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| 1 | Even low-grade inflammation impacts on small intestinal function显示文摘Independent of the cause and location,inflammation-even when minimal-has clear effects on gastrointestinal morphology and function.These result in altered digestion,absorption and barrier function.There is evidence of reduced villus height and crypt depth,increased permeability,as well as altered sugar and peptide absorption in the small intestine after induction of inflammation in experimental models,which is supported by some clinical data.Identification of inflammatory factors which may promote the process of gastrointestinal dysfunction as well as clinical research to verify experimental observations of inflammatory modulation of gastrointestinal function are required.Moreover,nutritional strategies to support functional restitution are needed. | Katri Peuhkuri Heikki Vapaatalo Riitta Korpela | 2010 | World Journal of Gastroenterology2010，16，9： | 9 |
| 2 | Probiotic intervention has strain-specific anti-inflammatory effects in healthy adults显示文摘AIM: To evaluate the effects of three potentially anti- inflammatory probiotic bacteria from three different genera on immune variables in healthy adults in a clinical setting based on previous in vitro characterization of cytokine responses. METHODS: A total of 62 volunteers participated in this randomized, double-blind and placebo-controlled parallel group intervention study. The volunteers were randomized to receive a milk-based drink containing either Lactobacillus rhamnosus GG (LGG), Bifidobacterium animalis ssp. lactis Bb12 (Bb12), or Propionibacterium freudenreichii ssp. shermanii JS (PJS) or a placebo drink for 3 wk. Venous blood and saliva samples were taken at baseline and on d 1, 7 and 21. Fecal samples were collected at baseline and at the end of intervention. RESULTS: The serum hsCRP expressed as the median AUC0-21 (minus baseline) was 0.018 mg/L in the placebo group, -0.240 mg/L in the LGG group, 0.090 mg/L in the Bb12 group and -0.085 mg/L in the PJS group (P = 0.014). In vitro production of TNF-α from in vitro cultured peripheral blood mononuclear cells (PBMC) was significantly lower in subjects receiving LGG vs placebo. IL-2 production from PBMC in the Bb12 group was significantly lower compared with the other groups. CONCLUSION: In conclusion, probiotic bacteria have strain-specific anti-inflammatory effects in healthy adults. | Riina A Kekkonen Netta Lummela Heli Karjalainen Sinikka Latvala Soile Tynkkynen Salme Jrvenp Hannu Kautiainen Ilkka Julkunen Heikki Vapaatalo Riitta Korpela | 2008 | World Journal of Gastroenterology2008，14，13： | 6 |
| 3 | Elevated pro-inflammatory and lipotoxic mucosal lipids characterise irritable bowel syndrome显示文摘AIM:To investigate the pathophysiology of irritable bowel syndrome(IBS)by comparing the global mucosal metabolic profiles of IBS patients with those of healthy controls.METHODS:Fifteen IBS patients fulfilling the Rome Ⅱcriteria,and nine healthy volunteers were included in the study.A combined lipidomics(UPLC/MS)and metabolomics(GC×GC-TOF)approach was used to achieve global metabolic profiles of mucosal biopsies from the ascending colon.RESULTS:Overall,lipid levels were elevated in patients with IBS.The most significant upregulation was seen for pro-inflammatory lysophosphatidylcholines.Other lipid groups that were significantly upregulated in IBS patients were lipotoxic ceramides,glycosphingolipids,and di-and triacylglycerols.Among the metabolites,the cyclic ester 2(3H)-furanone was almost 14-fold upregulated in IBS patients compared to healthy subjects(P=0.03).CONCLUSION:IBS mucosa is characterised by a distinct pro-inflammatory and lipotoxic metabolic profile.Especially,there was an increase in several lipid species such as lysophospholipids and ceramides. | Kajsa Kajander Eveliina Myllyluoma Sinikka Kyrnpalo Martin Rasmussen Pentti Sipponen Ismo Mattila Tuulikki Seppnen-Laakso Heikki Vapaatalo Matej Orei Riitta Korpela | 2009 | World Journal of Gastroenterology2009，15，48： | 5 |
| 4 | Local corticosterone production and angiotensin-Ⅰconverting enzyme shedding in a mouse model of intestinal inflammation显示文摘AIM: To investigate local corticosterone production and angiotensin-Ⅰ converting enzyme(ACE) protein expression and their interaction in healthy and inflamed intestine.METHODS: Acute intestinal inflammation was induced to six weeks old male Balb/c mice by administration of either 3% or 5% dextran sodium sulfate(DSS) in drinking water for 7 d(n = 12 in each group). Healthy controls(n = 12) were given tap water. Corticosterone production and ACE protein shedding were measured from ex vivo incubates of the small and large intestine using EIA and ELISA, respectively. Morphological changes of the intestinal wall were assessed in hematoxylin-eosin stained tissue preparations of jejunum and distal colon. Effects of angiotensin Ⅱ, captopril and metyrapone on corticosterone production was assessed by incubating pieces of small intestine of healthy mice in the presence of 0.1, 1 or 10 μmol/L angiotensin Ⅱ, 1, 10 or 100 μmol/L captopril or 1, 10 or 100 μmol/L metyrapone solutions and measuring corticosterone released to the incubation buffer after 90 min(n = 5 in each group).RESULTS: Both concentrations of DSS induced inflammation and morphological changes in large intestines but not in small intestines. Changes were observed as distortions of the crypt structure, mucosal erosion, immune cell infiltration to the mucosa and submucosal edema. Ex vivo corticosterone production(2.9 ± 1.0 ng/mL vs 2.0 ± 0.8 ng/mL, P = 0.034) and ACE shedding(269.2 ± 97.1 ng/m L vs 175.7 ± 52.2 ng/mL, P = 0.016) were increased in small intestines in 3% DSS group compared to the controls. In large intestine, corticosterone production was increased compared to the controls in both 3% DSS(229 ± 81 pg/mL vs 158 ± 30 pg/mL, P = 0.017) and 5% DSS groups(366 ± 163 pg/mL vs 158 ± 30 pg/mL, P = 0.002). Large intestine ACE shedding was increased in 5% DSS group(41.5 ± 9.0 ng/mL vs 20.9 ± 5.2 ng/mL, P = 0.034). Angiotensin Ⅱ treatment augmented corticosterone production in small intestine at concentration of 10 μmol/L(0.97 ± 0.21 ng/mg protein vs 0.40 ± 0.09 ng/mg protein, P = 0.036).CONCLUSION: Intestinal ACE shedding is increased by DSS-induced intestinal inflammation and parallels local corticosterone production. ACE product angiotensin Ⅱ stimulates corticosterone formation in healthy intestine. | Hanne Salmenkari Tomi Issakainen Heikki Vapaatalo Riitta Korpela | 2015 | World Journal of Gastroenterology2015，21，35： | 2 |
| 5 | Lactobacillus helveticus fermented milk lowers blood pressure in hypertensive subjects in 24-h ambulatory blood pressure measurement显示文摘 | JAUHIAINEN T VAPAATALO H POUSSA T | 2005 | American Journal of Hypertension2005，18，： | 1 |
| 6 | Angiotensin Ⅱ and vascular inflammation显示文摘 | Cheng ZJ Vapaatalo H Mervaala E | 2005 | Med Sci Monit2005，11，6： | 1 |
| 7 | Angiotensin Ⅱ and vascular inflammation显示文摘 | Cheng ZJ Vapaatalo H Mervaala E | 2005 | Med Sci Monit2005，11，6： | 1 |
| 8 | Long-term intervention with Lactobacillus helveticus fermented milk reducesaugmentation index in hypertensive subjects显示文摘 | JAUHIAINEN T RONNBACK M VAPAATALO H | 2010 | European Journal ofClinical Nutrition2010，64，： | 1 |
| 9 | Increased kidney xanthine oxidoreductase activity in salt-induced experimental hypertension显示文摘 | Laakso J Mervaala E Himberg JJ Teravainen TL Karppanen H Vapaatalo H | 1998 | Hypertension1998，32，： | 1 |
| 10 | Angiotensin Ⅱ and vascular inflammation显示文摘 | Vapaatalo H Mervaala E | 2005 | Med Sci Monit2005，11，6： | 1 |
| 11 | Angiotensin II and vascular inflammation 显示文摘 | Cheng Z J Vapaatalo H Mervaala E | 2005 | Med Sci Monit2005，11，6： | 1 |
| 12 | Antihypertensive peptides from milk proteins显示文摘 | P Jakala H Vapaatalo | 2010 | (3):251-2722010，，3： | 1 |
| 13 | Clinically important factors influen-cing endothelial function 显示文摘 | Vapaatalo H Mervaala E | 2001 | Med Sci Monit2001，7，5： | 1 |
| 14 | Calcium-sensitive potassium channal inhibitors antagonize genistein-and daidzein 3/ induced arterial relaxation in vitro显示文摘 | Nevala R Paukku K Korpela R Vapaatalo H | 2001 | Life Sci2001，69，： | 1 |
| 15 | Angiotensin Ⅱ and vascular inflammation显示文摘 | Cheng ZJ Vapaatalo H Mervaala E | 2005 | Med Sci Monit2005，11，6： | 1 |
| 16 | Effect of Lactobacillus GG Yoghurt in prevention of antibiotic associated diarrhoea 显示文摘 | Siitonen S Vapaatalo H Salminen S | | Annals of medicine0，22，： | 1 |
| 17 | a-lactorphin and β-lactorphin improve arterial function in sponta- neously hypertensive rats显示文摘 | Sipola M Finckenberg P Vapaatalo H | 2002 | Life Sci2002，71，： | 1 |
| 18 | Nitric oxide in inflammation and immune response显示文摘 | Moilanen E Vapaatalo H | 1995 | Ann Med1995，27，： | 1 |
| 19 | Angio- tensin (1-7) reduces intraocular pressure in the normo- tensive rabbit eye 显示文摘 | / Vaajanen A Vapaatalo H Kautiainen H | 2008 | Invest Ophthalmol Vis Sci2008，49，6： | 1 |
| 20 | Clinically important factors influencing endothelial function显示文摘 | VAPAATALO H MERVAALA E | | 0，，05： | 1 |
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