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| 1 | Impact of land use conversion on soil organic carbon stocks in an agro-pastoral ecotone of Inner Mongolia显示文摘Soil organic carbon(SOC) stocks in terrestrial ecosystems vary considerably with land use types. Grassland, forest, and cropland coexist in the agro-pastoral ecotone of Inner Mongolia, China. Using SOC data compiled from literature and field investigations, this study compared SOC stocks and their vertical distributions among three types of ecosystems. The results indicate that grassland had the largest SOC stock, which was 1.5-and 1.8-folds more than stocks in forest and cropland, respectively. Relative to the stock in 0–100 cm depth, grassland held more than 40% of its SOC stock in the upper 20 cm soil layer; forest and cropland both held over 30% of their respective SOC stocks in the upper 20 cm soil layer. SOC stocks in grazed grasslands were remarkably promoted after ≥20 years of grazing exclusion. Conservational cultivation substantially increased the SOC stocks in cropland, especially in the 0–40 cm depth. Stand ages, tree species, and forest types did not have obvious impacts on forest SOC stocks in the study area likely due to the younger stand ages. Our study implies that soil carbon loss should be taken into account during the implementation of ecological projects, such as reclamation and afforestation, in the arid and semi-arid regions of China. | ZHAO Wei HU Zhongmin LI Shenggong GUO Qun YANG Hao ZHANG Tonghui | 2017 | Journal of Geographical Sciences2017，27，8： | 8 |
| 2 | Expression of aquaporin-1 in SMMC-7221 liver carcinoma cells promotes cell migration显示文摘Migration of tumor cells is a crucial step in tumor invasion and metastasis. Here we provide evidence that aquaporin expression is involved in tumor cell migration. RT-PCR, immunofluorescence and Western blot analysis demonstrated the AQP1 protein expression on the plasma membrane of SMMC-7221 human hepatoma cells. SMMC-7221 cell clones with high (SMMC-7221hPf) and low (SMMC-7221lPf) water permeability were identified by functional assays with corresponding high and low AQP1 expression. Cell migration rate was remarka- bly higher in SMMC-7221hPf cells than SMMC-7221l Pf cells, assessed by Boyden chamber and wound healing assays, whereas cell growth and adhesion were not different. Adenovirus-mediated AQP1 ex- pression in SMMC-7221lPf cells increased their water permeability and migration rate. These results pro- vide the first evidence that aquaporin-mediated membrane water permeability enhances tumor cell migration and may be associated with tumor invasion and metastasis. | LI Yongming FENG Xuechao YANG Hong MA Tonghui | 2006 | Chinese Science Bulletin2006，51，20： | 5 |
| 3 | Nuclear Aurora kinase A switches m^(6)A reader YTHDC1 to enhance an oncogenic RNA splicing of tumor suppressor RBM4显示文摘Aberrant RNA splicing produces alternative isoforms of genes to facilitate tumor progression,yet how this process is regulated by oncogenic signal remains largely unknown.Here,we unveil that non-canonical activation of nuclear AURKA promotes an oncogenic RNA splicing of tumor suppressor RBM4 directed by m^(6)A reader YTHDC1 in lung cancer.Nuclear translocation of AURKA is a prerequisite for RNA aberrant splicing,specifically triggering RBM4 splicing from the full isoform(RBM4-FL)to the short isoform(RBM4-S)in a kinase-independent manner. | SiSi Li YangFan Qi JiaChuan Yu YuChao Hao Bin He MengJuan Zhang ZhenWei Dai TongHui Jiang SuYi Li Fang Huang Ning Chen Jing Wang MengYing Yang DaPeng Liang Fan An JinYao Zhao WenJun Fan YuJia Pan ZiQian Deng YuanYuan Luo Tao Guo Fei Peng ZhiJie Hou ChunLi Wang FeiMeng Zheng LingZhi Xu Jie Xu QingPing Wen BiLian Jin Yang Wang Quentin Liu | 2022 | Signal Transduction and Targeted Therapy2022，7，5： | 4 |
| 4 | Cytotoxic effect of evodiamine in SGC-7901 human gastric adenocarcinomacells via simultaneous induction of apoptosis and autophagy显示文摘 | Azhar Rasul Bo Yu Lili Zhong Muhammad Khan Hong Yang Tonghui Ma | 2012 | Oncology Reports2012，，5： | 1 |
| 5 | Cytotoxic effect of evodiamine in SGC-7901 human gastric adenocarcinomacells via simultaneous induction of apoptosis and autophagy显示文摘 | Azhar Rasul Bo Yu Lili Zhong Muhammad Khan Hong Yang Tonghui Ma | 2012 | Oncology Reports2012，，5： | 1 |
| 6 | Fourfold reduction of water permeability in inner medullary collecting duct of aquaporin-4 knockout mice显示文摘 | CHOU C L MA Tonghui YANG Baoxue | | 0，，： | 1 |
| 7 | A mechanism for the origin and development of the large-scale dunefield on the right flank of the lower reach of Laoha River,Northeast China显示文摘By viewing satellite imagery, a striking large-scale dunefield can be clearly perceived, with a size of nearly 63 km long and 11 km wide, and trending NE–SW, on the right flank of the lower Laoha River, Northeast China. By means of remote sensing imagery analysis and field observation as well as a comparison with a small-scale dunefield on the right flank of the lower Xiangshui River, analogous to the case of the lower Laoha River, this paper presents a new mechanism for its origin and development. The results show that:(1) the large-scale dunefield bears a tile-style framework overwhelmingly composed of transverse barchanoid ridges perpendicular to the predominant winds, and inlaid diverse blowouts.(2) The small-scale dunefield, referred to as a primary structural unit of the large one, is typical of an incipient dunefield, following the same rules of evolution as the larger.(3) A succession of barchanoid ridge chains can steadily migrate downwind in much the same manner as surface wave propagation in air or water stimulated by an incised valley, and ultimately tend to bear roughly the same wavelength and amplitude under stable climate and hydrologic regimes.(4) The first ridge chain acquires its sand source substantially from the downwind escarpments exposing the loose Quaternary sandy sediments to the air, while the ensuing ridges derive their sands dominantly from in situ deflation of the underlain Quaternary loose sandy sediments in blowouts, partly from the upwind ridges through northern elongated horns. Theoretically, the sands from riparian escarpments can be transported by wind to the downwind distal end of a dunefield after sufficient long duration.(5) The lower Laohahe region experienced probably three significant climatic changes in the past, corresponding to the three active dune belts, suggesting that once a large-scale dunefield occurs, it is nearly impossible to be completely stabilized, at least in its central portions. At present, seasonal shrinkage and stagnation of the lower Laoha River, widespread farming and afforestation in the valley, and establishing windbreaks downwind of the valley as well as surrounding the dunefield, appear to have significantly modified local flow fields and sand sources, engendering significant degradation of the dunefield. | Guang Han GuiFang Zhang Li You Liang Zhou Lin Yang XueYong Zhao YuLin Li TongHui Zhang | 2015 | Research in Cold and Arid Regions2015，7，1： | 1 |
| 8 | Cytotoxic effect of evodiamine in SGC-7901 human gastric adenocarcinomacells via simultaneous induction of apoptosis and autophagy显示文摘 | Azhar Rasul Bo Yu Lili Zhong Muhammad Khan Hong Yang Tonghui Ma | 2012 | Oncology Reports2012，，5： | 1 |
| 9 | AtMAC stabilizes the phragmoplast by crosslinking microtubules and actin filaments during cytokinesis显示文摘The phragmoplast,a structure crucial for the completion of cytokinesis in plant cells,is composed of antiparallel microtubules(MTs)and actin filaments(AFs).However,how the parallel structure of phragmoplast MTs and AFs is maintained,especially during centrifugal phragmoplast expansion,remains elusive.Here,we analyzed a new Arabidopsis thaliana MT and AF crosslinking protein(AtMAC).When AtMAC was deleted,the phragmoplast showed disintegrity during centrifugal expansion,and the resulting phragmoplast fragmentation led to incomplete cell plates.Overexpression of AtMAC increased the resistance of phragmoplasts to depolymerization and caused the formation of additional phragmoplasts during cytokinesis.Biochemical experiments showed that AtMAC crosslinked MTs and AFs in vitro,and the truncated AtMAC protein,N-CC1,was the key domain controlling the ability of AtMAC.Further analysis showed that N-CC1(51–154)is the key domain for binding MTs,and N-CC1(51–125)for binding AFs.In conclusion,AtMAC is the novel MT and AF crosslinking protein found to be involved in regulation of phragmoplast organization during centrifugal phragmoplast expansion,which is required for complete cytokinesis. | Pingzhou Du Yu Liu Lu Deng Dong Qian Xiuhua Xue Ting Yang Tonghui Li Yun Xiang Haiyun Ren | 2023 | Journal of Integrative Plant Biology2023，65，8： | 0 |
| 10 | Characteristics of TP53 germline variants and their correlations with Li-Fraumeni syndrome or Li-Fraumeni-like syndrome in Chinese tumor patients显示文摘Li-Fraumeni syndrome(LFS),a rare autosomal-dominant inheritance condition,is associated with a family cancer history as well as pathogenic/likely-pathogenic TP53 germline variants(P/LP TP53 GV).The current clinical methods for detecting LFS are limited.Here,we retrospectively investigate P/LP TP53 GV among Chinese cancer patients by next-generation sequencing and evaluate its relationship with a family cancer history.A total of 270 out of 19,226 cancer patients have TP53 GV,including 53 patients with P/LP TP53 GV.Patients with P/LP TP53 GV are mainly found in male with glioma,lung cancer or sarcoma.The median age of diagnosis for P/LP TP53 GV patients is significantly lower than that of non-P/LP TP53 GV patients(31-years vs.53-years;P<0.01).One LFS patient and 3 Li-Fraumeni-like syndrome(LFL)patients are among the 26 followed-up P/LP TP53 GV patients.Among 25 types of P/LP TP53 GV,the highest variant frequencies occurred at codon 175 and 248.p.M237 I,p.R158 H,p.C238 Y and p.C275 R,are firstly identified among the Chinese LFS/LFL patients.This study reports the(P/LP)TP53 GV characteristics of Chinese pan-cancer patients.These findings suggest analyzing the P/LP TP53 GV in cancer patients is an effective strategy for identifying cancer predisposition syndrome. | Panwen Tian Xiaoyan Zhang Sheng Yang Yu Fang Hongling Yuan Wei Li Honglin Zhu Fangping Zhao Jinlei Ding Yunshu Zhu Sizhen Wang Guochen Sun Hongbin Ni Tonghui Ma Ting Lei | 2022 | Journal of Genetics and Genomics2022，49，7： | 0 |
| 11 | How could N-methyl-D-aspartate receptor antagonists lead to excitation instead of inhibition?显示文摘N-methyl-D-aspartate receptors(NMDARs) are a family of ionotropic glutamate receptors mainly known to mediate excitatory synaptic transmission and plasticity. Interestingly, low-dose NMDAR antagonists lead to increased, instead of decreased, functional connectivity;and they could cause schizophrenia-and/or antidepressant-like behavior in both humans and rodents. In addition, human genetic evidences indicate that NMDAR loss of function mutations underlie certain forms of epilepsy, a disease featured with abnormal brain hyperactivity. Together, they all suggest that under certain conditions,NMDAR activation actually lead to inhibition, but not excitation,of the global neuronal network. Apparently, these phenomena are rather counterintuitive to the receptor's basic role in mediating excitatory synaptic transmission. How could it happen? Recently, this has become a crucial question in order to fully understand the complexity of NMDAR function, particularly in disease. Over the past decades, different theories have been proposed to address this question. These include theories of 'NMDARs on inhibitory neurons are more sensitive to antagonism', or 'basal NMDAR activity actually inhibits excitatory synapse', etc. Our review summarizes these efforts, and also provides an introduction of NMDARs,inhibitory neurons, and their relationships with the related diseases.Advances in the development of novel NMDAR pharmacological tools, particularly positive allosteric modulators, are also included to provide insights into potential intervention strategies. | Tonghui Su Yi Lu Yang Geng Wei Lu Yelin Chen | 2018 | Translational Neuroscience and Clinics2018，4，2： | 0 |
| 12 | Theoretical analysis of the elastic Kelvin-Helmholtz instability in explosive weldings显示文摘By considering the joint effects of the Kelvin-Helmholtz(KH) and Rayleigh-Taylor(RT) instabilities, this paper presents an interpretation of the wavy patterns that occur in explosive welding. It is assumed that the elasticity of the material at the interface effectively determines the wavelength, because explosive welding is basically a solid-state welding process. To this end, an analytical model of elastic hydrodynamic instabilities is proposed, and the most unstable mode is selected in the solid phase. Similar approaches have been widely used to study the interfacial behavior of solid metals in high-energy-density physics. By comparing the experimental and theoretical results, it is concluded that thermal softening,which significantly reduces the shear modulus, is necessary and sufficient for successful welding. The thermal softening is verified by theoretical analysis of the increase in temperature due to the impacting and sliding of the flyer and base plates, and some experimental observations are qualitatively validated.In summary, the combined effect of the KH and RT instabilities in solids determines the wavy morphology, and our theoretical results are in good qualitative agreement with experimental and numerical observations. | Yuanbo Sun Jianning Gou Cheng Wang Qiang Zhou Rui Liu Pengwan Chen Tonghui Yang Xiang Zhao | 2024 | Defence Technology(防务技术)2024，32，2： | 0 |
| 13 | Toward Establishing a Low-cost UAV Coordinated Carbon Observation Network(LUCCN):First Integrated Campaign in China显示文摘In this study,we introduce our newly developed measurement-fed-perception self-adaption Low-cost UAV Coordinated Carbon Observation Network(LUCCN)prototype.The LUCCN primarily consists of two categories of instruments,including ground-based and UAV-based in-situ measurement.We use the GMP343,a low-cost non-dispersive infrared sensor,in both ground-based and UAV-based instruments.The first integrated measurement campaign took place in Shenzhen,China,4 May 2023.During the campaign,we found that LUCCN’s UAV component presented significant data-collecting advantages over its ground-based counterpart owing to the relatively high altitudes of the point emission sources,which was especially obvious at a gas power plant in Shenzhen.The emission flux was calculated by a crosssectional flux(CSF)method,the results of which differed from the Open-Data Inventory for Anthropogenic Carbon dioxide(ODIAC).The CSF result was slightly larger than others because of the low sampling rate of the whole emission cross section.The LUCCN system will be applied in future carbon monitoring campaigns to increase the spatiotemporal coverage of carbon emission information,especially in scenarios involving the detection of smaller-scale,rapidly varying sources and sinks. | Dongxu YANG Tonghui ZHAO Lu YAO Dong GUO Meng FAN Xiaoyu REN Mingge LI Kai WU Jing WANG Zhaonan CAI Sisi WANG Jiaxu GUO Liangfu CHEN Yi LIU | 2024 | Advances in Atmospheric Sciences2024，41，1： | 0 |
| 14 | Synergetic N-doped carbon with MoPd alloy for robust oxygen reduction reaction显示文摘Synergistic catalysis opens up a new venue to improve the comprehensive application of the catalyst.Herein,a composite catalyst(Mo-Pd@N-C)consisting of the N-doped carbon derived from pyrolysis of spherical polypyrrole and MoPd nanoparticles(NPs)was constructed to emphasize the strong metal-support interaction for robust oxygen reduction reaction(ORR).The enhanced anchoring between the MoPd NPs and the substrate,and the N-species formed on the carbon matrix make the Mo-Pd@N-C deliver excellent performance with a half-wave potential of 0.945 V(vs.reversible hydrogen electrode(RHE))for ORR,superior than that of commercial Pt/C(0.86 V).More importantly,it shows a negligible half-wave potential decline(<5 mV)and only~20%of mass activity(MA)attenuation after 30,000 cycles stability test,obviously better than those of Pt/C(~70%of MA attenuation and~30 mV of half-wave potential decline after only 15,000 cycles).This work highlights a novel synergistic method to prolong the life and improve the commercial prospects of the catalysts. | Chaojie Cen Wenjing Tang Tonghui Zhao Yun Song Yun Yang Quanlong Xu Wei Chen | 2023 | Nano Research2023，16，7： | 0 |
| 15 | Progress in studies of angio-statin and its anti-tumor effects显示文摘Angiostatin is a 38 ku circulating angiogenesis inhibitor purified from the serum and urine of mice bearing a murine Lewis lung carcinoma. It is regarded as an internal fragment of plasminogen containing the first 4 Kringle structures. In vitro, angiostatin specifically inhibits endothe-lial cell proliferation. In vivo, it inhibits angiogenesis and suppresses the growth of such primary tumors as Lewis lung carcinoma and hemangioendotheliolma in mice. | Hong Yang Yin Wu Yuxin Li Tonghui Ma Baiqu Huang | 2001 | Chinese Science Bulletin2001，46，6： | 0 |
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