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| 1 | Effects of tyrosine kinase inhibitor E7080 and eNOS inhibitor L-NIO on colorectal cancer alone and in combination显示文摘Objective:To investigate the effects of E7080 and N5-(1-iminoethyl)-L-ornithine dihydrochloride(L-NIO)on colorectal cancer alone and in combination.Methods:HT29 colorectal cancer cell line from Sap Institute was used.Real-time cell analysis(xCELLigence system)was performed to determine the effects of E7080 and L-NIO on colorectal cell proliferation.While apoptosis was determined with Annexin V staining,and the effect of agents on angiogenesis was determined with chorioallantoic membrane(CAM)model.Results:We found that E7080 has a strong antiproliferative effect with an half maximum inhibition of concentration(IC50)value of 5.60×10–8mol/L.Also it has been observed that E7080 showed antiangiogenic and apoptotic effects on HT29 colorectal cancer cells.Antiangiogenic scores of E7080 were 1.2,1.0 and 0.6for 100,10 and 1 nmol/L E7080 concentrations,respectively.Furthermore,apoptosis has been detected in71%of HT29 colorectal cancer cells after administration of 100 nmol/L E7080 which may indicate strong apoptotic effect.Meanwhile administration of L-NIO alone did not show any effect,but the combination of E7080 with L-NIO increased the antiproliferative,antiangiogenic and apoptotic effects of E7080.Conclusions:Results of this study indicate that E7080 may be a good choice in treatment of colorectal tumors.Furthermore the increased effects of E7080 when combined with L-NIO raise the possibility to use a lower dose of E7080 and therefore avoid/minimize the side effects observed with E7080. | Ahmet Altun Tijen Kaya Temiz Ezgi Balc Zübeyde Ak n Polat Mustafa Turan | 2013 | Chinese Journal of Cancer Research2013，25，5： | 4 |
| 2 | Patients with Inflammatory Bowel Disease Have a Lower Response Rate to HBV Vaccination Compared to Controls显示文摘 | Mustafa Erhan Altun?z Ebubekir ?enate? Atakan Ye?il Turan ?alhan Ay?e Oya Kurda? ?vün? | 2012 | Digestive Diseases and Sciences2012，，4： | 3 |
| 3 | White matter hyperintensity progression is associated with incident probable dementia or mild cognitive impairment显示文摘Background White matter hyperintensity(WMH)on brain MRI is associated with developing dementia or mild cognitive impairment(MCI),but WMH progression over time has not been fully investigated as an independent risk factor.Methods We performed a post hoc analysis of the Systolic Blood Pressure Intervention Trial-Memory and Cognition in Decreased Hypertension(SPRINT MIND)trial.The primary outcome was incident probable dementia or MCI(dementia/MCI)before the follow-up MRI at 48 months from enrolment.The primary predictor was WMH progression,defined as the Z score difference between the follow-up and baseline WMH volumes.The secondary predictor was a binary WMH progression threshold(≥1.4 mL vs<1.4 mL).Results Among the 433 included patients,33(7.6%)developed dementia/MCI.There were 156(36.0%)patients who met the WMH progression threshold of≥1.4 mL,in whom the rate of dementia/MCI was 12.8%(20/156)vs 4.7%(13/277)of patients with<1.4 mL WMH progression(p=0.002).In multivariable logistic regression,the Z score of WMH progression was associated with dementia/MCI(OR 1.51,95%CI 1.12 to 2.04,p=0.007)as was the WMH progression threshold of≥1.4 mL(OR 2.89,95%CI 1.23 to 6.81,p=0.015).Conclusions In this post hoc analysis of SPRINT MIND,WMH progression over 48 months was associated with the development of probable dementia or MCI. | Adam de Havenon Kevin N Sheth Sharon D Yeatts Tanya N Turan Shyam Prabhakaran | 2022 | Stroke & Vascular Neurology2022，7，4： | 2 |
| 4 | Evolution of Microstructure, Residual Stress, and Tensile Properties of Mg–Zn–Y–La–Zr Magnesium Alloy Processed by Extrusion显示文摘The microstructure, texture, residual stress, and tensile properties of Mg–6 Zn–2 Y–1 La–0.5 Zr(wt%) magnesium alloy were investigated before and after extrusion process, which performed at 300 °C and 400 °C. The microstructural characterizations indicated that the as-cast alloy was comprised of α-Mg, Mg–Zn, Mg–Zn–La, and Mg–Zn–Y phases. During homogenization at 400 °C for 24 h, most of the secondary phases exhibited partial dissolution. Extrusion process led to a remarkable grain refi nement due to dynamic recrystallization(DRX). The degree of DRX and the DRXed grain size increased with increasing extrusion temperature. The homogenized alloy did not show a preferential crystallographic orientation, whereas the extruded alloys showed strong basal texture. The extrusion process led to a signifi cant improvement on the compressive residual stress and mechanical properties. The alloy extruded at 300 °C exhibited the highest basal texture intensity, the compressive residual stress and hardness, and yield and tensile strengths among the studied alloys. | Huseyin Zengin Yunus Turen Muhammet Emre Turan Fatih Ayd?n | 2019 | Acta Metallurgica Sinica(English Letters)2019，32，11： | 2 |
| 5 | Sunitinib-and sorafenib-inducednephrotic syndrome in a patient with gastrointestinaf stromal tumor显示文摘 | Turan N Benekli M Ozturk SC | 2012 | Ann Pharmacother2012，46，10： | 1 |
| 6 | Production of human milk fat analogue containing docosahexaenoic and araehidonie acids 显示文摘 | Turan D Sahin Yesil Ubuk N Akoh C C | 2012 | Journal of Agricultural and Food Chemistry2012，60，17： | 1 |
| 7 | Selenium alters the lipid content and protein profile or rat heart: An FTIR microspectroscopic study显示文摘 | TOYRAN N TURAN B SEVERCAN F | 2007 | Arch Biochem Biophys2007，458，2： | 1 |
| 8 | Theeffects of G-CSF and naproxen sodium on the serum TGF-betal level and fracture healing in rat tibias显示文摘 | KAYGUSUZ M A TURAN C C AYDIN N E | 2006 | Life Sci2006，80，1： | 1 |
| 9 | Vulvar syringoma exacerbated during pregnancy显示文摘 | Cem Turan Mustafa Ugur Lale Kutluay Selahattin Kükner Tülin Dabakoglu Tugrul Aydogdu Yusuf Ergün Omer Cobanoglu | 1996 | European Journal of Obstetrics and Gynecology1996，，1： | 1 |
| 10 | DNA methylation and gene expression differences in children conceived in vitro or in vivo 显示文摘 | Katari S Turan N Bibikova M | 2009 | HumMolGenet2009，18，20： | 1 |
| 11 | The effects of selenium supplementation on antioxidative enzyme activities and plasma and erythrocyte selenium levels显示文摘 | Turan B Dalay N Afrasyap L | 1993 | Acta Physiol Hung1993，81，1： | 1 |
| 12 | Assessment of total placenta previa by magnetic resonance imaging and ultrasonography to detect placenta accreta and its variants显示文摘 | Peker N Turan V Erqenoqlu M | 2013 | Ginekol Pol2013，84，3： | 1 |
| 13 | The prevention of pain from injection of rocuronium by ondansetron,lidocaine,tramadol,and fentanyl显示文摘 | Memi D Turan A Karamanlio lu B Süt N Pamuk Cu Z | 2002 | Anesth Analg2002，94，： | 1 |
| 14 | Use of pistachio shells as an adsorbent for the removal of zinc ( II ) ion 显示文摘 | Turan N G Mesci B | 2011 | Clean-Soil Air Water2011，39，5： | 1 |
| 15 | Matemal cardiac function in fetal growth restriction 显示文摘 | Bamfo J Kametas N Turan O | 2006 | Biog2006，113，： | 1 |
| 16 | The prevention of pain from injection of rocuronium by magnesium sulphate,lignocaine,sodium bicar-bonate and alfentanil显示文摘 | Turan A Memis D Karamanlioglu B Sut N Pamukcu Z | 2003 | Anaesth Intensive Care2003，31，： | 1 |
| 17 | The role of peroxynitrite in chemical preconditioning with 3-nitropropionic acid in rat hearts显示文摘 | Turan N Csonka C Csont T | 2006 | Cardiovasc Res2006，70，2： | 1 |
| 18 | Assessment of total pla- centa previa by magnetic resonance imaging and ultrasonography to detect placenta accreta and its variants显示文摘 | Peker N Turan V Ergenoglu M | 2013 | Ginekol Pol2013，84，3： | 1 |
| 19 | Assessment of total placenta previa by magnetic resonance imaging and ultrasonography to detect placenta accreta and its variants显示文摘 | Peker N Turan V Ergenoglu M | 2013 | Ginekol Pol2013，84，3： | 1 |
| 20 | Disturbing extremal behavior of spot rate dynamics显示文摘 | Turan G B Salih N N | 2003 | Journal of Empirical Finance2003，，10： | 1 |
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