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| 1 | Efficacy and safety of telaprevir- and simeprevir-based triple therapies for older patients with chronic hepatitis C显示文摘AIM To evaluate and compare the efficacy and safety of telaprevir(TVR)-and simeprevir(SMV)-based triple therapies in elderly patients, specifically patients aged 66 years or older.METHODS The present study enrolled 112 and 76 Japanese patients with chronic hepatitis C virus genotype 1b infection who were treated with a 12-wk TVR-based or SMV-based triple therapy, respectively, followed by a dual therapy that included pegylated interferon α and ribavirin(RBV) for 12 wk. The patients were categorized into two groups according to age as follows: A younger group of patients aged ≤ 65 years old and an older group of patients aged > 65 years old. Among the patients treated with TVR-based triple therapy, 34 patients were included in the older group. The median ages were 56 years(range: 28-65 years) in the younger group and 69 years(range: 66-81 years) in the older group. Among the patients treated with SMV-based triple therapy, 39 patients were included in the older group. The median ages were 59 years(range: 36-65 years) in the younger group and 71 years(range: 66-86 years) in the older group. The clinical, biochemical and virological data were analyzed before and during treatment.RESULTS Among the patients treated with the TVR-based triple therapy, no significant difference in the sustained virological response(SVR) was found between the younger(80.8%) and older(88.2%) groups. The SVR rates for patients with the interleukin 28B(IL28B)(rs8099917) TG/GGgenotypes(73.9% and 60.0% in the younger and older groups, respectively) were significantly lower than for patients with the IL28B TT-genotype(86.3% and 92.9%, respectively). The cumulative exposure to RBV for the entire 24-wk treatment period(as a percentage of the target dose) was significantly higher in the younger group than in the older group(91.7% vs 66.7%, respectively, P < 0.01), but the cumulative exposure to TVR was not significantly different between the younger and older groups(91.6% vs 81.9%, respectively). A multivariate analysis identified the TT-genotype of IL28B(OR = 8.160; 95%CI: 1.593-41.804, P = 0.012) and the adherence of RBV(> 60%)(OR = 11.052; 95%CI: 1.160-105.273, P = 0.037) as independent factors associated with the SVR. Adverse events resulted in discontinuation of the treatment in 11.3% and 14.7% of the younger and older groups, respectively. Among the patients treated with the SMV-based triple therapy, no significant difference in the SVR rare was found between the younger(81.1%) and older(82.1%) groups. The SVR rates for patients with the IL28B TG/GG-genotypes(77.8% and 64.7% in the younger and older groups, respectively) were significantly lower than for patients with the IL28 B TT-genotype(88.2% and 100%, respectively). A multivariate analysis identified the TT-genotype of IL28B as an independent factor associated with the SVR(OR = 9.677; 95%CI:1.114-84.087, P = 0.040). Adverse events resulted in discontinuation of the treatment in 7.0% and 14.3% of patients in the younger and older groups, respectively.CONCLUSION Both TVR- and SMV-based triple therapies can be successfully used to treat patients aged 66 years or older with genotype 1b chronic hepatitis C. Genotyping of the IL28B indicates a potential to achieve SVR in these difficult-to-treat elderly patients. | Satoshi Yamagiwa Toru Ishikawa Nobuo Waguri Soichi Sugitani Hiroto Wakabayashi Shogo Ohkoshi Takashi Tsukishiro Toru Takahashi Toshiaki Watanabe Shuji Terai | 2017 | World Journal of Hepatology2017，9，5： | 1 |
| 2 | Boron nitride as a lubricant additive显示文摘 | Yoshitsugu Kimura Toshiaki Wakabayashi Kazumi Okada Tetsuya Wada Hiroshi Nishikawa | 1999 | Wear1999，，2： | 1 |
| 3 | Self-Assembly of Tin Oxide Nanoparticles:Localized Percolating Network Formation in Polymer Matrix 显示文摘 | Atsymi Wakabayashi Yuki Sasakawa Toshiaki Dobashl etc | 2006 | Langmuir2006，，22： | 1 |
| 4 | Practical performance and action mechanism of ester lubricants in minimal quantity lubrication machining显示文摘 | Toshiaki Wakabayashi Satoshi Suda | 2008 | Journal of the Japan Petroleum In stitute2008，51，3： | 1 |
| 5 | Boron Nitride as a Lubricant Additive显示文摘 | Yoshitsugu Kimura Toshiaki Wakabayashi Kazumi Okada | 1999 | Wear1999，，232： | 1 |
| 6 | Boron nitride as a lubricant additive 显示文摘 | Yoshitsugu Kimura Toshiaki Wakabayashi Kazumi Oka- da | 1999 | Wear1999，，232： | 1 |
| 7 | Tribological action and optimal performance: research activities regarding MQL machining fluids显示文摘 | Wakabayashi Toshiaki Inasaki Ichiro Suda Satoshi | 2006 | Machining Science and Technology2006，10，1： | 1 |
| 8 | An Advanced Oscillation Mixing Method for Improving the Cooling Uniformity in Quenching显示文摘In quenching, the cooling uniformity is most important to diminish distortion occurring on work pieces. As a trial to accomplish uniform cooling, therefore, there exist various mixing methods of a quenchant and the quenchant circulation with an external pump has so far been the well accepted mixing method. However, this study proposes an advanced oscillation mixing method that can improve more the cooling uniformity in quenching. The proposed method includes a stirrer in oscillating motion, so that the simultaneous oscillating and mixing movements of the stirrer are considered to provide effectively the uniform cooling characteristics for the quenchant. In comparison with the case of the circulation pump mixing, the investigation using the oscillation mixing method has demonstrated the following two experimental facts: (1) the short vapor blanket stage caused by the quick breakage of the oil vapor blanket and (2) the reduced variation of the quenching distortion. | Hiroyuki Hoshino Hiromitsu Murakami Hideo Yokota Satoshi Suda Hideki Tsuge Koichi Terasaka Toshiaki Wakabayashi | 2004 | 材料热处理学报2004，25，5： | 0 |
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