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| 1 | Diagnostic efficacy of gadoxetic acid-enhanced MRI for hepatocellular carcinoma and dysplastic nodule显示文摘AIM:To evaluate the relationship between the signal intensity of hepatobiliary phase images on gadoxetic acid-enhanced magnetic resonance imaging(MRI)and histological grade.METHODS:Fifty-nine patients with 82 hepatocellular lesions were evaluated retrospectively.Hepatobiliary phase images on gadoxetic acid-enhanced MRI were classified into 3 groups:low,iso or high.Angiographyassisted computed tomography(CT)findings were also classified into 3 groups:CT during arterial portography,and CT hepatic arteriography:A:iso,iso or low;B:slightly low,iso or low;;and C:low,high.We correlated angiography-assisted CT,hepatobiliary phase findings during gadoxetic acid-enhanced MRI and histological grades.Furthermore,correlations between MRI findings and histological grade for each hemodynamic pattern were performed.Correlations among radiologicaland pathological findings were statistically evaluated using the chi-square test and Fisher's exact test.RESULTS:There was a significant correlation between histological grade and hemodynamic pattern(P<0.05).There was a significant correlation between histological grade and signal intensity in the hepatobiliary phase(P<0.05)in group A lesions.There was no significant correlation between histological grade and signal intensity in the hepatobiliary phase in group B or C lesions(P>0.05).CONCLUSION:Signal intensity in the hepatobiliary phase correlated with histological grade in the lesions that maintained portal blood flow,but did not correlate in lesions that showed decreased or defective portal blood flow. | Kazuhiro Saito Ryota Nishio Toru Saguchi Soichi Akata Koichi Tokuuye Fuminori Moriyasu Katsutoshi Sugimoto Junichi Taira Toshitaka Nagao | 2011 | World Journal of Gastroenterology2011，17，30： | 12 |
| 2 | 现代免疫佐剂研究显示文摘 | 王大勇 于庆海 周园 Yukihiro Noda Toshitaka Nabeshima | 2006 | 中国免疫学杂志2006，22，2： | 7 |
| 3 | Esophagus and regenerative medicine显示文摘In addition to squamous cell carcinoma,the incidence of Barrett's esophagus with high-grade dysplasia and esophageal adenocarcinoma is rapidly increasing worldwide.Unfortunately,the current standard of care for esophageal pathology involves resection of the affected tissue,sometimes involving radical esophagectomy.Without exception,these procedures are associated with a high morbidity,compromised quality of life,and unacceptable mortality rates.Regenerative medicine approaches to functional tissue replacement include the use of biological and synthetic scaffolds to promote tissue remodeling and growth.In the case of esophageal repair,extracellular matrix(ECM) scaffolds have proven to be effective for the reconstruction of small patch defects,anastomosis reinforcement,and the prevention of stricture formation after endomucosal resection(EMR).More so,esophageal cancer patients treated with ECM scaffolds have shown complete restoration of a normal,functional,and disease-free epithelium after EMR.These studies provide evidence that a regenerative medicine approach may enable aggressive resection of neoplastic tissue without the need for radical esophagectomy and its associated complications. | Ricardo Londono Blair A Jobe Toshitaka Hoppo Stephen F Badylak | 2012 | World Journal of Gastroenterology2012，18，47： | 4 |
| 4 | Underground laboratory JUNA shedding light on stellar nucleosynthesis显示文摘Extremely low background experiments to measure key nuclear reaction cross sections of astrophysical interest are conducted at the world’s deepest underground laboratory,the Jingping Underground laboratory for Nuclear Astrophysics(JUNA).High precision measurements provide reliable information to understand nucleosynthetic processes in celestial objects and resolve mysteries on the origin of atomic nuclei discovered in the first generations of Pop.III stars in the universe and meteoritic SiC grains in the solar system. | Toshitaka Kajino | 2023 | Nuclear Science and Techniques2023，34，3： | 4 |
| 5 | Evaluation of effects of a novel endoscopically applied radiofrequency ablation biliary catheter using an ex-vivo pig liver显示文摘 | Takao Itoi Hiroyuki Isayama Atsushi Sofuni Fumihide Itokawa Miho Tamura Yusuke Watanabe Fuminori Moriyasu Michel Kahaleh Nagy Habib Toshitaka Nagao Tomohisa Yokoyama Kazuhiko Kasuya Hiroshi Kawakami | 2012 | Journal of Hepato-Biliary-Pancreatic Sciences2012，，5： | 3 |
| 6 | Feasibility, safety, acceptability, and yield of office-based, screening transnasal esophagoscopy (with video)显示文摘 | Anne F. Peery Toshitaka Hoppo Katherine S. Garman Evan S. Dellon Norma Daugherty Susan Bream Alejandro F. Sanz Jon Davison Melissa Spacek Diane Connors Ashley L. Faulx Amitabh Chak James D. Luketich Nicholas J. Shaheen Blair A. Jobe | 2012 | Gastrointestinal Endoscopy2012，，5： | 2 |
| 7 | Cellular irinotecan resistance in colorectal cancer and overcoming irinotecan refractoriness through various combination trials including DNA methyltransferase inhibitors: a review显示文摘Treatment with pharmacological drugs for colorectal cancer(CRC)remains unsatisfactory.A major cause of failure in pharmacotherapy is the resistance of colon cancer cells to the drugs,creating an urgent issue.In this review,we summarize previous studies on the resistance of CRC cells to irinotecan and discuss possible reasons for refractoriness.Our review presents the following five major causes of irinotecan resistance in human CRC:(1)cellular irinotecan resistance is induced mainly through the increased expression of the drug efflux transporter,ABCG2;(2)cellular irinotecan resistance is also induced in association with a nuclear receptor,pregnane/steroid X receptor(PXR/SXR),which is enriched in the CYP3A4 gene enhancer region in CRC cells by exposing the cells to SN-38;(3)irinotecan-resistant cells possess either reduced DNA topoisomerase I(Top1)expression at both the mRNA and protein levels or Top1 missense mutations;(4)alterations in the tumor microenvironment lead to drug resistance through intercellular vesicle-mediated transmission of miRNAs;and(5)CRC stem cells are the most difficult targets to successfully treat CRC.In the clinical setting,CRC gradually develops resistance to initially effective irinotecan-based therapy.To solve this problem,several clinical trials,such as irinotecan plus cetuximab vs.cetuximab monotherapy,have been conducted.Another clinical trial on irinotecan plus guadecitabine,a DNA-methyltransferase inhibitor,has also been conducted. | Shogo Ozawa Toshitaka Miura Jun Terashima Wataru Habano | 2021 | Cancer Drug Resistance2021，4，4： | 2 |
| 8 | Diffusion-weighted imaging might be useful for reactive lymphoid hyperplasia diagnosis of the liver: A case report显示文摘BACKGROUND Reactive lymphoid hyperplasia(RLH)of the liver is a rare liver lesion.It is considered difficult to differentiate radiologically from hepatocellular carcinoma,metastatic liver tumor and other pathologies.CASE SUMMARY A 54-year-old woman presented to our hospital with RLH of the liver.The patient had a diagnosis of metastatic carcinoma of the liver from an unknown origin and subsequently underwent partial hepatectomy.However,histopathological analysis revealed RLH.The lesion showed perinodular enhancement in the arterial phase on contrast-enhanced computed tomography and magnetic resonance imaging.On diffusion-weighted imaging(DWI),we encountered linear hyperintensity along the portal tract consecutive to the liver lesion,which is a new characteristic radiologic finding.This finding corresponded to the lymphoid cell infiltration of the portal tract.Furthermore,there was strongly restricted diffusion on the apparent diffusion coefficient map.We used these characteristic radiologic findings to diagnose the lesion as a lymphoproliferative disease.CONCLUSION The linear hyperintensity consecutive to the liver lesion on DWI provided additional valuable diagnostic information. | Taro Tanaka Kazuhiro Saito Daisuke Yunaiyama Jun Matsubayashi Yuichi Nagakawa Maki Tanigawa Toshitaka Nagao | 2020 | World Journal of Clinical Cases2020，8，21： | 2 |
| 9 | Review of Subterahertz and Terahertz Gyrodevices at IAP RAS and FIR FU 显示文摘 | VLADIMIR BRATMAN MIKHAIL GLYAVIN TOSHITAKA IDEHARA | 2009 | IEEE Transaction on Plasma Science2009，37，1： | 1 |
| 10 | Experimental study on the ultimate strength of steel arches显示文摘 | Sakimoto Tatsuro Yamao Toshitaka Komatsu sadao | 1979 | Proceeding of the Japan Society of Civil Engineers1979，，286： | 1 |
| 11 | Expression of Transcription Factor E2F-1 in Pancreatic Ductal Carcinoma: An Immunohistochemical Study显示文摘 | Kazuto Yamazaki Takayuki Yajima Toshitaka Nagao Hiroki Shinkawa Fukuo Kondo Kyota Hanami Akira Asoh Isamu Sugano Yasuo Ishida | 2003 | Pathology - Research and Practice2003，，1： | 1 |
| 12 | Viral myocarditis: potential defense mechanisms within the cardiomyocyte against virus infection显示文摘 | Yajima Toshitaka | 2011 | EN2011，，5： | 1 |
| 13 | Long-Term Results of Subtotal Esophagectomy with Three-Field Lymphadenectomy for Carcinoma of the Thoracic Esophagus显示文摘 | Masamichi Baba Takashi Aikou Heiji Yoshinaka Shoji Natsugoe Toshitaka Fukumoto Hisaaki Shimazu Kouhei Akazawa | 1994 | Annals of Surgery1994，，3： | 1 |
| 14 | Effect of rhizomes of Atractylodes lancea and its constituents on the delay of gastric emptying显示文摘 | Yochiro N Toshitaka K Kazunori H | 2003 | Ethnopharmacol2003，84，1： | 1 |
| 15 | Balloon-occluded retrograde transvenous obliteration of gastric varix draining via the left inferior phrenic vein into the left hepatic vein显示文摘 | Kenji Ibukuro Koichi Mori Toshitaka Tsukiyama Yoshihiro Inoue Yukako Iwamoto Kazumi Tagawa | 1999 | CardioVascular and Interventional Radiology1999，，5： | 1 |
| 16 | Prediction of non‐biochemical recurrence rate after radical prostatectomy in a J apanese cohort: Development of a postoperative nomogram显示文摘 | Hidenori Okubo Makoto Ohori Yoshio Ohno Jun Nakashima Rie Inoue Toshitaka Nagao Masaaki Tachibana | 2014 | Int J Urol2014，，5： | 1 |
| 17 | Monitoring the process of ground failure in repeated landslides and associated stability assessments显示文摘 | | 1998 | Engineering Geology1998，50，12： | 1 |
| 18 | Efficacy and tolerability of once-weekly administration of 17.5?mg risedronate in Japanese patients with involutional osteoporosis: a comparison with 2.5-mg once-daily dosage regimen显示文摘 | Hideaki Kishimoto Masao Fukunaga Kazuhiro Kushida Masataka Shiraki Akira Itabashi Hajime Nawata Toshitaka Nakamura Hiroaki Ohta Kunio Takaoka Yasuo Ohashi | 2006 | Journal of Bone and Mineral Metabolism2006，，5： | 1 |
| 19 | Soluble adhesion molecules and C-reactive protein in the progression of silent cerebral infarction in patients with type 2 diabetes mellitus显示文摘 | Takahiko Kawamura Toshitaka Umemura Akio Kanai Masahito Nagashima Nobuhisa Nakamura Tomoko Uno Mikihiro Nakayama Takahisa Sano Yoji Hamada Jiro Nakamura Nigishi Hotta | 2006 | Metabolism2006，，4： | 1 |
| 20 | Cognitive impairment in diabetic patients:Can diabetic control prevent cognitive decline? 显示文摘 | Takahiko Kawamura Toshitaka Umemura Nigishi Hotta | 2012 | J Diabetes Inves- rig2012，183，5： | 1 |
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