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| 1 | AGNP精神科治疗药物监测共识指南:2011显示文摘治疗药物监测(Therapeutic drug monitoring,TDM),如通过定量测定血清或血浆药物浓度指导用药剂量优化,已经成为对患者进行精神药物治疗的很有价值的工具。在患者用药依从性难以判断、药物耐受性不佳、治疗剂量下无效以及可能存在药代动力学药物-药物相互作用等情况下,测定药物浓度是很有用的。在精神科,有可能明显获益于TDM的主要患者群体包括儿童、孕妇、老年患者、智力障碍患者、涉及司法的患者、已知或怀疑携带药代动力学相关基因变异的患者,以及合并躯体疾病影响药代动力学的患者。然而,只有将TDM充分整合到临床治疗过程中去,才能发挥其优化药物治疗的潜在优势。为了促进TDM的合理应用,神经精神药理学与药物精神病学协会(Arbeitsgemeinschaft für Neuropsychopharmakologie und Pharmakopsychiatrie,AGNP)的TDM专家组在2004年发表了精神药物治疗药物监测指南。之后,随着知识不断更新,又有许多可能需要进行TDM的新药上市。因此,本次更新将神经精神药物的种类扩展到了128种,并将其TDM必要性划分为从'强烈推荐'到'可能有用'的四个等级。经过大量细致且全面的文献检索与分门别类的汇总整理,将基于循证医学理念的'治疗参考浓度范围'和'剂量相关参考浓度范围'呈现给大家。本共识指南引入了'实验室警戒浓度'的新概念,即实验室需要马上告知治疗医生的药物浓度上限。本共识指南还给出了诸如药物作为细胞色素P450酶的底物和抑制剂的性质,代谢物与母药浓度比值的常见范围,以及与结果解释相关的内容,还提供了何时将TDM与遗传药理学检测相结合的建议。遵循本指南,有助于改善许多患者精神药物治疗的效果,特别是那些存在药代动力学异常的患者。TDM是一门交叉学科,有时针对看起来不一致的数据,需要多学科坦诚地讨论,只有这样,患者才能从这种合作中获益。 | Hiemke C Baumann P Bergemann N Conca A Dietmaier O Egberts K Fric M Gerlach M Greiner C Gründer G Haen E Havemann-Reinecke U Jaquenoud Sirot E Kirchherr H Laux G Lutz UC Messer T Müller MJ Pfuhlmann B Rambeck B Riederer P Schoppek B Stingl J Uhr M Ulrich S Waschgler R Zernig G 李文标(译) 果伟(译) 阮灿军(译) 贺静(译) 汤宜朗(审校) 王传跃(审校) | 2016 | 实用药物与临床2016，19，10： | 37 |
| 2 | Hepatic steatosis is associated with an increased risk of carotid atherosclerosis显示文摘AIM: Although an association between helatic steatosis and vascular risk factors has been described, direct relationships between fatty liver and atherosclerosis have not yet been investigated. The aim of the present study has been to investigate those relationships.METHODS: The Study of Health in Pomerania examined a random population sample aged between 20 and 79 years.A study population of 4 222 subjects without hepatitis B and C infections and without liver cirrhosis was available for the present analysis. Hepatic steatosis was defined sonographically and intima-media thickness (IMT) as well as plaque prevalence were estimated by carotid ultrasound.RESULTS: The prevalence rate of hepatic steatosis was 29.9%. Among subjects aged ≥45 years, an association between hepatic steatosis and IMT of the carotid arteries was found in bivariate analysis, but not after adjustment for atherosclerotic risk factors. Individuals with fatty liver had more often carotid plaques than persons without fatty liver (plaque prevalence rate 76.8% vs 66.6%; P<0.001).This association persisted after adjustment for confounding factors and was predominantly present in subjects with no to mild alcohol consumption.CONCLUSION: There is an independent association between hepatic steatosis and carotid atherosclerotic plaques. Metabolic changes due to nonalcoholic fatty liver disease may explain this relationship. | Henry V(o|¨)lzke Daniel M.Robinson Volker Kleine Roland Deutscher Wolfgang Hoffmann Jan Lüdemann Ulf Schminke Christof Kessler Ulrich John | 2005 | World Journal of Gastroenterology2005，11，12： | 29 |
| 3 | Bifunctional chimeric SuperCD suicide gene -YCD: YUPRT fusion is highly effective in a rat hepatoma model显示文摘AIM: To investigate the effects of catalytically superior gene-directed enzyme prodrug therapy systems on a rat hepatoma model.METHODS: To increase hepatoma cell chemosensitivity for the prodrug 5-fluorocytosine (5-FC), we generated a chimeric bifunctional SuperCD suicide gene, a fusion of the yeast cytosine deaminase (YCD) and the yeast uracil phosphoribosyltransferase (YUPRT) gene.RESULTS: In vitro stably transduced Morris rat hepatoma cells (MH) expressing the bifunctional SuperCD suicide gene (MH SuperCD) showed a clearly marked enhancement in cell killing when incubated with 5-FC as compared with MH ceils stably expressing YCD solely (MH YCD) or the cytosine deaminase gene of bacterial origin(MH BCD), respectively. In vivo, MH SuperCD tumors implanted both subcutaneously as well as orthotopically into the livers of syngeneic ACI rats demonstrated significant tumor regressions (P<0.01) under both high dose as well as low dose systemic 5-FC application,whereas MH tumors without transgene expression (MH naive) showed rapid progression. For the first time, an order of in vivo suicide gene effectiveness (SuperCD>>YCD > > BCD > > > negative control) was defi ned as a result of a directin vivo comparison of all three suicide genes.CONCLUSION: Bifunctional SuperCD suicide gene expression is highly effective in a rat hepatoma model,thereby significantly improving both the therapeutic index and the efficacy of hepatocellular carcinoma killing by fluorocytosine. | Florian Graepler Marie-Luise Lemken Wolfgang A Wybranietz Ulrike Schmidt Irina Smirnow Christine D GroB Martin Spiegel Andrea Schenk Schenk Hansj(o|¨)rg Graf Ulrike A Lauer Reinhard Vonthein Michael Gregor Sorin Armeanu Michael Bitzer Ulrich M.Lauer | 2005 | World Journal of Gastroenterology2005，11，44： | 2 |
| 4 | A role of stretch-activated potassium currents in the regulation of uterine smooth muscle contraction显示文摘早熟的出生的率是惊人的并且威胁社会和世界范围的保健系统。早产在超过 50% 盒子导致早熟的出生。Preterm 出生说明婴儿病态和死亡的 three-quarters。在 34 星期怀孕期前熬过出生的孩子经常面对终生的残疾。为劳动正在想要的 preterm 的当前的处理。没有处理被发现了通常有效,任何一个都系统地没在 48 h 以外被评估。preterm 劳动的处理的新途径绝望地被需要。从我们的实验室的最近的研究建议子宫的肌肉是有不同于另外的光滑的肌肉的子宫的松驰的规定的唯一的分隔空间。这里,我们讨论最近的证据机械地激活的 2 毛孔钾隧道, TREK-1,可以贡献在子宫的光滑的肌肉和变体与人的劳动联系了的那 TREK-1 基因发信号的收缩松驰, preterm 劳动可以导致 preterm 劳动和它的可能的预防的更好的理解。 | Iain L O BUXTON Nathanael HEYMAN Yi-ying WU Scott BARNETT Craig ULRICH | 2011 | Acta Pharmacologica Sinica2011，32，6： | 2 |
| 5 | Pcroxisome proliferator-activated receptor gamma as a molecular target of resveratrol-induced modulation of polyamine metabolism 显示文摘 | Ulrich S Loitsch SM Ran O | 2006 | Cancer Res2006，66，14： | 1 |
| 6 | Ethical climate, ethics stress, and the job satisfac- tion of nurses and social workers in the United States显示文摘 | ULRICH CONNIE PATRICIA O' DONELL CAROL TAY- LOR | 2007 | Social Science & Medicine2007，65，8： | 1 |
| 7 | Ethical climate, ethics stress,and the job satisfaction of nurses and social workers in The United States显示文摘 | Ulrich C O' Donnell P Taylor C | 2007 | Social Sci Med2007，65，8： | 1 |
| 8 | Brain choline concentrations may not be altered in euthymic bipolar disorder patients chronically treated with either lithium or sodium valproate 显示文摘 | Wu RH O'Donnell T Ulrich M | 2004 | Ann Gen Hosp Psychiatry2004，3，1： | 1 |
| 9 | Interaction of Vav with ENX-1,a putative transcriptional regulator of homeobox gene expression显示文摘 | Hobert O J allal B Ulrich A | 1996 | MCB1996，16，6： | 1 |
| 10 | Ethical Climate, Ethics Stress, and the Job Satisfaction of Nurses and Social Wokers in the United States 显示文摘 | Ulrich C O' Donnell P Taylor C | 2007 | Soc Sci Med2007，65，8： | 1 |
| 11 | Accuracy of cone-beam computed tomography at different resolutions assessed on the bony covering of the mandibular anterior teeth 显示文摘 | Patcas R Muller L Ulrich O | 2012 | Am J Orthod Dentofacial Orthop2012，141，1： | 1 |
| 12 | Physiological mechanisms regulating the expression of endothelial-type NO synthase显示文摘 | Li Huige Wallerath Thomas F o rstermann Ulrich | 2002 | Nitric Oxide2002，7，2： | 1 |
| 13 | Plant oil renewable resources as green alternatives in polymer science 显示文摘 | Michael A R Meier Jurgen O Metzger Ulrich S Schubert | 2007 | Chem Soc Rev2007，36，： | 1 |
| 14 | Stereotactic radio therapy of extracranial targets:CT-simulation and accuracy of treat ment in the stereotactic body frame显示文摘 | J(o)rn Wulf Ulrich H(a)dinger Ulrich Oppitz | 2000 | Radiotherapy and Oncology2000，57，2： | 1 |
| 15 | Molecular biomarkers in non-small-cell lung cancer: a retrospective analysis of data from the phase 3 FLEX study显示文摘 | Kenneth J O’Byrne Ulrich Gatzemeier Igor Bondarenko Carlos Barrios Corinna Eschbach Uwe M Martens Yevhen Hotko Cornelius Kortsik Luis Paz-Ares Jose R Pereira Joachim von Pawel Rodryg Ramlau Jae-Kyung Roh Chih-Teng Yu Christopher Stroh Ilhan Celik Armin Sc | 2011 | Lancet Oncology2011，，8： | 1 |
| 16 | Ethical climate,ethics stress, and the job satisfaction of nurses and social workers in the United States显示文摘 | Ulrich C O'Donnell P Taylor C et a/ | 2007 | Soc Sci Med2007，65，8： | 1 |
| 17 | Endometriosis and malignoma 显示文摘 | Ulrich U Richter O Wardelmann E | 2003 | Zentralbl Gynakol2003，125，： | 1 |
| 18 | Monocytes of allergies and non-allergics produce, store and release the neurotrophins NGF, BDNF and NT-3 显示文摘 | BETTINA R GERALD H ULRICH O | 2005 | Regulatory Peptides2005，124，： | 1 |
| 19 | Comparative study of sta bilization of anterior and posterior fixation显示文摘 | Woersdoerfer O Claes L | 1987 | Proc Arch Orthop Trauma Surg1987，106，： | 1 |
| 20 | Monocytes of allergics and non-allergics produce,store and release the neurotrophins NGF,BDNF and NT-3显示文摘 | BETTINA R GERALD H ULRICH O | 2005 | Regulatory Peptides2005，124，： | 1 |
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