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| 1 | Notch signaling pathway targeted therapy suppresses tumor progression and metastatic spread in pancreatic cancer显示文摘 | Shinichi Yabuuchi Shweta G. Pai Nathaniel R. Campbell Roeland F. de Wilde Elizabeth De Oliveira Preethi Korangath Mirte M. Streppel Zeshaan A. Rasheed Manuel Hidalgo Anirban Maitra N.V. Rajeshkumar | 2013 | Cancer Letters2013，，1： | 5 |
| 2 | Approach to early-onset colorectal cancer:Clinicopathological,familial,molecular and immunohistochemical characteristics显示文摘AIM:To characterize clinicopathological and familial features of early-onset colorectal cancer(CRC) and compare features of tumors with and without microsatellite instability(MSI).METHODS:Forty-five patients with CRC aged 45 or younger were included in the study.Clinical information,a three-generation family history,and tumor samples were obtained.MSI status was analyzed and mismatch repair genes were examined in the MSI families.Tumors were included in a tissue microarray and an immunohistochemical study was carried out with a panel of selected antibodies.RESULTS:Early onset CRC is characterized by advanced stage at diagnosis,right colon location,low-grade of differentiation,mucin production,and presence of polyps.Hereditary forms represent at least 21% of cases.Eighty-one percent of patients who died during followup showed a lack of expression of cyclin E,which could be a marker of poor prognosis.β-catenin expression was normal in a high percentage of tumors.CONCLUSION:Early-onset CRC has an important familial component,with a high proportion of tumors showing microsatellite stable.Cyclin E might be a poor prognosis factor. | Jose Perea Edurne Alvaro Yolanda Rodríguez Cristina Gravalos Eva Sánchez-Tomé Barbara Rivera Francisco Colina Pablo Carbonell Rogelio González-Sarmiento Manuel Hidalgo Miguel Urioste | 2010 | World Journal of Gastroenterology2010，16，29： | 3 |
| 3 | Exploiting novel molecular targets in gastrointestinal cancers显示文摘Novel molecular targets are being discovered as we learn more about the aberrant processes underlying various cancers. Efforts to translate this knowledge are starting to impact on the care of patients with gastrointestinal cancers. The epidermal growth factor receptor (EGFR) pathway and angiogenesis have been targeted successfully in colorectal cancer with cetuximab, panitunumab and bevacizumab. Similarly, EGFR-targeting with erlotinib yielded significant survival benefit in pancreatic cancer when combined with gemcitabine. The multi-targeting approach with sorafenib has made it the first agent to achieve significant survival benefit in hepatocellular carcinoma. Efforts to exploit the dysregulated Akt/mTOR pathway in GI cancer therapy are ongoing. These molecular targets can be disrupted by various approaches, including the use of monoclonal antibody to intercept extracellular ligands and disrupt receptor-ligand binding, and small molecule inhibitors that interrupt the activation of intracellular kinases. | Wen W Ma Manuel Hidalgo | 2007 | World Journal of Gastroenterology2007，13，44： | 3 |
| 4 | Integrated preclinical and clinical development of S- trans, trans -farnesylthiosalicylic acid (FTS, Salirasib) in pancreatic cancer显示文摘 | Daniel Laheru Preeti Shah N. V. Rajeshkumar Florencia McAllister Gretchen Taylor Howard Goldsweig Dung T. Le Ross Donehower Antonio Jimeno Sheila Linden Ming Zhao Dongweon Song Michelle A. Rudek Manuel Hidalgo | 2012 | Investigational New Drugs2012，，6： | 2 |
| 5 | Pancreatic cancer显示文摘 | Theresa Pluth Yeo Ralph H Hruban Steven D Leach Robb E Wilentz Taylor A Sohn Scott E Kern Christine A Iacobuzio-Donahue Anirban Maitra Michael Goggins Marcia I Canto Ross A Abrams Daniel Laheru Elizabeth M Jaffee Manuel Hidalgo Charles J Yeo | 2002 | Current Problems in Cancer2002，，4： | 2 |
| 6 | Automatically maintaining wrappers for semi-structured web sources 显示文摘 | Juan Raposo Alberto Pan Manuel Alvarez Justo Hidalgo | 2007 | Data & Knowledge Engineering2007，61，： | 1 |
| 7 | Ver- satile one-pot synthesis of supramolecular plastics and self-healing rubbers 显示文摘 | Damien Montarual Tournilhac Fran:ois Hidalgo Manuel | 2009 | J Am Chem Soc2009，131，23： | 1 |
| 8 | Microenvironmental hCAP-18/LL-37 promotes pancreatic ductal adenocarcinoma by activating its cancer stem cell compartment显示文摘 | Sainz Bruno Alcala Sonia Garcia Elena Sanchez-Ripoll Yolanda Azevedo Maria M Cioffi Michele Tatari Marianthi Miranda-Lorenzo Irene Hidalgo Manuel Gomez-Lopez Gonzalo Can?amero Marta Erkan Mert Kleeff Jorg Garcn?i?a-Silva Susana Sancho Patricia Hermann Pat | 2015 | Gut2015，，12： | 1 |
| 9 | A multicenter rendomized phase Ⅱ trial of granulocyte-colony stimulating factor-supported,platinum-based chemotherapy with flexible midcycle cisplation administration in patients with advanced ovarian carcinoma显示文摘 | Hidalgo M Mendiola C Manuel J | 1998 | Cancer1998，83，4： | 1 |
| 10 | The Development of Basic Competencies for Sustainability in Higher Education: An Educational Model显示文摘 | Luis Amador Hidalgo Juan Manuel Arj ona Fuentes | 2013 | US-China Education Review(B)2013，3，6： | 1 |
| 11 | Assessment of gefitinib - and C1 - 1040 - mediated changes in epidermal growth factor receptor signaling in HuCCT - 1 human cholangiocarcinoma by serial fine needle aspiration 显示文摘 | Manuel Hidalgo Maria Luz Amador Antonio Jimeno | 2006 | Mol Cancer Ther2006，5，： | 1 |
| 12 | Combined Targeted Treatment to Eliminate Tumorigenic Cancer Stem Cells in Human Pancreatic Cancer显示文摘 | Maria–Theresa Mueller Patrick C. Hermann Juliane Witthauer Belen Rubio–Viqueira Simon F. Leicht Stephan Huber Joachim W. Ellwart Mona Mustafa Peter Bartenstein Jan G. D’Haese Michael H. Schoenberg Frank Berger Karl–Walter Jauch Manuel Hidalgo Christopher | 2009 | Gastroenterology2009，，： | 1 |
| 13 | Phase I and pharmacologic study of OSI-774, an epidermal growthfactor receptor tyrosine kinase inhibitor,in patients with advanced solid malignancies显示文摘 | Manuel Hidalgo Lillian L Siu John Nemunaitis | 2001 | J Clin Oncol2001，19，13： | 1 |
| 14 | Contribution of Pyrrole Formation and Polymerization to theNonenzymatic Browning Produced by Amino Carbonyl Reactions显示文摘 | Rosario Zamora Manuel Alaiz Francisco J Hidalgo | 2000 | Agricultural and Food Chemistry2000，48，： | 1 |
| 15 | Pancreatic cancer显示文摘 | MANUEL HIDALGO MD | 2010 | N Engl J Med2010，362，： | 1 |
| 16 | The Winning Formulation: The Development of Paclitaxel in Pancreatic Cancer显示文摘 | Wen Wee Ma Manuel Hidalgo | 2013 | Clinical Cancer Research2013，，20： | 1 |
| 17 | Effect of starvation and refeeding on digestive enzyme activities in sturgeon ( Acipenser naccarii ) and trout ( Oncorhynchus mykiss )显示文摘 | Miriam Furné Manuel García-Gallego M. Carmen Hidalgo Amalia E. Morales Alberto Domezain Julio Domezain Ana Sanz | 2008 | Comparative Biochemistry and Physiology, Part A2008，，4： | 1 |
| 18 | Rural tourism in the south of spain: An opportunity for rural development 显示文摘 | Genoveva Millan Vazquez de la Torre Luis Amador Hidalgo Juan Manuel Arjona Fuentes | 2014 | Modem E- conomy2014，5，2： | 1 |
| 19 | Combined Targeted Treatment to Eliminate Tumorigenic Cancer Stem Cells in Human Pancreatic Cancer显示文摘 | Maria–Theresa Mueller Patrick C. Hermann Juliane Witthauer Belen Rubio–Viqueira Simon F. Leicht Stephan Huber Joachim W. Ellwart Mona Mustafa Peter Bartenstein Jan G. D’Haese Michael H. Schoenberg Frank Berger Karl–Walter Jauch Manuel Hidalgo Christopher | 2009 | Gastroenterology2009，，3： | 1 |
| 20 | Phase 2 Study of Erlotinib Combined With Adjuvant Chemoradiation and Chemotherapy in Patients With Resectable Pancreatic Cancer显示文摘 | Joseph M. Herman Katherine Y. Fan Aaron T. Wild Amy Hacker-Prietz Laura D. Wood Amanda L. Blackford Susannah Ellsworth Lei Zheng Dung T. Le Ana De Jesus-Acosta Manuel Hidalgo Ross C. Donehower Richard D. Schulick Barish H. Edil Michael A. Choti Ralph H. H | 2013 | International Journal of Radiation Oncology Biology Physics2013，，4： | 1 |
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