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| 1 | Plant abiotic stress response and nutrient use efficiency显示文摘Abiotic stresses and soil nutrient limitations are major environmental conditions that reduce plant growth,productivity and quality.Plants have evolved mechanisms to perceive these environmental challenges,transmit the stress signals within cells as well as between cells and tissues,and make appropriate adjustments in their growth and development in order to survive and reproduce.In recent years,significant progress has been made on many fronts of the stress signaling research,particularly in understanding the downstream signaling events that culminate at the activation of stress-and nutrient limitation-responsive genes,cellular ion homeostasis,and growth adjustment.However,the revelation of the early events of stress signaling,particularly the identification of primary stress sensors,still lags behind.In this review,we summarize recent work on the genetic and molecular mechanisms of plant abiotic stress and nutrient limitation sensing and signaling and discuss new directions for future studies. | Zhizhong Gong Liming Xiong Huazhong Shi Shuhua Yang Luis R.Herrera-Estrella Guohua Xu Dai-Yin Chao Jingrui Li Peng-Yun Wang Feng Qin Jigang Li Yanglin Ding Yiting Shi Yu Wang Yongqing Yang Yan Guo Jian-Kang Zhu | 2020 | Science China(Life Sciences)2020，63，5： | 94 |
| 2 | A Review on Lithium-ion Power Battery Thermal Management Technologies and Thermal Safety显示文摘Lithium-ion power battery has become one of the main power sources for electric vehicles and hybrid electric vehicles because of superior performance compared with other power sources. In order to ensure the safety and improve the performance, the maximum operating temperature and local temperature difference of batteries must be maintained in an appropriate range. The effect of temperature on the capacity fade and aging are simply investigated. The electrode structure, including electrode thickness, particle size and porosity, are analyzed. It is found that all of them have significant influences on the heat generation of battery. Details of various thermal management technologies, namely air based, phase change material based, heat pipe based and liquid based, are discussed and compared from the perspective of improving the external heat dissipation. The selection of different battery thermal management(BTM) technologies should be based on the cooling demand and applications, and liquid cooling is suggested being the most suitable method for large-scale battery pack charged/discharged at higher C-rate and in high-temperature environment. The thermal safety in the respect of propagation and suppression of thermal runaway is analyzed. | AN Zhoujian JIA Li DING Yong DANG Chao LI Xuejiao | 2017 | Journal of Thermal Science2017，26，5： | 41 |
| 3 | Incidence and mortality of cervical cancer in China,2013显示文摘Objective: Estimating the incidence and mortality rate of cervical cancer became necessary to establish prevention measures and healthy policies.The aim of this study was to estimate the updated incidence and mortality rate of cervical cancer in 2013 in China.Methods: According to the evaluation criteria developed by the National Central Cancer Registry of China,the data submitted from 255 cancer registries met the required standards in 2013.Cervical cancer cases were retrieved from the national database and combined with the 2013 national population data.The age-standardized incidence and mortality rates were based on the demographic structure of the national census 2000 and Segi's world population.Results: In 2013,the estimated number of new cases and deaths from cervical cancer were 100,700 and 26,400,respectively.The crude incidence of cervical cancer was 15.17/100,000.The age-standardized incidence rates based on the Chinese standard population(ASIRC) and the world standard population(ASIRW) were 11.30/100,000 and10.30/100,000,respectively.The incidence of cervical cancer in urban areas was 15.62/100,000 and the ASIRC was11.12/100,000.The incidence of cervical cancer in rural areas was 14.65/100,000 and the ASIRC was11.47/100,000.The mortality rate of cervical cancer was 3.98/100,000.The age-standardized mortality rates based on the Chinese(ASMRC) and world standard populations(ASMRW) were 2.76/100,000 and 2.62/100,000,respectively.The mortality rate of cervical cancer in urban areas was 3.85/100,000 and in rural areas was4.14/100,000.Cervical cancer incidence and mortality increased with age.Urban areas had a higher incidence of cervical cancer and lower mortality rates when compared with rural areas.Conclusions: Dynamic monitoring of cervical cancer incidence and mortality is the fundamental work of cervical cancer prevention and control.Cervical cancer is a serious issue in women's health,and prevention strategies need to be enhanced,such as human papilloma virus(HPV) vaccination and screening programs. | Bingbing Song Chao Ding Wangyang Chen Huixin Sun Maoxiang Zhang Wanqing Chen | 2017 | Chinese Journal of Cancer Research2017，29，6： | 35 |
| 4 | Toll-like receptor 4/nuclear factor-kappa B signaling detected in brain after early subarachnoid hemorrhage显示文摘背景发炎和免疫在 subarachnoid 出血(SAH ) 以后在早大脑损害的致病起一个重要作用。原子 factor-kappa B (NF-KB ) 为发炎和免疫调整许多基因必需品并且被像使用费的受体(TLR ) 激活。这研究试图检测在早 SAH 以后在老鼠大脑发信号的像使用费的受体 4/nuclear factor-kappa B (TLR4/NF-KB ) 的表示。老鼠被将斩首的方法和他们的大脑在血的单个注射以后在 0, 2, 4, 6, 12, 24 和 48 个小时被移开进 prechiasmatic 水塘, TLR4 的 mRNA 表示被 immunohistochemistry 并且西方的弄污被 Taqman 即时 RT-PCR,和蛋白质表示测量。肿瘤坏死 factor-alpha (TNF-) 的 NF-KB 活动和集中, interleukin-lbeta (IL-) 和 intedeukin-6 (IL-6 ) 被试金(ELISA ).Results TaqMan 即时 RT-PCR 并且西方的弄污识别了的连接酶的 immunosorbent 测量在在 mRNA 和蛋白质的 TLR4 表示的一个 biphasic 变化:一座起始的山峰(2-6 小时) 和持续举起(12-48 小时) 。染色的 Immunohistochemical 在 glial 房间和脉管的内皮细胞层主要显示出 TLR4-1ike 免疫反应的可诱导的表示。在象 NF-KB-regulated proinflammatory cytokines (TNF- , IL-1 和 IL-6 ) 的生产一样的 NF-KB 子单元 p65 的激活的一个类似的 biphasic 变化被 ELISA 检测。结论这些数据建议试验性的 SAH 导致在早大脑损害发信号的 TLR4 表示和 NF-KB 的重要起来规定。发信号的 TLR4/NF-KB 的激活可以在 SAH 以后调整煽动性的回答。 | MA Chun-xiao YIN Wei-ning CAI Bo-wen WU Jian WANG Jun-yi HE Min SUN Hong DING Jun-li YOU Chao | 2009 | Chinese Medical Journal2009，，13： | 33 |
| 5 | Fracture development in shale and its relationship to gas accumulation显示文摘有高石英,长石和碳酸盐的页岩,将有低泊松比率,高幼仔模量和高易碎物。作为结果,页岩是导致的在外部力量下面生产自然、导致的破裂。一般来说,在在页岩和在场的易碎的矿物质的体积的破裂开发之间有好关联。有高 TOC 或反常地高的压力的页岩开发得好破裂。页岩破裂开发也与全部的煤气的累积和免费煤气的体积显示出积极关联,即,页岩破裂越更好被开发,越 greater 煤气的累积并且因此越多更高煤气的生产。破裂为天然气和形成水提供迁居水管和累积空格,它为免费天然气的容量的增加是有利的。在页岩的更宽的破裂导致煤气的损失。在北美洲,从在页岩的高角度的破裂地区有页岩气体探索和高煤气的生产的高成功比率。在在四川盆的更低的古生代的海洋的器官的充满事的岩石中的好天然气表演或低收益制片人是仔细与在易碎的页岩的破裂开发的度有关。 | Wenlong Ding Chao Li Chunyan Li Changchun Xu Kai Jiu Weite Zeng Liming Wu | 2012 | Geoscience Frontiers2012，3，1： | 32 |
| 6 | Long-term follow-up of the effects of fecal microbiota transplantation in combination with soluble dietary fiber as a therapeutic regimen in slow transit constipation显示文摘As some studies have reported that strategies targeting the gut microbiota such as fecal microbiota transplantation(FMT) with or without other microecological therapy might have efficacy in treating slow transit constipation(STC), we conducted a singlecenter, open-label trial to study the long-term effect of FMT combined with soluble dietary fiber(pectin) on STC. Thirty-one adult patients with STC were enrolled into the trial. Patients received 6-day FMT procedures repeatedly for the first 3 months and soluble dietary fiber(pectin) daily during the follow-up. The rate of clinical remission and improvement, stool consistency, the Wexner constipation scale, and assessment of constipation-related symptoms were evaluated at week 4 and 1 year later. The clinical remission and improvement rates at week 4 were 69.0%(20/29) and 75.9%(22/29), respectively. At the end of the study,48.3%(14/29) of patients continued to have at least three complete spontaneous bowel movements per week and 58.6%(17/29)of patients showed clinical improvements. Stool consistency, the Wexner constipation scale, and constipation symptoms improved both at short-term and long-term follow-up. The results indicated that FMT in combination with soluble dietary fiber(pectin) had both short-term and long-term efficacy in treating STC. | Xueying Zhang Hongliang Tian Lili Gu Yongzhan Nie Chao Ding Xiaolong Ge Bo Yang Jianfeng Gong Ning Li | 2018 | Science China(Life Sciences)2018，61，7： | 33 |
| 7 | Suppression of Jasmonic Acid-Mediated Defense by Viral-Inducible MicroRNA319 Facilitates Virus Infection in Rice显示文摘MicroRNAs (miRNAs ) 是植物开发和主人病毒相互作用的枢轴的调节的人。然而,角色和涉及病毒的感染和主人危险性的特定的 miRNAs 的行动模式仍然保持大部分不清楚。在这研究,我们给那瑞斯看引起 miR319 的增加的累积,但是减少的破旧绝技病毒(RRSV ) 感染调整 miR319 的 TCP (TEOSINTE BRANCHED/CYCLOIDEA/PCF ) 的表示基因,特别 TCP21,在米饭植物。转基因的米饭植物 overexpressing miR319 或 downregulating TCP21 展出了像疾病的显型并且与野类型的植物比较显示出显著地更高的危险性到 RRSV。相反,仅仅温和的疾病症状在感染 RRSV 的线 overexpressing TCP21 并且特别在转基因的植物 overexpressing 被观察 miR319 抵抗的 TCP21。miR319 的 RRSV 感染和 overexpression 在米饭与 JA 生合成和信号相关的基因的 downregulated 表示一起引起了减少的内长的 jasmonic 酸(JA ) 层次。然而,有甲基 jasmonate 的米饭植物的治疗减轻了 RRSV 引起并且减少了病毒累积的疾病症状。一起拿,我们的结果建议由在米饭的 RRSV 感染的 miR319 的正式就职压制调停 JA 的防卫便于病毒感染和症状开发。 | Chao Zhang Zuomei Ding Kangcheng Wu Liang Yang Yang Li Zhen Yang Shan Shi Xiaojuan Liu Shanshan Zhao Zhirui Yang Yu Wang Luping Zheng Juan Wei Zhenguo Du Aihong Zhang Hongqin Miao Yi Li Zujian Wu Jianguo Wu | 2016 | Molecular Plant2016，9，9： | 27 |
| 8 | Cardioprotective effects of simvastatin on reversing electrical remodeling induced by myocardial ischemia-reperfusion in normocholesterolemic rabbits显示文摘背景:最近的研究表明了有 statin 的那个预告的处理在阻止心律不齐,而是它的电镀物品是有效的生理的机制不清楚。这研究被进行在颠倒在经历 ischemia-reperfusion 的兔子心的左室的 myocytes 的电的改变上调查 simvastatin 的 cardioprotective 效果,以便探索为 statin 的反没有节奏的效果负责的离子的机制。方法:45 只兔子随机被划分成三个组:ischemic-reperfusion 组(红外) , simvastatin 干预组(Statin ) 和假冒操作控制组(反对) 。Anesthetized 兔子被左前面的下降冠的动脉和 60 分钟的灌注的结扎在 5 mg x kg 的口头的 simvastatin 的一个 3 天的政府以后受到 30 分钟的局部缺血(-1) x d (在 Statin 组的 -1) 或在红外的安慰剂组织。单个室的 myocytes 被孤立从 infracted 区域的 epicardial 地区的酶的联盟者在 CON 动物在红外和 Statin 组和一样的解剖区域源于心。整个房间斑夹钳技术被用来记录膜离子电流,包括钠电流(我(Na )) , L 类型钙电流(我(Ca-L )) 并且短暂的外面的钾电流(我(到)) 。同时,浆液胆固醇的水平被检验。结果:在在三个组之中的浆液胆固醇集中没有有效差量。山峰我( Na )当前的密度(在 -30 mV )显著地在红外被减少((-22.46+/-5.32) pA/pF , n=12 )与反对相比((-42.78+/-5.48) pA/pF , n=16 , P<0.01 )并且 Statin ((-40.66+/-5.89) pA/pF , n=15 , P<0.01 ),当时山峰我( Na )在 Statin 组的当前的密度不与反对( P>0.05 )不同。山峰我( Ca-L )当前的密度(在 0 mV )显著地在红外被增加((-4.34+/-0.92) pA/pF , n=15 )与反对相比((-3.13+/-1.22) pA/pF , n=13 , P<0.05 )并且 Statin ((-3.46+/-0.85) pA/pF , n=16 , P<0.05 ),当时山峰我( Ca-L )在 Statin 的当前的密度不与反对( P>0.05 )不同。我(到)当前的密度(在 +60 mV )显著地在红外被减少(( 9.49+/-1.91 ) pA/pF , n=11 )与反对相比(( 17.41+/-3.13 ) pA/pF , n=15 , P<0.01 )并且 Statin (( 14.54+/-2.41 ) pA/pF , n=11 , P<0.01 ),尽管与反对( P<0.05 )相比在 Statin 组有细微减小。结论:ischemia-reperfusion 导致重要下面规定,这被暗示我(Na ) 并且我(到) 并且起来规定我(Ca-L ) ,它可以位于改变的电的活动和幸存的长反常的 transmembrane 动作电位持续时间下面室的 myocytes,因此在尖锐 ischemia-reperfusion 期间贡献室的心律不齐时期。有 simvastatin 的预告的处理能稀释这些变化并且颠倒没有降低浆液胆固醇水平的这电的改变,贡献在在胆固醇的减少的心律不齐独立人士的处理的 statin 的离子的机制。 | DING Chao FU Xiang-hua HE Zhen-shan CHEN Hui-xiao XUE Ling LI Jun-xia | 2008 | Chinese Medical Journal2008，，6： | 26 |
| 9 | Precise nanomedicine for intelligent therapy of cancer显示文摘Precise nanomedicine has been extensively explored for efficient cancer imaging and targeted cancer therapy, as evidenced by a few breakthroughs in their preclinical and clinical explorations. Here, we demonstrate the recent advances of intelligent cancer nanomedicine, and discuss the comprehensive understanding of their structure-function relationship for smart and efficient cancer nanomedicine including various imaging and therapeutic applications, as well as nanotoxicity. In particular, a few emerging strategies that have advanced cancer nanomedicine are also highlighted as the emerging focus such as tumor imprisonment, supramolecular chemotherapy, and DNA nanorobot. The challenge and outlook of some scientific and engineering issues are also discussed in future development. We wish to highlight these new progress of precise nanomedicine with the ultimate goal to inspire more successful explorations of intelligent nanoparticles for future clinical translations. | Huabing Chen Zhanjun Gu Hongwei An Chunying Chen Jie Chen Ran Cui Siqin Chen Weihai Chen Xuesi Chen Xiaoyuan Chen Zhuo Chen Baoquan Ding Qian Dong Qin Fan Ting Fu Dayong Hou Qiao Jiang Hengte Ke Xiqun Jiang Gang Liu Suping Li Tianyu Li Zhuang Liu Guangjun Nie Muhammad Ovais Daiwen Pang Nasha Qiu Youqing Shen Huayu Tian Chao Wang Hao Wang Ziqi Wang Huaping Xu Jiang-Fei Xu Xiangliang Yang Shuang Zhu Xianchuang Zheng Xianzheng Zhang Yanbing Zhao Weihong Tan Xi Zhang Yuliang Zhao | 2018 | Science China Chemistry2018，61，12： | 19 |
| 10 | Ammonium removal pathways and microbial community in GAC-sand dual media filter in drinking water treatment显示文摘A GAC-sand dual media filter(GSF) was devised as an alternative solution for drinking water treatment plant to tackle the raw water polluted by ammonium in place of expensive ozone-GAC processes or bio-pretreatments.The ammonium removal pathways and microbial community in the GSFs were investigated.The concentrations of ammonium,nitrite and nitrate nitrogen were monitored along the filter.Total inorganic nitrogen(TIN) loss occurred during the filtration.For 1 mg ammonium removal,the TIN loss was as high as 0.35 mg,DO consumption was 3.06 mg,and alkalinity consumption was 5.55 mg.It was assumed that both nitrification and denitrification processes occur in the filters to fit the TIN loss and low DO consumption.During the filtration,nitritation,nitrification and nitritation-anaerobic ammonium oxidation processes probably occur,while traditional nitrification and denitrification and simultaneous nitrification and denitrification processes may occur.In the GSFs,Nitrosomonas and Nitrospira are likely to be involved in nitrification processes,while Novosphingobium,Comamonadaceae and Oxalobacteraceae may be involved in denitrification processes. | Shuo Feng Shuguang Xie Xiaojian Zhang Zhiyu Yang Wei Ding Xiaobin Liao Yuanyuan Liu Chao Chen | 2012 | Journal of Environmental Sciences2012，24，9： | 14 |
| 11 | Trends in geographical disparities for cervical cancer mortality in China from 1973 to 2013:a subnational spatio-temporal study显示文摘Objective: This study was designed to explore the time trends in geographical variations of cervical cancer mortality in China's Mainland over the period 1973 to 2013,to provide subnational spatio-temporal patterns for targeted promotion of human papillomavirus vaccine in China.Methods: Data were extracted from three national retrospective death surveys and cancer registry.The rate ratio(RR) was estimated for the aggregated data for seven geographical regions using generalized linear models to evaluate time trends in geographical disparities of cervical cancer mortality.Results: There was a significant decrease in cervical cancer mortality in China from 1973–1975 to 2004–2005,but leveled off thereafter to 2011–2013.Compared to the period 1973–1975 the RR for the three last time periods were 0.33 [95% confidence interval(95% CI): 0.30–0.37] for 1990–1992,0.21(95% CI: 0.19–0.24) for 2004–2005 and 0.24(95% CI: 0.22–0.26) for 2011–2013.Females living in the Northwest China and Central China have a high risk of mortality from cervical cancer compared to the nationwide,with the RR being 2.09(95% CI:1.83–2.38) and 1.26(95% CI: 1.11–1.44) respectively,while the RRs for South China,Northeast China and Southwest China were below 1.00,indicating the lower death risk.Despite the mortality rate had increased slightly from 2004 to 2013,there was an encouraging sign that the geographical disparities in cervical cancer mortality had gradually narrowed over time across China.Conclusions: Although cervical cancer mortality in China has reduced to very low levels,the high risk of cervical cancer in Northwest China and Central China is still noteworthy.Public health policies including the promotion of vaccine should be targeted to further reduction of geographical disparities in cervical cancer mortality. | Changfa Xia Chao Ding Rongshou Zheng Siwei Zhang Hongmei Zeng Jinfeng Wang Yilan Liao Ningxu Zhang Zhixun Yang Wanqing Chen | 2017 | Chinese Journal of Cancer Research2017，29，6： | 13 |
| 12 | Impacts of continuously regenerating trap and particle oxidation catalyst on the NO_2 and particulate matter emissions emitted from diesel engine显示文摘Two continuously regenerating diesel particulate filter(CRDPF) with different configurations and one particles oxidation catalyst(POC) were employed to perform experiments in a controlled laboratory setting to evaluate their effects on NO 2,smoke and particle number emissions.The results showed that the application of the after-treatments increased the emission ratios of NO 2 /NOx significantly.The results of smoke emissions and particle number(PN) emissions indicated that both CRDPFs had sufficient capacity to remove more than 90% of total particulate matter(PM) and more than 97% of solid particles.However,the POC was able to remove the organic components of total PM,and only partially to remove the carbonaceous particles with size less than 30 nm.The negligible effects of POC on larger particles were observed due to its honeycomb structure leads to an inadequate residence time to oxidize the solid particles or trap them.The particles removal efficiencies of CRDPFs had high degree of correlations with the emission ratio of NO 2 /NOx.The PN emission results from two CRDPFs indicated that more NO 2 generating in diesel oxidation catalyst section could obtain the higher removal efficiency of solid particles.However this also increased the risk of NO 2 exposure in atmosphere. | Zhihua Liu Yunshan Ge Jianwei Tan Chao He Asad Naeem Shah Yan Ding LinxiaoYu Wei Zhao | 2012 | Journal of Environmental Sciences2012，24，4： | 11 |
| 13 | A direct coupling analysis method of hydroelastic responses of VLFS in complicated ocean geographical environment显示文摘In this paper a direct coupling analysis method (DCAM) of hydroelastic responses of a very large floating structures (VLFS) in complicated geographical environment is presented. In this method the three-dimensional hydroelasticity theory of floating bodies is combined with the shallow water wave theory, to allow for proper description of the influence of uneven seabed and sheltering effect of islands on the hydroelastic responses of a VLFS deployed near island and reefs in shallow sea. This method and the numerical procedures were verified and validated by comparison-between the predictions and the model test results of a 3-module VLFS and an 8-module VLFS in two simulated shallow sea regions with different seabed topography. | Jun Ding You-sheng Wu Ye Zhou Zhi-wei Li Chao Tian Xue-feng Wang Zheng-wei Zhang Xiao-long Liu | 2019 | Journal of Hydrodynamics2019，31，3： | 10 |
| 14 | Experimental cancer gene therapy by multiple anti-survivin hammerhead ribozymes显示文摘为癌症改进基因治疗的功效,我们设计了指向 survivin mRNA 的暴露的区域的四撞木鲛 ribozyme 侵入人体气管粘膜的病菌(到 R4 的 R1 ) 。除了在里面 vitro 描述,由教材扩展包括了劈开的顺序特性的一颗决心,为细胞增长并且为的试金在 vivo 肿瘤,生长被用来为 ribozyme 效率得分。survivin 表示的产生抑制经由 caspase-3-dependent 小径导致了有丝分裂的大祸和房间死亡。重要地, ribozyme 侵入人体气管粘膜的病菌的管理在一个 hepato 细胞的癌异种皮移植老鼠模型禁止了肿瘤生长。R1, R3 和 R4 ribozymes 的合作表示 synergistically 压制了 survivin 并且当这联合指向 survivin 抄本的所有主要形式,生产了大多数有势力反癌症效果。带在这份报告描述的多重撞木鲛 ribozymes 的侵入人体气管粘膜的病菌对癌症提供了柔韧的基因治疗策略。 | Qi Fei Hongyu Zhang Lili Fu Xinlan Dai Baomei Gao Min Ni Chao Ge Jinjun Li Xia Ding Yuwen Ke Xuebiao Yao Jingde Zhu | 2008 | Acta Biochimica et Biophysica Sinica2008，40，6： | 10 |
| 15 | A novel mouse model of human breast cancer stem-like cells with high CD44^+CD24^–/lower phenotype metastasis to human bone显示文摘背景转移到骨头的乳癌的一个令人满意的动物模型是无法获得的。在这研究,我们使用了人的乳癌像茎的房间和人的骨头到造人的乳癌的一个新奇“人来源”的模型骨胳的 metastasis.Methods 人乳癌像茎的房间, CD44+/CD24-/lower subpopulation,被分开并且有教养。在有像茎的房间的注射前,老鼠在正确或左的背面的胁腹与人的骨头被植入。在组 A, B,和 C 的动物与 1x105 被注射, 1x106 人乳癌像茎的房间,和 1x106 父母 MDA-MB-231 房间分别地。没有人的骨头的培植的积极控制组(D) 也与 1x106 MDA-MB-231 房间被注射。Immunohistochemistry 为 CD34, CD105,光滑的肌肉抗体, CD44, CD24, cytokine, CXC chemokine receptor-4 (CXCR4 ) ,和 osteopontin (OPN ) 的决心被执行。在骨头转移纸巾的 CD44, CD24, CXCR4,和 OPN 的 mRNA 层次被即时量的聚合酶链反应(PCR ) 分析。我们的结果表明了的结果那在组 B 的植入的人的骨头的房间,它收到了 1x106 癌症像茎的房间,染色为 CD44, CXCR4,和 OPN 强烈积极,而那些不另外的组出现了或最小的染色。而且,组 B 有人的骨头转移的最高的发生(77.8% , P=0.0230 ) 并且另外的织物转移的没有伴随物。即时 PCR 组 C 和 D 与那些相比在组 B 在变形骨头纸巾显示出 CD44, CXCR4,和 OPN mRNA 的增加,然而,在组 B 的 CD24 mRNA 的表示最低。在“新奇人的来源”的结论乳癌当模特儿,像茎的房间表明了的乳癌一个更高人的寻求骨头的能力。它的机制可能与更高的表情有关 CD44, CXCR4,和 OPN,和在乳癌的 CD24 的更低的表示像茎的房间。 | LING Li-jun WANG Shui LIU Xiao-an SHEN En-chao DING Qiang LU Chao XU Jian CAO Qin-hong ZHU Hai-qing WANG Feng | 2008 | Chinese Medical Journal2008，，20： | 10 |
| 16 | Effect of microRNA-155 on angiogenesis after cerebral infarction of rats through AT1R/VEGFR2 pathway显示文摘Objective:To explore the function and mechanism of microRNA-155 to regulate the angiogenesis after the cerebral infarction of rats through the angiotensin Ⅱ receptor 1(AT1R)/vascular endothelial growth factor(VEGF) signaling pathway.Methods:Female SD rats were chosen for the construction of cerebral infarction model of rats using the modified right middle cerebral artery occlusion.The real-time PCR(RT-PCR) method was employed to detect the expression of microRNA-155 in each group at different time points after the cerebral infarction(1 h,I d,3 d and 7 d).SD rats were randomly divided into four groups(n=20 rats):sham operation group(Sham group),MACO group,MACO+microRNA-155 mimic group,and MACO+microRNA-155 inhibitor group.Sham group was given the free graft,while MACO+microRNA-155 mimic group and MACO+microRNA-155 inhibitor group were treated with microRNA-155 mimic and microRNA-155 inhibitor respectively.The Zea Longa5-point scale was used to score the neurologic impairment of rats in each group;2,3,5-triphenyl tetrazolium chloride staining to evaluate the volume of cerebral infarction of rats in each group;the immunohistochemistry to detect the expression of CD31;Western blot and RT-PCR to detect the expression of AT1 R and VEGF receptor 2(VEGFR2).Results:The expression of microRNA-155 was increased in the cerebral ischemia tissue after the cerebral infarction.It was significantly increased at 1 d of ischemia and maintained at the high level for a long time.Rats in the Sham group had no symptom of neurologic impairment while rats in the MACO group had the obvious neurologic impairment.After being treated with microRNA-155 inhibitor,the neural function of MACO rats had been improved,with the decreased area of cerebral infarction.But after being treated with microRNA-155 mimic,the neural function was further worsened,with the increased area of cerebral infarction.Results of immunohistoehemical assay indicated that microRNA-155 inhibitor could up-regulate the expression of CD31,while microRNA-155 mimic could down-regulate the expression of CD31.The RT-PCR found that,after being treated with microRNA-155 inhibitor,MACO rats had the increased expression of ATIR and VEGFR2 messenger RNA(mRNA);but after being treated with microRNA-155 mimic,the expression of ATIR and VEGFR2 mRNA was decreased.Results of Western blot showed that,after being treated with microRNA-155 inhibitor,MACO rats had the increased expression of ATIR and VEGFR2 mRNA;but after being treated with microRNA-155 mimic,the expression of ATIR and VEGFR2 mRNA was decreased.Conclusions:The inhibition of microRNA-155 can improve the neurologic impairment of rats with the cerebral infarction,reduce the volume of cerebral infarction and effectively promote the angiogenesis in the region of ischemia,which may be mediated through AT1R/VEGFR2 pathway. | Ying-Chun Meng Zhen-Ying Ding Hai-Quan Wang Li-Ping Ning Chao Wang | 2015 | Asian Pacific Journal of Tropical Medicine2015，8，10： | 10 |
| 17 | Excision repair cross complementation group 1 polymorphisms and lung cancer risk: a meta-analysis显示文摘背景几研究评估了在在多样的人口,但是与冲突在各个分享相对小的样品的 results.By 的酶和肺癌症风险学习的编码切除修理十字互补组 1 的多型性( ERCC1 )之间的协会,由严密 methods.Methods Embase 执行证据的元分析是可能的,奥维德, Medline 和中国国家知识基础结构被寻找。另外的研究在原来的研究或评论文章从参考书被识别。满足包括标准的文章系统地被考察,并且报导数据用我们从七合格研究与肺癌症和 4332 控制发现了 3810 个案例的 meta-analysis.Results 的统计技术被聚集。T19007C 多型性没在肺癌症风险上显示出重要效果(C 等位基因对 T 等位基因:机会比率(或)=0.91, 95% 信心间隔(CI )=0.80-1.04;CC 对 TT:OR=0.76, 95% CI=0.56-1.02;CC 对(CT+TT ) :OR=0.96, 95% CI=-0.84-1.10 ) 。同样,当成层时,为肺癌症风险上的 T19007C 多型性没有重要主要效果由种族(汉语或白种人) 的分析。没有重要协会在 C8092A 多型性(3060 个病人和 2729 控制) 和肺癌症的风险之间被发现(等位基因对 C 等位基因:OR=1.03, 95% CI=0.95-1.11;AA 对 CC:OR=1.08, 95% CI=-0.88-1.33;AA 对(AC+CC ) :OR=1.08, 95% CI=-0.88-1.31 ) 我们几乎没在白种人或汉中国人民发现在 ERCC 1 的 T1900C 或 C8092A 多型性和肺癌症的风险之间的一个协会的小证据的 .Conclusion。 | CAO Chao ZHANG Yan-mei WANG Ran SUN Shi-fang CHEN Zhong-bo MA Hong-ying YU Yi-ming DING Qun-li SHU Li-hua DENG Zai-chun | 2011 | Chinese Medical Journal2011，，14： | 9 |
| 18 | Allele-aware chromosome-level genome assembly of Artemisia annua reveals the correlation between ADS expansion and artemisinin yield显示文摘Artemisia annua is the major natural source of artemisinin,an anti-malarial medicine commonly used worldwide.Here,we present chromosome-level haploid maps for two A.annua strains with different artemisinin contents to explore the relationships between genomic organization and artemisinin production.High-fidelity sequencing,optical mapping,and chromatin conformation capture sequencing were used to assemble the heterogeneous and repetitive genome and resolve the haplotypes of A.annua.Approximately 5o,ooo genes were annotated for each haplotype genome,and a triplication event that occurred approximately 58.12million years ago was examined for the first time in this species.A total of 3,903,467-5,193,414 variants(SNPs,indels,and structural variants)were identified in the 1.5-Gb genome during pairwise comparison between haplotypes,consistent with the high heterozygosity of this species.Genomic analyses revealed a correlation between artemisinin concents and the copy number of amorpha-4,11-dienes ynthasegenes.This correlation was further confirmed by resequencing of 36A.annua samples with varied artemisinin contents.Circular consensus sequencing of transcripts facilitated the detection of paralog expression.Collectively,our study provides chromosome-level allele-aware genome assemblies for two A.annua strains and new insights into the biosynthesis of artemisinin and its regulation,which will contribute to conquering malaria worldwide. | Baosheng Liao Xiaofeng Shen Li Xiang Shuai Guo Shiyu Chen Ying Meng Yu Liang Dandan Ding Junqi Bai Dong Zhang Tomasz Czechowski Yi Li Hui Yao Tingyu Mai Caroline Howard Chao Sun Haitao Liu Jiushi Liu Jin Pei Jihai Gao Jigang Wang Xiaohui Qiu Zhihai Huang Hongyi Li Ling Yuan Jianhe Wei lan Graham Jiang Xu Boli Zhang Shilin Chen | 2022 | Molecular Plant2022，15，8： | 9 |
| 19 | Petrogenesis and Tectonics of the Naruo Porphyry Cu(Au) Deposit Related Intrusion in the Duolong Area,Central Tibet显示文摘The Duolong area is the most important part of the Western Bangong-Nujiang Suture Zone porphyry Cu(Au) metallogenic belt, in Tibet, China. Here new detailed data are presented from LAICP-MS zircon U-Pb, whole-rock geochemical, and in-situ zircon Hf isotope analyses for igneous rocks in the large Naruo deposit(2.51 Mt of Cu and 82 t of Au) which is located ~2 km NE of the Duolong(Duobuza and Bolong) super-large gold-rich porphyry copper deposit. We integrated our results with previous research of other porphyry deposits in the Duolong area and have identified the timing, geodynamic setting, and petrogenesis of the mineralization-associated magmatic events. Based on the measurements, the Duolong area porphyry Cu(Au) deposit formations are associated with Early Cretaceous intermediate-felsic magmatism, which is consistent with U-Pb zircon ages of 120 Ma. All the main intrusive rocks in the ore-concentrated area have similar lithogeochemical characteristics; they show a relative enrichment in both light rare earth elements(LREEs) and large-ion lithophile elements(LILEs: Rb, Ba, K, etc.) and relative depletion in both heavy rare earth elements(HREEs) and high field strength elements(HFSEs: Nb, Ta, Zr, Hf, etc.). Moreover, the granite porphyry shows positive εHf(t) values between 1.38–7.37 suggesting that magmas were potentially derived from the partial melting of a depleted mantle wedge that had been metasomatized by subducted slab-derived fluids or melts. This paper points out that the formation of the porphyry-epithermal Cu(Au) deposit in the Duolong area was dominated by northward subduction of the Bangongco Tethys Plate beneath the Qiangtang block in the Early Cretaceous(124–114 Ma), when the subducted oceanic crust reached 50–70 km underground and generated different degrees of phase transformation, which lead to a melt produced by dehydration of amphibole minerals, a metasomatized mantle wedge, and induced mantle partial melting that produced the magma. Those deposits occurred in a continental arc tectonic setting, which is similar to the continental margin arc environment of the ocean-continent subduction setting of the Andes metallogenic belt in South America. | DING Shuai CHEN Yuchuan TANG Juxing ZHENG Wenbao LIN Bin YANG Chao | 2017 | Acta Geologica Sinica(English Edition)2017，91，2： | 9 |
| 20 | Variation in cis-regulation of a NAC transcription factor contributes to drought tolerance in wheat显示文摘Drought is a major environmental factor limiting wheat production worldwide,and developing drought-tolerant cultivars is a central challenge for wheat breeders globally.Therefore,it is important to identify genetic components determining drought tolerance in wheat.In this study,we identified a wheat NAC gene(TaNAC071-A)that is tightly associated with drought tolerance by a genome-wide association study.Knockdown of TaNAC071-A in wheat attenuated plant drought tolerance,whereas its overexpression significantly enhanced drought tolerance through improved water-use efficiency and increased expression of stress-responsive genes.This heightened water-saving mechanism mitigated the yield loss caused by water deficit.Further candidate gene association analysis showed that a 108-bp insertion in the promoter of TaNAC071-A alters its expression level and contributes to variation in drought tolerance among wheat accessions.This insertion contains two MYB cis-regulatory elements(CREs)that can be directly bound by the MYB transcription activator,TaMYBL1,thereby leading to increased TaNAC071-A expression and plant drought tolerance.Importantly,introgression of this 108-bp insertion allele,TaNAC071-AIn-693,into drought-sensitive cultivars could improve their drought tolerance,demonstrating that it is a valuable genetic resource for wheat breeding.Taken together,our findings highlight a major breakthrough in determining the genetic basis underlying phenotypic variation in wheat drought tolerance and showcase the potential of exploiting CRE-containing indels for improving important agronomical traits. | Hude Mao Shumin Li Bin Chen Chao Jian Fangming Mei Yifang Zhang Fangfang Li Nan Chen Tian Li Linying Du Li Ding Zhongxue Wang Xinxiu Cheng Xiaojing Wang Zhensheng Kang | 2022 | Molecular Plant2022，15，2： | 9 |
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