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| 1 | Induction of ischemic tolerance in rat liver via reduced nicotinamide adenine dinucleotide phosphate oxidase in Kupffer cells显示文摘AIM: To elucidate the mechanisms of hepatocyte preconditioning by H2O2 to better understand the pathophysiology of ischemic preconditioning. METHODS: The in vitro effect of H2O2 pretreatment was investigated in rat isolated hepatocytes subjected to anoxia/reoxygenation. Cell viability was assessed with propidium iodide fluorometry. In other experiments, rat livers were excised and subjected to warm ischemia/ reperfusion in an isolated perfused liver system to determine leakage of liver enzymes. Preconditioning was performed by H2O2 perfusion, or by stopping the perfusion for 10 min followed by 10 min of reperfusion. To inhibit Kupffer cell function or reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, gadolinium chloride was injected prior to liver excision, or diphenyleneiodonium, an inhibitor of NADPH oxidase, was added to the perfusate, respectively. Histological detection of oxygen radical formation in Kupffer cells was performed by perfusion with nitro blue tetrazolium. RESULTS: Anoxia/reoxygenation decreased hepatocyte viability compared to the controls. Pretreatment with H2O2 did not improve such hepatocyte injury. In liver perfusion experiments, however, H2O2 preconditioning reduced warm ischemia/reperfusion injury, which wasreversed by inhibition of Kupffer cell function or NADPH oxidase. Histological examination revealed that H2O2 preconditioning induced oxygen radical formation in Kupffer cells. NADPH oxidase inhibition also reversed hepatoprotection by ischemic preconditioning. CONCLUSION: H2O2 preconditioning protects hepato- cytes against warm ischemia/reperfusion injury via NADPH oxidase in Kupffer cells, and not directly. NADPH oxidase also mediates hepatoprotection by ischemic preconditioning. | Kazuaki Tejima Masahiro Arai Hitoshi Ikeda Tomoaki Tomiya Mikio Yanase Yukiko Inoue Takako Nishikawa Naoko Watanabe Natsuko Ohtomo Masao Omata Kenji Fujiwara | 2007 | World Journal of Gastroenterology2007，13，38： | 2 |
| 2 | Has the Earth's sixth mass extinction already arrived 显示文摘 | Barnosky A D Matzke N Tomiya S | 2011 | Nature2011，471，： | 1 |
| 3 | Insulin and glucogen therapy of acute hepatic failure显示文摘 | FUJIWARA K OGATA I TOMIYA T | 1991 | Dig Dis Sei1991，36，： | 1 |
| 4 | Significance of branched chain amino acids as posgible 9timulators of hepatocyte growth factor显示文摘 | Tomiya T Omata M l:ujiwara K | 2004 | Biocbem Biophy Res Commun2004，513，2： | 1 |
| 5 | Leucine stimulates HGF production by hepatic stellate cells through mTOR pathway 显示文摘 | Tomiya T Nishikawa T lnoue Y | 2007 | Biochem Biophys Res Commun2007，358，1： | 1 |
| 6 | Simultaneous determination of N-acetylaspartylglutamate and N-acetylaspartate in rat brain homogenate using high-performance liquid chromatography with pre-column fluorescence derivatization显示文摘 | Kotaro Arai Takeshi Fukushima Masayuki Tomiya | 2008 | J Chromatogr B2008，875，： | 1 |
| 7 | TGF-α levels in liver and blood correlate better than HGF with hepatocyte proliferation during liver regeneration 显示文摘 | Tomiya T Ogata I Fujiwara K | 1998 | Am J Pathol1998，153，： | 1 |
| 8 | Kinetics and mechanism of ozone decomposition in basic aqueous solution 显示文摘 | Tomiyas H Fukutomi H Gordon G | 1985 | J Phys Chem1985，24，： | 1 |
| 9 | Serum transforming growth factor-alpha level can be a parameter for evaluating liver regeneration after partial hepatectomy in patients with liver cancer显示文摘 | Tomiya T Hayashi S Yanase M | 1997 | Semin Oncol1997，24，： | 1 |
| 10 | Expression of transforming growth factor alpha and -beta in hepatic lobes after hemihepatic portal vein embolization 显示文摘 | Kusaka K Imamura H Tomiya T | 2006 | Dig Dis Sci2006，51，8： | 1 |
| 11 | Registration of remote sensing image data basedon waveleltransform显示文摘 | Tomiya M Ageishi A | 2003 | ISPRS Arcbiv2003，，： | 1 |
| 12 | Comparing N-glycan processing in mammalian cell lines to native and engineered lepidopteran insect cell lines显示文摘 | Noboru Tomiya Someet Narang Yuan C. Lee Michael J. Betenbaugh | 2004 | Glycoconjugate Journal2004，，6： | 1 |
| 13 | Is yield enhancement by CO 2 enrichment greater in genotypes with a higher capacity for nitrogen fixation?显示文摘 | Masafumi Otera Makie Kokubun Hiroko Tabei Toshinori Matsunami Tomiya Maekawa Masumi Okada | 2011 | Agricultural and Forest Meteorology2011，，10： | 1 |
| 14 | TGF-αlevels in liver and blood correlate better than HGF with hepatocyte proliferation during liver regeneration显示文摘 | Tomiya T Ogata I Fujiwara K | 1998 | Am J Pathol1998，153，3： | 1 |
| 15 | Lithium insertion and extraction kinetics of Li1+xV3O8显示文摘 | Jin K Takashi M Tomiya K | 1999 | J Power Sources1999，83，： | 1 |
| 16 | Significance of branched chain amino acids as possible stimulators of hepatocyte growth factor 显示文摘 | Tomiya T Omata M Fujiwara K | 2004 | Biechcm Biophys Rcs Commun2004，313，2： | 1 |
| 17 | Lithium insertion and extraction kinetics of Li1+xV3O8显示文摘 | JIN K TAKASHI M TOMIYA K | 1999 | Journal of Powex Sources1999，83，： | 1 |
| 18 | Branched-chain amino acids, hepatocyte growth factor and protein production in the liver 显示文摘 | TOMIYA T OMATA M FUJIWARA K | 2004 | Hepatol Res2004，30，： | 1 |
| 19 | Significance of branched chain amino acids as possible stimulators of hepatocyte growth factor 显示文摘 | TOMIYA T OMATA M FUJIWARA K | 2004 | Biochem Biophys Res Commun2004，313，2： | 1 |
| 20 | Liver-targeting of primaquine-(poly-γ-glutamic acid)and its degradation in rat hepatocytes显示文摘 | TOMIYA N JARDIM J G HOU J | 2013 | Bioorganic and Medicinal Chemistry2013，21，17： | 1 |
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