|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Clinical relevance of fluorodeoxyglucose positron emission tomography/computed tomography and magnifying endoscopy with narrow band imaging in decision-making regarding the treatment strategy for esophageal squamous cell carcinoma显示文摘BACKGROUND Recent advances in endoscopic technology,especially magnifying endoscopy with narrow band imaging(ME-NBI)enable us to detect superficial esophageal squamous cell carcinoma(ESCC),but determining the appropriate method of resection,endoscopic resection(ER)vs surgical resection,is often challenging.Recently,several studies have reported that 18F-fluorodeoxyglucose positron emission tomography(FDG-PET)is a useful indicator for decision-making regarding treatment for superficial ESCC.Although,there are not enough reports on association between FDG-PET uptake and clinicopathological characteristics of superficial ESCC.And,there are not enough reports on evaluating the usefulness of combination of FDG-PET and ME-NBI for determining the treatment strategy for superficial ESCC.This study evaluated clinical relevance of FDG-PET and ME-NBI in decision-making regarding the treatment strategy for ESCC.AIM To investigate the association between FDG uptake and the clinicopathological characteristics of superficial ESCC and its usefulness of combination of FDG-PET and ME-NBI for determining the treatment strategy for superficial ESCC.METHODS A database of all patients with superficial ESCC who had undergone both MENBI and FDG-PET for pre-treatment staging at Aichi Cancer Center Hospital between January 2008 and November 2018 was retrospectively analyzed.FDG uptake was defined positive or negative whether the primary lesion was visualized or could be distinguished from the background,or not.The invasion depth of ESCC was classified according to the Japan Esophageal Society.Primary endpoint is to evaluate the association between FDG uptake and clinicopathological characteristics of superficial ESCC.Secondary endpoint is to investigate the efficacy of combination of FDG-PET and ME-NBI for determining the treatment strategy for superficial ESCC.RESULTS A total of 82 lesions in 82 patients were included.FDG-PET showed positive uptake in 29(35.4%)lesions.Univariate analysis showed that uptake of FDG-PET had significant correlations with circumferential extension(P=0.014),pathological depth of tumor invasion(P<0.001),infiltrative growth pattern(P<0.001),histological grade(P=0.002),vascular invasion(P=0.001),and lymphatic invasion(P<0.001).On multivariate analysis,only depth of tumor invasion was independently correlated with FDG-PET/computed tomography visibility(P=0.018).The sensitivity,specificity,positive predictive value(PPV),negative predictive value(NPV),and accuracy of Type B2 in ME-NBI for the invasion depth of T1a muscularis mucosae and T1b upper submucosal layer were 68.4%/79.4%/50.0%/89.3%/76.8%,respectively,and those of Type B3 for the depth of T1b middle and deeper submucosal layers(SM2 and SM3)were 46.7%/100%/100%/89.3%/90.2%,respectively.On the other hand,those of FDGPET for SM2 and SM3 were 93.3%/77.6%/48.2%/98.1%/80.5%,respectively,whereas,if the combination of positive FDG uptake and type B2 and B3 was defined as an indicator for radical esophagectomy or definitive chemoradiotherapy,the sensitivity,specificity,PPV,NPV,and accuracy were 78.3%/91.5%/78.3%/91.5%/87.8%,respectively.CONCLUSION FDG uptake was correlated with the invasion depth of superficial ESCC.Combined use of FDG-PET and ME-NBI,especially with the microvascular findings of Type B2 and B3,is useful to determine whether ER is indicated for the lesion. | Kazuhiro Toriyama Masahiro Tajika Tsutomu Tanaka Makoto Ishihara Yutaka Hirayama Sachiyo Onishi Nobumasa Mizuno Takamichi Kuwahara Nozomi Okuno Shinpei Matsumoto Eiichi Sasaki Tetsuya Abe Yasushi Yatabe Kazuo Hara Keitaro Matsuo Tsuneo Tamaki Yasumasa Niwa | 2019 | World Journal of Gastroenterology2019，25，46： | 7 |
| 2 | 中国内蒙自治区马饲育环境土壤中马红球菌的分布(英文)显示文摘对中国内蒙古自治区饲育马土壤环境中马红球菌的分布知之甚少;为此,在中国内蒙古通辽近郊、内蒙古南部锡林郭勒盟大草原、内蒙古东部呼伦贝尔大草原等马场共收集了108份土壤样品进行了马红球菌的检测。结果,锡林郭勒盟大草原和呼伦贝尔大草原的马红球菌分离率为25.9%~30.0%,通辽近郊土壤中分离率高达82.3%。这说明在通辽近郊马红球菌的分离菌数是草原土壤中马红球菌分离菌数的10倍。应用PCR技术检测了488株的毒力相关基因,相对分子质量分别为15000~17000(VapA)和20000(VapB)。所有的分离株都未检出毒力相关基因。这些无毒力分离株的质粒资料显示,各种大小的潜在质粒的发生率为13.3%~21.5%。本研究结果截然不同于我们新近对蒙古国的调查结论:马红球菌在蒙古国乌兰巴托的马群中不存在。造成这一差异的原因可能在于蒙古国的游牧生活和内蒙古的非游牧生活。 | 丁壮 Shinji TAKAI Hiroo MADARAME 常爽 黄海楠 霍晓伟 高明华 谭忠田 高双成 Fumiko HATORI Yukako SASAKI Tsutomu KAKUDA Shiro TSUBAKI | 2008 | 中国兽医学报2008，28，1： | 3 |
| 3 | Characterization of QTL for unique agronomic traits of new-plant-type rice varieties using introgression lines of IR64显示文摘To enhance the yield potential of an elite indica rice cultivar,an introgression(BC_3-derived) line of IR64,YTH288,was developed using a new-plant-type cultivar,IR66215-44-2-3,as a donor parent.YTH288 has agronomically valuable characteristics such as large panicles,few unproductive tillers,and large leaves inherited from NPT.To identify the genetic basis of these traits,we used 167 F_2 plants derived from a cross between IR64 and YTH288 to conduct QTL analysis for five agronomic traits:days to heading(DTH),culm length(CL),flag leaf length(FLL),flag leaf width(FLW),and filled spikelet number per panicle(FSN).Six putative QTL were detected:four on chromosome4(for CL,FLL,FLW,and FSN) and two on chromosome 2(for DTH and FLL).All QTL with the IR66215-44-2-3 allele,except that for FLL on chromosome 2,had positive effects on each trait.To confirm the effects of these putative QTL,we developed NILs with the IR64 genetic background by marker-assisted selection.We observed significant differences in several agronomic traits between IR64 and NILs that carried these QTL on chromosomes2 and 4.Additionally,four IR64-NILs carrying chromosomal segments derived from different NPT varieties on the long arm of chromosome 4 exhibited similar pleiotropic To enhance the yield potential of an elite indica rice cultivar, an introgression(BC3-derived) line of IR64, YTH288, was developed using a new-plant-type cultivar,IR66215-44-2-3, as a donor parent. YTH288 has agronomically valuable characteristics such as large panicles, few unproductive tillers, and large leaves inherited from NPT.To identify the genetic basis of these traits, we used 167 F2 plants derived from a cross between IR64 and YTH288 to conduct QTL analysis for five agronomic traits: days to heading(DTH), culm length(CL), flag leaf length(FLL), flag leaf width(FLW), and filled spikelet number per panicle(FSN). Six putative QTL were detected: four on chromosome4(for CL, FLL, FLW, and FSN) and two on chromosome 2(for DTH and FLL). All QTL with the IR66215-44-2-3 allele, except that for FLL on chromosome 2, had positive effects on each trait. To confirm the effects of these putative QTL, we developed NILs with the IR64 genetic background by marker-assisted selection. We observed significant differences in several agronomic traits between IR64 and NILs that carried these QTL on chromosomes2 and 4. Additionally, four IR64-NILs carrying chromosomal segments derived from different NPT varieties on the long arm of chromosome 4 exhibited similar pleiotropiceffects for unique agronomic traits. These NILs can be used as research materials for studying each trait and as breeding materials for yield improvement of indica rice cultivars. | Analiza G.Tagle Daisuke Fujita Leodegario A.Ebron Mary Jeanie Telebanco-Yanoria Kazuhiro Sasaki Tsutomu Ishimaru Yoshimichi Fukuta Nobuya Kobayashi | 2016 | The Crop Journal2016，4，1： | 2 |
| 4 | Association of Plasma Homocysteine Concentration With Atherosclerotic Carotid Plaques and Lacunar Infarction显示文摘 | Tsutomu Sasaki Manabu Watanabe Yoji Nagai Taku Hoshi Masashi Takasawa Masaru Nukata Akihiko Taguchi Kazuo Kitagawa Naokazu Kinoshita Masayasu Matsumoto | 2002 | Stroke: Journal of the American Heart Association2002，，6： | 2 |
| 5 | Expression of survivin, an inhibitor of apoptosis protein, in tumors of the nervous system显示文摘 | Tsutomu Sasaki Beatriz M. Lopes Gerald R. Hankins Gregory A. Helm | 2002 | Acta Neuropathologica2002，，1： | 1 |
| 6 | Augmentation of Postnatal Neovascularization With Autologous Bone Marrow Transplantation显示文摘 | Satoshi Shintani Toyoaki Murohara Hisao Ikeda Takafumi Ueno Ken-ichiro Sasaki Junli Duan Tsutomu Imaizumi | 2001 | Circulation: Journal of the American Heart Association2001，，6： | 1 |
| 7 | Chronic HCV infection was associated with severe insulin resistance and mild atherosclerosis: a population-based study in an HCV hyperendemic area显示文摘 | Ichiro Miyajima Takumi Kawaguchi Ako Fukami Yumiko Nagao Hisashi Adachi Satoshi Sasaki Tsutomu Imaizumi Michio Sata | 2013 | Journal of Gastroenterology2013，，1： | 1 |
| 8 | Prognosis of recurrent non?small cell lung cancer following completeresection显示文摘 | Hidefumi Sasaki Ayumi Suzuki Tsutomu Tatematsu Masayuki Shitara Yu Hikosaka Katsuhiro Okuda Satoru Moriyama Motoki Yano Yoshitaka Fujii | 2014 | Oncology Letters2014，，4： | 1 |
| 9 | A-type proanthocyanidins from peanut skins显示文摘 | Hongxiang Lou Yoshimitsu Yamazaki Tsutomu Sasaki Masaru Uchida Hideoki Tanaka Syuichi Oka | 1999 | Phytochemistry1999，，2： | 1 |
| 10 | Phase II study of S-1 as first-line treatment for elderly patients over 75 years of age with advanced gastric cancer: the Tokyo Cooperative Oncology Group study显示文摘 | Wasaburo Koizumi Toshikazu Akiya Atsushi Sato Toshikazu Sakuyama Eisaku Sasaki Takashi Tomidokoro Tsutomu Hamada Mototsugu Fujimori Yoshinori Kikuchi Ken Shimada Tetsuya Mine Kensei Yamaguchi Tsuneo Sasaki Minoru Kurihara | 2010 | Cancer Chemotherapy and Pharmacology2010，，： | 1 |
| 11 | Gastric phenotype signet-ring cell carcinoma of the stomach with multiple bone metastases effectively treated with sequential methotrexate and 5-fluorouracil显示文摘 | Tsutomu Mizoshita Hiromi Kataoka Eiji Kubota Yasuyuki Okamoto Takaya Shimura Yoshinori Mori Tsuneya Wada Naotaka Ogasawara Makoto Sasaki Takeshi Kamiya Takashi Joh | 2008 | International Journal of Clinical Oncology2008，，4： | 1 |
| 12 | Angiogenesis and Vasculogenesis Are Impaired in the Precocious-Aging klotho Mouse显示文摘 | Toshifumi Shimada Yoshiaki Takeshita Toyoaki Murohara Ken-ichiro Sasaki Kimiyasu Egami Satoshi Shintani Yosuke Katsuda Hisao Ikeda Yo-ichi Nabeshima Tsutomu Imaizumi | 2004 | Circulation2004，，9： | 1 |
| 13 | Characterization of the human p57KIP2 gene: Alternative splicing, insertion/deletion polymorphisms in VNTR sequences in the coding region, and mutational analysis显示文摘 | Takashi Tokino Tsutomu Urano Tomohisa Furuhata Mieko Matsushima Takashi Miyatsu Shin Sasaki Yusuke Nakamura | 1996 | Human Genetics1996，，5： | 1 |
| 14 | Chronic HCV infection was associated with severe insulin resistance and mild atherosclerosis: a population-based study in an HCV hyperendemic area显示文摘 | Ichiro Miyajima Takumi Kawaguchi Ako Fukami Yumiko Nagao Hisashi Adachi Satoshi Sasaki Tsutomu Imaizumi Michio Sata | 2013 | Journal of Gastroenterology2013，，1： | 1 |
| 15 | Expression of survivin, an inhibitor of apoptosis protein, in tumors of the nervous system显示文摘 | Tsutomu Sasaki Beatriz M. Lopes Gerald R. Hankins Gregory A. Helm | 2002 | Acta Neuropathologica2002，，1： | 1 |
| 16 | Phase II study of S-1 as first-line treatment for elderly patients over 75?years of age with advanced gastric cancer: the Tokyo Cooperative Oncology Group study显示文摘 | Wasaburo Koizumi Toshikazu Akiya Atsushi Sato Toshikazu Sakuyama Eisaku Sasaki Takashi Tomidokoro Tsutomu Hamada Mototsugu Fujimori Yoshinori Kikuchi Ken Shimada Tetsuya Mine Kensei Yamaguchi Tsuneo Sasaki Minoru Kurihara | 2010 | Cancer Chemotherapy and Pharmacology2010，，6： | 1 |
| 17 | Deletion or methylation of CDKN2A/2B and PVT1 rearrangement occur frequently in highly aggressive B-cell lymphomas harboring 8q24 abnormality显示文摘 | Yasuhiko Tsutsumi Yoshiaki Chinen Natsumi Sakamoto Hisao Nagoshi Kazuhiro Nishida Satoru Kobayashi Yuichi Yokokawa Tomohiko Taki Nana Sasaki Mio Yamamoto-Sugitani Tsutomu Kobayashi Yosuke Matsumoto Shigeo Horiike Junya Kuroda Masafumi Taniwaki | 2013 | Leukemia & Lymphoma2013，，12： | 1 |
| 18 | Dose-escalation and pharmacokinetic study of nanoparticle curcumin, a potential anticancer agent with improved bioavailability, in healthy human volunteers显示文摘 | Masashi Kanai Atsushi Imaizumi Yoshihiko Otsuka Hiroki Sasaki Momo Hashiguchi Kazu Tsujiko Shigemi Matsumoto Hiroshi Ishiguro Tsutomu Chiba | 2012 | Cancer Chemotherapy and Pharmacology2012，，1： | 1 |
| 19 | Highly selective methoxycarbonylation of aliphatic diamines with methyl phenyl carbonate to the corresponding methyl N -alkyl dicarbamates显示文摘 | Tsutomu Yoshida Masaaki Sasaki Fumiaki Hirata Yukio Kawamani Koji Inazu Akio Ishikawa Kazuhito Murai Tsuneo Echizen Toshihide Baba | 2005 | Applied Catalysis A, General2005，，2： | 1 |
| 20 | Expression of survivin, an inhibitor of apoptosis protein, in tumors of the nervous system显示文摘 | Tsutomu Sasaki M Beatriz S Lopes | 2002 | Acta Neuropathol2002，104，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员