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| 1 | Radioprotective Effect of Lyophyllum Decastes and the Effect on Immunological Functions in Irradiated Mice显示文摘In this study, to explore the radiation protection effects of Lyophyllum Decastes Sing (LDS), a hot distilled-water extract of LDS was orally administered at a dosage of 250mg/kg every other day for a period of 2 weeks in irradiated mice. An automatic blood cell counter was used to measure white blood cells (lymphocytes, monocyte, and granulocytes) one day before X-ray irradiation, and 3 hours, 12 hours, 24 hours, 3 days, 7 days, 15 days and 30 days after irradiation. The Dunnett test was used to examine statistical significance of differences. The peripheral blood cell counts in the Lyophyllum-administered non-irradiation group revealed an increase in the numbers of leukocytes, lymphocytes and monocytes. For 2 Gy whole body radiation, a significant statistical difference was found between the X-ray group and the Lyophyllum plus X-ray group in the numbers of leukocytes, lymphocytes and monocytes. The results suggest that Lyophyllum restrains blood cell-count falling after irradiation, which is probably mediated at least in part by hemopoietic function, and NK and LAK activities seems to play a role in preventing secondary infections associated with irradiation. | Takashi Nakamura Yuka Itokawa Masayuki Tajima Yuuichi Ukawa Kwang-Ho Cho Jung-Sook Choi Torao Ishida Yeunhwa Gu | 2007 | Journal of Traditional Chinese Medicine2007，27，1： | 13 |
| 2 | Effects of Fuscoporia obliqua on Postprandial Glucose Excursion and Endothelial Dysfunction in Type 2 Diabetic Patients显示文摘Postprandial hyperglycemia has been reported to elicit endothelial dysfunction and provoke future cardiovascular complications. A reduction of postprandial blood glucose levels by the glucosidase inhibitor Fuscoporia obliqua was associated with a risk reduction of cardiovascular complications, but the effects of Fuscoporia obliqua on endothelial function have never been elucidated. This study is aimed to assess the efficacy of Fuscoporia obliqua on postprandial metabolic parameters and endothelial function in type 2 diabetic patients. Postprandial peak glucose (14.47±1.27 vs. 8.50±0.53 mmol/liter), plasma glucose excursion (PPGE), and change in the area under the curve (AUC) glucose after a single loading of test meal (total 450 kcal; protein 15.3%; fat 32.3%; carbohydrate 51.4%) were significantly higher in the diet-treated type 2 diabetic patients (n=14) than the age-and sex-matched controls (n=12). The peak forearm blood flow response and total reactive hyperemic flow (flow debt repayment) during reactive hyperemia, indices of resistance artery endothelial function on strain-gauge plethysmography, were unchanged before and after meal loading in the controls. But those of the diabetics were significantly decreased 120 and 240 min after the test meal. A prior administration of Fuscoporia obliqua decreased postprandial peak glucose, PPGE, and AUC glucose. The peak forearm blood flow and flow debt repayment were inversely well correlated with peak glucose, PPGE, and AUC glucose, but not with AUC insulin or the other lipid parameters. Even a single loading of the test meal was shown to impair the endothelial function in type 2 diabetic patients, and the postprandial endothelial dysfunction was improved by a prior use of Fuscoporia obliqua. Fuscoporia obliqua might reduce macrovascular complication by avoiding endothelial injury in postprandial hyperglycemic status. | Toshihiro Maenaka Masami Oshima Yuka Itokawa Takashi Masubuchi Yasuyuki Takagi Jung-Sook Choi Torao Ishida Yeunhwa Gu | 2008 | Journal of Traditional Chinese Medicine2008，28，1： | 4 |
| 3 | A Trial Study of Propranolol and Zhigancao Decoction on the Central Depressant and Anti-osteoporosic Action in Ovariectomized Rats显示文摘Objective: This study was originally designed to observe the effects of propranolol (a β-blocker) and Zhigancao Decoction (炙甘草汤 ZGCD) on bone mass in ovariectomized rats. Methods: Thirty-eight female Sprague-Dawley rats were divided into four groups initially, a sham-operated group (Sham, n=7), a model ovariectomized (OVX) group (Model, n=7), a propranolol group (Pro, n=12) and a ZGCD group (ZGCD, n=12). After 15 weeks of treatment, the expected effects were not found. In order to verify the situations of the experiment, we modified the study by administering calcitonin to a subgroup of the tested Pro and ZGCD rats. Results: The Pro and ZGCD treatments showed decreased heart rate and plasma norepinephrine level, but neither an increased bone mass nor any bone metabolism differences from the model rats were found. However, the OVX-induced bone loss was prevented by the sequent treatment of calcitonin. Conclusions: The results provide no evidence that the β-blocker propranolol may stimulate bone formation, and do not justify its use for clinical treatment of osteoporosis. | Zhang Wenping Masayuki Kanehara Zhang Yanjun Guo Yi Shigeru Urata Hiroyuki Nakazawa Takayasu Murakami Atushi Takeda Torao Ishida | 2008 | Journal of Traditional Chinese Medicine2008，28，1： | 3 |
| 4 | Effect of acupuncture at acupoint of Shenshu (BL 23) on the bones of ovariectomized rats显示文摘OBJECTIVE: To investigate the effect of acupuncture at acupoint of Shenshu(BL 23) in ovariectomized rats and sham-operated rats.METHODS: Female Sprague-Dawley rats were divided into the following four groups(n = 12 each):sham operation only(Sham), sham operation with acupuncture(Sham + ACP), ovariectomy only(OVX), and ovariectomy with acupuncture(OVX +ACP). Operations were performed at the 9 th week of age. Acupuncture of Shenshu(BL 23) was started at the 11 th week of age and conducted 3 times per week until the 26 th week of age.RESULTS: Among ovariectomized rats, the acupuncture-treated rats had significantly lower bodyweights and cross-linked N-telopeptide of type 1 collagen levels in the urine after 3 weeks of acupuncture treatment, higher bone mineral density of the lumbar vertebra after 7 weeks, and smaller trabecular separation of the sixth lumbar vertebra,measured by micro-computed tomography, after17 weeks than control rats. These effects were not observed in sham-operated rats. Blood concentrations of estradiol were significantly higher in the OVX + ACP group than in the untreated group. Acupuncture treatment increased plasma testosterone levels in sham-operated rats, while this increase was not observed in OVX rats.CONCLUSION: Acupuncture of Shenshu(BL 23)prevents bone loss and structural changes by suppressing bone resorption. | Atsushi Takeda Teruhiko Koike Shigeru Urata Torao Ishida Yoshiharu Oshida | 2018 | Journal of Traditional Chinese Medicine2018，38，1： | 2 |
| 5 | Determination of oversulfated chondroitin sulfate and dermatan sulfate impurities in heparin by capillary electrophoresis显示文摘 | SOMSEN G W TAK Y H TORAO J S | 2009 | J Chromatogr A2009，216，18： | 1 |
| 6 | A Practical Use of CFD for Ventilation of Underground Works 显示文摘 | DIEGO I TORNO S TORAO J | 2011 | Tunnelling and Underground Space Technology2011，26，1： | 1 |
| 7 | Association analysis of SLC22A4, SLC22A5 and DLG5 in Japanese patients with Crohn disease显示文摘 | Keiko Yamazaki Masakazu Takazoe Torao Tanaka Toshiki Ichimori Susumu Saito Aritoshi Iida Yoshihiro Onouchi Akira Hata Yusuke Nakamura | 2004 | Journal of Human Genetics2004，，12： | 1 |
| 8 | Effect of gateball practice on bone mineral density in elderly women显示文摘 | Hhoji Miyamoto Toshihiro Ishiko Torao Kitamura | 1999 | Japanese Society of Physical Education1999，44，： | 1 |
| 9 | Association analysis of SLC22A4, SLC22A5 and DLG5 in Japanese patients with Crohn disease显示文摘 | Keiko Yamazaki Masakazu Takazoe Torao Tanaka Toshiki Ichimori Susumu Saito Aritoshi Iida Yoshihiro Onouchi Akira Hata Yusuke Nakamura | 2004 | Journal of Human Genetics2004，，12： | 1 |
| 10 | Effect of Tangzhiqing on glucose and lipid metabolism in genetically type2 diabetes KKAy mice 显示文摘 | Wei Wang Torao Ishida Toshihiro Miura | 2008 | Journal of health science2008，54，2： | 1 |
| 11 | Association analysis of SLC22A4, SLC22A5 and DLG5 in Japanese patients with Crohn disease显示文摘 | Keiko Yamazaki Masakazu Takazoe Torao Tanaka Toshiki Ichimori Susumu Saito Aritoshi Iida Yoshihiro Onouchi Akira Hata Yusuke Nakamura | 2004 | Journal of Human Genetics2004，，12： | 1 |
| 12 | Infartion of supperior cerebellar artery presenting as cerebellar symptoms 显示文摘 | Torao S Sobue G Lzumi M | 1998 | Stroke1998，27，： | 1 |
| 13 | Effects of Chinese Herbal Medicine Based on Hachimi-jio-gan on Osteopenia in Rats显示文摘The effects of Chinese herbal medicines including Hachimi-jio-gan(HJG)and/or Hochu-ekki-to(HET)on osteopenia inrats were investigated.The Chinese herbal medicines were administrated for 8 weeks(7 times/week)starling from 1 weekafter ovariectomy.HJG and Prescription-2(Prsc-2,the prescription based on HJG)showed protective effect on bone loss ofthe vertebrae after ovariectomy.However,Prescription-1(the prescription based on HJG and HE-T)had no effect.Then,wemade osteopenia model in rats by prednisolone and low calcium diet.Prsc-2 and HJG were administrated for 20 weeks withprednisolone.These Chinese remedies showed protective effects for osteopenia,with better indices on bone loss of the limbsthan HJG alone in the osteopenia rats.It can be concluded that Prsc-2 is more effective than HJG for bone loss induced byvarious factors,and the additives in Prsc-2 may enhance the therapeutic effect. | Masayuki Kanehara Takeshi Ogirima Kaori Tano Toshihiro Maenaka Torao Ishida | 2006 | Journal of Traditional Chinese Medicine2006，26，1： | 1 |
| 14 | Association analysis of SLC22A4, SLC22A5 and DLG5 in Japanese patients with Crohn disease显示文摘 | Keiko Yamazaki Masakazu Takazoe Torao Tanaka Toshiki Ichimori Susumu Saito Aritoshi Iida Yoshihiro Onouchi Akira Hata Yusuke Nakamura | 2004 | Journal of Human Genetics2004，，12： | 1 |
| 15 | An Ageusia and Dysosmia Patient Treated by Acupuncture显示文摘 | 张文平 Torao Ishida | 2006 | Chinese Journal of Integrated Traditional and Western Medicine2006，12，1： | 0 |
| 16 | Effects of Propolis on Peripheral White Cells, Antioxidative Activity and Tumor Growth in Irradiated mice显示文摘The effect of continuous water-soluble propolis administration on radioactivity-induced reduction of hemocytes, and the antioxidant and antitumor effects were investigated. Following a 1-week adjustment period, water-soluble propolis was administered intraperitoneally to male ICR mice at a dose of 100 mg/kg every other day for 2 weeks. Following administration, 2 Gy whole-body irradiation was performed and the counts of leukocytes, lymphocytes, and granulocytes and monocytes in the peripheral blood were determined 1, 3, 7, 15 and 30 days after irradiation. In the second experiment, water-soluble propolis was similarly administered to the mice for 2 weeks after a 1-week adjustment period, and 2 Gy whole-body irradiation was performed. The antioxidant effects in hemocytes were then investigated using 2,2’-azobis(2-amidinopropane) dihydrochloride (AAPH), a radical generator. In the third experiment, 1×106 Sarcoma-180 cells were inoculated into the right thigh of mice, which were divided into four groups: control, water-soluble propolis-treated, 6 Gy irradiated and water-soluble propolis-treated + 6 Gy irradiated groups, and changes in tumor size were measured for 20 days. Results show that administration of water-soluble propolis inhibits the reduction of hemocytes caused by whole-body irradiation, enhances antioxidant effects against radioactivity, and inhibits tumor growth. | Takashi Nakamura Yuka Itokawa Kwang-Ho Cho Jung-Sook Choi Ikukatsu Suzuki Toshihoro Miura Torao Ishida Yeunhwa Gu | 2006 | Journal of Traditional Chinese Medicine2006，26，4： | 0 |
| 17 | The More Efficacious Acupoints of Zusanli and Sanyinjiao Than That of Non-acupoints on Bone Mass in Osteopenic显示文摘Objective: To clarify whether the acupoints of Zusanli (ST36) and Sanyinjiao (SP6) have specific actions other than non-acupoints to bone. Methods: Forty Sprague-Dawley female rats were divided into five groups: Sham operated (sham) group; Ovariectomized (OVX, model) group; non-acupuncture group; OVX, needling on Zusanli and Sanyinjiao (Acp-A) group; OVX, needling on the reverse sides of Zusanli and Sanyinjiao (Acp-B) group; OVX, periostineal stimulation on the same height as points of Zusanli and Sanyinjiao (Acp-C) group. The experiment was continued for 23 weeks and then all animals were sacrificied. Results: OVX had a significantly higher body weight and lower bone mineral density (BMD) on the lumbar vertebrae, total femora and tibiae than sham rats, however, Acp-A showed a higher BMD compared with the other OVX groups. On the other hand, bone weights, bone strength and bone morphometry such as trabecular volume, trabecular separation, labeled width and bone formation rate also showed the same improvements in Acp-A as compared to the other OVX rats. Conclusion: The stimulation on Zusanli and Sanyinjiao specifically prevented the development of osteopenic rats compared with non-acupoints. | 张文平 KANEHARA Masayuki 张艳军 于志锋 张国霞 杨幼新 孙玉敏 张建梅 ISHIDA Torao | 2005 | Chinese Journal of Integrated Traditional and Western Medicine2005，11，3： | 0 |
| 18 | Effects of the Chinese Herbal Medicine Based on Hachimi-jio-gan in Male Rats with the Adenine-Induced Osteopenia显示文摘In the adenine-induced renal failure rats, reversibility of renal failure and recovery of bone mineral density (BMD) by discontinuation of adenine-rich diet were reported: We think that the effect to bone metabolism with medication may be able to be evaluated as reinforcement of the BMD recovery. We have so far investigated the Chinese herbal medicine based on Hachimi-jio-gan (HJG) which are more effective than HJG alone. In this study, we investigated the effects of our Chinese herbal prescription on BMD in the adenine-treated rats compared to that of vitamin D3treatment. Young male rats were administrated 100 mg/ml adenine for 8 weeks, and they showed renal failure and bone loss. The adenine-treated rats were divided into the following 3 groups, that is, the group experienced no treatment (control), the group givenour Chinese herbal medicine (HAO), and the group given vitamin D3 (VD3) medication. It is likely that VD3 medication was less effective for increase of the femoral BMD than increase of the spinal BMD. In contrast, HAO was effective for increase of the femoral BMD. The VD3 group showed low deoxypyridinoline (Dpd: bone resorption maker) as compared to the control group.However, the HAO group showed same or slightly high Dpd. It is suggested that VD3 may increase BMD by reduction of bone resorption, while HAO may show effect on BMD by activating bone metabolism. It is indicated that HAO may become a curative medicine for bone loss because of the different target site from vitamin D3. | Takeshi Ogirima Kaori Tano Masayuki Kanehara Ming Gao Xiuyun Wang Yi Guo Yanjun Zhang Liping Guo Torao Ishida | 2005 | Journal of Traditional Chinese Medicine2005，25，3： | 0 |
| 19 | Different frequencies of electroacupuncture and semen coicis decrease glial fibrillary acidic protein expression in rats with hemisection spinal cord injury显示文摘This study established the following groups of rats:a normal group,a sham surgery group,a spinal cord injury model group,a low-frequency electroacupuncture group,a high-frequency electroacupuncture group and a semen coicis group.In all but the normal and sham surgery groups,the left half of T10 was transected.Four hours after model induction,5-Hz and 100-Hz electroacupuncture were used to stimulate the acupoints Huantiao (GB 30),Zusanli (ST 36),Zhiyang (DU 9) and Xuanshu (DU 5),or crude extract from semen coicis was intraperitoneally injected,for 8 consecutive weeks.The results indicated that electroacupuncture stimulation and intraperitoneal injection of semen coicis improved the morphology of spinal cord tissue,promoted the recovery of motion-evoked potentials,suppressed glial fibrillary acidic protein expression,and ameliorated motor function in rats with hemisection spinal cord injury.The effects of high-frequency (100 Hz) electroacupuncture and semen coicis were significant. | Chunguang Hou Zhongzheng Li Yi Guo Yongming Guo Yangyang Liu Chao Wang Ishida Torao | 2011 | Neural Regeneration Research2011，6，24： | 0 |
| 20 | Research on the effect of Histamine in acupuncture显示文摘Objective To observe acupuncture effects, we analyze the function of Histamine on acupoints, and provide evidence for the research on generation mechanism of the acupuncture effects. | Torao Ishida ZHANG Xiu-yu GUO Yi GUO Yong-ming | 2009 | World Journal of Acupuncture-Moxibustion2009，19，2： | 0 |
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