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| 1 | Multiplex RT-PCR-based detections of CEA, CK20 and EGFR in colorectal cancer patients显示文摘AIM: To develop a multiplex reverse transcription polymerase chain reaction (RT-PCR) method detecting cir-culating tumor cells in the peripheral blood of colorectal cancer (CRC) patients. METHODS: Peripheral blood samples were collected from 88 CRC patients and 40 healthy individuals from the blood donors' clinic and subsequently analyzed by multiplex RT-RCR for the expression of carcinoembryonic antigen (CEA), cytokeratin 20 (CK20) and epidermal growth factor receptor (EGFR) mRNA. The analysis involved determining the detection rates of CEA, CK20 and EGFR transcripts vs disease stage and overall survival. Median follow-up period was 19 mo (range 8-28 mo). RESULTS: Rates of CEA, CK20 and EGFR detection in CRC patients were 95.5%, 78.4% and 19.3%, respectively. CEA transcripts were detected in 3 healthy volunteer samples (7.5%), whereas all control samples were tested negative for CK20 and EGFR transcripts. The increasing number of positive detections for CEA, CK20 and EGFR transcripts in each blood sample was positively correlated with Astler-Coller disease stage (P< 0.001) and preoperative serum levels of CEA (P=0.029) in CRC patients. Data analysis using Kaplan-Meier estimator documented signif icant differences in the overall survival of the different CRC patient groups as formed according to the increasing number of positivity for CEA, CK20 and EGFR transcripts. CONCLUSION: These data suggest that multiplex RTPCR assay can provide useful information concerning disease stage and overall survival of CRC patients. | Aikaterini Tsouma Chrysanthi Aggeli Panagiotis Lembessis George N Zografos Dimitris P Korkolis Dimitrios Pectasides Maria Skondra Nikolaos Pissimissis Anastasia Tzonou Michael Koutsilieris | 2010 | World Journal of Gastroenterology2010，16，47： | 19 |
| 2 | Intratympanic and Systemic Steroids for Sudden Hearing Loss显示文摘 | Petros Koltsidopoulos Athanasios Bibas Aristides Sismanis Anastasia Tzonou Ioannis Seggas | 2013 | Otology & Neurotology2013，，4： | 2 |
| 3 | Insulin-like growth factor 1 in hepatocellular carcinoma and metastatic liver cancer in men显示文摘 | Stuver SO Kuper H Tzonou A | 2000 | Int J Cancer2000，87，1： | 1 |
| 4 | Flavonoids, vitamin C and adenocarcinoma of the stomach显示文摘 | P. Lagiou E. Samoli A. Lagiou J. Peterson A. Tzonou J. Dwyer D. Trichopoulos | 2004 | Cancer Causes and Control2004，，1： | 1 |
| 5 | Insulin-likegrowth factor 1 in relation to prostate cancer and benignprostatic hyperplasia显示文摘 | Mantzoros CS Tzonou A Signorello LB | 1997 | Br J Cancer1997，76，： | 1 |
| 6 | Immunohistochemical evaluation of nm23-Hl gene product in transitional cell carcinoma of the bladder显示文摘 | Nakopoulou L L Constandinides C A Tzonou A | 1996 | Histopathology1996，28，5： | 1 |
| 7 | Insulin-like growth factor- Iin hepatocellular carcinoma and metastatic liver cancer in man 显示文摘 | Stuver SO Kuper H Tzonou A | 2000 | Int J Cancer2000，87，1： | 1 |
| 8 | Insulin-like growth factor 1 in hepatocellular carcinoma and metastatic liver cancer in men显示文摘 | Stuver SO Kuper H Tzonou A | | 0，，01： | 1 |
| 9 | Tobacco smoking,alcohol consumption and their interaction in the causation of hepatocellular carcinoma显示文摘 | Kuper H Tzonou A Kaklamani E Hsieh CC Lagiou P Adami HO | | International Journal of Cancer0，，： | 1 |
| 10 | Immunohistochemical evaluation of nm23H1 gene product in transitional cell carcinoma of bladder显示文摘 | Nokopoulou LL Constandinides CA Tzonou A | 1996 | Histopathology1996，28，5： | 1 |
| 11 | Hormonal therapy for menopause and ovarian cancer in a collaborative re-analysis of European studies 显示文摘 | Negri E Tzonou A Beral V et a1 | 1999 | Inter J Cancer1999，80，6： | 1 |
| 12 | Insulin - like growth factor 1 in hepatocellular carcinoma and metastatic liver cancer in men显示文摘 | Stuver SO Kuper H Tzonou A | 2000 | Int J Cancer2000，87，1： | 1 |
| 13 | Immunohistochemical evaluation of nm23-H1 gene product in transitional cell carcinoma of the bladder 显示文摘 | Nakopoulou LL Constandinides CA Tzonou A | 1996 | Histopathology1996，28，5： | 1 |
| 14 | Diet and cancer of the prostate:a case-control study in Greece显示文摘 | Tzonou A Signorello LB Lagiou P | 1999 | Int J cancer1999，80，： | 1 |
| 15 | Tobacco, ethanol, coffee, pancreatitis, diabetes mellitus, and cholelithiasis as risk factors for pancreatic carcinoma显示文摘 | Victoria Kalapothaki Anastasia Tzonou Chung-cheng Hsieh Nektaria Toupadaki Anna Karakatsani Dimitrios Trichopoulos | 1993 | Cancer Causes and Control1993，，4： | 1 |
| 16 | Peripheral neuropathy does not invariably coexist with autonomic neuropathy in diabetes mellitus 显示文摘 | Tentolouris N Pagoni S Tzonou A | 2001 | Eur J Intern Med2001，12，： | 1 |
| 17 | Reproductive variables, tobacco, ethanol, coffee and somatometry as risk factors for ovarian cancer 显示文摘 | Polychronopoulou A Tzonou A Hsieh C C | 1993 | Int J Cancer1993，55，3： | 1 |
| 18 | Hormonal therapy for menopause and ovarian cancer in a collaborative re-analysis of European studies 显示文摘 | Tzonou A Beral V | 1999 | Int J Cancer1999，80，6： | 1 |
| 19 | Birth Order, as a Proxy for Age at Infection, in the Etiology of Hepatocellular Carcinoma显示文摘 | Hannah Kuper Chung-cheng Hsieh Sherri O. Stuver Lorelei A. Mucci Anastasia Tzonou Xenophon Zavitsanos Pagona Lagiou Dimitrios Trichopoulos | 2000 | Epidemiology2000，，6： | 1 |
| 20 | The epidemiology of benign prostatic hyperplasia: a study in Greece显示文摘 | Signorello LB Tzonou A Lagiou P | 1999 | BJU Int1999，84，3： | 1 |
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