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| 1 | Shear wave velocity is a useful marker for managing nonalcoholic steatohepatitis显示文摘AIM:To investigate whether a noninvasive measurement of tissue strain has a potential usefulness for management of nonalcoholic steatohepatitis(NASH).METHODS:In total 26 patients,23 NASHs and 3 normal controls were enrolled in this study.NASH was staged based on Brunt criterion.At a region of interest(ROI),a shear wave was evoked by implementing an acoustic radiation force impulse(ARFI),and the propagation velocity was quantif ied.RESULTS:Shear wave velocity(SWV) could be reproducibly quantified at all ROIs in all subjects except for 4 NASH cases,in which a reliable SWV value was not calculated at several ROIs.An average SWV of 1.34 ± 0.26 m/s in fibrous stage 0-1 was significantly slower than 2.20 ± 0.74 m/s and 2.90 ± 1.01 m/s in stages 3 and 4,respectively,but was not significantly different from 1.79 ± 0.78 m/s in stage 2.When a cutoff value was set at 1.47 m/s,receiver operating characteristic analysis showed significance to dissociate stages 3 and 4 from stage 0-1(P=0.0092) with sensitivity,specificity and area under curve of 100%,75% and 94.2%,respectively.In addition,the correlation between SWV and hyaluronic acid was significant(P<0.0001),while a tendency toward negative correlation was observed with serum albumin(P=0.053).CONCLUSION:The clinical implementation of ARFI provides noninvasive repeated evaluations of liver stiffness at an arbitrary position,which has the potential to shed new light on NASH management. | Akihiko Osaki Tomoyuki Kubota Takeshi Suda Masato Igarashi Keisuke Nagasaki Atsunori Tsuchiya Masahiko Yano Yasushi Tamura Masaaki Takamura Hirokazu Kawai Satoshi Yamagiwa Toru Kikuchi Minoru Nomoto Yutaka Aoyagi | 2010 | World Journal of Gastroenterology2010，16，23： | 30 |
| 2 | Active treatments are a rational approach for hepatocellular carcinoma in elderly patients显示文摘AIM: To determine whether an active intervention is beneficial for the survival of elderly patients with hepa-tocellular carcinoma (HCC). METHODS: The survival of 740 patients who received various treatments for HCC between 1983 and 2011 was compared among different age groups using Cox regression analysis. Therapeutic options were principal-ly selected according to the clinical practice guidelines for HCC from the Japanese Society of Hepatology. The treatment most likely to achieve regional control capa-bility was chosen, as far as possible, in the following order: resection, radiofrequency ablation, percutaneous ethanol injection, transcatheter arterial chemoembo-lization, transarterial oily chemoembolization, hepatic arterial infusion chemotherapy, systemic chemotherapy including molecular targeting, or best supportive care.Each treatment was used alone, or in combination, with a clinical goal of striking the best balance be-tween functional hepatic reserve and the volume of the targeted area, irrespective of their age. The percent survival to life expectancy was calculated based on a Japanese national population survey. RESULTS: The median ages of the subjects during each 5-year period from 1986 were 61, 64, 67, 68 and 71 years and increased significantly with time (P<0.0001). The Child-Pugh score was comparable among younger (59 years of age or younger), middle-aged (60-79 years of age), and older (80 years of age or older) groups (P=0.34), whereas the tumor-node-metastasis stage tended to be more advanced in the younger group (P=0.060). Advanced disease was significantly more frequent in the younger group compared with the middle-aged group (P=0.010), whereas there was no difference between the middle-aged and elderly groups (P=0.75). The median sur-vival times were 2593, 2011, 1643, 1278 and 1195 d for 49 years of age or younger, 50-59 years of age, 60-69 years of age, 70-79 years of age, or 80 years of age or older age groups, respectively, whereas the me-dian percent survival to life expectancy were 13.9%, 21.9%, 24.7%, 25.7% and 37.6% for each group, respectively. The impact of age on actual survival time was significant (P=0.020) with a hazard ratio of 1.021, suggesting that a 10-year-older patient has a 1.23-fold higher risk for death, and the overall survival was the worst in the oldest group. On the other hand, when the survival benefit was evaluated on the basis of per-cent survival to life expectancy, age was again found to be a significant explanatory factor (P=0.022); how-ever, the oldest group showed the best survival among the five different age groups. The youngest group revealed the worst outcomes in this analysis, and the hazard ratio of the oldest against the youngest was 0.35 for death. The survival trends did not differ substan-tially between the survival time and percent survival tolife expectancy, when survival was compared overall or among various therapeutic interventions. CONCLUSION: These results suggest that a thera-peutic approach for HCC should not be restricted due to patient age. | Takeshi Suda Aiko Nagashima Shyunsaku Takahash Tsutomu Kanefuji Kenya Kamimura Yasushi Tamura Ma-saaki Takamura Masato Igarashi Hirokazu Kawai Satoshi Yamagiwa Minoru Nomoto Yutaka Aoyagi | 2013 | World Journal of Gastroenterology2013，19，24： | 4 |
| 3 | Effect of double platinum agents, combination of miriplatintransarterial oily chemoembolization and cisplatinhepatic arterial infusion chemotherapy, in patients with hepatocellular carcinoma: Report of two cases显示文摘Hepatocellular carcinoma(HCC) is one of the most common cancers and the third highest cause of cancerassociated mortality worldwide. The treatment of HCC is complicated by its variable biological behavior and the frequent coexistence of chronic liver disease, particularly cirrhosis. To date, multiple treatment modalities have been developed according to the stage of the tumor and the hepatic functional reserve, including transarterial treatments such as transarterial chemoembolization, transarterial oily chemoembolization(TOCE), and hepatic arterial infusion chemotherapy(HAIC). We conducted a phase I and II study of the combination therapy with double platinum agents, miriplatin and cisplatin, and confirmed its safety and efficacy. Here, we describe two cases of unresectable HCC who were successfully treated by miriplatin-TOCE/cisplatin-HAIC combination therapy, resulting in complete responses with no significant adverse events. This report will provide that the combination therapy can be the therapeutic option for HCC patients in the advanced stage. | Kohei Ogawa Kenya Kamimura Yukari Watanabe Yosuke Motai Daisuke Kumaki Ryoya Seki Akira Sakamaki Satoshi Abe Hirokazu Kawai Takeshi Suda Satoshi Yamagiwa Shuji Terai | 2017 | World Journal of Clinical Cases2017，5，6： | 4 |
| 4 | Involvement of parasympathetic pelvic efferent pathway in psychological stress-induced defecation显示文摘AIM:To investigate the role of the pelvic nerve pathway in stress-induced acceleration of colorectal transit and defecation in rats.METHODS:Surgical transection of rectal nerves(rectal branches of the pelvic nerve),vagotomy(Vag) or adrenalectomy(Adx) were performed bilaterally in rats.Number of fecal pellet output of these rats was measured during 1-h water avoidance stress(WAS).To evaluate the colonic transit,rats were given phenol red through the catheter indwelled in the proximal colon and subjected to WAS.After WAS session,entire colon and rectum were isolated and distribution of phenol red was measured.Distal colonic and rectal transit was evaluated using glass bead.Rats were inserted the glass bead into the distal colon and evacuation rate of the bead was measured.Neural activation was assessed by immunohistochemical staining of c-Fos and PGP9.5 in colonic whole-mount preparations of longitudinal muscle myenteric plexus(LMMP).RESULTS:In the sham-operated rats(sham op),WAS significantly increased defecation and accelerated colorectal transit with marked elevation of plasma corticosterone level.Compared with sham-operated rats,increase in the excretion of fecal pellets during WAS was significantly reduced by rectal nerve transection(RNT)(sham op:6.9 ± 0.8 vs RNT:4.3 ± 0.6,P < 0.05) or Vag(sham op:6.4 ± 0.8 vs Vag:3.7 ± 1.1,P < 0.05),although corticosterone level remained elevated.Adx-rats significantly increased the defecation despite the lower corticosterone level.Distribution pattern of phenol red showed RNT inhibited distal colonic and rectal transit accelerated by WAS,while Vag inhibited proximal colonic transit.Suppression of distal colonic and rectal transit by RNT was further confirmed by the bead evacuation rate(sham op:80.0% vs RNT:53.8%).WAS significantly increased the number of c-Fos-immunoreactive neural cells in the LMMP of the proximal and distal colon,whereas c-Fos expression was decreased by RNT in the distal colon(sham op:9.0 ± 2.0 vs RNT:4.4 ± 1.0,P < 0.05) and decreased by Vag in the proximal colon.CONCLUSION:Pelvic nerve conveys WAS stimuli from the brain to the distal colon,and directly activate the myenteric neurons,followed by the increase of its motility. | Kazunori Suda Hiromi Setoyama Masanobu Nanno Satoshi Matsumoto Mitsuhisa Kawai | 2013 | World Journal of Gastroenterology2013，19，8： | 4 |
| 5 | Rational arrangement of measuring shear wave speed in the liver显示文摘BACKGROUND Shear wave speed has been widely applied to quantify a degree of liver fibrosis. However, there is no standardized procedure, which makes it difficult to utilize the speed universally. AIM To provide procedural standardization of shear wave speed measurement. METHODS Point shear wave elastography (pSWE) was measured in 781 patients, and twodimensional shear wave elastography (2dSWE) was measured on the same day in 18 cases. Regions-of-interest were placed at 12 sites, and the median and robust coefficient-of-variation (CVR) were calculated. A residual sum-of-square (Σdi2) was computed for bootstrap values of 1000 iterations in 18 cases with each assumption of 1 to 12 measurements. The proportion of the Σdi2 (%Σdi2) was calculated as the ratio of Σdi2 to pSWE after converting it based on the correlation between pSWE and 2dSWE. RESULTS The CVR showed a significantly broader distribution in the left lobe (P < 0.0001),and the smallest CVR in the right anterior segment that covered 95% cases was 40.4%. pSWE was significantly higher in the left lobe than in the right lobe (1.63 ± 0.78 m/s vs 1.61 ± 0.78 m/s, P = 0.0004), and the difference between the lobes became further discrete when the subjects were limited to the cases with a CVR less than 40.4% in any segment (1.76 ± 0.80 m/s vs 1.70 ± 0.82 m/s, P < 0.0001). The highest values of the CVR in every 0.1 m/s interval were plotted in convex upward along pSWE and peaked at 1.93 m/s. pSWE and 2dSWE were significantly correlated (P < 0.0001, r = 0.95). In 216000 resamples from 18 cases, the %Σdi2 of 12 sites was 8.0% and gradually increased as the acquisition sites decreased to reach a significant difference with a %Σdi2 of 7 sites (P = 0.027). CONCLUSION These data suggest that shear wave speed should be measured at 8 or more sites of spreading in both lobes. | Takeshi Yokoo Tsutomu Kanefuji Takeshi Suda Itsuo Nagayama Takahiro Hoshi Satoshi Abe Shinichi Morita Hiroteru Kamimura Kenya Kamimura Atsunori Tsuchiya Masaaki Takamura Kazuyoshi Yagi Shuji Terai | 2019 | World Journal of Gastroenterology2019，25，20： | 3 |
| 6 | Growth process of small pancreatic carcinoma: A case report with imaging observation for 22 months显示文摘This report describes serial observations of the growth process of a small invasive ductal carcinoma (IDC) of the pancreas from imaging studies. Histopathological studies showed IDC with macroscopic retention cysts proximal to an intraductal papillary-mucinous adenoma with mild atypia of the branch duct type in the pancreatic body, with no relation between the two lesions. IDC was demonstrated as an extremely low-echoic mass resembling a cyst with an unclear margin on the initial endoscopic ultrasonography. We misinterpreted the low-echoic mass as a benign intraductal mucinous-papillary neoplasm (IPMN) based on findings of other imaging studies, and the patient was followed-up. The mass increased from 7 mm to 13 mm in diameter over 22 mo, and remained smaller than 10 mm in diameter for about 420 d. The tumor volume doubling time was 252 d. The Ki67 labeling index was 15.9%, similar to that described in previous reports. Hence, IDC may grow slowly while remaining small. | Takeshi Hisa Hiroki Ohkubo Satoshi Shiozawa Hiroki Ishigame Masato Takamatsu Masayuki Furutake Bunsei Nobukawa Koichi Suda | 2008 | World Journal of Gastroenterology2008，14，12： | 2 |
| 7 | Phylogenetic relationships between toxic and non-toxic strains of the genus Microcystis based on 16S to 23S internal transcribed spacer sequence显示文摘 | Shigeto Otsuka Shoichiro Suda Renhui Li Masayuki Watanabe Hiroshi Oyaizu Satoshi Matsumoto Makoto M Watanabe | 1999 | FEMS Microbiology Letters1999，，1： | 1 |
| 8 | Recent advance in the treatment of hilar cholangiocarcinoma: hepatectomy with vascular resection显示文摘 | Masaru Miyazaki Fumio Kimura Hiroaki Shimizu Hiroyuki Yoshidome Masayuki Ohtsuka Atsushi Kato Hideyuki Yoshitomi Satoshi Nozawa Katsunori Furukawa Noboru Mitsuhashi Dan Takeuchi Kousuke Suda Isaku Yoshioka | 2007 | Journal of Hepato-Biliary-Pancreatic Surgery2007，，5： | 1 |
| 9 | Recent advance in the treatment of hilar cholangiocarcinoma: hepatectomy with vascular resection显示文摘 | Masaru Miyazaki Fumio Kimura Hiroaki Shimizu Hiroyuki Yoshidome Masayuki Ohtsuka Atsushi Kato Hideyuki Yoshitomi Satoshi Nozawa Katsunori Furukawa Noboru Mitsuhashi Dan Takeuchi Kousuke Suda Isaku Yoshioka | 2007 | Journal of Hepato - Biliary - Pancreatic Surgery2007，，5： | 1 |
| 10 | Recent advance in the treatment of hilar cholangiocarcinoma: hepatectomy with vascular resection显示文摘 | Masaru Miyazaki Fumio Kimura Hiroaki Shimizu Hiroyuki Yoshidome Masayuki Ohtsuka Atsushi Kato Hideyuki Yoshitomi Satoshi Nozawa Katsunori Furukawa Noboru Mitsuhashi Dan Takeuchi Kousuke Suda Isaku Yoshioka | 2007 | Journal of Hepato - Biliary - Pancreatic Surgery2007，，5： | 1 |
| 11 | Therapeutic potential of AMPA receptor antagonist perampanel against cerebral ischemia: beyond epileptic disorder显示文摘Stroke is a leading cause of mortality and severe neurological disability worldwide;however,curative therapeutic options are limited.Although recanalization therapy using endovascular thrombectomy has demonstrated great benefits in the functional outcome of patients with acute ischemic stroke,the rate of excellent clinical outcomes remains limited.Therefore,the current recanalization therapeutic approach may require adjunctive therapy to improve outcomes. | Satoshi Suda Kazumi Kimura | 2019 | Neural Regeneration Research2019，14，9： | 1 |
| 12 | Practical performance and action mechanism of ester lubricants in minimal quantity lubrication machining显示文摘 | Toshiaki Wakabayashi Satoshi Suda | 2008 | Journal of the Japan Petroleum In stitute2008，51，3： | 1 |
| 13 | Preparation of a platinum and palladium/polyimide nanocomposite film as a precursor of metal-doped carbon molecular sieve membrane via supercritical impregnation 显示文摘 | Satoshi Yoda Atsushi Hasegawa Hiroyuki Suda | 2004 | Chemistry of Materials2004，16，12： | 1 |
| 14 | Study of intra-abdominal fat distribution in sigmoid colon cancer in Japanese patients by use of MDCT data显示文摘 | Toshihiro Ogura Tomohiro Tachikawa Yoshiko Nishimura Satoshi Suda Younosuke Shimomura Masatoshi Oya Atsushi Kono | 2009 | Radiological Physics and Technology2009，，2： | 1 |
| 15 | Robot-assisted Thoracoscopic Lymphadenectomy Along the Left Recurrent Laryngeal Nerve for Esophageal Squamous Cell Carcinoma in the Prone Position: Technical Report and Short-term Outcomes显示文摘 | Koichi Suda Yoshinori Ishida Yuichiro Kawamura Kazuki Inaba Seiichiro Kanaya Satoshi Teramukai Seiji Satoh Ichiro Uyama | 2012 | World Journal of Surgery2012，，7： | 1 |
| 16 | Aggressive surgical approach for stage IV gallbladder carcinoma based on Japanese Society of Biliary Surgery classification显示文摘 | Hiroaki Shimizu Fumio Kimura Hiroyuki Yoshidome Masayuki Ohtsuka Atsushi Kato Hideaki Yoshitomi Satoshi Nozawa Katunori Furukawa Noboru Mitsuhashi Dan Takeuchi Kosuke Suda Isaku Yoshioka Masaru Miyazaki | 2007 | Journal of Hepato - Biliary - Pancreatic Surgery2007，，4： | 1 |
| 17 | Low-crosstalk 2X2 thermo-optic switch with silicon wirewaveguides显示文摘 | Shoji Yuya Kintaka Kenji Suda Satoshi | 2010 | Optics Express2010，18，9： | 1 |
| 18 | Discovery of a strongly r-process enhanced extremely metal-poor star LAMOST J110901.22+075441.8显示文摘We report the discovery of an extremely metal-poor(EMP) giant,LAMOST J110901.22+075441.8, which exhibits a large excess of r-process elements with [Eu/Fe] ~ +1.16. The star is one of the newly discovered EMP stars identified from the LAMOST low-resolution spectroscopic survey and a highresolution follow-up observation with the Subaru Telescope. Stellar parameters and elemental abundances have been determined from the Subaru spectrum. Accurate abundances for a total of 23 elements including 11 neutron-capture elements from Sr through Dy have been derived for LAMOST J110901.22+075441.8. The abundance pattern of LAMOST J110901.22+075441.8 in the range of C through Zn is in line with the 'normal' population of EMP halo stars, except that it shows a notable underabundance in carbon. The heavy element abundance pattern of LAMOST J110901.22+075441.8 is in agreement with other well studied cool r-II metal-poor giants such as CS 22892-052 and CS 31082-001. The abundances of elements in the range from Ba through Dy match the scaled solar r-process pattern well.LAMOST J110901.22+075441.8 provides the first detailed measurements of neutroncapture elements among r-II stars at such low metallicity with [Fe/H]-3.4, and exhibits similar behavior as other r-II stars in the abundance ratio of Zr/Eu as well as Sr/Eu and Ba/Eu. | Hai-Ning Li Wako Aoki Satoshi Honda Gang Zhao Norbert Christlieb Takuma Suda | 2015 | Research in Astronomy and Astrophysics2015，15，8： | 1 |
| 19 | Tribological action and optimal performance: research activities regarding MQL machining fluids显示文摘 | Wakabayashi Toshiaki Inasaki Ichiro Suda Satoshi | 2006 | Machining Science and Technology2006，10，1： | 1 |
| 20 | An Advanced Oscillation Mixing Method for Improving the Cooling Uniformity in Quenching显示文摘In quenching, the cooling uniformity is most important to diminish distortion occurring on work pieces. As a trial to accomplish uniform cooling, therefore, there exist various mixing methods of a quenchant and the quenchant circulation with an external pump has so far been the well accepted mixing method. However, this study proposes an advanced oscillation mixing method that can improve more the cooling uniformity in quenching. The proposed method includes a stirrer in oscillating motion, so that the simultaneous oscillating and mixing movements of the stirrer are considered to provide effectively the uniform cooling characteristics for the quenchant. In comparison with the case of the circulation pump mixing, the investigation using the oscillation mixing method has demonstrated the following two experimental facts: (1) the short vapor blanket stage caused by the quick breakage of the oil vapor blanket and (2) the reduced variation of the quenching distortion. | Hiroyuki Hoshino Hiromitsu Murakami Hideo Yokota Satoshi Suda Hideki Tsuge Koichi Terasaka Toshiaki Wakabayashi | 2004 | 材料热处理学报2004，25，5： | 0 |
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