vet Mic2010，143，： | 1 |
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