|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Gastric adenocarcinoma arising in gastritis cystica profunda presenting with selective loss of KCNE2 expression显示文摘Gastritis cystica profunda(GCP) is a rare condition caused by ectopic entrapment of gastric glands,probably secondary to the disruption of muscularis mucosae.GCP is often associated with gastric adenocarcinoma,and loss of the KCNE2 subunit from potassium channel complexes is considered a common primary target molecule leads to both GCP and malignancy.In this study,we,for the first time,analyzed the expression of KCNE2 in surgically excised tissue from human gastric cancer associated with GCP and confirmed that reduced KCNE2 expression correlates with disease formation. | Natsumi Kuwahara Riko Kitazawa Koto Fujiishi Yusa Nagai Ryuma Haraguchi Sohei Kitazawa | 2013 | World Journal of Gastroenterology2013，19，8： | 11 |
| 2 | Effect of probiotic Lactobacillus plantarum Dad-13 powder consumption on the gut microbiota and intestinal health of overweight adults显示文摘BACKGROUND Shifting on lifestyle,diet,and physical activity contributed on increasing number of obese people around the world.Multiple factors influence the development of obesity.Some research suggested that gut microbiota(GM)plays an important role in nutrient absorption and energy regulation of individuals,thus affecting their nutritional status.Report of Indonesia Basic Health Research showed that the prevalence of obesity in every province tended to increase.Although the root cause of obesity is excessive calorie intake compared with expenditure,the differences in gut microbial ecology between healthy and obese humans may affect energy homeostasis.GM affect body weight,especially obesity.Probiotics that are consumed while alive and able to colonize in the intestine are expected to increase the population of good bacteria,especially Bifidobacteria and Lactobacilli,and suppress pathogens such as Enterobacteriaceae and Staphylococcus.The strain of L.plantarum Dad-13 has been demonstrated to survive and colonize in the gastrointestinal tract of healthy Indonesian adults who consume fermented milk containing L.plantarum Dad-13.The consumption of probiotic L.plantarum Dad-13 powder decreased E.coli and non-E.coli coliform bacteria in school-aged children in Indonesia.L.plantarum is a dominant bacterium in the average Indonesian’s GM.For this reason,this bacterium is probably a more suitable probiotic for Indonesians.AIM To determine the effect of the consumption of indigenous probiotic Lactobacillus plantarum Dad-13 powder in overweight adults in Yogyakarta(Indonesia).METHODS Sixty overweight volunteers with a body mass index(BMI)equal to or greater than 25 consume indigenous probiotic powder L.plantarum Dad-13(2×109 CFU/gram/sachet)for 90 d.The study was a randomized,double-blind,placebocontrolled study.The volunteers filled in a diary on a daily basis,which consisted of questions on study product intake(only during ingestion period),other food intake,number of bowel movements,fecal quality(consistency and color),any medications received,and any symptom of discomfort,such as diarrhea,constipation,vomiting,gassing,sensation of illness,etc.Fecal samples and the subjects’diaries were collected on the morning of day 10+1,which was marked as the end of the baseline period and the start of the ingestion period.During the ingestion period(from day 11 to day 101),several parameters to measure and analyze the results included body weight and height(once a month),the lipid profile,GM analysis using MiSeq,short-chain fatty acid(SCFA)analysis using gas chromatography,and the measurement of fecal pH using a pH meter.RESULTS The consumption of indigenous probiotic powder L.plantarum Dad-13 caused the average body weight and BMI of the probiotic group to decrease from 84.54±17.64 kg to 83.14±14.71 kg and 33.10±6.15 kg/m2 to 32.57±5.01 kg/m2,respectively.No significant reduction of body weight and BMI in the placebo group was observed.An analysis of the microbiota showed that the number of Bacteroidetes,specifically Prevotella,increased significantly,while that of Firmicutes significantly decreased.No significant change in lipid profile in both groups was found.Also,no significant change in SCFAs(e.g.,butyrate,propionate,acetic acid)and pH level was found after the consumption of the probiotic.CONCLUSION No significant differences in pH before and after ingestion were observed in both the probiotic and placebo groups as well as in the lipid profile of both cholesterol and triglyceride,high-density lipoprotein(HDL),low-density lipoprotein(LDL),and the LDL/HDL ratio.In addition,no significant changes in the concentration of SCFAs(e.g.,acetic acid,propionate,and butyrate)were found after consumption.Interestingly,a significant decrease in body weight and BMI(P<0.05)was determined in the treatment group.An analysis of GM shows that L.plantarum Dad-13 caused the Firmicutes population to decrease and the Bacteroidetes population(especially Prevotella)to increase. | Endang Sutriswati Rahayu Mariyatun Mariyatun Nancy Eka Putri Manurung Pratama Nur Hasan Phatthanaphong Therdtatha Riko Mishima Husnita Komalasari Nurul Ain Mahfuzah Fathyah Hanum Pamungkaningtyas Wahyu Krisna Yoga Dina Aulia Nurfiana Stefanie Yolanda Liwan Mohammad Juffrie Agung Endro Nugroho Tyas Utami | 2021 | World Journal of Gastroenterology2021，27，1： | 6 |
| 3 | Cdx2 expression and its promoter methylation during metaplasia-dysplasia-carcinoma sequence in Barrett's esophagus显示文摘AIM:To examine how the expression of caudal type homebox transcription factor 2(Cdx2) is regulated in the development of malignancy in Barrett's esophagus.METHODS:Cdx2,mucin(MUC) series(MUC2,MUC5AC and MUC6),p53 and E-cadherin expression in Barrett's esophagus and adenocarcinoma specimens were examined by immunostaining.Isolated clusters of cells from(1) MUC2 and Cdx2-positive intestinal metaplastic mucosa;(2) MUC5AC and MUC6-positive,and MUC2 and Cdx2-negative high-grade dysplasia(HD),or intramucosal adenocarcinoma(IMC);and(3) MUC5AC,MUC6 and Cdx2-positive poorly-differentiated invasive adenocarcinoma(PDA) were analyzed by methylationspecific polymerase chain reaction using sets of primers for detecting methylation status of the Cdx2 gene.RESULTS:Most of the non-neoplastic Barrett's esophageal mucosa showing intestinal-type metaplasia with or without low-grade dysplasia was positive for E-cadherin,MUC series and Cdx2,but negative for p53.A portion of the low-grade to HD was positive for E-cadherin,MUC5AC,MUC6 and p53,but negative for MUC2 and Cdx2.The definite IMC area was strongly positive for MUC5AC,MUC6 and p53,but negative for MUC2 and Cdx2.Methylation of the Cdx2 promoter was not observed in intestinal metaplasia,while hypermethylation of part of its promoter was observed in hot dipped and IMC.Hypermethylation of a large fraction of the Cdx2 promoter was observed in PDA.CONCLUSION:Cdx2 expression is restored irrespective of the methylation status of its promoter.Apparent positive immunohistochemical results can be a molecular mark for gene silencing memory. | Kenji Makita Riko Kitazawa Shuho Semba Koto Fujiishi Miku Nakagawa Ryuma Haraguchi Sohei Kitazawa | 2013 | World Journal of Gastroenterology2013，19，4： | 5 |
| 4 | Comparison of patient acceptance of sodium phosphate versus polyethylene glycol plus sodium picosulfate for colon cleansing in Japanese显示文摘 | Naoki Hosoe Manabu Nakashita Hiroyuki Imaeda Tomohisa Sujino Rieko Bessho Riko Ichikawa Nagamu Inoue Takanori Kanai Toshifumi Hibi Haruhiko Ogata | 2012 | Journal of Gastroenterology and Hepatology2012，，10： | 2 |
| 5 | Basic fibroblast growth factor regulates proliferation and motility of human hepatoma cells by an autocrine mechanism显示文摘 | Motoaki Kin Michio Sata Takato Ueno Takuji Torimura Sadataka Inuzuka Riko Tsuji Kodo Sujaku Masaharu Sakamoto Hiroshi Sugawara Seisyu Tamaki Kyuichi Tanikawa | 1997 | Journal of Hepatology1997，，4： | 2 |
| 6 | A model predictive control approach to mierogrid operation optimization显示文摘 | PARISIO A RIKOS E GLIELMO L | 2014 | IEEE Trans on Control Systems Technology2014，22，5： | 1 |
| 7 | Telerobotics experiments via internet显示文摘 | RIKO SAFARIC | 2001 | IEEE Transactions on Industrial Electronics Magazition2001，48，3： | 1 |
| 8 | Stability and power quality issues in microgrids under weather disturbances study of photovoltaie integration显示文摘 | Rikos E Tselepis E Hoyer-Klick C | 2008 | IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing2008，1，3： | 1 |
| 9 | Caged compounds of a 2-deoxyglucose:facile synthesis and their photoreactivity显示文摘 | SOICHIRO W RIKO H MICHIKO I | 1998 | Bioorg Med Chem Let1998，8，： | 1 |
| 10 | Neonatal tracheobiliary fis- tula diagnosed by MR cholangiopancreatography 显示文摘 | Kumagai T Higuehi R Riko M | 2011 | J Pediatr Gastroenterol Nutr2011，52，3： | 1 |
| 11 | Increased expression of membrane type 1 matrix metalloproteinase and matrix metalloproteinase-2 with tumor dedifferentiation in hepatocellular carcinomas显示文摘 | RIKO O TAKUJI T MOTOAKI K | 1999 | Human Pathol1999，30，4： | 1 |
| 12 | Malignant lymphoma of the spleen in Japan: A clinicopathological analysis of 115 cases显示文摘 | Kei Shimizu‐Kohno Yoshizo Kimura Junichi Kiyasu Hiroaki Miyoshi Maki Yoshida Riko Ichikawa Daisuke Niino Koichi Ohshima | 2012 | Pathology International2012，，9： | 1 |
| 13 | Rate-dependent changes in atrial action potential duration after short-duration rapid atrial pacing in human显示文摘 | Ichiro W Riko M Kimie O | 2002 | Circulation Journal2002，66，： | 1 |
| 14 | Self-similarity law of particle size distribution and energy law in size reduction of solids显示文摘 | MOYURU O RIKO O YOSHITAKE Y | 1992 | PhysicaA1992，191，2： | 1 |
| 15 | Hearing loss in early infancy:incidence, detection and assessment显示文摘 | Riko K Hyde ML Alberti PW | 1985 | Laryngoscope1985，95，： | 1 |
| 16 | Hypermethylation of epithelial-cadherin gene promoter is associated with Epstein-Barr virus in nasopharyngeal carcinoma显示文摘 | Sopaporn Niemhom Sohei Kitazawa Riko Kitazawa Sakan Maeda Juvady Leopairat | 2008 | Cancer Detection and Prevention2008，，2： | 1 |
| 17 | Stability andpower quality issues in microgrids under weather disturbances study ofphotovoltaic integration 显示文摘 | RIKOS E TSELEPIS E HOYER KLICK C | 2008 | IEEE Journal of Selected Topics in Ap-plied Earth Observations and Remote Sensing2008，1，3： | 1 |
| 18 | Chemerin enhances insulin signaling and potentiates insulin-stimulated glucose uptake in 3T3-L1 adipocytes显示文摘 | Michiko Takahashi Yutaka Takahashi Kenichi Takahashi Fyodor N. Zolotaryov Kyoung Su Hong Riko Kitazawa Keiji Iida Yasuhiko Okimura Hidesuke Kaji Sohei Kitazawa Masato Kasuga Kazuo Chihara | 2008 | FEBS Letters2008，，5： | 1 |
| 19 | Estrogen upregulates nitric oxide synthase expression in cultured rat hepatic sinusoidal endothelial cells显示文摘 | Masaharu Sakamoto Takato Ueno Toru Nakamura Osamu Hashimoto Ryuichiro Sakata Motoaki Kin Riko Ogata Takumi Kawaguchi Takuji Torimura Michio Sata | 2001 | Journal of Hepatology2001，，6： | 1 |
| 20 | Thermal properties of ethylene octene copolymer(Engage)/dimethyldioctadecyl quaternary ammonium chloride-modified montmorillonite clay nanocomposites显示文摘 | Ganesh Latta Quentin Lineberry Riko Ozao | 2008 | J Mater Sci2008，43，8： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员