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| 1 | Pandemic of the aging society—sporadic cerebral small vessel disease显示文摘Age-related sporadic cerebral small vessel disease(CSVD)has gained increasing attention over the past decades because of its increasing prevalence associated with an aging population.The widespread application of and advances in brain magnetic resonance imaging in recent decades have significantly increased researchers’understanding in the in vivo evolution of CSVD,its impact upon the brain,its risk factors,and the mechanisms that explain the various clinical manifestation associated with sporadic CSVD.In this review,we aimed to provide an update on the pathophysiology,risk factors,biomarkers,and the determinants and spectrum of the clinical manifestation of sporadic CSVD. | Alexander Yuk Lun Lau Bonaventure Yiu Ming Ip Ho Ko Bonnie Yin Ka Lam Lin Shi Karen Ka Yan Ma Lisa Wing Chi Au Yannie Oi Yan Soo Thomas Wai Hong Leung Adrian Wong Vincent Chung Tong Mok | 2021 | Chinese Medical Journal2021，，2： | 3 |
| 2 | Inhibition of the CDK9-cyclin T1 protein-protein interaction as a new approach against triple-negative breast cancer显示文摘Cyclin-dependent kinase 9(CDK9) activity is correlated with worse outcomes of triplenegative breast cancer(TNBC) patients. The heterodimer between CDK9 with cyclin T1 is essential for maintaining the active state of the kinase and targeting this protein-protein interaction(PPI) may offer promising avenues for selective CDK9 inhibition. Herein, we designed and generated a library of metal complexes bearing the 7-chloro-2-phenylquinoline CN ligand and tested their activity against the CDK9cyclin T1 PPI. Complex 1 bound to CDK9 via an enthalpically-driven binding mode, leading to disruption of the CDK9-cyclin T1 interaction in vitro and in cellulo. Importantly, complex 1 showed promising anti-metastatic activity against TNBC allografts in mice and was comparably active compared to cisplatin. To our knowledge, 1 is the first CDK9-cyclin T1 PPI inhibitor with anti-metastatic activity against TNBC. Complex 1 could serve as a new platform for the future design of more efficacious kinase inhibitors against cancer, including TNBC. | Sha-Sha Cheng Yuan-Qing Qu Jia Wu Guan-Jun Yang Hao Liu Wanhe Wang Qi Huang Feng Chen Guodong Li Chun-Yuen Wong Vincent Kam Wai Wong Dik-Lung Ma Chung-Hang Leung | 2022 | Acta Pharmaceutica Sinica B2022，12，3： | 2 |
| 3 | CD24 + Liver Tumor-Initiating Cells Drive Self-Renewal and Tumor Initiation through STAT3-Mediated NANOG Regulation显示文摘 | Terence Kin Wah Lee Antonia Castilho Vincent Chi Ho Cheung Kwan Ho Tang Stephanie Ma Irene Oi Lin Ng | 2011 | Cell Stem Cell2011，，1： | 2 |
| 4 | Risk stratification in symptomatic intracranial atherosclerotic disease with conventional vascular risk factors and cerebral haemodynamics显示文摘Background and purpose Symptomatic intracranial atherosclerotic stenosis(sICAS)is associated with a considerable risk of recurrent stroke despite contemporarily optimal medical treatment.Severity of luminal stenosis in sICAS and its haemodynamic significance quantified with computational fluid dynamics(CFD)models were associated with the risk of stroke recurrence.We aimed to develop and compare stroke risk prediction nomograms in sICAS,based on vascular risk factors and these metrics.Methods Patients with 50%-99%sICAS confirmed in CT angiography(CTA)were enrolled.Conventional vascular risk factors were collected.Severity of luminal stenosis in sICAS was dichotomised as moderate(50%-69%)and severe(70%-99%).Translesional pressure ratio(PR)and wall shear stress ratio(WSSR)were quantified via CTA-based CFD modelling;the haemodynamic status of sICAS was classified as normal(normal PR&WSSR),intermediate(otherwise)and abnormal(abnormal PR&WSSR).All patients received guideline-recommended medical treatment.We developed and compared performance of nomograms composed of these variables and independent predictors identified in multivariate logistic regression,in predicting the primary outcome,recurrent ischaemic stroke in the same territory(SIT)within 1 year.Results Among 245 sICAS patients,20(8.2%)had SIT.The D2H2A nomogram,incorporating diabetes,dyslipidaemia,haemodynamic status of sICAS,hypertension and age≥50 years,showed good calibration(P for Hosmer-Lemeshow test=0.560)and discrimination(C-statistic 0.73,95%CI 0.60 to 0.85).It also had better performance in risk reclassification and provided larger net benefits in decision curve analysis,compared with nomograms composed of conventional vascular risk factors only,and plus the severity of luminal stenosis in sICAS.Sensitivity analysis in patients with anterior-circulation sICAS showed similar results.Conclusions The D2H2A nomogram,incorporating conventional vascular risk factors and the haemodynamic significance of sICAS as assessed in CFD models,could be a useful tool to stratify sICAS patients for the risk of recurrent stroke under contemporarily optimal medical treatment. | Xuan Tian Hui Fang Linfang Lan Hing Lung Ip Jill Abrigo Haipeng Liu Lina Zheng Florence S Y Fan Sze Ho Ma Bonaventure Ip Bo Song Yuming Xu Jingwei Li Bing Zhang Yun Xu Yannie O Y Soo Vincent Mok Ka Sing Wong Thomas W Leung Xinyi Leng | 2023 | Stroke & Vascular Neurology2023，8，1： | 2 |
| 5 | The Role of Swine in the Generation of Novel Influenza Viruses 显示文摘 | Ma W Lager K M Vincent A L | 2009 | Zoonoses Public Health2009，20，： | 1 |
| 6 | Very low birth weight newborns do not need repeat screening for congenital hypothyroidism显示文摘 | Rodd C Dussault JH | 2002 | J Pediatr2002，140，3： | 1 |
| 7 | Preparation and Luminescence of New Nd3 ~ Doped Chlore-sulphide Glass-ceramics 显示文摘 | Vincent S Ma H L Zhang X H et 81 | 2006 | Optical Materials2006，29，： | 1 |
| 8 | Characterization of a newly emerged genetic cluster of HINI and HIN2 swine influenza virus in the United States显示文摘 | Vincent A L Ma W Lager K M | 2009 | Virus Genes2009，39，2： | 1 |
| 9 | Molecular and physiologic actions of insulin related to production of nitric oxide in vascular endothelium显示文摘 | VINCENT MA MONTAGNANI M QUON MJ | 2003 | Curr Diab Rep2003，，3： | 1 |
| 10 | Swine influenza viruses a North American perspective显示文摘 | Vincent AL Ma W Lager KM | 2008 | Adv Virus Res2008，72，： | 1 |
| 11 | Antiviral amento- avone from Selaginella sinensis显示文摘 | MA S C HE Y H VINCENT E O | 2001 | Biol Pharm Bull2001，24，3： | 1 |
| 12 | Constructing collaborative desktop storage caches for large scientific datasets显示文摘 | Vazhkudai S S MA Xiao-song Vincent W | 2006 | ACM Transactions on Storage2006，2，3： | 1 |
| 13 | Vascular recruitment in skeletal muscle during exercise and hyperinsulinemia assessed by contrast ultrasound显示文摘 | Dawson D Vincent MA Barrett EJ | | 0，，： | 1 |
| 14 | Inhibiting NOS blocks microvascular recruitment and blunts muscle glucose uptake in response to insulin显示文摘 | Vincent MA Barrett EJ Lindner JR | 2003 | Am J Physiol Endocrinol Metab2003，285，1： | 1 |
| 15 | Cerium oxide nanoparticle-induced pulmonary inflammation and alveolar macrophage functional change in rats显示文摘 | Jane Y. Ma Hongwen Zhao Robert R. Mercer Mark Barger Murali Rao Terence Meighan Diane Schwegler-Berry Vincent Castranova Joseph K. Ma | 2011 | Nanotoxicology2011，，3： | 1 |
| 16 | Evaluation of hemagglutinin subtype 1 swine influenza viruses from the United States显示文摘 | Vincent AL Lager KM Ma W | 2006 | Vet Microbiol2006，118，34： | 1 |
| 17 | Corrosion behavior of NiTi alloy in fetal bovine serum显示文摘 | Ruiqiang Hang Shengli Ma Vincent Ji Paul K. Chu | 2010 | Electrochimica Acta2010，，20： | 1 |
| 18 | Aurone derivatives as Vps34 inhibitors that modulate autophagy显示文摘We report in this study the identification of a natural product-like antagonist(1a) of Vps34 as a potent autophagy modulator via structure-based virtual screening. Aurone derivative 1a strongly inhibited Vps34 activity in cell-free and cell-based assays. Significantly, 1a prevents autophagy in human cells induced either by starvation or by an mT OR inhibitor. In silico modeling and kinetic data revealed that 1a could function as an ATP-competitive inhibitor of Vps34. Moreover, it suppressed autophagy in vivo and without inducing heart or liver damage in mice. 1a could be utilized as a new motif for more selective and efficacious antagonists of Vps34 for the potential treatment of autophagy-related human diseases. | Guodong Li Joshua William Boyle Chung-Nga Ko Wu Zeng Vincent Kam Wai Wong Jian-Bo Wan Philip Wai Hong Chan Dik-Lung Ma Chung-Hang Leung | 2019 | Acta Pharmaceutica Sinica B2019，9，3： | 1 |
| 19 | Lupeol targets liver tumor‐initiating cells through phosphatase and tensin homolog modulation显示文摘 | Terence Kin Wah Lee Antonia Castilho Vincent Chi Ho Cheung Kwan Ho Tang Stephanie Ma Irene Oi Lin Ng | 2011 | Hepatology2011，，1： | 1 |
| 20 | Evaluation of hemagglutinin subtype 1 swine influenza viruses from the United States 显示文摘 | Vincent A L Lager K M Ma W | 2006 | Vet Microbiol2006，118，34： | 1 |
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