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| 1 | Changes in plasma ghrelin levels, gastric ghrelin production, and body weight after Helicobacter pylori cure显示文摘 | Hiroyuki Osawa Hiroto Kita Hirohide Ohnishi Masamitsu Nakazato Yukari Date Christopher L. Bowlus Yumiko Ishino Eiko Watanabe Tomomi Shiiya Hiroaki Ueno Hiroko Hoshino Kiichi Satoh Kentaro Sugano | 2006 | Journal of Gastroenterology2006，，10： | 1 |
| 2 | Monitoring and mathematical modeling of mitochondrial ATP in myotubes at single-cell level reveals two distinct population with different kinetics显示文摘Backgrounds ATP is the major energy source for myotube contraction,and is quickly produced to compensate ATP consumption and to maintain sufficient ATP level.ATP is consumed mainly in cytoplasm and produced in mitochondria during myotube contraction.To understand the mechanism of ATP homeostasis during myotube contraction,it is essential to monitor mitochondrial ATP at single-cell level,and examine how ATP is produced and consumed in mitochondria.Methods:We established C2C12 cell line stably expressing fluorescent probe of mitochondrial ATP,and induced differentiation into myotubes・We gave electric pulse stimulation to the differentiated myotubes,and measured mitochondrial ATP.We constructed mathematical model of mitochondrial ATP at single-cell level,and analyzed kinetic parameters of ATP production and consumption.Results:We performed hierarchical clustering analysis of time course of mitochondrial ATP,which resulted in two clusters.Cluster 1 showed strong transient increase,whereas cluster 2 showed weak transient increase.Mathematical modeling at single-cell level revealed that the ATP production rate of cluster 1 was larger than that of cluster 2,and that both regulatory pathways of ATP production and consumption of cluster 1 were faster than those of cluster 2.Cluster 1 showed larger mitochondrial mass than cluster 2,suggesting that cluster 1 shows the similar property of slow muscle fibers,and cluster 2 shows the similar property of fast muscle fibers.Conclusions Cluster 1 showed the stronger mitochondrial ATP increase by larger ATP production rate,but not smaller consumption.Cluster 1 might reflect the larger oxidative capacity of slow muscle fiber. | Naoki Matsuda Ken-ichi Hironaka Masashi Fujii Takumi Wada Katsuyuki Kunida Haruki Inoue Miki Eto Daisuke Hoshino Yasuro Furuichi Yasuko Manabe Nobuharu LFujii Hiroyuki Noji Hiromi Imamura Shinya Kuroda | 2020 | Quantitative Biology2020，8，3： | 1 |
| 3 | Evaluation of wind noise in passenger car compartment in consideration of auditory masking and sound localization显示文摘 | Hiroyuki Hoshino Hiroyasu Katoh | 1999 | Sea Paper1999，1，： | 1 |
| 4 | Prognostic Impact of Hypoxia-Inducible miRNA-210 in Patients with Lung Adenocarcinoma显示文摘 | Jun Osugi Yuka Kimura Yuki Owada Takuya Inoue Yuzuru Watanabe Takumi Yamaura Mitsuro Fukuhara Satoshi Muto Naoyuki Okabe Yuki Matsumura Takeo Hasegawa Athushi Yonechi Mika Hoshino Mitsunori Higuchi Yutaka Shio Hiroyuki Suzuki Mitsukazu Gotoh James L. Muls | 2015 | Journal of Oncology2015，，： | 1 |
| 5 | Soluble interleukin‐6 receptor is a serum biomarker for the response of esophageal carcinoma to neoadjuvant chemoradiotherapy显示文摘 | Yosuke Makuuchi Kazufumi Honda Yoshiaki Osaka Ken Kato Takashi Kojima Hiroyuki Daiko Hiroyasu Igaki Yoshinori Ito Sumito Hoshino Shingo Tachibana Takafumi Watanabe Koh Furuta Shigeki Sekine Tomoko Umaki Yukio Watabe Nami Miura Masaya Ono Akihiko Tsuchida | 2013 | Cancer Sci2013，，8： | 1 |
| 6 | Cigarette smoke extract induces endothelial cell injury via JNK pathway显示文摘 | Shigenori Hoshino Mitsuhiro Yoshida Koji Inoue Yukihiro Yano Masahiko Yanagita Hidenori Mawatari Hiroyuki Yamane Takashi Kijima Toru Kumagai Tadashi Osaki Isao Tachiba Ichiro Kawase | 2005 | Biochemical and Biophysical Research Communications2005，，1： | 1 |
| 7 | Prevention of postoperative complications in skull base surgery for nasal or paranasal sinus carcinoma invading the skull base显示文摘 | Shigeru Nishizawa Naoki Yokota Tetsuo Yokoyama Hiroyuki Mukodaka Takahiro Watanabe Tomoyuki Hoshino Yoshio Ueda | 2001 | Journal of Clinical Neuroscience2001，，4： | 1 |
| 8 | Near-ultraviolet electroluminescence from polysilanes 显示文摘 | HIROYUKI Suzuki SATOSHI Hoshino | 1998 | Thin Solid Films1998，331，： | 1 |
| 9 | Continuous production of an antibiotic polypeptide(Nisin)byLactococcus lactis using a bioreactor coupled to a microfiltration module显示文摘 | MASAYUKI TANIGUCHI KAZUHIRO HOSHINO HIROYUKI URASA-KI | 1994 | Journal of Fermentation and Bioengineering1994，77，6： | 1 |
| 10 | Relationship between saturation field and film texture in NiFeCo/Cu giant magnetoresistive multilayers显示文摘 | Ryoichi Nakatani Katsumi Hoshino Hiroyuki Hoshiya Yutaka Sugita | 1997 | Journal of Magnetism and Magnetic Materials1997，，1： | 1 |
| 11 | Anti-stress effect of theanine on students during pharmacy practice: Positive correlation among salivary α-amylase activity, trait anxiety and subjective stress显示文摘 | Keiko Unno Naoki Tanida Naoto Ishii Hiroyuki Yamamoto Kazuaki Iguchi Minoru Hoshino Atsushi Takeda Hayato Ozawa Tsutomu Ohkubo Lekh Raj Juneja Hiroshi Yamada | 2013 | Pharmacology, Biochemistry and Behavior2013，，： | 1 |
| 12 | Evaluation of pretreatment with Pleurotus ostreatus for enzymatic hydrolysis of rice straw显示文摘 | Masayuki Taniguchi Hiroyuki Suzuki Daisuke Watanabe Kenji Sakai Kazuhiro Hoshino Takaaki Tanaka | 2005 | Journal of Bioscience and Bioengineering2005，，6： | 1 |
| 13 | Determination of bisphenol A in canned vegetables and fruit by high performance liquid chromatography显示文摘 | Terumitsu Yoshida Masakazu Horie Youji Hoshino Hiroyuki Nakazawa Masakazu Horie Hiroyuki Nakazawa | 2001 | Food Additives & Contaminants: Part A2001，，1： | 1 |
| 14 | An Advanced Oscillation Mixing Method for Improving the Cooling Uniformity in Quenching显示文摘In quenching, the cooling uniformity is most important to diminish distortion occurring on work pieces. As a trial to accomplish uniform cooling, therefore, there exist various mixing methods of a quenchant and the quenchant circulation with an external pump has so far been the well accepted mixing method. However, this study proposes an advanced oscillation mixing method that can improve more the cooling uniformity in quenching. The proposed method includes a stirrer in oscillating motion, so that the simultaneous oscillating and mixing movements of the stirrer are considered to provide effectively the uniform cooling characteristics for the quenchant. In comparison with the case of the circulation pump mixing, the investigation using the oscillation mixing method has demonstrated the following two experimental facts: (1) the short vapor blanket stage caused by the quick breakage of the oil vapor blanket and (2) the reduced variation of the quenching distortion. | Hiroyuki Hoshino Hiromitsu Murakami Hideo Yokota Satoshi Suda Hideki Tsuge Koichi Terasaka Toshiaki Wakabayashi | 2004 | 材料热处理学报2004，25，5： | 0 |
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