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| 1 | Structure of MERS-CoV spike receptor-binding domain complexed with human receptor DPP4显示文摘最近的尖铁 glycoprotein (S) 鉴别中东呼吸症候群 coronavirus (MERS-CoV ) 指向细胞的受体, dipeptidyl peptidase 4 (DPP4 ) 。顺序比较和当模特儿的分析在病毒的尖铁上揭示了一个通常认为的受体绑定领域(RBD ) ,它调停这个相互作用。我们报导 3.0 Å MERS-CoV RBD 的决定水晶结构跳了到人的 DPP4 的细胞外的领域。我们的结果证明 MERS-CoV RBD 由一个核心和受体绑定子域组成。受体绑定子域与 DPP4 β 交往;推进器然而并非它的内在的 hydrolase 领域。MERS-CoV RBD 和相关 SARS-CoV RBD 分享他们的核心子域的结构的类似的高度,但是在受体绑定子域是尤其是分叉的。Mutagenesis 研究在为到 DPP4 和入口的病毒的绑定是批评的进目标房间的受体绑定子域识别了几关键残余。在在 MERS-CoV RBD 和 DPP4 之间的接口的原子细节提供病毒和受体相互作用的结构的理解,它能对 MERS-CoV 感染指导治疗学和疫苗的开发。 | Nianshuang Wang Xuanling Shi Liwei Jiang Senyan Zhang Dongli Wang Pei Tong Dongxing Guo Lili Fu Ye Cui Xi Liu Kelly C Arledge Ying-Hua Chen Linqi Zhang Xinquan Wang | 2013 | Cell Research2013，23，8： | 26 |
| 2 | EXPERIMENTAL STUDY OF FLOWFIELD STRUCTURE AROUND AN OGIVE-CYLINDER显示文摘The flowfield structure and their aerodynamic characteristics over an ogive cylinder were studied by means of flow visualization and surface pressure measurement in a water tunnel and a wind tunnel. The existence of multi asymmetric vortices over long slender bodies was experimentally confirmed at large angles of attack and in the subcritical Reynolds number range. The spatial 3 D characteristics of the multi vortices system were analyzed and a physical model was developed. The topological structure of different patterns in cross flow plane was studied and the mechanism governing the formation of asymmetric vortices and multi vortices was discussed from the viewpoint of stability of the topological structure. It was concluded that the maximum in the sectional side force distribution curve are not caused by the shedding of higher position vortex, but by the cross over to the symmetric plane of the lower position vortex. | Ph.D.Candidate:Wang Gang Fluid Mechanics Institute, Beijing University of Aeronautics and Astronautics, Beijing 100083, China,Supervisor: Deng Xue ying (Beijing University of Aeronautics and Astronautics) Members of Dissertation Defense Committee: Tong Bing gang (Graduate School of the Chinese Academy of Sciences),Chairman Gu Zhi fu (Peking University) Yang Qi de (China Aerodynamics Research and Development Center) Lv Zhi yong (Beijing University of Aeronautics and Astronautics) Liu Pei qing (Beijing University of Aeronautics and Astronautics) | 2003 | Journal of Hydrodynamics2003，15，5： | 18 |
| 3 | Oral berberine improves brain dopa/dopamine levels to ameliorate Parkinson’s disease by regulating gut microbiota显示文摘The phenylalanine-tyrosine-dopa-dopamine pathway provides dopamine to the brain.Iin this process,tyrosine hydroxylase(TH)isthe rate-limiting enzyme that hydroxylates tyrosine and generates levodopa(L-dopa)with tetranydrobiopterin(BH_(4))as a coenzyme.Here,we show that oral berberine(BBR)might supply H^(·) through dihydroberberine(reduced BBR produced by bacterial nitroreductase)and promote the production of BHl from dihydrobiopterin;the increased BH,enhances TH activity,which accelerates the production of L-dopa by the gut bacteria.Oral BBR acts in a way similar to vitamins.The L-dopa produced by theintestinal bacteria enters the brain through the circulation and is transformed to dopamine.To verify the gut-brain dialog activatedby BBR's effect,Enterococcus foecalis or Enterococcus faecium was transplanted into Parkinson's disease(PD)mice.The bacteriasignificantly increased brain dopamine and ameliorated PD manifestation in mice;additionally,combination of BBR with bacteriashowed better therapeutic effect than that with bacteria alone.Moreover,2,4,6-trimethy-pyranylium tetrafluoroborate(TMP-TFB)-derivatized matrix-assisted laser desorption mass spectrometry(MALDI-MS)imaging of dopamine identihed elevated striataldopamine levels in mouse brains with oral Enterococcus,and BBR strengthened the imaging intensity of brain dopamine.Theseresults demonstrated that BBR was an agonist of TH in Enterococcus and could lead to the production of L-dopa in the gut.Furthermore,a study of 28 patients with hyperlipidemia conhrmed that oral BBR increased bloodfecal L-dopa by the intestinalbacteria.Hence,BBR might improve the brain function by upregulating the biosynthesis of-dopa in the gut microbiota through avitamin-like effect. | Yan Wang Qian Tong Shu-Rong Ma Zhen-Xiong Zhao Li-Bin Pan Lin Cong Pei Han Ran Peng Hang Yu Yuan Lin Tian-Le Gao Jia-Wen Shou Xiao-Yang Li Xian-Feng Zhang Zheng-Wei Zhang Jie Fu Bao-Ying Wen Jin-Bo Yu Xuetao Cao Jian-Dong Jiang | 2021 | Signal Transduction and Targeted Therapy2021，6，3： | 16 |
| 4 | Effects of ultrasonic vibration on plastic deformation of AZ31 during the tensile process显示文摘An investigation on the plastic behavior of AZ31 magnesium alloy under ultrasonic vibration(with a frequency of 15 kHz and a maximum output of 2 kW) during the process of tension at room temperature was conducted to reveal the volume effect of the vibrated plastic deformation of AZ31.The characteristics of mechanical properties and microstructures of AZ31 under routine and vibrated tensile processes with different amplitudes were compared.It is found that ultrasonic vibration has a remarkable influence on the plastic behavior of AZ31 which can be summarized into two opposite aspects:the softening effect which reduces the flow resistance and improves the plasticity,and the hardening effect which decreases the formability.When a lower amplitude or vibration energy is applied to the tensile sample,the softening effect dominates,leading to a decrease of AZ31 deformation resistance with an increase of formability.Under the application of a high-vibrating amplitude,the hardening effect dominates,resulting in the decline of plasticity and brittle fracture of the samples. | Tong Wen Li Wei Xia Chen Chun-lei Pei | 2011 | International Journal of Minerals,Metallurgy and Materials2011，18，1： | 15 |
| 5 | Removing phosphorus from aqueous solutions by using iron- modified corn straw biochar显示文摘修改铁的玉米稻草 biochar 被用作吸附物把磷从农业流量移开。什么时候有一个总数的农业流量 1.86 mg ī的磷(TP ) | Fenglin LIU Jiane ZUO Tong CHI Pei WANG Bo YANG | 2015 | Frontiers of Environmental Science & Engineering2015，9，6： | 13 |
| 6 | Role of P-selectin and anti-P-selectin monoclonal antibody in apoptosis during hepatic/renal ischemia-reperfusion injury显示文摘AIM To evaluale the potential role of P-selectinand anti-P-selectin monoclonal antibody(mAb)in apoptosis during hepatic/renal ischemia-reperfusion injury.METHODS Plasma P-selectin level,hepatic/renal P-selectin expression and cell apoptosiswere detected in rat model of hepatic/ renalischemia-reperfusion injury.ELISA,immunohist-ochemistry and TUNEL were used.Someischemia-reperfusion rats were treated with anti-P-selectin mAb.RESULTS Hepatic/renal function insuffic-iency,up-regulated expression of P-selectin inplasma and hepatic/renal tissue,hepatic/renalhistopathological damages and cell apoptosiswere found in rats with hepatic/renal ischemia-reperfusion injury,while these changes becameless conspicuous in animals treated with anti-P-selectin mAb.CONCLUSION P-selectin might mediateneutrophil infiltration and cell apoptosis andcontribute to hepatic/renal ischemia-reperfusioninjury,anti-P-selectin mAb might be an efficientapproach for the prevention and treatment ofhepatic/renal ischemia-reperfusion injury. | Pei Wu Xiao Li Tong Zhou Ming Jun Zhang Jin Lian Chen Wei Ming Wang Nan Chen De Chang Dong | 2000 | World Journal of Gastroenterology2000，6，2： | 10 |
| 7 | Numerical simulation for determining three zones in the goaf at a fully-mechanized coal face显示文摘According to the theory of ventilation network, a model for a filtration flow field in goaf was built and simulation soft- ware for determining the three zones in goaf has been developed. This software uses no-gap-connection between Visual Basic (VB) and Excel to exchange data, uses Component Object Model (COM) component of MATLAB to plot charts of the three zones and to export the corresponding coordinates of the isolines. An example shows that this software is convenient and simple. By using it, the three zones can be easily determined. The software is convenient in studies and analyses of the three zones in goaf. | HE Xiao-gang ZHANG Ren-wei PEI Xiao-dong SUN Yong TONG Bo-gen HUANG Hua-shan | 2008 | Journal of China University of Mining and Technology2008，18，2： | 10 |
| 8 | The role played by traditional Chinese medicine in preventing and treating COVID-19 in China显示文摘Traditional Chinese medicine(TCM),an ancient system of alternative medicine,played an active role in the prevention and control of COVID-19 in China.It improved the clinical symptoms of patients,reduced the mortality rate,improved the recovery rate,and effectively relieved the operating pressure on the national medical system during critical conditions.In light of the current global pandemic,TCM-related measures might open up a new channel in the control of COVID-19 in other countries and regions.Here,we summarize the TCM-related measures that were widely used in China,including TCM guidelines,the Wuchang pattern,mobile cabin hospitals,integrated treatment of TCM and modern medicine for critical patients,and non-medicine therapy for convalescent patients,and describe how TCM effectively treated patients afflicted with the COVID-19.Effective TCM therapies could,therefore,be recommended and practiced based on the existing medical evidence from increased scientific studies. | Qingwei Li Han Wang Xiuyang Li Yujiao Zheng Yu Wei Pei Zhang Qiyou Ding Jiaran Lin Shuang Tang Yikun Zhao Linhua Zhao Xiaolin Tong | 2020 | Frontiers of Medicine2020，14，5： | 10 |
| 9 | U–Pb Zircon Geochronology and Geochemistry of the Neoproterozoic Liujiaping Group Volcanics in the Northwest Margin of the Yangtze Block:Implications For the Breakup of the Rodinia Supercontinent显示文摘Investigation of the petrogenesis and the origin of zircons from the volcanic rocks of the Liujiaping Group of the back-Longmenshan tectonic belt in the northwest margin of the Yangtze Block is conducted by analysis of U–Pb geochronology and geochemistry. Results show that selected zircons are characterized by internal oscillatory zonings and high Th/U ratios(0.43–1.18), indicating an igneous origin. Geochronological results of LA–ICP–MS U–Pb dating of the Liujiaping Group zircons yield an age of 809 ± 11 Ma(MSWD = 2.2), implying that the volcanic rocks were formed in the Late Neoproterozoic. Geochemical analysis shows that the rocks are calc-alkaline, supersaturated in Al, and metaluminous to weakly peraluminous. Rare-earth elements are present at high concentrations(96.04–265.48 ppm) and show a rightward incline and a moderately negative Eu anomaly, similar to that of continental rift rhyolite. Trace element geochemistry is characterized by evident negative anomalies of Nb, Ta, P, Th, Ti, inter alia, and strong negative anomalies of K, Rb, Sr, et al. We conclude that the Liujiaping Group volcanic rocks resulted from typical continental crust source petrogenesis and were formed in a continental margin setting, which had no relation to subduction, and thus, were the products of partial melting of the lower crust due to crustal thickening caused by active continental margin subduction and arc–continent collision orogeny in the northwestern Yangtze Block and were triggered by the breakup of the Rodinia supercontinent during the Neoproterozoic. | LI Zuochen PEI Xianzhi LI Ruibao PEI Lei LIU Chengjun CHEN Youxin XU Tong YANG Jie WEI Bo | 2015 | Acta Geologica Sinica(English Edition)2015，89，4： | 8 |
| 10 | Comparison of result judgment algorithm of test for interfering factors in the bacterial endotoxins test among Chinese, Japanese, European, American, and Indian pharmacopeias显示文摘 | Pei Yusheng Cai Tong Gao Hua Tan Dejiang Zhang Yuchen Zhang Guolai | 2014 | Chinese Medical Journal2014，，15： | 7 |
| 11 | Berberine treats atherosclerosis via a vitamine-like effect downregulating Choline-TMA-TMAO production pathway in gut microbiota显示文摘Trimethylamine-N-oxide(TMAO)derived from the gut microbiota is an atherogenic metabolite.This study investigates whether or not berberine(BBR)could reduce TMAO production in the gut microbiota and treat atherosclerosis.Effects of BBR on TMAO production in the gut microbiota,as well as on plaque development in atherosclerosis were investigated in the culture of animal intestinal bacterial,HFD-fed animals and atherosclerotic patients,respectively.We found that oral BBR in animals lowers TMAO biosynthesis in intestine through interacting with the enzyme/co-enzyme of choline-trimethylamine lyase(CutC)and flavincontaining monooxygenase(FMO)in the gut microbiota.This action was performed by BBR’s metabolite dihydroberberine(a reductive BBR by nitroreductase in the gut microbiota),via a vitamine-like effect down-regulating Choline-TMA-TMAO production pathway.Oral BBR decreased TMAO production in animal intestine,lowered blood TMAO and interrupted plaque formation in blood vessels in the HFD-fed hamsters.Moreover,21 patients with atherosclerosis exhibited the average decrease of plaque score by 3.2%after oral BBR(0.5 g,bid)for 4 months(^(*)P<0.05,n=21);whereas the plaque score in patients treated with rosuvastatin plus aspirin,or clopidogrel sulfate or ticagrelor(4 months,n=12)increased by 1.9%.TMA and TMAO in patients decreased by 38 and 29%in faeces(^(*)P<0.05;^(*)P<0.05),and 37 and 35%in plasma(^(***)P<0.001;^(*)P<0.05),after 4 months on BBR.BBR might treat atherosclerotic plaque at least partially through decreasing TMAO in a mode of action similar to that of vitamins. | Shu-Rong Ma Qian Tong Yuan Lin Li-Bin Pan Jie Fu Ran Peng Xian-Feng Zhang Zhen-Xiong Zhao Yang Li Jin-Bo Yu Lin Cong Pei Han Zheng-Wei Zhang Hang Yu Yan Wang Jian-Dong Jiang | 2022 | Signal Transduction and Targeted Therapy2022，7，8： | 6 |
| 12 | Geochronology, Geochemistry and Tectonic Setting of the Bairiqiete Granodiorite Intrusion(Rock Mass) from the Buqingshan Tectonic Mélange Belt in the Southern Margin of East Kunlun显示文摘This study focuses on the zircon U–Pb geochronology and geochemistry of the Bairiqiete granodiorite intrusion(rock mass) from the Buqingshan tectonic mélange belt in the southern margin of East Kunlun. The results show that the zircons are characterized by internal oscillatory zoning and high Th/U(0.14–0.80), indicative of an igneous origin. LA–ICP–MS U–Pb dating of zircons from the Bairiqiete granodiorite yielded an age of 439.0 ± 1.9 Ma(MSWD = 0.34), implying that the Bairiqiete granodiorite formed in the early Silurian. Geochemical analyses show that the rocks are medium-K calc-alkaline, relatively high in Al2O3(14.57–18.34 wt%) and metaluminous to weakly peraluminous. Rare-earth elements have low concentrations(45.49–168.31 ppm) and incline rightward with weak negative to weak positive Eu anomalies(δEu = 0.64–1.34). Trace-element geochemistry is characterized by negative anomalies of Nb, Ta, Zr, Hf and Ti and positive anomalies of Rb, Th and Ba. Moreover, the rocks have similar geochemical features with adakites. The Bairiqiete granodiorite appears to have a continental crust source and formed in a subduction-related island-arc setting. The Bairiqiete granodiorite was formed due to partial melting of the lower crust and suggests subduction in the Buqingshan area of the Proto-Tethys Ocean. | LI Zuochen PEI Xianzhi LI Ruibao PEI Lei LIU Chengjun CHEN Youxin LIU Zhanqing CHEN Guochao XU Tong YANG Jie WEI Bo | 2014 | Acta Geologica Sinica(English Edition)2014，88，2： | 5 |
| 13 | Coriander Genomics Database:a genomic,transcriptomic,and metabolic database for coriander显示文摘Coriander(Coriandrum sativum L.),also known as cilantro,is a globally important vegetable and spice crop.Its genome and that of carrot are models for studying the evolution of the Apiaceae family.Here,we developed the Coriander Genomics Database(CGDB,http://gffzzc8ce0bd092c048a1hx5b9bxx0unxn6qf5.ffgz.tsg.suse.edu.cn/)to collect,store,and integrate the genomic,transcriptomic,metabolic,functional annotation,and repeat sequence data of coriander and carrot to serve as a central online platform for Apiaceae and other related plants.Using these data sets in the CGDB,we intriguingly found that seven transcription factor(TF)families showed significantly greater numbers of members in the coriander genome than in the carrot genome.The highest ratio of the numbers of MADS TFs between coriander and carrot reached 3.15,followed by those for tubby protein(TUB)and heat shock factors.As a demonstration of CGDB applications,we identified 17 TUB family genes and conducted systematic comparative and evolutionary analyses.RNA-seq data deposited in the CGDB also suggest dose compensation effects of gene expression in coriander.CGDB allows bulk downloading,significance searches,genome browser analyses,and BLAST searches for comparisons between coriander and other plants regarding genomics,gene families,gene collinearity,gene expression,and the metabolome.A detailed user manual and contact information are also available to provide support to the scientific research community and address scientific questions.CGDB will be continuously updated,and new data will be integrated for comparative and functional genomic analysis in Apiaceae and other related plants. | Xiaoming Song Fulei Nie Wei Chen Xiao Ma Ke Gong Qihang Yang Jinpeng Wang Nan Li Pengchuan Sun Qiaoying Pei Tong Yu Jingjing Hu Xinyu Li Tong Wu Shuyan Feng Xiu-Qing Li Xiyin Wang | 2020 | Horticulture Research2020，7，1： | 4 |
| 14 | Outbreaks of Acute Respiratory Disease Associated with Human Adenovirus Infection in Closed Camps,China,December 2011–March 2014显示文摘Summary What is already known on this topic?Human adenovirus(HAdV)was frequently associated with acute respiratory disease(ARD)outbreaks in military camps.What is added by this report?HAdV-B7,HAdV-B14,and HAdV-B55 were determined to be responsible for 3,2,and 4 ARD outbreaks in military camps,China,respectively,with a total attack rate of 28.0%during 2011 to 2014. | Juan Du Xiaodong Zhao Fang Tang Doudou Huang Guangqian Pei Xiaoai Zhang Baogui Jiang Qingbin Lu Wei Liu Yigang Tong | 2021 | China CDC weekly2021，3，38： | 4 |
| 15 | Preferential gene retention increases the robustness of cold regulation in Brassicaceae and other plants after polyploidization显示文摘Cold stress profoundly affects plant growth and development and is a key factor affecting the geographic distribution and evolution of plants.Plants have evolved adaptive mechanisms to cope with cold stress.Here,through the genomic analysis of Arabidopsis,three Brassica species and 17 other representative species,we found that both cold-related genes(CRGs)and their collinearity were preferentially retained after polyploidization followed by genome instability,while genome-wide gene sets exhibited a variety of other expansion mechanisms.The coldrelated regulatory network was increased in Brassicaceae genomes,which were recursively affected by polyploidization.By combining our findings regarding the selective retention of CRGs from this ecological genomics study with the available knowledge of cold-induced chromosome doubling,we hypothesize that cold stress may have contributed to the success of polyploid plants through both increasing polyploidization and selectively maintaining CRGs during evolution.This hypothesis requires further biological and ecological exploration to obtain solid supporting evidence,which will potentially contribute to understanding the generation of polyploids and to the field of ecological genomics. | Xiao-Ming Song Jin-Peng Wang Peng-Chuan Sun Xiao Ma Qi-Hang Yang Jing-Jing Hu Sang-Rong Sun Yu-Xian Li Ji-Gao Yu Shu-Yan Feng Qiao-Ying Pei Tong Yu Nan-Shan Yang Yin-Zhe Liu Xiu-Qing Li Andrew H.Paterson Xi-Yin Wang | 2020 | Horticulture Research2020，7，1： | 4 |
| 16 | Arbitrary cylindrical vector beam generation enabled by polarization-selective Gouy phase shifter显示文摘Cylindrical vector beams(CVBs),which possess polarization distribution of rotational symmetry on the transverse plane,can be developed in many optical technologies.Conventional methods to generate CVBs contain redundant interferometers or need to switch among diverse elements,thus being inconvenient in applications containing multiple CVBs.Here we provide a passive polarization-selective device to substitute interferometers and simplify generation setup.It is accomplished by reversing topological charges of orbital angular momentum based on a polarization-selective Gouy phase.In the process,tunable input light is the only condition to generate a CVB with arbitrary topological charges.To cover both azimuthal and radial parameters of CVBs,we express the mapping between scalar Laguerre–Gaussian light on a basic Poincaré sphere and CVB on a high-order Poincaré sphere.The proposed device simplifies the generation of CVBs enormously and thus has potential in integrated devices for both quantum and classic optical experiments. | JUNLIANG JIA KEPENG ZHANG GUANGWEI HU MAPING HU TONG TONG QUANQUAN MU HONG GAO FULI LI CHENG-WEI QIU PEI ZHANG | 2021 | Photonics Research2021，9，6： | 4 |
| 17 | High-throughput sequencing exclusively identified a novel Torque teno virus genotype in serum of a patient with fatal fever显示文摘Torque teno virus(TTV) has been found to be prevalent world-wide in healthy populations and in patients with various diseases, but its etiological role has not yet been determined. Using high-throughput unbiased sequencing to screen for viruses in the serum of a patient with persistent high fever who died of suspected viral infection and prolonged weakness, we identified the complete genome sequence of a TTV(isolate Hebei-1). The genome of TTV-Hebei-1 is 3649 bp in length, encoding four putative open reading frames, and it has a G+C content of 49%. Genomic comparison and a BLASTN search revealed that the assembled genome of TTV-Hebei-1 represented a novel isolate, with a genome sequence that was highly heterologous to the sequences of other reported TTV strains. A phylogenetic tree constructed using the complete genome sequence showed that TTV-Hebei-1 and an uncharacterized Taiwan Residents strain, TW53A37, constitute a new TTV genotype. The patient was strongly suspected of carrying a viral infection and died eventually without any other possible causes being apparent. No virus other than the novel TTV was identified in his serum sample. Although a direct causal link between the novel TTV genotype infection and the patient's disease could not be confirmed, the findings suggest that surveillance of this novel TTV genotype is necessary and that its role in disease deserves to be explored. | Zhiqiang Mi Xin Yuan Guangqian Pei Wei Wang Xiaoping An Zhiyi Zhang Yong Huang Fan Peng Shasha Li Changqing Bai Yigang Tong | 2014 | Virologica Sinica2014，29，2： | 4 |
| 18 | A novel mosquito-borne reassortant orbivirus isolated from Xishuangbanna,China显示文摘Dear Editor,The genus Orbivirus,within the family Reoviridae,includes 22 virus species(King et al.,2011).They are distributed globally,but are particularly prevalent in Europe,Asia,and Africa.In addition,they can be transmitted by ticks or other hematophagous insect vectors,including Culicoides,mosquitoes,and sandflies(Belaga- | Shaozhen Xing Xiaofang Guo Xianglilan Zhang Qiumin Zhao Lingli Li Shuqing Zuo Xiaoping An Guangqian Pei Qiang Sun Shi Cheng Yunfei Wang Hang Fan Zhiqiang Mi Yong Huang Zhiyi Zhang Hongning Zhou Jiusong Zhang Yigang Tong | 2017 | Virologica Sinica2017，32，2： | 4 |
| 19 | Sex-specific and Dose-response Relationship between the Incidence of Gallstones and Components of the Metabolic Syndrome in Jinchang Cohort:A Prospective Study显示文摘Gallstones is a very common gastrointestinal disease,involving the formation of masses in the gall bladder or biliary tract,due to abnormally high concentrations of cholesterol or bilirubin in the bile[1].There is a 10%–20%prevalence of gallstones worldwide,and>20%of patients with gallstones show clinical symptoms,implying a substantial disease burden[1]. | YANG Jing Li HUANG Jun Jun CHENG Ning ZHANG De Sheng LIU Si Min HUANG Wen Ya LI Na HUANG Pei Yao DING Jiao LIU Nian BAO Kai Fang DING Jie CHEN Xiao Liang ZHENG Tong Zhang BAI Ya Na | 2020 | Biomedical and Environmental Sciences2020，33，8： | 4 |
| 20 | Synthesis and biological evaluation of novel N-(alkoxyphenyl)-aminocarbonylbenzoic acid derivatives as PTP1B inhibitors显示文摘基于 petroselinic 酸看了好禁止的活动的事实(IC50 = 6.99 mol/L ) 对在 vitro 的蛋白质酷氨酸 phophatase 1B (PTP1B ) ,一系列新奇的 N-(alkoxyphenyl )-aminocarbonylbenzoic 酸衍生物被设计并且综合。结果显示大多数衍生物对 PTP1B 显示出更多的有势力活动。特别,在 vitro 与 106 nmol/L 的 IC50 加重 13 举办明显的活动。 | Yuan Feng Tong Pei Zhang Feng Chen Ling Hua Hao Fei Ye Jin Ying Tian Song Wu | 2010 | Chinese Chemical Letters2010，21，12： | 4 |
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