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| 1 | Dietary encapsulated essential oils and organic acids mixture improves gut health in broiler chickens challenged with necrotic enteritis显示文摘Background:The poultry industry is in need of effective antibiotic alternatives to control outbreaks of necrotic enteritis(NE)due to Clostridium perfringens.In the present study,we investigated the effects of dietary supplementation with a blend of encapsulated essential oils and organic acids(BLJ)on growth performance and gut health using a coinfection model of NE in broiler chickens.Methods:Two hundred and eighty-eight one-day-old male Arbor Acres broiler chicks were randomly assigned using a 2×2 factorial design into two groups fed either 0 or 500 mg/kg dietary BLJ and co-challenged(or not challenged for the control)with Eimeria spp./C.perfringens.Results:Infected birds fed the BLJ-supplemented diet exhibited an improved feed conversion ratio throughout the trial(P<0.01),a higher villus height and villus height/crypt depth ratio,and reduced intestinal C.perfringens counts,liver C.perfringens carriage,gut lesion scores and serum fluorescein isothiocyanate dextran(FITC-D)concentrations at 7 d postinfection compared with those of birds without BLJ supplementation(P<0.05).NE-infected birds fed BLJ exhibited significantly upregulated claudin-1 and IGF-2 mRNA levels(P<0.05),increased A20 mRNA expression and significantly downregulated TRAF-6,TNFSF15 and TOLLIP mRNA levels in the jejunum at 7 d post-infection compared with those in birds without BLJ supplementation(P<0.05).Compared with the uninfected and untreated birds,the uninfected birds fed BLJ displayed increased relative abundances of Lactobacillus and Coprococcus but reduced Rikenellaceae levels.Compared with the unsupplemented NE-challenged birds,infected birds fed BLJ showed an increased relative abundance of Unclassified_Lachnospiraceae and a significantly decreased relative abundance of Erysipelotrichaceae.Conclusion:BLJ supplementation improved growth performance and gut health in NE-infected broiler chickens by strengthening the intestinal barrier function,positively modulating the gut microbiota community and differentially regulating intestinal immune responses.Our results also suggested that adding BLJ effectively controlled NE infections after experimental Eimeria and Clostridium perfringens coinfection. | Van Hieu Pham Liugang Kan Jinyu Huang Yanqiang Geng Wenrui Zhen Yuming Guo Waseem Abbas Zhong Wang | 2020 | Journal of Animal Science and Biotechnology2020，11，3： | 8 |
| 2 | Application of GIS and Modelling in Health Risk Assess- ment for Urban Road Mobility 显示文摘 | Van - Hieu Vu Xuan - Quynh Le Ngoc - Ho Pham | 2013 | Environmental Science and Pollution Research2013，20，8： | 1 |
| 3 | Synthesis of febrifuginol analogues and evaluation of their biological activities显示文摘 | Huong Doan Thi Mai Giang Vo Thanh Van Hieu Tran Van Nam Vu Van Loi Vu Bich Ngan Truong Thi Dao Phi Van Minh Chau Van Cuong Pham | 2014 | Tetrahedron Letters2014，，52： | 1 |
| 4 | Vulnerability to Flood in the Vietnamese Mekong Delta: Mapping and Uncertainty Assessment显示文摘 | Van Pham Dang Tri Nguyen Hieu Trung Vo Quoc Thanh | 2013 | Journal of Environmental Science and Engineering(B)2013，2，4： | 0 |
| 5 | Deep learning long short-term memory combined with discrete element method for porosity prediction in gravel-bed rivers显示文摘The porosity of gravel riverbed material often is an essential parameter to estimate the sediment transport rate,groundwater-river flow interaction,river ecosystem,and fluvial geomorphology.Current methods of porosity estimation are time-consuming in simulation.To evaluate the relation between porosity and grain size distribution(GSD),this study proposed a hybrid model of deep learning Long Short-Term Memory(LSTM)combined with the Discrete Element Method(DEM).The DEM is applied to model the packing pattern of gravel-bed structure and fine sediment infiltration processes in threedimensional(3D)space.The combined approaches for porosity calculation enable the porosity to be determined through real time images,fast labeling to be applied,and validation to be done.DEM outputs based on the porosity dataset were utilized to develop the deep learning LSTM model for predicting bed porosity based on the GSD.The simulation results validated with the experimental data then segregated into 800 cross sections along the vertical direction of gravel pack.Two DEM packing cases,i.e.,clogging and penetration are tested to predict the porosity.The LSTM model performance measures for porosity estimation along the z-direction are the coefficient of determination(R^(2)),root mean squared error(RMSE),and mean absolute error(MAE)with values of 0.99,0.01,and 0.01 respectively,which is better than the values obtained for the Clogging case which are 0.71,0.14,and 0.03,respectively.The use of the LSTM in combination with the DEM model yields satisfactory results in a less complex gravel pack DEM setup,suggesting that it could be a viable alternative to minimize the simulation time and provide a robust tool for gravel riverbed porosity prediction.The simulated results showed that the hybrid model of the LSTM combined with the DEM is reliable and accurate in porosity prediction in gravel-bed river test samples. | Duong Tran Anh Ahad Hasan Tanim Daniel Prakash Kushwaha Quoc Bao Pham Van Hieu Bui | 2023 | International Journal of Sediment Research2023，38，1： | 0 |
| 6 | Dietary coated essential oil and organic acid mixture supplementation improves health of broilers infected with avian pathogenic Escherichia coli显示文摘Colibacillosis caused by avian pathogenic Escherichia coli(APEC)is a very prevalent disease in poultry farms in China.The exploration of effective non-antibiotic substances is of great significance for the control of APEC infections.This experiment evaluated the efficacy of coated essential oil and organic acid(EOA)supplementation to prevent E.coli O78 infection in broiler chickens.A total of 288 one-day-old male broiler chicks were randomly distributed into 4 groups with 6 replicates per group.Chickens were fed a diet either supplemented with EOA(500 mg/kg feed)or not,and either uninfected or infected with E.coli O78 intratracheally.Results showed that E.coli O78 infection reduced body weight gain,increased mortality and the ratio of feed to gain along with cecal and liver E.coli load,damaged gut mucosa,induced local and systemic inflammation,and altered cecal microbial composition,diversity and function(P<0.05).Supplemental EOA improved feed conversion efficiency,lowered gross lesion scores and cecal E.coli population,enhanced intestinal goblet cells and serum IgG concentration,and tended to decrease serum IL-12 production(P<0.05).Essential oil and organic acid addition downregulated IFN-γmRNA,tended to decrease mucin-2 mRNA levels while upregulating IL-10 mRNA,and tended to increase ZO-1 gene expression in the jejuna of infected birds at 7 d after E.coli O78 challenge(P<0.05).The 16S rRNA gene sequencing indicated that both EOA addition and E.coli O78 challenge altered the diversity and composition of the cecal microbiota community.Furthermore,infected birds fed EOA showed decreased Bacteroidetes and genus Lactobacillus abundance compared with the infected control.LEfSe analysis showed that Firmicutes,Ruminococcaceae,Clostridiales,Clostridia,Lactobacillus,Lactobacilaceae,and cc-115 were enriched in the non-infected but EOA-treated group(P<0.05).Collectively,dietary EOA supplementation could mildly alleviate E.coli-induced gut injury and inflammation. | Van Hieu Pham Waseem Abbas Jinyu Huang Fangshen Guo Kaichen Zhang Linhua Kong Wenrui Zhen Yuming Guo Zhong Wang | 2023 | Animal Nutrition2023，，1： | 0 |
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