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| 1 | Management of thrombocytopenia due to liver cirrhosis:A review显示文摘Thrombocytopenia is a common complication in liver disease and can adversely affect the treatment of liver cirrhosis,limiting the ability to administer therapy and delaying planned surgical/diagnostic procedures because of an increased risk of bleeding.Multiple factors,including splenic sequestration,reduced activity of the hematopoietic growth factor thrombopoietin,bone marrow suppression by chronic hepatitis C virus infection and anti-cancer agents,and antiviral treatment with interferon-based therapy,can contribute to the development of thrombocytopenia in cirrhotic patients.Of these factors,the major mechanisms for thrombocytopenia in liver cirrhosis are(1)platelet sequestration in the spleen;and(2)decreased production of thrombopoietin in the liver.Several treatment options,including platelet transfusion,interventional partial splenic embolization,and surgical splenectomy,are now available for severe thrombocytopenia in cirrhotic patients.Although thrombopoietin agonists and targeted agents are alternative tools for noninvasively treating thrombocytopenia due to liver cirrhosis,their ability to improve thrombocytopenia in cirrhotic patients is under investigation in clinical trials.In this review,we propose a treatment approach to thrombocytopenia according to our novel concept of splenic volume,and we describe the current management of thrombocytopenia due to liver cirrhosis. | Hiromitsu Hayashi Toru Beppu Ken Shirabe Yoshihiko Maehara Hideo Baba | 2014 | World Journal of Gastroenterology2014，20，10： | 19 |
| 2 | Long-term outcomes of extended radical resection combined with intraoperative radiation therapy for pancreatic cancer显示文摘 | Hiroshi Takamori Takehisa Hiraoka Keiichiro Kanemitsu Tatsuya Tsuji Hiroshi Tanaka Akira Chikamoto Kei Horino Toru Beppu Masahiko Hirota Hideo Baba | 2008 | Journal of Hepato - Biliary - Pancreatic Surgery2008，，6： | 2 |
| 3 | Functional assessment versus conventional volumetric assessment in the prediction of operative outcomes after major hepatectomy显示文摘 | Hiromitsu Hayashi Toru Beppu Hirohisa Okabe Hideyuki Kuroki Shigeki Nakagawa Katsunori Imai Hidetoshi Nitta Akira Chikamoto Takatoshi Ishiko Hideo Baba | 2014 | Surgery2014，，： | 2 |
| 4 | Identification of CXCL5/ENA‐78 as a factor involved in the interaction between cholangiocarcinoma cells and cancer‐associated fibroblasts显示文摘 | Hirohisa Okabe Toru Beppu Mitsuharu Ueda Hiromitsu Hayashi Takatoshi Ishiko Toshiro Masuda Ryu Otao Hasita Horlad Kosuke Mima Keisuke Miyake Masaaki Iwatsuki Yoshifumi Baba Hiroshi Takamori Hirofumi Jono Satoru Shinriki Yukio Ando Hideo Baba | 2012 | Int J Cancer2012，，10： | 1 |
| 5 | Assessment of safety in hepatic resection for hepatocellular carcinoma focusing on indirect hyperbilirubinemia显示文摘 | Toshiro Masuda Toru Beppu Shigeki | 2013 | J Hepatobiliary Pancreat2013，20，3： | 1 |
| 6 | Chemotherapy and Targeted Therapy for Patients with Initially Unresectable Colorectal Liver Metastases, Focusing on Conversion Hepatectomy and Long-Term Survival显示文摘 | Toru Beppu Yuji Miyamoto Yasuo Sakamoto Katsunori Imai Hidetoshi Nitta Hiromitsu Hayashi Akira Chikamoto Masayuki Watanabe Takatoshi Ishiko Hideo Baba | 2014 | Annals of Surgical Oncology2014，，3： | 1 |
| 7 | Percutaneous radiofrequency ablation‐assisted laparoscopic hepatectomy显示文摘 | Toru Beppu Hidetoshi Nitta Masayo Tsukamoto Katsunori Imai Hiromitsu Hayashi Hirohisa Okabe Daisuke Hashimoto Akira Chikamoto Takatoshi Ishiko Hideo Baba | 2014 | Asian J Endosc Surg2014，，2： | 1 |
| 8 | Conformal radiation therapy for portal vein tumor thrombosis of hepatocellular carcinoma显示文摘 | Ryo Toya Ryuji Murakami Yuji Baba Ryuichi Nishimura Shoji Morishita Osamu Ikeda Koichi Kawanaka Toru Beppu Shinichi Sugiyama Takashi Sakamoto Yasuyuki Yamashita Natsuo Oya | 2007 | Radiotherapy and Oncology2007，，3： | 1 |
| 9 | Carcinogenesis of Intraductal Papillary Mucinous Neoplasm of the Pancreas: Loss of MicroRNA-101 Promotes Overexpression of Histone Methyltransferase EZH2显示文摘 | Osamu Nakahara Hiroshi Takamori Masaaki Iwatsuki Yoshifumi Baba Yasuo Sakamoto Hiroshi Tanaka Akira Chikamoto Kei Horino Toru Beppu Keiichiro Kanemitsu Yumi Honda Ken-ichi Iyama Hideo Baba | 2012 | Annals of Surgical Oncology2012，，3： | 1 |
| 10 | Detection of liver metastases secondary to pancreatic cancer: utility of combined helical computed tomography during arterial portography with biphasic computed tomography-assisted hepatic arteriography显示文摘 | Yoshiaki Ikuta Hiroshi Takamori Osamu Ikeda Hiroshi Tanaka Yasuo Sakamoto Daisuke Hashimoto Nobuyuki Ozaki Osamu Nakahara Satoshi Furuhashi Shinya Abe Toru Beppu Shinya Shimada Yasuyuki Yamashita Hideo Baba | 2010 | Journal of Gastroenterology2010，，12： | 1 |
| 11 | Fused 99m-Tc-GSA SPECT/CT imaging for the preoperative evaluation of postoperative liver function: can the liver uptake index predict postoperative hepatic functional reserve?显示文摘 | Morikatsu Yoshida Shinya Shiraishi Fumi Sakaguchi Daisuke Utsunomiya Kuniyuki Tashiro Seiji Tomiguchi Hirohisa Okabe Toru Beppu Hideo Baba Yasuyuki Yamashita | 2012 | Japanese Journal of Radiology2012，，3： | 1 |
| 12 | Systemic inflammatory respnse syndrome and oragn dysfunction following gastrointestinal surgery显示文摘 | Toru Beppu Kouichi Doi | 2004 | Crit Care Med2004，25，23： | 1 |
| 13 | Therapeutic factors considered according to the preoperative splenic volume for a prolonged increase in platelet count after partial splenic embolization for liver cirrhosis显示文摘 | Hiromitsu Hayashi Toru Beppu Kazutoshi Okabe Toshiro Masuda Hirohisa Okabe Takatoshi Ishiko Hideo Baba | 2010 | Journal of Gastroenterology2010，，5： | 1 |
| 14 | High CD44s expression is associated with the EMT expression profile and intrahepatic dissemination of hepatocellular carcinoma after local ablation therapy显示文摘 | Kosuke Mima Hiromitsu Hayashi Katsunori Imai Hideyuki Kuroki Shigeki Nakagawa Hirohisa Okabe Akira Chikamoto Masayuki Watanabe Toru Beppu Hideo Baba | 2013 | Journal of Hepato-Biliary-Pancreatic Sciences2013，，4： | 1 |
| 15 | Chemotherapy and Targeted Therapy for Patients with Initially Unresectable Colorectal Liver Metastases, Focusing on Conversion Hepatectomy and Long-Term Survival显示文摘 | Toru Beppu Yuji Miyamoto Yasuo Sakamoto Katsunori Imai Hidetoshi Nitta Hiromitsu Hayashi Akira Chikamoto Masayuki Watanabe Takatoshi Ishiko Hideo Baba | 2014 | Annals of Surgical Oncology2014，，3： | 1 |
| 16 | Therapeutic factors considered according to the preoperative splenic volume for a prolonged increase in platelet count after partial splenic embolization for liver cirrhosis显示文摘 | Hiromitsu Hayashi Toru Beppu Kazutoshi Okabe | 2010 | Gastroenterol2010，45，： | 1 |
| 17 | Cutaneous metastases secondary to pancreatic cancer显示文摘AIM: To evaluate prognoses after cutaneous metastases, derived from pancreatic cancer. METHODS: We treated two patients with cutaneous metastases from pancreatic cancer. We reviewed 40 reported patients in addition to our cases and analyzed clinical features of cutaneous metastases from pancreatic cancer. RESULTS: The median survival time (MST) was 5 mo after diagnoses of cutaneous metastases. The cumulative 2-year survival rate was 3.5%. The most frequent site of cutaneous metastases was the umbilicus. The MST of patients who were treated with chemotherapy or chemoradiotherapy (CRT) was 6.5 mo, which was statistically longer in comparison to patients without treatment. Prognoses of cutaneous metastases are similar to other metastatic sites from pancreatic cancer. Receiving chemotherapy or CRT was the only prognostic factor of cutaneous metastases from pancreatic cancer.CONCLUSION: The prognoses of cutaneous metastases are similar to other metastatic pancreatic cancers. Receiving chemotherapy or CRT was the only prognostic factor of cutaneous metastases from pancreatic cancer. | Kei Horino Hiroshi Takamori Yoshiaki Ikuta Osamu Nakahara Akira Chikamoto Takatoshi Ishiko Toru Beppu Hideo Baba | 2012 | World Journal of Gastrointestinal Oncology2012，4，7： | 0 |
| 18 | The impact of associating liver partition and portal vein ligation for staged hepatectomy(ALPPS)on liver tumors with unusual indications显示文摘An associating liver partition and portal vein ligation for staged hepatectomy(ALPPS)has been developed as a novel surgical technique for patients with insufficient future liver remnant volume even after portal vein embolization(PVE)±hepatic arterial or venous embolization or conventional two-stage hepatectomy(TSH)(1-5).ALPPS was thought to be a breakthrough but high-risk procedure;however,it recently became a safer technique after the developing phase(1-3).Conversion surgery is strongly recommended for patients with initially unresectable liver tumors that are deemed resectable by systemic chemotherapy or hepatic arterial chemotherapy/embolization(6,7).The primarily targeted diseases are colorectal liver metastases(CRLM)and hepatocellular carcinoma(HCC).ALPPS is indicated for patients undergoing not only primary surgery but also conversion surgery. | Kensuke Yamamura Toru Beppu Tatsunori Miyata Shinichi Akahoshi Takatoshi Ishiko | 2022 | Hepatobiliary Surgery and Nutrition2022，11，3： | 0 |
| 19 | Does laparoscopic liver resection for colorectal liver metastases provide a true survival benefit compared with open liver resection?显示文摘The recent Southampton consensus guideline and two previous international consensus meetings held in Louisville and Morioka in 2008 and 2014,respectively have recommended laparoscopic liver resection(LLR)as a standard procedure for selected patients with colorectal liver metastases(CRLM)(1-3).The Oslo-CoMet and LapOpHuva studies are the only two randomized controlled trials(RCTs)that have provided solid evidence showing that LLR is a safer,less invasive,and more cost-effective approach with higher health-related quality of life and oncological outcomes equivalent to those of open liver resection(OLR)for patients with CRLM(4-6). | Shinichi Akahoshi Toru Beppu Yasuhisa Mori Koichi Kinoshita Nobutaka Sato Ken Kikuchi | 2020 | Hepatobiliary Surgery and Nutrition2020，9，5： | 0 |
| 20 | Prognostic Impact of Surgical Margin Width in Hepatectomy for Colorectal Liver Metastasis显示文摘As for resection for colorectal liver metastasis (CRLM), secur-ing an adequate surgical margin is important for achieving a better prognosis. However, it is often difficult to achieve ade-quate margins for the resection of CRLM. So the current sur-vival impact of sub-centi/millimeter surgical margins in he-patectomy for CRLM should be evaluated. In the current era of multidisciplinary treatment options, this review focused on the prognostic impact of a sub-centi/millimeter surgical margin width in hepatectomy for CRLM. We systematically reviewed retrospective studies that clearly described the sur-gical margin width for hepatectomy for CRLM. We selected studies conducted since 2000 that involved patients diag-nosed as having CRLM. We focused on studies that investi-gated not only surgical margins, but also microscopic surgical curability such as R0 (microscopically complete resection) or R1 (microscopically incomplete resection), which clearly de-scribe their definitions. Based on our literature review, 1, 2, or 5 mm was considered the minimum surgical margin width for hepatectomy for CRLM. Although a surgical margin width of 1 mm is acceptable for hepatectomy for CRLM, submil-limeter margins, which are defined as R1 in many reports, are only acceptable for limited patients such as those who have undergone preoperative chemotherapy. Zero-mm mar-gins are also acceptable in limited patients such as those who show a good response to preoperative chemotherapy. New chemotherapy agents have been reported to reduce the prognostic impact of a narrow surgical margin width. The incidence of margin recurrence, which is a major concern regarding R1 resection of CRLM, is about 20-30% according to the majority of earlier reports. As evaluations of the actual prognostic impact of the surgical margin remain difficult, fur-ther study is warranted. | Katsunori Sakamoto Toru Beppu Kohei Ogawa Kei Tamura Masahiko Honjo Naotake Funamizu Yasutsugu Takada | 2023 | Journal of Clinical and Translational Hepatology2023，11，3： | 0 |
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