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| 1 | Unexpected metastasis of intraductal papillary neoplasm of the bile duct without an invasive component to the brain and lungs:A case report显示文摘BACKGROUND Despite an expanding number of studies on intraductal papillary neoplasm of the bile duct(IPNB),distant metastasis remains unexplained especially in cases of carcinoma in situ.In the present study,we report a rare and interesting case of IPNB without invasive components that later metastasized to lungs and brain.CASE SUMMARY A 69-year-old male was referred to our hospital due to suspected cholangiocarcinoma.Laboratory tests on admission reported a mild elevation of alkaline phosphatase,γ-glutamyl transpeptidase,and total bilirubin in serum.Endoscopic retrograde cholangiography revealed a filling defect in the common bile duct(CBD)extending to the left hepatic duct.Peroral cholangioscopy delineated a tumor in the CBD that had a papillary pattern.Multidetector computed tomography and magnetic resonance cholangiopancreatography detected partial blockage ot interlude in the CBD leading to cholestasis without evidence of metastasis.Therefore,a diagnosis of IPNB cT1N0M0 was established.Left hepatectomy with bile duct reconstruction was performed.Pathological examination confirmed an intraepithelial neoplasia pattern without an invasive component and an R0 resection achievement.The patient was monitored carefully by regular examinations.However,at 32 mo after the operation,a 26 mm tumor in the lungs and a 12 mm lesion in the brain were detected following a suspicious elevated CA 19-9 level.Video-assisted thoracoscopic surgery of left upper lobectomy and stereotactic radiotherapy are indicated.In addition to histopathological results,a genomic profiling analysis using whole exome sequencing subsequently confirmed lung metastasis originating from bile duct cancer.CONCLUSION This case highlights the important role of genomic profiling analysis using whole exome sequencing in identifying the origin of metastasis in patients with IPNB. | Nguyen Hai Nam Kojiro Taura Masashi Kanai Keita Fukuyama Norimitsu Uza Hirona Maeda Yojiro Yutaka Toyofumi F Chen-Yoshikawa Manabu Muto Shinji Uemoto | 2020 | World Journal of Gastroenterology2020，26，3： | 5 |
| 2 | Development and appli cation of new mouse models to study the pathogenesis of Clostridium perfringens type C enterotoxemias显示文摘 | Uza Saputo J Sayeed S | 2009 | Infect Immun2009，77，： | 1 |
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| 5 | Concentration of copper, fine,chromium, iron and nickel in the abdominal aorta of patients deceased with coronary heart disease 显示文摘 | Vlad M Caseanu E Uza G | 1994 | J Trace Elem Electrolytes Health Dis1994，8，： | 1 |
| 6 | The associated reaction rating scale:a clinical tool to measure associated reactions in the hemiplegie upper limb显示文摘 | Macfarlane A Turner-Stokes L De S -uza L | 2002 | Clin Rehabil2002，16，7： | 1 |
| 7 | Serum zinc and copper in patients with cerebral vascular disease 显示文摘 | Uza G Comes L Uza D | 1995 | Rom J Intem Med1995，33，12： | 1 |
| 8 | Factors associated with the professional competencies of public health nurses employed by local government agencies in Japan显示文摘 | Saeki K Izumi H Uza M | 2007 | Public Health Nurs2007，24，5： | 1 |
| 9 | Knowledge and behavior relating to malaria in malaria endemic villages of KHAMMOUANE province, LAO PDR显示文摘 | Miyoko Uza Samlane Phommpida | 2002 | Southeast Asian J Trop Public Health2002，33，2： | 1 |
| 10 | SR-PSOX/CXCL16 plays a critical role in the progression of colonic inflammation显示文摘 | Uza N Nakase H Yamamoto S | 2011 | Gut2011，60，11： | 1 |
| 11 | Application of wheat meal solvent retention capacity tests within soft wheat breeding populations显示文摘 | GUTTIERI M J BECKER C e'UZA E J | 2004 | Cereal Chemistry2004，81，2： | 1 |
| 12 | Toll-like receptor activation in basophils contributes to the development of IgG4-related disease显示文摘 | Tomohiro Watanabe Kouhei Yamashita Toshiharu Sakurai Masatoshi Kudo Masahiro Shiokawa Norimitsu Uza Yuzo Kodama Kazushige Uchida Kazuichi Okazaki Tsutomu Chiba | 2013 | Journal of Gastroenterology2013，，2： | 1 |
| 13 | Endoscopic stent placement above the intact sphincter of Oddi for biliary strictures after living donor liver transplantation显示文摘 | Akira Kurita Yuzo Kodama Ryuki Minami Yojiro Sakuma Katsutoshi Kuriyama Wataru Tanabe Yuji Ohta Takahisa Maruno Masahiro Shiokawa Yugo Sawai Norimitsu Uza Shujiro Yazumi Atsushi Yoshizawa Shinji Uemoto Tsutomu Chiba | 2013 | Journal of Gastroenterology2013，，9： | 1 |
| 14 | Serum zinc and copper in patients with cerebral vascular disease 显示文摘 | Uza G Comes L Uza D | 1995 | Rom J Intern Med1995，33，12： | 1 |
| 15 | SR - PSOX/CXCL16 plays a critical role in the progression of colonic inflammation 显示文摘 | Uza N Nakase H Yamamoto S | 2011 | Gut2011，60，11： | 1 |
| 16 | Surgical procedures not connect-ed with transplantation in patients after kidney or kidney and pan-creas transplant with stable function of graft显示文摘 | Kauza B Ziobrowski I Durlik M | 2012 | Pol Przegl Chir2012，84，4： | 1 |
| 17 | Factors associated with the professional competencies of public health nurses employed by local government agencies in Japan显示文摘 | Saeki K Izumi H Uza M | | 0，，05： | 1 |
| 18 | Effect of geometry on the effective moisture transfer diffusion coefficient 显示文摘 | TUTUNCU M A LAB UZA T P | 1996 | J Food Eng1996，30，34： | 1 |
| 19 | Thoracic pedicle:surgical anatomic evaluation and relations显示文摘 | Ugur HC Attar A UzA | 2001 | J Spinal Disord2001，14，1： | 1 |
| 20 | SR-PSOX/CXCL16 plays a critical role in the progression of colonic inflammation显示文摘 | Uza N Nakase H Yamamoto S | 2011 | Gut2011，60，11： | 1 |
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