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| 1 | Increased catabolism and decreased unsaturation of ganglioside in patients with inflammatory bowel disease显示文摘AIM: To investigate whether accelerated catabolism of ganglioside and decreased ganglioside content contribute to the etiology of pro-inflammatory intestinal disease. METHODS: Intestinal mucosa from terminal ileum or colon was obtained from patients with ulcerative colitis or inflammatory Crohn's disease(n = 11) undergoing bowel resection and compared to control samples of normal intestine from patients with benign colon polyps(n = 6) and colorectal cancer(n = 12) in this observational case-control study. Gangliosides and phospholipids of intestinal mucosa were characterized by class and ceramide or fatty acid composition using liquid chromatography triple-quad mass spectrometry. Content and composition of ganglioside classes GM1, GM3, GD3, GD1 a, GT1 and GT3 were compared among subject groups. Content and composition of phospholipid classes phosphatidylcholine(PC) and phosphatidylethanolamine were compared among subject groups. Unsaturation index of individual ganglioside and phospholipid classes was computed and compared among subject groups. Ganglioside catabolism enzymes beta-hexosaminidase A(HEXA) and sialidase-3(NEU3) were measured in intestinal mucosa using western blot and compared among subject groups. RESULTS: Relative GM3 ganglioside content was 2-fold higher(P < 0.05) in intestine from patients with inflammatory bowel disease(IBD) compared to control intestine. The quantity of GM3 and ratio of GM3/GD3 was also higher in IBD intestine than control tissue(P < 0.05). Control intestine exhibited 3-fold higher(P < 0.01) relative GD1 a ganglioside content than IBD intestine. GD3 and GD1 a species of ganglioside containing three unsaturated bonds were present in control intestine, but were not detected in IBD intestine. The relative content of PC containing more than two unsaturated bonds was 30% lower in IBD intestine than control intestine(P < 0.05). The relative content of HEXA in IBD intestine was increased 1.7-fold(P < 0.05) and NEU3 was increased 8.3-fold(P < 0.01) compared to normal intestine. Intestinal mucosa in IBD is characterized by increased GM3 content, decreased GD1 a, and a reduction in polyunsaturated fatty acid constituents in GD3, GD1 a and PC.CONCLUSION: This study suggests a new paradigm by proposing that IBD occurs as a consequence of increased metabolism of specific gangliosides. | John J Miklavcic Glen K Shoemaker Vera C Mazurak M Tom Clandinin Tasha DL Hart Kareena L Schnabl Gordon M Lees Bodil MK Larsen Oliver F Bathe Alan BR Thomson M Tom Clandinin | 2015 | World Journal of Gastroenterology2015，21，35： | 3 |
| 2 | Deriving simulation models from bond graphs with algebraic loops显示文摘 | Felez J Vera C | 2000 | Journal of Franklin Institute2000，，337： | 1 |
| 3 | Deriving Simulation Models from Bond Graphs with Algebraic Loops-The Extension to Multibond Graph Systems显示文摘 | Cacho R Felez J Vera C | 2000 | Journal of The Franklin Institute2000，337，4： | 1 |
| 4 | Determination of partition and diffusion coefficients of components of two rubber adhesives in different multilayer materials显示文摘 | Nerin C Gaspar J Vera P | 2013 | International Journal of Adhesion and Adhesives2013，40，： | 1 |
| 5 | Bond Graph Assisted Models for Hydro-Pneumatic Suspensions in Crane Vehicles 显示文摘 | FELEZ J VERA C | 1987 | Vehicle System Dynamics1987，16，56： | 1 |
| 6 | Experimental investigation of smouldering in biomass 显示文摘 | Carvalho E R Gurgel Veras C A CarvalhoJr J A | 2002 | Biomass and Bioenergy2002，22，4： | 1 |
| 7 | Insulin-like growth factor-I cDNA cloning, gene expression and potential use as a growth rate indicator in Nile tilapia, Oreochromis niloticus 显示文摘 | Vera Cruz E M Brown C L Adam Luckenbach J | 2006 | Aquaculture2006，251，： | 1 |
| 8 | An event-based architecture definition language 显示文摘 | LUCKHAM D C VERA J | 1995 | IEEE Trans Software Engineer- ing1995，9，21： | 1 |
| 9 | Random deletion in a scale free random graph process显示文摘 | COOPER C FRIEZE A VERA J | 2004 | Internet Math2004，26，1： | 1 |
| 10 | The effects of lowering LDL cholesterol with simvastatin plus ezetimibe in patients with chronic kidney disease (Study of Heart and Renal Protection): a randomised placebo-controlled trial显示文摘 | Colin Baigent Martin J Landray Christina Reith Jonathan Emberson David C Wheeler Charles Tomson Christoph Wanner Vera Krane Alan Cass Jonathan Craig Bruce Neal Lixin Jiang Lai Seong Hooi Adeera Levin Lawrence Agodoa Mike Gaziano Bertram Kasiske Robert Wal | 2011 | The Lancet2011，，9784： | 1 |
| 11 | Bond gaph assisted models for hydro - pneumatic suspensions in crane vehicles 显示文摘 | J Felez C Vera | 1987 | Vehicle system dynamics1987，16，56： | 1 |
| 12 | Bind graph assisted models for hydropneumatic suspensions in crane vehicles显示文摘 | Felez J Vera C | 1987 | Vehicle System Dynamics1987，16，： | 1 |
| 13 | Predictive value of endometrial pattern and thickness in the result of in vitro fertilization and embryo transfer显示文摘 | Vera J A Arguello B Crisosto C A | 1995 | Rev Chil Obstet Ginecol1995，60，3： | 1 |
| 14 | Repeated use of supported H3PW12O40 catalysts in the liquid phase estefification of acetic acid with butanol 显示文摘 | Yori J C Vera C R | 2005 | Applied Catalysis A :General2005，288，： | 1 |
| 15 | Efficacy of pazopanib in progressive, radioiodine-refractory, metastatic differentiated thyroid cancers: results of a phase 2 consortium study显示文摘 | Keith C Bible Vera J Suman Julian R Molina Robert C Smallridge William J Maples Michael E Menefee Joseph Rubin Kostandinos Sideras John C Morris Bryan McIver Jill K Burton Kevin P Webster Carolyn Bieber Anne M Traynor Patrick J Flynn Boon Cher Goh Hui Tan | 2010 | Lancet Oncology2010，，10： | 1 |
| 16 | Deriving Simulation Models From Bond Graphs with Algebraic Loops-The Extension to Multibond Graph Systems显示文摘 | Cacho R Felez J Vera C | 2000 | Journal of The Franklin Institute2000，337，： | 1 |
| 17 | Repeated use of supported H3PWI2 04o catalysts in the liquid phase es- terification of acetic acid with butanol 显示文摘 | SEPULVEDA J H YORI J C VERA C R | 2005 | Appl Catal A: Gen2005，288，12： | 1 |
| 18 | Repeated use of supported H3PW12O40 catalysts in the liquid phase estification of acetic acid with butanol显示文摘 | SEPULVEDA J H YORI J C VERA C R | 2005 | Applied Catalysis A:General2005，288，： | 1 |
| 19 | Deriving simulation models from bond graphs with algebraic loops:the extension to multibond graph systems显示文摘 | Cacho R Felez J Vera C | 2000 | Journal of the Franklin Institute2000，337，： | 1 |
| 20 | An event-based architecture definition language显示文摘 | Luckham D C Vera J | 1995 | IEEE Transactions on Software Engineering1995，21，9： | 1 |
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