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| 1 | 间歇性血流限制不能减少前十字韧带重建后萎缩(英文)显示文摘Background:A previous study has reported a 50% reduction in disuse atrophy of the quadriceps during the first 14 days after anterior cruciate ligament(ACL) reconstruction.A follow-up trial is needed to confirm these promising results.The present study aims to investigate the effect of an occlusion stimulus on quadriceps atrophy after ACL reconstruction.Methods:A total of 24 subjects participated in the study.They were randomized into two groups.Starting the 2nd day after surgery,the occlusion group received an occlusion stimulus for 5 min,followed by removal of the occlusive pressure for 3 min.This was repeated five times in one training session,twice daily.During the period of occlusive stimulus,the subjects performed 20 low load exercises for the quadriceps.The control group followed the same exercise protocol,but without the occlusion stimulus.Changes in quadriceps anatomical cross section area(ACSA) were measured using axial magnetic resonance(MR) images at 40% and 50% of the length of the femur.Results:Both groups had a significant reduction of quadriceps ACSA from 2 days before surgery to 16 days after surgery.During the intervention period,the occlusion group lost 13.8% ± 1.1%(mean ± SEM) and the control group lost 13.1% ± 1.0% of their quadriceps ACSA,respectively.There was no significant difference between the occlusion and control groups with regards to atrophy of the quadriceps muscles.Conclusion:In conflict with other studies using a similar protocol,application of blood flow restriction the first 14 days after ACL reconstruction did not reduce quadriceps ACSA muscle atrophy measured by MR in a population of athletes. | Erik Iversen Vibeke Rostad Arne Larmo | 2016 | Journal of Sport and Health Science2016，5，1： | 11 |
| 2 | Novel understanding of ABC transporters ABCB1/MDR/P-glycoprotein, ABCC2/MRP2, and ABCG2/BCRP in colorectal pathophysiology显示文摘AIM: To evaluate ATP-binding cassette(ABC) transporters in colonic pathophysiology as they had recently been related to colorectal cancer(CRC) development. METHODS: Literature search was conducted on Pub Med using combinations of the following terms: ABC transporters, ATP binding cassette transporter proteins, inflammatory bowel disease, ulcerative, colitis, Crohns disease, colorectal cancer, colitis, intestinal inflammation, intestinal carcinogenesis, ABCB1/P-glycoprotein(P-gp/CD243/MDR1), ABCC2/multidrug resistance protein 2(MRP2) and ABCG2/breast cancer resistance protein(BCRP), Abcb1/Mdr1 a, abcc2/Mrp2, abcg2/Bcrp, knock-out mice, tight junction, membrane lipid function. RESULTS: Recently, human studies reported thatchanges in the levels of ABC transporters were early events in the adenoma-carcinoma sequence leading to CRC. A link between ABCB1, high fat diet and gut microbes in relation to colitis was suggested by the animal studies. The finding that colitis was preceded by altered gut bacterial composition suggests that deletion of Abcb1 leads to fundamental changes of hostmicrobiota interaction. Also, high fat diet increases the frequency and severity of colitis in specific pathogenfree Abcb1 KO mice. The Abcb1 KO mice might thus serve as a model in which diet/environmental factors and microbes may be controlled and investigated in relation to intestinal inflammation. Potential molecular mechanisms include defective transport of inflammatory mediators and/or phospholipid translocation from one side to the other of the cell membrane lipid bilayer by ABC transporters affecting inflammatory response and/or function of tight junctions, phagocytosis and vesicle trafficking. Also, diet and microbes give rise to molecules which are potential substrates for the ABC transporters and which may additionally affect ABC transporter function through nuclear receptors and transcriptional regulation. Another critical role of ABCB1 was suggested by the finding that ABCB1 expression identifies a subpopulation of pro-inflammatory Th17 cells which were resistant to treatment with glucocorticoids. The evidence for the involvement of ABCC2 and ABCG2 in colonic pathophysiology was weak. CONCLUSION: ABCB1, diet, and gut microbes mutually interact in colonic inflammation, a well-known risk factor for CRC. Further insight may be translated into preventive and treatment strategies. | Vibeke Andersen Katrine Svenningsen Lina Almind Knudsen Axel Kornerup Hansen Uffe Holmskov Allan Stensballe Ulla Vogel | 2015 | World Journal of Gastroenterology2015，21，41： | 10 |
| 3 | Biomarkers in inflammatory bowel diseases:Current status and proteomics identification strategies显示文摘Unambiguous diagnosis of the two main forms of inflammatory bowel diseases(IBD):Ulcerative colitis(UC)and Crohn’s disease(CD),represents a challenge in the early stages of the diseases.The diagnosis may be established several years after the debut of symptoms.Hence,protein biomarkers for early and accurate diagnostic could help clinicians improve treatment of the individual patients.Moreover,the biomarkers could aid physicians to predict disease courses and in this way,identify patients in need of intensive treatment.Patients with low risk of disease flares may avoid treatment with medications with the concomitant risk of adverse events.In addition,identification of disease and course specific biomarker profiles can be used to identify biological pathways involved in the disease development and treatment.Knowledge of disease mechanisms in general can lead to improved future development of preventive and treatment strategies.Thus,the clinical use of a panel of biomarkers represents a diagnostic and prognostic tool of potentially great value.The technological development in recent years within proteomic research(determination and quantification of the complete protein content)has made the discovery of novel biomarkers feasible.Several IBD-associated protein biomarkers are known,but none have been successfully implemented in daily use to distinguish CD and UC patients.The intestinal tissue remains an obvious place to search for novel biomarkers,which blood,urine or stool later can be screened for.When considering the protein complexity encountered in intestinal biopsysamples and the recent development within the field of mass spectrometry driven quantitative proteomics,a more thorough and accurate biomarker discovery endeavor could today be performed than ever before.In this review,we report the current status of the proteomics IBD biomarkers and discuss various emerging proteomic strategies for identifying and characterizing novel biomarkers,as well as suggesting future targets for analysis. | Tue Bennike Svend Birkelund Allan Stensballe Vibeke Andersen | 2014 | World Journal of Gastroenterology2014，20，12： | 9 |
| 4 | Polymorphisms in NF-κB,PXR,LXR,PPARγ and risk of inflammatory bowel disease显示文摘AIM:To investigate the contribution of polymorphisms in nuclear receptors to risk of inflammatory bowel disease(IBD) . METHODS:Genotypes of nuclear factor(NF) -κB(NFKB1) NFκB-94ins/del(rs28362491) ;peroxisome proliferatoractivated receptor(PPAR) -γ(PPARγ) PPARγPro12Ala(rs1801282) and C1431T(rs 3856806) ;pregnane X receptor(PXR) (NR1I2) PXR A-24381C(rs1523127) ,C8055T(2276707) ,and A7635G(rs 6785049) ;and liver X receptor(LXR) (NR1H2) LXR T-rs1405655-C and T-rs2695121-C were assessed in a Danish case-control study of 327 Crohn's disease patients,495 ulcerative colitis(UC) patients,and 779 healthy controls.Odds ratio(OR) and 95%CI were estimated by logistic regression models. RESULTS:The PXR A7635G variant,the PPARγPro12Ala and LXR T-rs2695121-C homozygous variant genotypes were associated with risk of UC(OR:1.31,95% CI:1.03-1.66,P=0.03,OR:2.30,95%CI:1.04-5.08,P=0.04,and OR:1.41,95%CI:1.00-1.98,P=0.05,respectively) compared to the corresponding homozygous wild-type genotypes.Among never smokers,PXR A7635G and the LXR T-rs1405655-C and T-rs2695121-C variant genotypes were associated with risk of IBD(OR:1.41,95%CI:1.05-1.91,P=0.02,OR:1.63,95%CI:1.21-2.20,P=0.001,and OR:2.02,95%CI:1.36-2.99,P=0.0005,respectively) compared to the respective homozygous variant genotypes.PXR A7635G(rs6785049) variant genotype was associated with a higher risk of UC diagnosis before the age of 40 years and with a higher risk of extensive disease(OR:1.34,95%CI:1.03-1.75 and OR:2.49,95%CI:1.24-5.03,respectively) . CONCLUSION:Common PXR and LXR polymorphisms may contribute to risk of IBD,especially among never smokers. | Vibeke Andersen Jane Christensen Anja Ernst Bent A Jacobsen Anne Tjφnneland Henrik B Krarup Ulla Vogel | 2011 | World Journal of Gastroenterology2011，17，2： | 4 |
| 5 | Efficacy and safety of granulocyte, monocyte/macrophage adsorptive in pediatric ulcerative colitis显示文摘AIM: To investigate efficacy and safety for granulocyte, monocyte apheresis in a population of pediatric patients with ulcerative colitis.METHODS: The ADAPT study was a prospective, openlabel, multicenter study in pediatric patients with moderate, active ulcerative colitis with pediatric ulcerative colitis activity index(PUCAI) of 35-64. Patients received one weekly apheresis with Adacolumn granulocyte, monocyte/macrophage adsorptive(GMA) apheresis over 5 consecutive weeks, optionally followed by up to 3 additional apheresis treatments over 3 consecutive weeks. The primary endpoint was the change in mean PUCAI between baseline and week 12; the secondary endpoint was improvement in PUCAI categorized as(Significant Improvement, PUCAI decrease of ≥ 35), Moderate Improvement(PUCAI decrease of 20 < 35), Small Improvement(PUCAI decrease of 10 < 20) or No change(PUCAI decrease of < 10). RESULTS: Twenty-five patients(mean age 13.5 years; mean weight 47.7 kg) were enrolled. In the intention-to-treat set(ITT), the mean value for PUCAI improvement was 22.3 [95%CI: 12.9-31.6; n = 21]. In the per-protocol(PP) set, the mean improvement was 36.3 [95%CI: 31.4-41.1; n = 8]. Significant Improvement was recorded for 9 out of 20 patients(45%); 5 out of 20 patients(25%) had Moderate Improvement and one patient(5%) had No Change in PUCAI score at week 12. In the PP set, six out of eight patients(75%) showed Significant Improvement; and in two out of eight patients(25%) Moderate Improvement was recorded. The endoscopic activity index(EAI) decreased by 3 points on average. Seven(7) out of 21(33%) patients in ITT and 4 out of 8(50%) patients in PP have used steroids during the clinical investigation. The mean steroid dosage for these patients in the ITT set decreased from a mean 12.4 mg to 10 mg daily on average from Baseline to week 12.CONCLUSION: Adacolumn; GMA apheresis treatment was effective in pediatric patients with moderate active Ulcerative Colitis. No new safety signals were reported. The present data contribute to considering GMA apheresis as a therapeutic option in pediatric patients having failed first line therapy. | Tarja Ruuska Peter Küster Lena Grahnquist Fredrik Lindgren Anne Vibeke Wewer | 2016 | World Journal of Gastroenterology2016，22，17： | 3 |
| 6 | Aroma development in high pressure treated beef and chicken meat compared to raw and heat treated显示文摘 | Sabrina Schindler Ulrich Krings Ralf G. Berger Vibeke Orlien | 2010 | Meat Science2010，，2： | 2 |
| 7 | Serum tumor markers and PET/CT imaging for tumor recurrence detection显示文摘 | Vibeke Kruse Veronique Cocquyt Marleen Borms Alex Maes Christophe Wiele | 2013 | Annals of Nuclear Medicine2013，，2： | 2 |
| 8 | Colorectal cancer in patients with inflammatory bowel disease:Can we predict risk?显示文摘The inflammatory bowel diseases(IBD),Crohn's disease(CD) and ulcerative colitis(UC),may be complicated by colorectal cancer(CRC).In a recent populationbased cohort study of 47 347 Danish patients with IBD by Tine Jess and colleagues 268 patients with UC and 70 patients with CD developed CRC during 30 years of observation.The overall risk of CRC among patients with UC and CD was comparable with that of the general population.However,patients diagnosed with UC during childhood or as adolescents,patients with long duration of disease and those with concomitant primary sclerosing cholangitis were at increased risk.In this commentary,we discuss the mechanisms underlying carcinogenesis in IBD and current investigations of genetic susceptibility in IBD patients.Further advances will depend on the cooperative work by epidemiologist and molecular geneticists in order to identify genetic polymorphisms involved in IBD-associated CRC.The ultimate goal is to incorporate genotypes and clinical parameters into a predictive model that will refine the prediction of risk for CRC in colonic IBD.The challenge will be to translate these new findings into clinical practice and to determine appropriate preventive strategies in order to avoid CRC in IBD patients.The achieved knowledge may also be relevant for other inflammation-associated cancers. | Vibeke Andersen Jonas Halfvarson Ulla Vogel | 2012 | World Journal of Gastroenterology2012，18，31： | 2 |
| 9 | Environmental factors and risk of developing paediatric inflammatory bowel disease — A population based study 2007–2009显示文摘 | Christian Jakobsen Anders Paerregaard Pia Munkholm Vibeke Wewer | 2012 | Journal of Crohn’s and Colitis2012，，： | 2 |
| 10 | Infliximab Dependency in a National Cohort of Children with Crohn?s Disease显示文摘 | Vibeke Wewer Lene Riis Ida Vind Steffen Husby Pia Munkholm Anders Paerregaard | 2006 | Journal of Pediatric Gastroenterology and Nutrition2006，，1： | 1 |
| 11 | C - reaction protein,early forecast of independent element , increased neck's atherosclerosis rate 显示文摘 | Trine M Helle AS Vibeke EH | 2000 | Circulation2000，104，1： | 1 |
| 12 | Central precocious puberty in girls:Internal genitalia before,during,and after treatment with long-acting gonadotropin-releasing hormone analogues显示文摘 | Anne-Mette Bak Jensen Vibeke Brocks Kirsten Holm | 1998 | J Pediatr1998，132，1： | 1 |
| 13 | Glassy-Cell Carcinoma of the Cervix: Case Report with a Light and Electron Microscopy Study显示文摘 | Stein Meling Paulsen Kristen C. Hansen Vibeke Thue Nielsen | 1980 | Ultrastructural Pathology1980，，3： | 1 |
| 14 | Long-term risk of cancer in ulcerative colitis: A population-based cohort study from Copenhagen County显示文摘 | Karen V. Winther Tine Jess Ebbe Langholz Pia Munkholm Vibeke Binder | 2004 | Clinical Gastroenterology and Hepatology2004，，12： | 1 |
| 15 | Long-term risk of cancer in ulcerative colitis: A population-based cohort study from Copenhagen County显示文摘 | Karen V. Winther Tine Jess Ebbe Langholz Pia Munkholm Vibeke Binder | 2004 | Clinical Gastroenterology and Hepatology2004，，12： | 1 |
| 16 | The role of water in the setting of wool part I: Degree of set显示文摘 | | 1970 | Journal of the Textile Institute1970，，8： | 1 |
| 17 | Endothelin and Von will ebrand Factor as parameters of endothelial function in idiopathic dilated cardiomyopathy:different stimuli for release before and after heart transplantation显示文摘 | Wroblewski H Vibeke BS | 1999 | Am Heart J1999，137，1： | 1 |
| 18 | Endothelin and Von Willebrand factor as parameters of endothelial function in idiopathic dilated cardiomyopathy: different stimuli for release before and after heart transplantation 显示文摘 | Galatius SS Wroblewski H Vibeke BS | 1999 | Am Heart J1999，137，： | 1 |
| 19 | C -Reactive Protein, dietary n- 3 fatty acids and the exent of coronary artery disease 显示文摘 | Trine M Helle AS Vibeke EH | 2001 | Am J Cardio12001，88，10： | 1 |
| 20 | Heritability in Inflammatory Bowel Disease: From the First Twin Study to Genome-Wide Association Studies显示文摘 | Hannah Gordon Frederik Trier Moller Vibeke Andersen Marcus Harbord | 2015 | Inflammatory Bowel Diseases2015，，6： | 1 |
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