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| 1 | Antibody markers in the diagnosis of inflammatory boweldisease显示文摘Inflammatory bowel disease(IBD), including Crohn's disease and ulcerative colitis, is a chronic intestinal inflammation of unknown etiology. The diagnosis of IBD is based on endoscopic, radiologic and histopathologic criteria. Recently, the search for a noninvasive marker that could augment or replace part of this diagnostic process has become a focus of IBD research. In this review, antibody markers, including microbial antibodies, autoantibodies and peptide antibodies, will be described, focusing on their common features. At present, no single marker with qualities that are satisfactory for the diagnosis and treatment of IBD has been identified, although panels of some antibodies are being evaluated with keen interest. The discovery of novel IBD-specific and sensitive markers is anticipated. Such markers could minimize the use of endoscopic and radiologic examinations and could enable clinicians to implement individualized treatment plans designed to improve the long-term prognosis of patients with IBD. | Keiichi Mitsuyama Mikio Niwa Hidetoshi Takedatsu Hiroshi Yamasaki Kotaro Kuwaki Shinichiro Yoshioka Ryosuke Yamauchi Shuhei Fukunaga Takuji Torimura | 2016 | World Journal of Gastroenterology2016，22，3： | 12 |
| 2 | study to determine guidelines for pediatric colonoscopy显示文摘AIM To investigated characteristics, diagnosis, bowelcleansing preparation, sedation, and colonoscope length and diameter in Japanese pediatric patients receiving total colonoscopy.METHODS The present study evaluated consecutive patients aged ≤ 15 years who had undergone their first colonoscopy in Kurume University between January 2007 and February 2015. Data were retrospectively analyzed. We identified 110 pediatric patients who had undergone colonoscopy that had reached the cecum, allowing the observation of the total colon.RESULTS Hematochezia, abdominal pain, and diarrhea were the most common symptoms. For bowel-cleansing preparation, pediatric patients aged ≤ 12 years were treated with magnesium citrate, and patients aged 13-15 years were treated with polyethylene glycol 4000. For sedation, thiamylal with pentazocine, which has an analgesic effect, was used in patients aged ≤ 6 years, and midazolam with pentazocine was used in patients aged ≥ 7 years. Regarding the choice of endoscope, short and thin endoscopes were selected for younger patients, particularly patients aged ≤ 3 years. Positive diagnoses were made in 78 patients(70.9%). Inflammatory bowel disease(n = 49, 44.5%), including ulcerative colitis(n = 37, 33.6%) and Crohn's disease(n = 12, 10.9%), was the most common diagnosis. CONCLUSION Colonoscopy offers a high diagnostic capability for pediatric patients with gastrointestinal symptoms. The selection of appropriate management the performance of colonoscopy is important in pediatric patients. | Shinichiro Yoshioka Hidetoshi Takedatsu Shuhei Fukunaga Kotaro Kuwaki Hiroshi Yamasaki RyosukeYamauchi Atsushi Mori Hiroshi Kawano Tadahiro Yanagi Tatsuki Mizuochi Kosuke Ushijima Keiichi Mitsuyama Osamu Tsuruta Takuji Torimura | 2017 | World Journal of Gastroenterology2017，23，31： | 10 |
| 3 | Diagnosis of early gastric cancer using narrow band imaging and acetic acid显示文摘AIM: To determine whether the endoscopic findings of depressed-type early gastric cancers(EGCs) could precisely predict the histological type.METHODS: Ninety depressed-type EGCs in 72 patients were macroscopically and histologically identified. We evaluated the microvascular(MV) and mucosal surface(MS) patterns of depressed-type EGCs using magnifying endoscopy(ME) with narrow-band imaging(NBI)(NBI-ME) and ME enhanced by 1.5% acetic acid, respectively. First, depressed-type EGCs were classified according to MV pattern by NBI-ME. Subsequently, EGCs unclassified by MV pattern were classified according to MS pattern by enhanced ME(EME) images obtained from the same angle.RESULTS: We classified the depressed-type EGCs into the following 2 MV patterns using NBI-ME: a fine-network pattern that indicated differentiated adenocarcinoma(25/25, 100%) and a corkscrew pattern that likely indicated undifferentiated adenocarcinoma(18/23, 78.3%). However, 42 of the 90(46.7%) lesions could not be classified into MV patterns by NBI-ME. These unclassified lesions were then evaluated for MS patterns using EME, which classified 33(81.0%) lesions as MS patterns, diagnosed as differentiated adenocarcinoma. As a result, 76 of the 90(84.4%) lesions were matched with histological diagnoses using a combination of NBI-ME and EME.CONCLUSION: A combination of NBI-ME and EME was useful in predicting the histological type of depressedtype EGC. | Ken Matsuo Hidetoshi Takedatsu Michita Mukasa Hiroaki Sumie Hikaru Yoshida Yasutomo Watanabe Jun Akiba Keita Nakahara Osamu Tsuruta Takuji Torimura | 2015 | World Journal of Gastroenterology2015，21，4： | 9 |
| 4 | Clinical characteristics and management of gastric tube cancer with endoscopic submucosal dissection显示文摘AIM:To identify the characteristics of gastric tube cancer(GTC) and the complications associated with endoscopic submucosal dissection(ESD) for GTC.METHODS:Between 2007 and 2012,11 individualswith early gastric cancer in the reconstructed gastric tube after esophagectomy who underwent ESD in this hospital were studied.The characteristics of GTC were identified,and the complications of ESD for GTC were analyzed at three phases:preoperative,intraoperative,and postoperative.RESULTS:A total of 11 consecutive patients with 11 GTCs were selected for this study.All cases underwent en bloc resections by ESD.The median procedure time was 142 min.The average GTC diameter was 26.1 mm,and the average size of the resected lesions was 45.5 mm.The histopathological diagnosis in all cases was a differentiated adenocarcinoma.In the preoperative phase,anastomotic strictures(5/11,45%) and food residues(4/11,36.4%) in the gastric tube were the main complications.In the intraoperative phase,bleeding was observed in 5 cases(45%).The postoperative complications observed were delayed bleeding in 2 cases(18.2%) and stenosis in one case(9.1%).The case with stenosis was successfully treated using endoscopic balloon dilatation.CONCLUSION:Minor complications were frequently observed.However,all GTCs underwent en bloc resection with ESD without any serious complications.ESD is considered a useful treatment for GTC. | Michita Mukasa Hidetoshi Takedatsu Ken Matsuo Hiroaki Sumie Hikaru Yoshida Atsushi Hinosaka Yasutomo Watanabe Osamu Tsuruta Takuji Torimura | 2015 | World Journal of Gastroenterology2015，21，3： | 8 |
| 5 | Prediction of colorectal tumor grade and invasion depth through narrow-band imaging scoring显示文摘AIM To determine the usefulness of assigning narrow-band imaging(NBI) scores for predicting tumor grade and invasion depth in colorectal tumors.METHODS A total of 161 colorectal lesions were analyzed from138 patients who underwent endoscopic or surgical resection after conventional colonoscopy and magnifying endoscopy with NBI. The relationships between the surface and vascular patterns of the lesions, as visualized with NBI, and the tumor grade and depth of submucosa(SM) invasion were determined histopathologically.Scores were assigned to distinct features of the surface microstructures of tubular and papillary-type lesions.Using a multivariate analysis, a model was developed for predicting the tumor grade and depth of invasion based on NBI-finding scores.RESULTS NBI findings that correlated with a high tumor grade were associated with the 'regular/irregular'(P < 0.0001)surface patterns and the 'avascular area' pattern(P =0.0600). The vascular patterns of 'disrupted vessels'(P = 0.0714) and 'thick vessels'(P = 0.0133) but none of the surface patterns were associated with a depth of invasion of ≥ 1000 μm. In our model, a total NBIfinding score ≥ 1 was indicative of a high tumor grade(sensitivity: 0.97; specificity: 0.24), and a total NBIfinding score ≥ 9(sensitivity: 0.56; specificity: 1.0) was predictive of a SM invasion depth ≥ 1000 μm. Scores less than these cutoff values signified adenomas and a SM invasion depth < 1000 μm, respectively. Associations were also noted between selected NBI findings and tumor tissue architecture and histopathology.CONCLUSION Our multivariate statistical model for predicting tumor grades and invasion depths from NBI-finding scores may help standardize the diagnosis of colorectal lesions and inform therapeutic strategies. | Yasuhiko Maeyama Keiichi Mitsuyama Tetsuhiro Noda Shiuchiro Nagata Tsutomu Nagata Shinichiro Yoshioka Hikaru Yoshida Michita Mukasa Hiroaki Sumie Hiroshi Kawano Jun Akiba Yuko Araki Tatsuyuki Kakuma Osamu Tsuruta Takuji Torimura | 2018 | World Journal of Gastroenterology2018，24，42： | 4 |
| 6 | Surgically treated diaphragmatic perforation after radiofrequency ablation for hepatocellular carcinoma显示文摘We review 6 cases of diaphragmatic perforation, with and without herniation, treated in our institution. All patients with diaphragmatic perforation underwent radiofrequency ablation(RFA) treatments for hepatocellular carcinoma(HCC) performed at Kurume University Hospital and Tobata Kyoritsu Hospital. We investigated the clinical profiles of the 6 patients between January 2003 and December 2013. We further describe the clinical presentation, diagnosis, and treatment of diaphragmatic perforation. The change in the volume of liver and the change in the Child-Pugh score from just after the RFA to the onset of perforation was evaluated using a paired t-test. At the time of perforation, 4 patients had herniation of the viscera, while the other 2 patients had no herniation. The majority of ablated tumors were located adjacent to the diaphragm, in segments 4, 6, and 8. The average interval from RFA to the onset of perforation was 12.8 mo(range, 6-21 mo). The median Child-Pugh score at the onset of perforation(8.2) was significantly higher compared to the median Child-Pugh score just after RFA(6.5)(P = 0.031). All patients underwent laparotomy and direct suture of the diaphragm defect, with uneventful post-surgical recovery. Diaphragmatic perforation after RFA is not a matter that can be ignored. Clinicians should carefully address this complication by performing RFA for HCC adjacent to diaphragm. | Sachiko Nagasu Koji Okuda Ryoko Kuromatsu Yoriko Nomura Takuji Torimura Yoshito Akagi | 2017 | World Journal of Gastrointestinal Surgery2017，9，12： | 3 |
| 7 | STAT3 deficiency prevents hepatocarcinogenesis and promotes biliary proliferation in thioacetamide-induced liver injury显示文摘AIM To elucidate the role of STAT3 in hepatocarcinogenesis and biliary ductular proliferation following chronic liver injury. METHODS We investigated thioacetamide(TAA)-induced liver injury, compensatory hepatocyte proliferation, and hepatocellular carcinoma(HCC) development in hepatic STAT3-deficient mice. In addition, we evaluated TAAinduced biliary ductular proliferation and analyzed the activation of sex determining region Y-box9(SOX9) and Yes-associated protein(YAP), which regulate the transdifferentiation of hepatocytes to cholangiocytes.RESULTS Both compensatory hepatocyte proliferation and HCC formation were significantly decreased in hepatic STAT3-deficient mice as compared with control mice. STAT3 deficiency resulted in augmentation of hepatic necrosis and fibrosis. On the other hand, biliary ductular proliferation increased in hepatic STAT3-deficient livers as compared with control livers. SOX9 and YAP were upregulated in hepatic STAT3-deficient hepatocytes.CONCLUSION STAT3 may regulate hepatocyte proliferation as well as transdifferentiation into cholangiocytes and serve as a therapeutic target for HCC inhibition and biliary regeneration. | Mitsuhiko Abe Takafumi Yoshida Jun Akiba Yu Ikezono Fumitaka Wada Atsutaka Masuda Takahiko Sakaue Toshimitsu Tanaka Hideki Iwamoto Toru Nakamura Michio Sata Hironori Koga Akihiko Yoshimura Takuji Torimura | 2017 | World Journal of Gastroenterology2017，23，37： | 2 |
| 8 | Basic fibroblast growth factor regulates proliferation and motility of human hepatoma cells by an autocrine mechanism显示文摘 | Motoaki Kin Michio Sata Takato Ueno Takuji Torimura Sadataka Inuzuka Riko Tsuji Kodo Sujaku Masaharu Sakamoto Hiroshi Sugawara Seisyu Tamaki Kyuichi Tanikawa | 1997 | Journal of Hepatology1997，，4： | 2 |
| 9 | Serum vascular endothelial growth factor as a predictor of response and survival in patients with advanced hepatocellular carcinoma undergoing hepatic arterial infusion chemotherapy显示文摘 | Takashi Niizeki Shuji Sumie Takuji Torimura Junichi Kurogi Ryoko Kuromatsu Hideki Iwamoto Hajime Aino Masahito Nakano Atsushi Kawaguchi Tatsuyuki Kakuma Michio Sata | 2012 | Journal of Gastroenterology2012，，6： | 2 |
| 10 | Overexpression of angiopoietin-1 and angiopoietin-2 in hepatocellular carcinoma显示文摘 | Torimura T Ueno T Kin M | | 0，，05： | 1 |
| 11 | Autocrine motility factor enhances hepatoma cell invasion across the basement membrane through activation of beta1 integrins显示文摘 | Torimura T Ueno T Kin M | 2001 | Hepatology2001，34，1： | 1 |
| 12 | 显示文摘 | Torimura T Sata M Ueno T | 1998 | Hum Pathol1998，29，9： | 1 |
| 13 | Increased expression of vascular endothelial growth factor is associated with tumor progression in hepatocellular carcinoma 显示文摘 | Sata M Ueno T | 1998 | Hum Pathol1998，，29： | 1 |
| 14 | Serum vascular endothelial growth factor as a predictor of response and survival in patients with advanced hepatocellular carcinoma undergoing hepatic arterial infusion chemotherapy显示文摘 | Niizei T Smie S Torimura T | | 0，，06： | 1 |
| 15 | Vandetanib,an inhibitor of VEGF receptor-2 and EGF receptor,suppresses tumor development and im- proves prognosis of liver cancer in mice 显示文摘 | Inoue K Torimura T Nakamura T | 2012 | Clin Cancer Res2012，18，14： | 1 |
| 16 | Autoerine motility factor enhances hepatoma cell invasion across the basement membrane through activation of betal integrins 显示文摘 | Torimura T Ueno T Kin M | 2001 | Hepatology2001，34，1： | 1 |
| 17 | Reduced contractility and histological changes in the gallbladder due to portal hypertension in a hamster cirrhosis model 显示文摘 | Sakata R Ueno T Torimura T | 1997 | Digestion1997，58，5： | 1 |
| 18 | The RNA degradation pathway regulates the function of GAS5 a non - coding RNA in mammalian cells显示文摘 | Hidenori Tani Masaki Torimura Nobuyoshi Akimitsu | 2013 | PLoS One2013，8，55： | 1 |
| 19 | The singnificance of colocalization of plasminogen activator inhibitor type 1 and vitronectin in hepatic fibrosis显示文摘 | Inuzuka S Ueno T Torimura T | 1997 | Scand J Gastroenterol1997，32，10： | 1 |
| 20 | Increased expression of vascular endothelial growth factor is associated with tumor progression in hepatocellular carcinoma显示文摘 | Torimura T Sata M Ueno T | 1998 | Hum Pathol1998，29，9： | 1 |
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