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| 1 | Wnt and BMP signaling crosstalk in regulating dental stem cells:Implications in dental tissue engineering显示文摘Tooth is a complex hard tissue organ and consists of multiple cell types that are regulated by important signaling pathways such as Wnt and BMP signaling.Serious injuries and/or loss of tooth or periodontal tissues may significantly impact aesthetic appearance,essential oral functions and the quality of life.Regenerative dentistry holds great promise in treating oral/dental disorders.The past decade has witnessed a rapid expansion of our understanding of the biological features of dental stem cells,along with the signaling mechanisms governing stem cell self-renewal and differentiation.In this review,we first summarize the biological characteristics of seven types of dental stem cells,including dental pulp stem cells,stem cells from apical papilla,stem cells from human exfoliated deciduous teeth,dental follicle precursor cells,periodontal ligament stem cells,alveolar bone-derived mesenchymal stem cells(MSCs),and MSCs from gingiva.We then focus on how these stem cells are regulated by bone morphogenetic protein(BMP)and/or Wnt signaling by examining the interplays between these pathways.Lastly,we analyze the current status of dental tissue engineering strategies that utilize oral/dental stem cells by harnessing the interplays between BMP and Wnt pathways.We also highlight the challenges that must be addressed before the dental stem cells may reach any clinical applications.Thus,we can expect to witness significant progresses to be made in regenerative dentistry in the coming decade. | Fugui Zhang Jinlin Song Hongmei Zhang Enyi Huang Dongzhe Song Viktor Tollemar Jing Wang Jinhua Wang Maryam Mohammed Qiang Wei Jiaming Fan Junyi Liao Yulong Zou Feng Liu Xue Hu Xiangyang Qu Liqun Chen Xinyi Yu Hue H.Luu Michael J.Lee Tong-Chuan He Ping Ji | 2016 | Genes & Diseases2016，3，4： | 16 |
| 2 | Multifaceted signaling regulators of chondrogenesis:Implications in cartilage regeneration and tissue engineering显示文摘Defects of articular cartilage present a unique clinical challenge due to its poor self-healing capacity and avascular nature.Current surgical treatment options do not ensure consistent regeneration of hyaline cartilage in favor of fibrous tissue.Here,we review the current understanding of the most important biological regulators of chondrogenesis and their interactions,to provide insight into potential applications for cartilage tissue engineering.These include various signaling pathways,including fibroblast growth factors(FGFs),transforming growth factor b(TGF-b)/bone morphogenic proteins(BMPs),Wnt/b-catenin,Hedgehog,Notch,hypoxia,and angiogenic signaling pathways.Transcriptional and epigenetic regulation of chondrogenesis will also be discussed.Advances in our understanding of these signaling pathways have led to promising advances in cartilage regeneration and tissue engineering. | Jordan D.Green Viktor Tollemar Mark Dougherty Zhengjian Yan Liangjun Yin Jixing Ye Zachary Collier Maryam K.Mohammed Rex C.Haydon Hue H.Luu Richard Kang Michael J.Lee Sherwin H.Ho Tong-Chuan He Lewis L.Shi Aravind Athiviraham | 2015 | Genes & Diseases2015，2，4： | 9 |
| 3 | Stem cells, growth factors and scaffolds in craniofacial regenerative medicine显示文摘Current reconstructive approaches to large craniofacial skeletal defects are often complicated and challenging.Critical-sized defects are unable to heal via natural regenerative processes and require surgical intervention,traditionally involving autologous bone(mainly in the form of nonvascularized grafts)or alloplasts.Autologous bone grafts remain the gold standard of care in spite of the associated risk of donor site morbidity.Tissue engineering approaches represent a promising alternative that would serve to facilitate bone regeneration even in large craniofacial skeletal defects.This strategy has been tested in a myriad of iterations by utilizing a variety of osteoconductive scaffold materials,osteoblastic stem cells,as well as osteoinductive growth factors and small molecules.One of the major challenges facing tissue engineers is creating a scaffold fulfilling the properties necessary for controlled bone regeneration.These properties include osteoconduction,osteoinduction,biocompatibility,biodegradability,vascularization,and progenitor cell retention.This review will provide an overview of how optimization of the aforementioned scaffold parameters facilitates bone regenerative capabilities as well as a discussion of common osteoconductive scaffold materials. | Viktor Tollemar Zach J.Collier Maryam K.Mohammed Michael J.Lee Guillermo A.Ameer Russell R.Reid | 2016 | Genes & Diseases2016，3，1： | 3 |
| 4 | Infections in human liver recipients: different patterns early and late after transplantation显示文摘 | L. Barkholt B -G. Ericzon J. Tollemar A -S. Malmborg A. Ehrnst H. Wilczek J. Andersson | 1993 | Transplant International1993，，2： | 1 |
| 5 | Changes in the spectrum and risk factors for invasive candidiasis in liver transplant recipients:prospective,multicenter,case-controlled study显示文摘 | Husain S Tollemar J Dominguez EA | 2003 | Transplantation2003，75，12： | 1 |
| 6 | PCR and other non-culture methods for diagnosis of invasive Candida infections in allogeneic bone marrow and solid organ transplant recipients显示文摘 | Chryssanthou E Klingsport L Tollemar J | 1999 | Mycoses1999，42，4： | 1 |
| 7 | A retrospective clinical comparison between antifungal treatment with liposomal amphotericin B (AmBisome) and conventional amphotericin B in transplant recipients 显示文摘 | Tollemar J Andersson S Ringden O | 1992 | Mycoses1992，35，90： | 1 |
| 8 | PCR and other non-culture methods for diagnosis of invasive candida infections in allogeneic bone marrow and solid organ transplant recipients显示文摘 | Chryssanthou E Klingsport L Tollemar J | 1999 | Mycoses1999，42，4： | 1 |
| 9 | Iiposomal ampbotericin b prevents invasive fungal infections in liver transplant recipients显示文摘 | TOLLEMAR J HOCKERSTEDT K ERICZON B G | 1995 | Transpl1995，59，： | 1 |
| 10 | A randomized,doubleblind,placebo-controlled,study of single-dose rituximab as induction in renal transplantation显示文摘 | Tyden G Genberg H Tollemar J | 2009 | Transplantation2009，87，9： | 1 |
| 11 | Cyclosporine-associated central nervous system toxicity显示文摘 | Tollemar J Ringden O Ericzon BG | 1988 | N Engl J Med1988，318，： | 1 |
| 12 | Prophylax- is with liposomal amphotericin B (AmBisome) prevents fungal infections in liver transplant recipients: long-term results of a randomized, placebo-controlled trial显示文摘 | Tollemar J Hockerstedt K Ericzon BG | 1995 | Trans- plantProc1995，27，1： | 1 |
| 13 | Transplantation of porcine fetal pancreas to diabetic patients显示文摘 | Groth C Tibell A Tollemar J | 1994 | Lancet1994，344，： | 1 |
| 14 | PCR and other non-culture methods for diagnosis of invasive Candida infections in allogeneic bone marrow and solid organ transplant recipients显示文摘 | Chryssanthou E Klingsport L Tollemar J | 1999 | Mycoses1999，42，4： | 1 |
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